Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM95Y82)

• Drug Name: AZ960 Drug Info
• Synonyms: AZ 960; AZ-960
• Cross-matching ID:
  PubChem CID: 25099184
  ChEBI ID: CHEMBL1774055
  CAS Number: CAS 905586-69-8
  TTD Drug ID: D0OP3D

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mucin type O-glycan biosynthesis	1.94	3.86e-2	20/36 (55.56%)	GALNT7;GALNT2;GALNT12;...
Other types of O-glycan biosynthesis	1.93	1.93e-2	29/47 (61.7%)	GALNT7;GALNT2;GALNT12;...
Nucleotide excision repair	-1.74	2.12e-2	40/47 (85.11%)	POLE;RAD23A;LIG1;...
Fanconi anemia pathway	-1.75	2.47e-2	36/54 (66.67%)	POLI;FANCC;REV3L;...
Glycine, serine and threonine metabolism	-1.82	9.90e-3	31/40 (77.5%)	CTH;AGXT;PGAM1;...
Mismatch repair	-1.83	8.84e-3	22/23 (95.65%)	RFC5;MSH6;LIG1;...
Ribosome	-1.91	0.00e+0	113/158 (71.52%)	RPL19;MRPL15;RPS14;...
Cell cycle	-2.01	0.00e+0	110/124 (88.71%)	EP300;BUB1;CCNA1;...
DNA replication	-2.42	0.00e+0	34/36 (94.44%)	POLE;POLA2;LIG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