Details of the Drug

General Information of Drug (ID: DMA16BR)

Drug Name
Vorapaxar
Synonyms
Vorapaxar; 618385-01-6; Zontivity; SCH-530348; SCH530348; UNII-ZCE93644N2; CHEMBL493982; CHEBI:82702; ZCE93644N2; MK-5348; ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate; Ethyl [(1r,3ar,4ar,6r,8ar,9s,9as)-9-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-Yl]ethenyl}-1-Methyl-3-Oxododecahydronaphtho[2,3-C]furan-6-Yl]carbamate; Vorapaxar [USAN:INN]; Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]etheny
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Approved [1]
Stroke 8B20 Investigative [2]
ATC Code
B01AC26: Vorapaxar
B01AC: Platelet aggregation inhibitors excl. heparin
B01A: ANTITHROMBOTIC AGENTS
B01: ANTITHROMBOTIC AGENTS
B: BLOOD AND BLOOD FORMING ORGANS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 492.6
Logarithm of the Partition Coefficient (xlogp) 5.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1 h []
Bioavailability
The bioavailability of drug is 100% []
Clearance
The drug present in the plasma can be removed from the body at the rate of 0.34 mL/min/kg [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 3 - 4 days [3]
Metabolism
The drug is metabolized via the CYP3A4 and CYP 2J2 []
Unbound Fraction
The unbound fraction of drug in plasma is 0.01% [3]
Vd
The volume of distribution (Vd) of drug is 424 L []
Chemical Identifiers
Formula
C29H33FN2O4
IUPAC Name
ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-benzo[f][2]benzofuran-6-yl]carbamate
Canonical SMILES
CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
InChI
InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
InChIKey
ZBGXUVOIWDMMJE-QHNZEKIYSA-N
Cross-matching ID
PubChem CID
10077130
ChEBI ID
CHEBI:82702
CAS Number
618385-01-6
UNII
ZCE93644N2
DrugBank ID
DB09030
TTD ID
D0VA0I
INTEDE ID
DR1708
ACDINA ID
D00732
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proteinase activated receptor 1 (F2R) TTL935N PAR1_HUMAN Antagonist [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2J2 (CYP2J2)
Main DME 		DERSX5P CP2J2_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Myocardial infarction
ICD Disease Classification BA41-BA43
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proteinase activated receptor 1 (F2R) DTT F2R 4.89E-02 -0.32 -0.77
Cytochrome P450 2J2 (CYP2J2) DME CYP2J2 2.00E-01 -1.92E-02 -9.96E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 5.08E-01 -8.08E-02 -5.30E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 136 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 4.2446 6.6298 3.8942 13.2515
JM1 CTRP2 4.0915 6.3819 3.8122 14.003
BL-70 CTRP2 2.5568 2.9949 2.5568 23.2346
Pfeiffer CTRP2 2.7622 4.1635 2.7549 21.8908
KMS-26 CTRP2 2.8228 8.4134 1.6851 25.5086
GA-10 CTRP2 2.8965 4.5906 2.8709 21.0577
DB CTRP2 3.1787 6.4438 2.7994 20.4328
MV4-11 CTRP2 3.2282 4.5956 3.2149 18.8064
Daudi CTRP2 3.4136 5.8571 3.2223 18.1913
SUP-HD1 CTRP2 3.4156 6.3886 3.0747 18.7193
Mono-Mac-1 CTRP2 3.568 5.7337 3.4199 17.0098
OCI-Ly3 CTRP2 3.5871 9.817 1.8571 22.775
KMS-34 CTRP2 3.6396 5.0598 3.609 16.1242
LP-1 CTRP2 3.7004 6.0881 3.4743 16.4082
