Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9QU5Y)

• Drug Name: GSK343 Drug Info
• Synonyms: compound 6 [PMID 24900432]; GSK 343
• Cross-matching ID:
  PubChem CID: 71268957
  ChEBI ID: CHEMBL2204995
  CAS Number: CAS 1346704-33-3
  TTD Drug ID: D02TVQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.47	0.00e+0	19/20 (95%)	MSMO1;DHCR24;SQLE;...
Complement and coagulation cascades	2.38	0.00e+0	76/85 (89.41%)	CLU;TFPI;C7;...
Biosynthesis of unsaturated fatty acids	2.31	0.00e+0	21/27 (77.78%)	SCD;FADS1;FADS2;...
PPAR signaling pathway	2.30	0.00e+0	66/74 (89.19%)	HMGCS1;SCD;CD36;...
Terpenoid backbone biosynthesis	2.25	0.00e+0	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
Phagosome	2.03	1.57e-3	118/152 (77.63%)	CD36;SFTPA2;SFTPD;...
Metabolism of xenobiotics by cytochrome P450	1.95	1.35e-3	49/77 (63.64%)	ADH1B;AKR1C1;CYP1B1;...
Cholesterol metabolism	1.91	4.72e-3	44/50 (88%)	CD36;LDLR;LPL;...
Glutathione metabolism	1.86	7.34e-3	43/57 (75.44%)	GPX3;G6PD;IDH1;...
Steroid hormone biosynthesis	1.84	1.23e-2	43/61 (70.49%)	AKR1C2;AKR1C1;CYP1B1;...
Ovarian steroidogenesis	1.84	1.12e-2	41/51 (80.39%)	CYP1B1;AKR1C3;LDLR;...
Synthesis and degradation of ketone bodies	1.83	1.10e-2	9/10 (90%)	HMGCS1;ACAT2
Fatty acid biosynthesis	1.82	1.09e-2	16/18 (88.89%)	FASN;ACSL1;ACSL3;...
Lysosome	1.77	2.29e-2	115/128 (89.84%)	NEU1;LIPA;NPC1;...
AMPK signaling pathway	1.73	2.96e-2	106/120 (88.33%)	SCD;CD36;FASN;...
Bladder cancer	-2.09	1.08e-2	40/41 (97.56%)	CDKN1A;MAP2K2;DAPK3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