Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9SKW8)

Drug Name
Capivasertib Drug Info
Synonyms
AZD5363; 1143532-39-1; AZD-5363; capivasertib; AZD 5363; UNII-WFR23M21IE; WFR23M21IE; cc-638; 4-Amino-N-[(1s)-1-(4-Chlorophenyl)-3-Hydroxypropyl]-1-(7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)piperidine-4-Carboxamide; C21H25ClN6O2; (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE; 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide; 4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1
Cross-matching ID
PubChem CID
25227436
ChEBI ID
CHEMBL2325741
CAS Number
CAS 1143532-39-1
TTD Drug ID
D01ZAQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.24 0.00e+0 34/36 (94.44%) LIG1;MCM5;PRIM1;...
Mismatch repair 2.17 0.00e+0 22/23 (95.65%) LIG1;MSH2;MSH6;...
Homologous recombination 1.92 5.33e-3 35/41 (85.37%) BRCA1;RPA3;TOPBP1;...
Cell cycle 1.88 6.66e-3 110/124 (88.71%) CDKN1B;WEE1;MYC;...
Fanconi anemia pathway 1.81 1.28e-2 36/54 (66.67%) BRCA1;FANCL;FANCI;...
Nucleotide excision repair 1.80 1.24e-2 40/47 (85.11%) LIG1;POLE2;CUL4B;...
MicroRNAs in cancer 1.72 2.59e-2 146/310 (47.1%) IRS2;SPRY2;CDKN1B;...
Base excision repair 1.71 2.47e-2 29/33 (87.88%) LIG1;POLE2;PCNA;...
D-Glutamine and D-glutamate metabolism 1.65 4.50e-2 5/5 (100%) DGLUCY;GLUD1;GLUD2
Spliceosome 1.64 4.48e-2 101/150 (67.33%) HSPA2;RBM8A;SF3A2;...
Pathways of neurodegeneration -1.64 3.75e-2 354/475 (74.53%) BID;CYBB;DCTN6;...
TNF signaling pathway -1.64 3.65e-2 103/112 (91.96%) NOD2;CSF1;CASP10;...
Viral protein interaction with cytokine and cytokine re... -1.66 3.31e-2 84/100 (84%) CCL4;CXCR5;IL2RA;...
Glycine, serine and threonine metabolism -1.66 3.27e-2 31/40 (77.5%) PSPH;ALAS1;MAOA;...
Central carbon metabolism in cancer -1.67 3.28e-2 67/70 (95.71%) MTOR;NRAS;SCO2;...
Fat digestion and absorption -1.68 3.12e-2 35/43 (81.4%) PLA2G3;PLPP1;PLA2G1B;...
Folate biosynthesis -1.74 1.90e-2 23/26 (88.46%) QDPR;ALPP;GCH1;...
Protein export -1.75 1.53e-2 17/23 (73.91%) SRP54;SEC61A2;SEC61G;...
Spinocerebellar ataxia -1.76 1.54e-2 128/143 (89.51%) PLCB3;ADRM1;PSMB6;...
Rheumatoid arthritis -1.80 9.10e-3 78/93 (83.87%) ATP6V1F;ATP6V0A1;CTSL;...
Staphylococcus aureus infection -1.86 6.61e-3 72/95 (75.79%) HLA-DMB;ICAM1;KRT14;...
Amino sugar and nucleotide sugar metabolism -1.86 6.19e-3 38/48 (79.17%) GNPDA1;FPGT;HK3;...
Steroid hormone biosynthesis -1.90 3.27e-3 43/61 (70.49%) STS;UGT2B17;COMT;...
Galactose metabolism -1.92 2.59e-3 26/31 (83.87%) HK3;B4GALT1;GALK1;...
Parkinson disease -1.93 2.76e-3 176/249 (70.68%) COX8A;NDUFA10;VDAC2;...
Pertussis -1.93 2.94e-3 64/76 (84.21%) NOS2;C1S;TNF;...
Glutathione metabolism -1.94 2.10e-3 43/57 (75.44%) GSTA4;SRM;GPX2;...
IL-17 signaling pathway -1.98 0.00e+0 84/94 (89.36%) IL17A;CSF3;FADD;...
Prion disease -1.99 0.00e+0 209/273 (76.56%) CREB3L2;CYBB;COX8A;...
Toll-like receptor signaling pathway -2.01 0.00e+0 94/104 (90.38%) MAP2K1;MAP2K4;MAPK14;...
Biosynthesis of unsaturated fatty acids -2.02 0.00e+0 21/27 (77.78%) ELOVL1;SCD5;ACOX1;...
Arginine and proline metabolism -2.02 0.00e+0 39/50 (78%) CNDP2;SRM;CKM;...
Ferroptosis -2.05 0.00e+0 36/41 (87.8%) SAT1;ATG5;CYBB;...
Citrate cycle (TCA cycle) -2.06 0.00e+0 30/30 (100%) IDH3G;IDH3B;MDH2;...
Legionellosis -2.16 0.00e+0 51/57 (89.47%) TLR2;ARF1;TLR5;...
Fructose and mannose metabolism -2.20 0.00e+0 30/33 (90.91%) FPGT;HK3;PMM2;...
Glycolysis / Gluconeogenesis -2.22 0.00e+0 56/67 (83.58%) ALDOB;PKM;BPGM;...
Steroid biosynthesis -2.26 0.00e+0 19/20 (95%) SOAT1;EBP;TM7SF2;...
Protein processing in endoplasmic reticulum -2.32 0.00e+0 127/171 (74.27%) HERPUD1;CALR;TRAM1;...
Proteasome -2.32 0.00e+0 44/46 (95.65%) PSME3;PSMC3;PSMD6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H