ST486 CTRP2 3.7279 6.793 3.2786 17.0484
KMS-21-BM CTRP2 3.801 6.463 3.4703 16.1222
KMS-12-BM CTRP2 3.8217 6.076 3.61 15.5496
MOLT-16 CTRP2 3.8366 5.5732 3.7453 15.0213
WSU-DLCL2 CTRP2 3.877 4.9506 3.8656 14.4776
THP-1 CTRP2 3.9054 7.3961 3.2398 16.6946
NALM-6 CTRP2 3.9996 7.2346 3.4039 15.8051
GDM-1 CTRP2 4.0064 7.2981 3.3859 15.8551
KE-37 CTRP2 4.0105 6.2233 3.7734 14.3861
Ku812 CTRP2 4.0336 7.7968 3.2093 16.4634
MOLM-13 CTRP2 4.0417 6.0267 3.8636 13.9646
KHM-1B CTRP2 4.136 7.1769 3.5715 14.7843
F-36P CTRP2 4.1821 8.5142 3.0478 16.705
MOTN-1 CTRP2 4.2251 7.6109 3.4872 14.8679
JVM-3 CTRP2 4.2731 6.4819 3.9764 12.8616
RPMI-8226 CTRP2 4.2918 6.6926 3.9225 13.0098
Mino CTRP2 4.2949 6.5819 3.9654 12.8396
P12-Ichikawa CTRP2 4.3171 7.7751 3.5124 14.5246
EM-2 CTRP2 4.3254 7.8508 3.4882 14.5978
PL21 CTRP2 4.3305 7.8261 3.5042 14.5219
KMS-20 CTRP2 4.3413 7.3217 3.7296 13.6111
NU-DUL-1 CTRP2 4.4238 5.8794 4.318 11.1633
JURL-MK1 CTRP2 4.438 6.9409 3.9851 12.3597
L-540 CTRP2 4.4535 5.8912 4.3475 10.9661
RS4;11 CTRP2 4.4718 8.194 3.4851 14.2317
TF-1 CTRP2 4.5074 7.7885 3.7023 13.2774
KE-97 CTRP2 4.5716 6.5979 4.2581 10.9447
CML-T1 CTRP2 4.5744 7.1392 4.0496 11.7361
Ki-JK CTRP2 4.5846 9.5693 2.9551 16.0696
SU-DHL-1 CTRP2 4.5964 6.4685 4.3309 10.5999
L-428 CTRP2 4.6082 8.6612 3.4068 14.2028
RPMI-8402 CTRP2 4.6245 6.6678 4.289 10.6775
MOLM-6 CTRP2 4.6317 8.2142 3.6367 13.2214
JJN-3 CTRP2 4.6782 8.6216 3.4942 13.6786
SET-2 CTRP2 4.6862 6.9281 4.2533 10.6423
M-07e CTRP2 4.7026 7.7961 3.8978 11.9978
BV-173 CTRP2 4.7053 6.0155 4.5908 9.321
NCO2 CTRP2 4.7093 6.7791 4.337 10.2567
RCH-ACV CTRP2 4.765 7.7141 3.9978 11.4391
OCI-AML-3 CTRP2 4.8186 7.5145 4.1416 10.7288
Karpas-620 CTRP2 4.8491 8.1648 3.8759 11.7176
OCI-AML-5 CTRP2 4.9129 7.9507 4.0385 10.9035
KYO-1 CTRP2 4.9281 6.8014 4.56 8.7946
PF-382 CTRP2 4.9643 8.8776 3.6509 12.3548
K-562 CTRP2 5.025 7.6346 4.2958 9.5875
REC-1 CTRP2 5.0545 8.4506 3.9419 10.9527
Peer CTRP2 5.0791 9.408 3.5032 12.6928
OCI-AML-2 CTRP2 5.0795 8.1189 4.1238 10.1508
MHH-CALL-3 CTRP2 5.1142 7.9372 4.2433 9.5803
SU-DHL-8 CTRP2 5.1163 7.1053 4.6268 8.0315
NCI-H929 CTRP2 5.1178 7.2685 4.5555 8.3114
Ri-1 CTRP2 5.1319 8.5652 3.9612 10.6913
HT CTRP2 5.1911 7.6753 4.4417 8.5873
JeKo-1 CTRP2 5.2052 8.3257 4.1464 9.7601
NU-DHL-1 CTRP2 5.2103 8.1658 4.2279 9.4138
NOMO-1 CTRP2 5.226 10.2013 3.2498 13.3992
HEL 92.1.7 CTRP2 5.2387 7.9013 4.3815 8.7176
OPM-2 CTRP2 5.2581 8.6797 4.0253 10.1364
KMS-28BM CTRP2 5.3084 7.1723 4.7912 6.8849
U-937 CTRP2 5.3314 9.1631 3.8572 10.6658
MOLM-16 CTRP2 5.344 7.9352 4.4666 8.1202
HL-60 CTRP2 5.3527 8.0092 4.4393 8.212
KO52 CTRP2 5.3956 12.2669 2.3772 16.5042
KMS-11 CTRP2 5.4511 8.0651 4.5052 7.7141
SUP-T11 CTRP2 5.5192 8.4893 4.3607 8.1603
HDLM-2 CTRP2 5.6028 8.6394 4.3628 7.9694
KMS-18 CTRP2 5.6252 9.4959 3.958 9.6109
SEM CTRP2 5.694 8.7158 4.4065 7.5919
EB1 CTRP2 5.7249 9.1158 4.2349 8.2452
KMS-27 CTRP2 5.7512 9.3184 4.157 8.5167
SUP-B15 CTRP2 5.7663 7.9682 4.842 5.6179
HPB-ALL CTRP2 5.8037 8.3711 4.6748 6.2389
DEL CTRP2 5.8287 10.4911 3.6389 10.5221
DND-41 CTRP2 5.9495 10.2676 3.8532 9.3883
