Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA14PR)

Drug Name
TPCA-1 Drug Info
Synonyms TPCA1
Cross-matching ID
PubChem CID
9903786
ChEBI ID
CHEMBL91403
CAS Number
CAS 507475-17-4
TTD Drug ID
D0E0XV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.38 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
Cysteine and methionine metabolism 2.24 0.00e+0 43/50 (86%) PSAT1;PHGDH;CBS;...
Ribosome 2.18 0.00e+0 113/158 (71.52%) RSL24D1;RPS27L;RPL26L1;...
Alanine, aspartate and glutamate metabolism 2.09 1.78e-3 27/37 (72.97%) ASNS;ASS1;GOT1;...
Arginine biosynthesis 2.00 4.28e-3 17/22 (77.27%) ASS1;GOT1;ARG2;...
Pantothenate and CoA biosynthesis 1.90 9.52e-3 14/21 (66.67%) ALDH2;BCAT1;AASDHPPT;...
Protein export 1.86 1.33e-2 17/23 (73.91%) SRPRB;SEC63;SPCS3;...
Proximal tubule bicarbonate reclamation 1.77 2.77e-2 21/23 (91.3%) PCK2;CA2;GLUD2;...
Valine, leucine and isoleucine degradation 1.75 3.09e-2 42/48 (87.5%) ALDH2;BCAT1;ALDH6A1;...
One carbon pool by folate 1.75 2.78e-2 15/20 (75%) MTHFD2;SHMT2;MTHFD2L;...
Protein processing in endoplasmic reticulum 1.71 3.96e-2 127/171 (74.27%) HERPUD1;DDIT3;ATF4;...
Pathways in cancer -1.87 1.59e-3 474/531 (89.27%) MMP2;WNT7A;DAPK1;...
Chemokine signaling pathway -1.88 1.64e-3 163/192 (84.9%) CCL19;GNB2;CCL21;...
Yersinia infection -1.88 1.70e-3 120/137 (87.59%) FYB1;MAPK1;MAP2K2;...
HIF-1 signaling pathway -1.88 1.76e-3 105/109 (96.33%) EP300;PLCG2;PFKP;...
Kaposi sarcoma-associated herpesvirus infection -1.89 1.42e-3 172/193 (89.12%) GNB2;E2F1;CXCL2;...
Human papillomavirus infection -1.92 9.83e-4 284/331 (85.8%) ATP6V0D1;LAMA2;ATP6V0B;...
Toll-like receptor signaling pathway -1.92 1.02e-3 94/104 (90.38%) MAPK11;IFNAR2;IKBKG;...
Epithelial cell signaling in Helicobacter pylori infect... -1.93 1.07e-3 62/70 (88.57%) PAK1;ATP6V0D1;CSK;...
Small cell lung cancer -1.93 1.12e-3 90/92 (97.83%) E2F3;CDK6;NOS2;...
Fructose and mannose metabolism -1.95 1.17e-3 30/33 (90.91%) PFKP;PFKFB4;PFKM;...
Chagas disease -1.96 6.15e-4 93/102 (91.18%) IFNGR2;TNF;RELA;...
Toxoplasmosis -1.96 6.47e-4 103/112 (91.96%) HLA-DRB1;LAMA2;BAD;...
Cytokine-cytokine receptor interaction -1.98 6.83e-4 246/295 (83.39%) CCL21;TNFSF9;CXCL2;...
Amoebiasis -1.98 7.23e-4 99/102 (97.06%) C9;COL4A3;CXCL2;...
Pentose phosphate pathway -1.99 7.68e-4 25/30 (83.33%) PRPS2;G6PD;RGN;...
Herpes simplex virus 1 infection -2.00 8.19e-4 165/498 (33.13%) POU2F2;IRF9;SRSF6;...
Pertussis -2.00 8.78e-4 64/76 (84.21%) SERPING1;MAPK1;CALML5;...
AGE-RAGE signaling pathway in diabetic complications -2.02 9.46e-4 97/100 (97%) PRKCZ;IL1B;PLCG2;...
ECM-receptor interaction -2.05 0.00e+0 80/88 (90.91%) LAMB2;LAMC1;LAMB1;...
Epstein-Barr virus infection -2.05 0.00e+0 189/202 (93.56%) MAPK11;IFNAR2;CD3G;...
Rheumatoid arthritis -2.06 0.00e+0 78/93 (83.87%) CXCL2;CSF2;TNFRSF11A;...
Legionellosis -2.08 0.00e+0 51/57 (89.47%) IL1B;HSPA2;HSPD1;...
RIG-I-like receptor signaling pathway -2.09 0.00e+0 64/70 (91.43%) DDX3X;IRF3;MAVS;...
Measles -2.12 0.00e+0 133/139 (95.68%) IFNAR2;CD3G;IKBKG;...
Influenza A -2.13 0.00e+0 156/172 (90.7%) NUP98;IL33;ADAR;...
NF-kappa B signaling pathway -2.19 0.00e+0 90/104 (86.54%) IKBKG;RIPK1;TRADD;...
NOD-like receptor signaling pathway -2.24 0.00e+0 145/181 (80.11%) BIRC2;GABARAPL1;CARD8;...
Viral protein interaction with cytokine and cytokine re... -2.25 0.00e+0 84/100 (84%) CCL21;CXCL2;CXCL11;...
TNF signaling pathway -2.27 0.00e+0 103/112 (91.96%) CXCL2;CSF2;RPS6KA5;...
IL-17 signaling pathway -2.42 0.00e+0 84/94 (89.36%) CCL17;MAPK11;IL5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H