Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMA16BR)

Drug Name
Vorapaxar Drug Info
Synonyms
Vorapaxar; 618385-01-6; Zontivity; SCH-530348; SCH530348; UNII-ZCE93644N2; CHEMBL493982; CHEBI:82702; ZCE93644N2; MK-5348; ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate; Ethyl [(1r,3ar,4ar,6r,8ar,9s,9as)-9-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-Yl]ethenyl}-1-Methyl-3-Oxododecahydronaphtho[2,3-C]furan-6-Yl]carbamate; Vorapaxar [USAN:INN]; Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]etheny
Cross-matching ID
PubChem CID
10077130
ChEBI ID
CHEMBL493982
CAS Number
CAS 618385-01-6
TTD Drug ID
D0VA0I
INTEDE Drug ID
DR1708
ACDINA Drug ID
D00732

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 1.99 2.07e-2 19/20 (95%) MSMO1;DHCR24;DHCR7;...
PPAR signaling pathway 1.98 1.04e-2 66/74 (89.19%) HMGCS1;SCD;FABP4;...
Synthesis and degradation of ketone bodies 1.97 6.91e-3 9/10 (90%) HMGCS1;ACAT2;HMGCS2;...
Valine, leucine and isoleucine degradation 1.95 7.78e-3 42/48 (87.5%) HMGCS1;ABAT;ALDH6A1;...
Butanoate metabolism 1.95 6.22e-3 23/28 (82.14%) HMGCS1;ABAT;ALDH5A1;...
Alanine, aspartate and glutamate metabolism 1.95 5.18e-3 27/37 (72.97%) ASS1;ABAT;ASRGL1;...
Oxidative phosphorylation 1.79 2.81e-2 93/133 (69.92%) LHPP;ATP5ME;NDUFB11;...
Primary bile acid biosynthesis 1.79 2.59e-2 15/17 (88.24%) AMACR;CH25H;ACOX2;...
Peroxisome 1.77 3.11e-2 72/82 (87.8%) AMACR;ACSL3;GSTK1;...
Cytosolic DNA-sensing pathway -1.79 4.12e-2 52/63 (82.54%) CASP1;AIM2;NFKBIB;...
Ribosome biogenesis in eukaryotes -1.86 3.80e-2 52/108 (48.15%) NOP56;POP4;GNL2;...
Proteasome -1.92 2.85e-2 44/46 (95.65%) PSMB8;PSMA3;PSME4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H