SUP-T1 CTRP2 6.1238 12.5821 2.8415 13.1952
U266B1 CTRP2 6.17 11.5002 3.4205 10.7577
RL CTRP2 6.1973 10.1488 4.1182 7.8038
Kasumi-2 CTRP2 6.397 11.536 3.5867 9.6481
P31/FUJ CTRP2 6.4249 8.9849 4.878 4.2157
Reh CTRP2 6.4822 10.9081 3.9671 7.9162
MOLT-13 CTRP2 6.5667 11.8041 3.5874 9.3393
JVM-2 CTRP2 6.5965 9.0944 4.9515 3.6317
TALL-1 [Human adult T-ALL] CTRP2 6.6235 10.9322 4.0647 7.2638
MOLP-2 CTRP2 6.6829 9.1566 4.983 3.3695
HD-MY-Z CTRP2 6.8524 10.2059 4.5925 4.7083
AML-193 CTRP2 6.8613 8.4207 5.4483 1.2993
Ci-1 CTRP2 6.955 7.94 5.7051 0.3682
EHEB CTRP2 6.963 9.3745 5.0686 2.6306
RPMI-6666 CTRP2 7.0236 10.4144 4.6118 4.3732
OCI-M1 CTRP2 7.0237 8.6939 5.4193 1.2332
Kasumi-1 CTRP2 7.0381 12.2179 3.7415 7.9049
HuNS1 CTRP2 7.0529 13.1976 3.2696 9.7952
EJM CTRP2 7.1403 19.2481 0.3322 20.0539
Raji CTRP2 7.2429 10.9529 4.5029 4.498
Granta-519 CTRP2 7.2512 21.3186 -0.6118 22.4746
SIG-M5 CTRP2 7.2655 8.3539 5.6804 0.2692
MC116 CTRP2 7.2731 8.2063 5.7384 0.1525
NB4 CTRP2 7.3954 11.2041 4.485 4.3588
SU-DHL-6 CTRP2 7.4167 10.8573 4.6629 3.6304
LAMA-84 CTRP2 7.4518 11.2689 4.4914 4.2577
SKM-1 CTRP2 7.4833 10.096 5.055 2.0672
Karpas-299 CTRP2 7.5141 14.6907 2.8766 10.5936
Hs 611.T CTRP2 7.5282 10.4761 4.909 2.555
SU-DHL-10 CTRP2 7.5426 8.6011 5.6999 0.14
SU-DHL-4 CTRP2 7.5561 10.176 5.0609 1.97
SR CTRP2 7.5648 9.8105 5.2265 1.3871
MM1.S CTRP2 7.7266 9.3047 5.5129 0.4391
AMO1 CTRP2 7.7394 8.7639 5.7151 0.0809
KM-H2 CTRP2 7.7823 11.7346 4.4843 3.8634
L-363 CTRP2 7.8361 9.2952 5.5621 0.2882
HuT 78 CTRP2 7.95 10.3692 5.1878 1.1963
CMK CTRP2 7.9666 12.2513 4.3591 4.1175
Karpas-422 CTRP2 8.1051 9.5691 5.5676 0.197
Jurkat CTRP2 8.1446 10.184 5.354 0.6122
P3HR-1 CTRP2 8.194 9.5952 5.5915 0.1435
HEL CTRP2 8.2501 9.4238 5.6699 0.0568
MHH-CALL-4 CTRP2 8.3152 9.9382 5.5155 0.2224
SK-MM-2 CTRP2 8.4645 18.3104 1.7926 13.1026
ME1 CTRP2 8.5064 10.8809 5.2413 0.7024
KMM-1 CTRP2 8.736 10.9147 5.3248 0.4237
OCI-Ly19 CTRP2 8.8398 25.5202 -1.4733 21.9702
KCL-22 CTRP2 8.888 10.6126 5.4899 0.1378
⏷ Show the Full List of 136 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.8101 10.215 4.5577 4.917
TE8 CTRP2 8.0737 15.0294 3.11 8.8273
TE-5 CTRP2 5.679 9.6826 3.9125 9.6881
TE-11 CTRP2 5.8036 8.8772 4.4226 7.296
TE-6 CTRP2 6.2871 9.3502 4.5892 5.6638
TE-4 CTRP2 6.4565 11.5504 3.6268 9.3741
OE21 CTRP2 6.5097 10.2868 4.2974 6.4914
KYSE-410 CTRP2 6.5192 11.3663 3.7681 8.677
OE33 CTRP2 6.7568 24.0719 -2.3828 27.3771
TE-14 CTRP2 7.1536 20.4324 -0.2474 21.679
KYSE-140 CTRP2 7.3016 16.3077 1.9191 14.5486
EC-GI-10 CTRP2 7.3504 9.3923 5.2928 1.3579
KYSE-510 CTRP2 7.6018 12.1989 4.1483 5.4126
KYSE-450 CTRP2 7.6553 9.0792 5.5688 0.3452
KYSE-180 CTRP2 7.684 13.1238 3.7604 6.8393
KYSE-70 CTRP2 7.7918 11.9778 4.3768 4.2655
OE19 CTRP2 7.8417 9.3017 5.5619 0.2866
COLO 680N CTRP2 7.9532 10.4718 5.1463 1.3229
KYSE-520 CTRP2 7.9554 10.9113 4.9585 1.9393
TE-1 CTRP2 8.0071 13.0752 3.9992 5.4546
TE-10 CTRP2 8.0216 10.5804 5.1352 1.3043
KYSE-150 CTRP2 8.1194 9.3696 5.6426 0.0976
TE-9 CTRP2 8.1978 9.6985 5.5565 0.1904
KYSE-30 CTRP2 8.6507 14.273 3.846 5.2383
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.1938 10.9149 5.0813 1.3397
