Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM9SY8E)

Drug Name
PT630 Drug Info
Cross-matching ID
PubChem CID
11673176
TTD Drug ID
D7K0GP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.30 0.00e+0 34/36 (94.44%) RFC3;SSBP1;POLE2;...
Cell cycle 2.28 0.00e+0 110/124 (88.71%) CCNB1;CDC20;PLK1;...
Spliceosome 2.26 0.00e+0 101/150 (67.33%) HSPA8;DDX42;SRSF1;...
Ribosome biogenesis in eukaryotes 2.06 0.00e+0 52/108 (48.15%) RPP40;IMP3;POP5;...
Mismatch repair 1.94 2.44e-3 22/23 (95.65%) RFC3;SSBP1;MSH2;...
RNA transport 1.91 2.03e-3 128/186 (68.82%) NUP85;EIF2S3;RPP40;...
Fanconi anemia pathway 1.86 3.49e-3 36/54 (66.67%) REV1;CENPX;RMI1;...
Oocyte meiosis 1.77 1.60e-2 90/129 (69.77%) CCNB1;CDC20;PLK1;...
RNA degradation 1.68 4.34e-2 53/79 (67.09%) EXOSC4;LSM6;LSM3;...
mRNA surveillance pathway 1.68 4.27e-2 71/98 (72.45%) PPP2R3C;SRRM1;CPSF6;...
Nitrogen metabolism 1.66 4.49e-2 16/17 (94.12%) CA2;GLUD2;GLUD1;...
Base excision repair 1.64 4.83e-2 29/33 (87.88%) POLE2;POLE3;NEIL3;...
RNA polymerase 1.64 4.74e-2 23/31 (74.19%) POLR3K;POLR2K;POLR2D;...
Type I diabetes mellitus -1.66 2.66e-2 38/43 (88.37%) LTA;GAD2;FASLG;...
Autophagy -1.66 2.60e-2 113/169 (66.86%) TSC2;TBK1;RRAS;...
Parathyroid hormone synthesis, secretion and action -1.67 2.59e-2 98/106 (92.45%) ADCY7;CREB3L2;MMP13;...
Estrogen signaling pathway -1.67 2.63e-2 119/137 (86.86%) PIK3CA;HBEGF;ADCY9;...
NF-kappa B signaling pathway -1.68 2.57e-2 90/104 (86.54%) CD40LG;TNFRSF1A;TNFSF14;...
Phagosome -1.70 2.11e-2 118/152 (77.63%) HLA-B;RAC1;ATP6V1F;...
Viral protein interaction with cytokine and cytokine re... -1.71 2.13e-2 84/100 (84%) CXCR1;LTA;PF4;...
Other glycan degradation -1.71 2.17e-2 13/18 (72.22%) HEXA;MANBA;MAN2B1;...
Antigen processing and presentation -1.71 2.26e-2 60/78 (76.92%) KIR2DL1;KIR2DS4;HLA-A;...
Malaria -1.72 2.24e-2 44/50 (88%) IL6;KLRK1;THBS3;...
Th17 cell differentiation -1.72 2.28e-2 95/107 (88.79%) TGFBR1;TBX21;ZAP70;...
Allograft rejection -1.76 1.50e-2 32/38 (84.21%) FASLG;HLA-A;IFNG;...
Pertussis -1.77 1.19e-2 64/76 (84.21%) MAPK13;RELA;C3;...
Cytokine-cytokine receptor interaction -1.77 1.09e-2 246/295 (83.39%) CXCR1;LTA;PRLR;...
Asthma -1.78 1.07e-2 25/31 (80.65%) PRG2;CCL11;TNF;...
Autoimmune thyroid disease -1.80 6.64e-3 46/53 (86.79%) FASLG;HLA-A;TPO;...
Non-small cell lung cancer -1.82 5.08e-3 70/72 (97.22%) PIK3CA;PLCG2;TP53;...
Steroid biosynthesis -1.83 4.38e-3 19/20 (95%) FDFT1;HSD17B7;SC5D;...
Bladder cancer -1.84 4.74e-3 40/41 (97.56%) MMP2;MMP1;HBEGF;...
Inflammatory bowel disease -1.85 5.17e-3 58/65 (89.23%) IL12RB1;RORC;HLA-DRA;...
Leishmaniasis -1.85 5.69e-3 67/77 (87.01%) FCGR3B;NFKBIB;HLA-DMB;...
Th1 and Th2 cell differentiation -1.85 6.32e-3 80/92 (86.96%) TBX21;ZAP70;STAT6;...
Hematopoietic cell lineage -1.87 7.11e-3 90/99 (90.91%) CSF1R;CD34;CD4;...
TNF signaling pathway -1.94 2.03e-3 103/112 (91.96%) CXCL10;CREB3L2;TNFRSF1A;...
IL-17 signaling pathway -1.96 2.37e-3 84/94 (89.36%) TRAF3IP2;CXCL10;MAPK14;...
Rheumatoid arthritis -1.99 0.00e+0 78/93 (83.87%) HLA-DMB;HLA-DQB1;CXCL2;...
Graft-versus-host disease -2.05 0.00e+0 32/42 (76.19%) KIR2DL1;FASLG;HLA-A;...
Mitophagy -2.06 0.00e+0 56/68 (82.35%) TFEB;RHOT2;TBK1;...
Lysosome -2.21 0.00e+0 115/128 (89.84%) AP1B1;MAN2B1;FUCA1;...
Staphylococcus aureus infection -2.29 0.00e+0 72/95 (75.79%) KRT33B;FGG;FCGR3B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H