BxPC-3 CTRP2 5.3306 14.9058 1.0056 21.5271
Panc 08.13 CTRP2 5.4381 10.8128 3.1378 13.3953
Panc 03.27 CTRP2 5.7595 9.1103 4.268 8.0349
HuP-T4 CTRP2 6.3889 14.6569 2.0217 15.8353
HPAC CTRP2 6.7272 10.8999 4.1595 6.6955
SU.86.86 CTRP2 6.7618 9.9611 4.647 4.6253
Panc 10.05 CTRP2 6.9597 12.7317 3.4296 9.3052
MIA PaCa-2 CTRP2 7.1014 12.7252 3.5387 8.6274
PaTu 8988s CTRP2 7.1411 10.9613 4.429 4.9415
HPAF-II CTRP2 7.2077 15.0202 2.4853 12.6105
SNU-213 CTRP2 7.2882 12.5007 3.785 7.3321
QGP-1 CTRP2 7.3187 9.3213 5.3065 1.3406
Hs 766T CTRP2 7.3321 12.4324 3.8496 7.0033
Panc 05.04 CTRP2 7.3739 14.3759 2.9281 10.6202
KP-4 CTRP2 7.4025 13.0245 3.6112 7.8568
PaTu 8988t CTRP2 7.4321 8.4962 5.6951 0.1788
SW1990 CTRP2 7.4673 12.9601 3.6886 7.4468
Panc 04.03 CTRP2 7.4961 10.7649 4.7564 3.1696
PSN1 CTRP2 7.6817 10.6189 4.9346 2.2939
YAPC CTRP2 7.7089 9.7576 5.323 0.9633
PaTu 8902 CTRP2 7.7694 8.9771 5.6516 0.1554
Capan-2 CTRP2 7.8232 15.2836 2.8102 10.3609
DAN-G CTRP2 7.8262 9.1288 5.619 0.1909
PK-45H CTRP2 7.8999 15.0256 2.9904 9.5488
HuP-T3 CTRP2 7.9657 10.6817 5.0634 1.5787
AsPC-1 CTRP2 8.0149 13.1383 3.9745 5.5404
CFPAC-1 CTRP2 8.0635 9.7067 5.5013 0.3241
L3.3 CTRP2 8.0983 11.9839 4.5615 3.2077
KP-2 CTRP2 8.2794 13.9087 3.7823 5.9404
TCC-Pan2 CTRP2 8.281 11.781 4.7558 2.3303
SUIT-2 CTRP2 8.3922 9.8286 5.5823 0.1184
PK-59 CTRP2 8.4546 11.0562 5.1488 0.9682
Panc 02.03 CTRP2 8.5061 10.2532 5.4755 0.2344
KP-3 CTRP2 8.6103 11.1071 5.1988 0.7529
SNU-410 CTRP2 8.9166 23.6033 -0.4716 19.3527
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.0526 10.9317 4.3815 5.266
COLO 792 CTRP2 3.2532 5.9626 3.0202 19.4074
WM266-4 CTRP2 4.8481 7.3898 4.2267 10.3145
WM115 CTRP2 6.5994 9.8416 4.5862 5.1377
MeWo CTRP2 6.7764 10.6711 4.3091 5.9956
RPMI-7951 CTRP2 6.8482 9.7028 4.834 3.7295
Hs 895.T CTRP2 6.9075 13.6643 2.9277 11.4095
SK-MEL-28 CTRP2 7.089 8.121 5.6941 0.3214
CJM [Human melanoma] CTRP2 7.1604 9.8689 4.963 2.789
SK-MEL-30 CTRP2 7.3014 10.2363 4.8805 2.9316
SK-MEL-2 CTRP2 7.3162 8.333 5.7091 0.1913
COLO 829 CTRP2 7.3524 10.9011 4.6005 3.9598
Hs 934.T CTRP2 7.3687 9.0317 5.4567 0.8082
IGR-37 CTRP2 7.386 8.6004 5.6374 0.3115
LOX-IMVI CTRP2 7.3953 10.0989 5.0017 2.3597
A2058 CTRP2 7.4384 8.3956 5.7337 0.1159
IGR-39 CTRP2 7.4955 14.7844 2.8169 10.8553
WT2-iPS CTRP2 7.5138 8.8533 5.5951 0.3492
IPC-298 CTRP2 7.5314 10.9058 4.7129 3.2932
Hs 688(A).T CTRP2 7.6301 14.9718 2.8233 10.6141
COLO 800 CTRP2 7.7199 10.1487 5.163 1.4622
SK-MEL-1 CTRP2 7.7624 8.8304 5.7005 0.0931
HMCB CTRP2 7.7687 9.8924 5.2965 0.9997
A101D CTRP2 7.7881 9.0869 5.6194 0.2009
WM88 CTRP2 7.8313 10.7457 4.9629 2.0421
Hs 940.T CTRP2 7.8492 17.664 1.6615 14.537
UACC-62 CTRP2 7.8874 11.8365 4.5021 3.6689
Mel JuSo CTRP2 7.9035 11.7951 4.5311 3.5407
SK-MEL-3 CTRP2 7.9048 22.6802 -0.7785 21.7788
K029AX CTRP2 7.9143 9.1483 5.6451 0.1317
SK-MEL-5 CTRP2 7.9156 12.1982 4.352 4.2071
SK-MEL-31 CTRP2 7.9264 14.3517 3.3353 8.1662
Hs 294T CTRP2 7.9445 9.2974 5.6037 0.1833
WM983B CTRP2 7.9535 12.7322 4.1262 5.0307
IGR-1 CTRP2 7.9862 9.6424 5.4938 0.3682
Hs 936.T CTRP2 8.0793 9.062 5.732 0.0313
G-361 CTRP2 8.1007 12.892 4.1449 4.7727
Mel Ho CTRP2 8.1256 9.4418 5.62 0.1218
WM1799 CTRP2 8.2382 9.5494 5.6233 0.0994
WM793 CTRP2 8.2791 13.5466 3.9519 5.2898
UACC-257 CTRP2 8.2824 12.528 4.4232 3.514
A-375 CTRP2 8.3573 9.6699 5.6241 0.082
HT-144 CTRP2 8.4797 14.2674 3.7419 5.8401
MDA-MB-435S CTRP2 8.6267 10.107 5.5702 0.0961
RVH-421 CTRP2 8.6321 14.0992 3.9148 5.0032
Hs 839.T CTRP2 8.98 18.3426 2.1363 11.1328
Hs 944.T CTRP2 10.27 21.8235 1.3375 12.0692
Hs 852.T CTRP2 12.6583 33.2824 -2.5348 19.1634
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 4.9275 8.7474 3.6778 12.3323
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly CTRP2 4.6242 13.0441 1.3004 22.1369
SK-N-SH CTRP2 6.7721 12.5858 3.3586 9.9145
MHH-NB-11 CTRP2 6.8287 12.0087 3.688 8.4711
CHP-126 CTRP2 7.0385 12.3205 3.6914 8.1089
SK-N-FI CTRP2 7.2196 14.3913 2.8053 11.356
NH-6 CTRP2 7.3345 13.4286 3.3645 8.9537
SK-N-DZ CTRP2 7.5182 8.7122 5.65 0.2328
KP-N-SI9s CTRP2 7.7591 15.775 2.5236 11.5532
SK-N-BE(2) CTRP2 7.8317 12.2072 4.2947 4.5327
NB1 CTRP2 8.0633 10.0852 5.3566 0.648
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 3.8492 14.3796 -0.0692 28.1441
SNU-478 CTRP2 6.2296 11.9286 3.2552 11.3221
HuCC-T1 CTRP2 6.9416 9.9046 4.8011 3.7268
HuH-28 CTRP2 7.6097 9.7471 5.2774 1.1819
SNU-869 CTRP2 7.794 9.3816 5.5122 0.4096
SNU-308 CTRP2 8.0651 9.7574 5.4831 0.3594
SNU-1196 CTRP2 8.2145 11.2588 4.9464 1.7506
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CADO-ES1 CTRP2 4.4008 6.8315 3.9877 12.4534
SK-N-MC CTRP2 4.6378 6.8993 4.2137 10.9282
SK-ES-1 CTRP2 5.1731 9.3719 3.6085 12.0468
TC71 CTRP2 5.5997 8.4573 4.4499 7.6129
Hs 822.T CTRP2 6.4094 13.2902 2.721 13.1275
SaOS-2 CTRP2 6.4307 12.7893 2.9882 12.0257
A-673 CTRP2 6.504 8.8475 5.005 3.558
SJSA-1 CTRP2 7.0804 11.3262 4.2092 5.9261
Hs 888.T CTRP2 7.6671 19.47 0.6313 18.2248
MG-63 CTRP2 7.7082 13.2146 3.7332 6.9125
HOS CTRP2 8.0205 10.6565 5.1025 1.4078
U2OS CTRP2 8.3339 10.2329 5.4153 0.3933
CAL-78 CTRP2 8.3945 10.4963 5.3412 0.5241
G-292 clone A141B1 CTRP2 8.6991 10.7223 5.3807 0.334
MHH-ES-1 CTRP2 9.1704 14.8706 3.8839 4.5146
SW1353 CTRP2 12.7166 29.063 -0.493 14.3362
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 73 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 CTRP2 4.3307 8.5251 3.1928 15.752
HCC1954 CTRP2 5.2471 9.8281 3.453 12.5209
DU4475 CTRP2 5.3978 8.3767 4.3036 8.6685
MDA-MB-453 CTRP2 5.569 9.2543 4.0278 9.439
HCC1569 CTRP2 5.965 10.2718 3.8642 9.3124
HCC1395 CTRP2 5.9759 10.279 3.8697 9.2675
AU565 CTRP2 6.0185 10.2555 3.9172 8.9858
EFM-192A CTRP2 6.0831 9.7106 4.2435 7.4941
T-47D CTRP2 6.5676 12.9557 3.0144 11.6691
HCC38 CTRP2 6.5835 9.1729 4.9035 3.8498
CAL-51 CTRP2 6.7236 10.9437 4.1352 6.8024
SK-BR-3 CTRP2 6.7806 12.1166 3.5978 8.9229
KPL-1 CTRP2 6.8782 7.5652 5.817 0.1399
HCC1419 CTRP2 6.9122 9.897 4.7846 3.8361
MDA-MB-468 CTRP2 6.926 10.4744 4.5142 4.9163
ZR-75-30 CTRP2 6.9373 9.7393 4.8777 3.425
HCC1500 CTRP2 7.0614 9.8506 4.9075 3.1354
ZR-75-1 CTRP2 7.0747 12.3056 3.7255 7.9111
HCC1937 CTRP2 7.4619 15.175 2.5999 11.7459
BT-474 CTRP2 7.5192 8.9249 5.5698 0.4052
Hs 578Bst CTRP2 7.5956 13.3108 3.6087 7.5738
CAL-85-1 CTRP2 7.5979 10.6282 4.8812 2.5801
HCC202 CTRP2 7.7555 13.1895 3.7777 6.6683
HMC-1-8 CTRP2 7.7902 8.8734 5.6956 0.0938
MDA-MB-361 CTRP2 7.8031 13.8015 3.5157 7.6369
CAL-120 CTRP2 7.8302 9.1974 5.5957 0.2287
CAL-148 CTRP2 7.8354 9.3415 5.5446 0.3231
HDQ-P1 CTRP2 7.9069 9.7731 5.4095 0.5987
CAMA-1 CTRP2 7.9355 9.4599 5.5411 0.2932
HCC1143 CTRP2 8.0874 14.9523 3.1567 8.627
MDA-MB-157 CTRP2 8.118 10.0933 5.3776 0.5687
JIMT-1 CTRP2 8.1282 9.7868 5.4976 0.3085
MDA-MB-231 CTRP2 8.1338 15.9863 2.6888 10.3482
MDA-MB-415 CTRP2 8.2048 15.069 3.1809 8.3647
HCC1806 CTRP2 8.2244 13.3074 4.0291 5.0627
HCC1428 CTRP2 8.2591 10.9912 5.082 1.2895
BT-20 CTRP2 8.4694 15.0619 3.3611 7.3072
MCF-7 CTRP2 8.7691 10.5073 5.4835 0.1657
BT-549 CTRP2 8.8346 18.7716 1.8294 12.4186
BT 145 CTRP2 6.0201 10.6697 3.7115 9.8413
BT 231 CTRP2 6.3739 10.5159 4.0769 7.6518
BT164 CTRP2 6.7244 11.6712 3.7757 8.2875
BT 248 CTRP2 6.7572 8.6591 5.2727 2.0985
BT 444 CTRP2 6.9649 9.5749 4.9748 2.9987
BT 320 CTRP2 6.9975 14.022 2.8194 11.6802
BT147 CTRP2 7.0095 9.8895 4.8545 3.4167
BT 112 CTRP2 7.0601 11.9855 3.8719 7.3366
BT 330 CTRP2 7.1124 10.7136 4.5288 4.58
BT 239 CTRP2 7.3067 12.8104 3.647 7.8611
BT 498 CTRP2 7.4162 8.668 5.6244 0.3271
BT 422 CTRP2 7.448 8.8239 5.5779 0.4214
BT 428 CTRP2 7.4606 14.3803 2.9897 10.2377
BT 504 CTRP2 7.4978 11.3824 4.4677 4.2899
BT 172 CTRP2 7.6245 13.3327 3.6183 7.4925
BT 482 CTRP2 7.6409 10.4253 4.9979 2.1083
BT 131 CTRP2 7.6647 9.0488 5.5841 0.3089
BT 286 CTRP2 7.9265 12.8613 4.0479 5.3704
BT 333 CTRP2 7.9444 10.1052 5.294 0.8863
BT 187 CTRP2 7.9476 11.7841 4.5628 3.3711
BT 328 CTRP2 7.9612 21.4485 -0.1244 19.9418
BT 340 CTRP2 8.1267 16.4521 2.4572 11.2265
BT 271 CTRP2 8.1513 16.8702 2.2711 11.8753
BT 179 CTRP2 8.2231 13.0332 4.1557 4.5818
BT 224 CTRP2 8.3434 10.0059 5.502 0.2359
BT 139 CTRP2 8.4974 13.9991 3.8781 5.3019
BT 416 CTRP2 8.5099 17.3676 2.2826 11.2902
BT 228 CTRP2 8.857 16.2549 3.0498 7.9689
BT 216 CTRP2 9.5613 18.6988 2.3532 9.5753
BT 245 CTRP2 9.7727 23.2337 0.3236 15.8599
BT 359 CTRP2 9.7751 21.0785 1.3632 12.6485
BT 159 CTRP2 9.7897 16.568 3.4789 5.2976
BT 232 CTRP2 11.2249 22.8107 1.4847 10.4162
BT 440 CTRP2 11.3632 23.7867 1.1171 11.3943
⏷ Show the Full List of 73 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.9485 9.0909 5.6774 0.0878
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-466 CTRP2 4.288 8.6195 3.1069 16.2006
ONS-76 CTRP2 5.5671 8.5119 4.3933 7.9197
42-MG-BA CTRP2 5.9907 11.569 3.2372 11.8571
SW1783 CTRP2 6.1028 11.9601 3.1351 12.0543
Becker CTRP2 6.2338 10.1483 4.1481 7.6105
SNU-738 CTRP2 6.236 10.3333 4.0575 7.9858
M059K CTRP2 6.351 14.2775 2.1804 15.3177
KNS-81 CTRP2 6.8471 8.6435 5.3373 1.733
KNS-60 CTRP2 6.8528 9.6682 4.854 3.6419
SF268 CTRP2 6.8757 11.8951 3.7796 8.0158
Hs 683 CTRP2 6.9732 10.5854 4.4937 4.9282
D283 Med CTRP2 7.2817 10.2482 4.8624 3.0261
T98G CTRP2 7.3742 14.3142 2.9586 10.5
SF295 CTRP2 7.4176 9.2375 5.3949 0.9625
SF126 CTRP2 7.468 11.0582 4.6014 3.8046
LN-229 CTRP2 7.5065 14.4423 2.9928 10.152
GMS-10 CTRP2 7.5546 12.0761 4.1753 5.3706
NMC-G1 CTRP2 7.622 9.0007 5.5846 0.3253
DK-MG CTRP2 7.6722 13.7193 3.4643 8.0338
CCF-STTG1 CTRP2 7.6782 11.9364 4.3233 4.6193
Daoy CTRP2 7.6912 10.4765 5.0036 2.0371
CAS-1 CTRP2 7.7309 8.9361 5.6517 0.165
SNU-201 CTRP2 7.756 9.2049 5.5632 0.316
A-172 CTRP2 7.7805 17.6795 1.6027 14.8544
SNU-626 CTRP2 7.8031 9.8603 5.3265 0.8871
LN-18 CTRP2 7.9139 8.8464 5.7476 0.0343
U-118MG CTRP2 7.9473 9.6089 5.4903 0.3913
SNB-75 CTRP2 7.9532 14.7215 3.1752 8.7518
YH-13 CTRP2 7.9695 12.6458 4.177 4.8137
U-87MG ATCC CTRP2 7.9711 9.1561 5.6631 0.0995
KG-1-C CTRP2 8.007 13.3233 3.8819 5.9118
SNU-1105 CTRP2 8.0482 9.1332 5.6979 0.0564
SF539 CTRP2 8.095 16.8288 2.251 12.0365
TM-31 CTRP2 8.1155 11.9993 4.5646 3.1776
8-MG-BA CTRP2 8.1624 13.7786 3.7679 6.1488
DBTRG-05MG CTRP2 8.268 14.4573 3.5155 6.9851
SNU-489 CTRP2 8.3078 9.6816 5.6027 0.1101
GaMG CTRP2 8.3749 14.1802 3.716 6.072
U-251MG CTRP2 8.3876 14.8144 3.4248 7.1731
SW1088 CTRP2 8.5207 17.1866 2.3777 10.928
KALS-1 CTRP2 8.7605 14.9586 3.5963 6.0424
GOS-3 CTRP2 9.4504 16.3237 3.3895 5.9888
GB-1 CTRP2 10.9765 21.249 2.0534 8.8717
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-1-A CTRP2 5.4106 8.7638 4.126 9.3757
JHUEM-2 CTRP2 5.6043 17.7471 -0.1776 24.4687
AN3-CA CTRP2 5.9217 9.074 4.4262 7.0423
JHUEM-1 CTRP2 6.1274 9.4282 4.4212 6.6638
HEC-151 CTRP2 6.3415 8.7489 4.9311 4.1366
JHUEM-7 CTRP2 6.7556 11.2194 4.023 7.2129
HEC-265 CTRP2 6.8273 8.0449 5.5967 0.8043
RL95-2 CTRP2 7.1275 8.9028 5.385 1.2513
MFE-296 CTRP2 7.325 12.3391 3.8899 6.8508
EFE-184 CTRP2 7.9956 12.1656 4.4166 3.8646
HEC-108 CTRP2 8.0178 9.1304 5.6883 0.0678
HEC-6 CTRP2 8.1075 12.8358 4.1754 4.6474
HEC-1-B CTRP2 8.1242 11.8813 4.6229 2.956
KLE CTRP2 8.2008 20.0558 0.7445 16.9832
EN CTRP2 8.2591 10.9088 5.116 1.1882
HEC-59 CTRP2 8.2608 9.5317 5.6372 0.0826
HEC-251 CTRP2 8.2672 9.7669 5.5583 0.1719
MFE-319 CTRP2 8.2782 15.7728 2.8925 9.3628
ESS-1 CTRP2 8.484 14.5619 3.6067 6.3502
HEC-50B CTRP2 9.0491 10.6407 5.5366 0.0756
JHUEM-3 CTRP2 9.6738 23.8944 -0.0666 17.1157
Ishikawa (Heraklio) 02 ER- CTRP2 7.4304 8.5048 5.6913 0.1859
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR14TKB CTRP2 0.8267 3.6183 -2.8939 1.9287
UO-31 CTRP2 5.2396 10.9121 2.9111 14.7405
786-O CTRP2 6.1182 9.1334 4.5609 6.0945
A-498 CTRP2 7.035 9.906 4.8636 3.3452
BFTC-909 CTRP2 7.2847 9.302 5.2962 1.4087
TUHR4TKB CTRP2 7.4704 10.6859 4.777 3.1218
RCC10RGB CTRP2 7.5034 9.0968 5.4948 0.6063
OS-RC-2 CTRP2 7.6624 12.0273 4.27 4.8493
KMRC-1 CTRP2 7.6992 11.781 4.4101 4.2536
TUHR10TKB CTRP2 7.7461 9.0042 5.633 0.1905
VMRC-RCW CTRP2 7.7746 15.0195 2.9043 10.074
ACHN CTRP2 7.886 11.857 4.4918 3.7095
KMRC-2 CTRP2 7.9103 15.65 2.6938 10.6705
KMRC-20 CTRP2 8.0479 11.8668 4.5849 3.177
769-P CTRP2 8.1695 11.0181 5.0257 1.5324
Caki-2 CTRP2 8.2156 12.6844 4.312 4.0015
VMRC-RCZ CTRP2 8.2581 14.4129 3.53 6.9421
Caki-1 CTRP2 9.3971 14.3931 4.222 3.1174
SNU-1272 CTRP2 10.0501 18.6351 2.6915 7.7798
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 CTRP2 1.8553 9.1466 0.367 32.5851
SNU-C1 CTRP2 2.2541 6.9956 1.614 27.4623
SNU-407 CTRP2 4.4219 7.5626 3.7123 13.4624
SW48 CTRP2 4.7949 9.2096 3.3294 14.0628
LS513 CTRP2 4.9076 7.9295 4.0429 10.8989
T84 CTRP2 5.0981 8.4277 3.9948 10.6331
HT-55 CTRP2 5.1489 7.6394 4.4169 8.7913
SW620 CTRP2 5.4751 8.2418 4.4415 7.9233
C2BBe1 CTRP2 5.6817 9.9585 3.7775 10.2456
CL-11 CTRP2 5.7065 8.5051 4.5222 7.0817
SNU-61 CTRP2 5.7396 13.1326 2.2432 16.2943
LoVo CTRP2 5.8179 12.3457 2.703 14.3523
LS1034 CTRP2 5.8498 9.5629 4.1204 8.4691
CCK-81 CTRP2 6.031 11.426 3.3424 11.3469
SW1417 CTRP2 6.1703 10.8282 3.7566 9.3652
HCT 15 CTRP2 6.1812 9.6863 4.3362 6.9195
SW1116 CTRP2 6.2733 10.1584 4.1749 7.4253
COLO 320 CTRP2 6.3287 10.5157 4.0411 7.8835
SNU-C4 CTRP2 6.3837 9.6876 4.4973 5.8765
SW948 CTRP2 6.4743 9.5594 4.6311 5.1607
GP2d CTRP2 6.6743 12.5929 3.2792 10.409
OUMS-23 CTRP2 6.9633 10.8164 4.3741 5.4322
HCC-56 CTRP2 6.9778 8.0991 5.6512 0.5063
HT115 CTRP2 7.01 10.9596 4.3376 5.5095
LS411N CTRP2 7.1736 8.8767 5.4217 1.0816
DLD-1 CTRP2 7.1996 8.2847 5.6788 0.3028
SK-CO-1 CTRP2 7.3846 9.5719 5.2326 1.5338
CW-2 CTRP2 7.5596 13.338 3.5702 7.7816
KM12 CTRP2 7.5953 10.7663 4.8166 2.8239
HCT 116 CTRP2 7.628 10.0364 5.1625 1.5461
RCM-1 [Human ESC] CTRP2 7.7373 9.2325 5.545 0.3619
SNU-C5 CTRP2 7.8066 13.9494 3.4467 7.9042
HT-29 CTRP2 7.9678 8.979 5.7219 0.0466
LS180 CTRP2 7.9834 10.7287 5.0525 1.5995
COLO205 CTRP2 7.9946 9.7668 5.4502 0.4587
SNU-503 CTRP2 8.0226 9.7416 5.4715 0.4001
NCI-H508 CTRP2 8.0526 10.4755 5.1943 1.102
NCI-H716 CTRP2 8.1199 11.0131 5.0022 1.6484
COLO201 CTRP2 8.1298 9.268 5.6807 0.0611
MDST8 CTRP2 8.1582 14.4129 3.4636 7.3363
RKO CTRP2 8.3088 10.0657 5.4669 0.3049
SNU-C2A CTRP2 8.3722 18.3246 1.7196 13.4987
LS123 CTRP2 8.4562 10.898 5.2124 0.8003
COLO 678 CTRP2 8.4873 18.6518 1.6424 13.5867
HCT 8 CTRP2 8.7485 14.781 3.6713 5.7755
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Li-7 CTRP2 2.5997 15.5163 -1.7985 35.153
JHH-5 CTRP2 4.6649 8.5731 3.5038 13.6729
PLC/PRF/5 CTRP2 5.5563 8.1367 4.568 7.2171
JHH-4 CTRP2 5.6055 8.7056 4.3324 8.0902
HLF CTRP2 5.7313 10.471 3.5651 11.0262
SNU-878 CTRP2 5.9025 10.4037 3.7454 9.9313
SNU-449 CTRP2 6.0091 9.3107 4.3817 7.0568
SNU-886 CTRP2 6.3719 8.9498 4.8548 4.4028
SNU-761 CTRP2 6.7276 11.4875 3.8692 7.8962
SNU-423 CTRP2 7.1164 11.8545 3.977 6.8183
SNU-398 CTRP2 7.188 12.0107 3.9522 6.808
JHH-6 CTRP2 7.2028 8.0825 5.756 0.1437
SNU-387 CTRP2 7.2245 14.2604 2.8736 11.0809
SNU-182 CTRP2 7.2413 10.7092 4.6182 4.0397
JHH-1 CTRP2 7.7159 10.797 4.8742 2.4769
Hep-G2 CTRP2 7.8722 9.3666 5.5502 0.2983
HuH-1 CTRP2 7.9505 11.6027 4.6472 3.0544
Hep 3B2.1-7 CTRP2 7.9998 10.0823 5.329 0.7553
SK-HEP-1 CTRP2 8.3517 9.5287 5.6695 0.0477
SNU-475 CTRP2 8.5138 15.9177 2.9831 8.6843
JHH-2 CTRP2 8.6409 15.7258 3.159 7.846
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 136 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1341 CTRP2 2.6057 4.3144 2.5873 22.9706
NCI-H1395 CTRP2 3.3587 9.1124 1.9429 23.0814
Calu-6 CTRP2 3.7411 5.9934 3.5445 16.0311
DMS 53 CTRP2 4.1811 10.3964 2.1713 20.0936
HCC44 CTRP2 4.3148 10.4835 2.2585 19.4354
NCI-H1568 CTRP2 4.5351 8.3387 3.483 14.0793
NCI-H1581 CTRP2 4.7064 8.9401 3.3721 14.1026
EKVX CTRP2 4.7234 10.1834 2.7921 16.3866
NCI-H1703 CTRP2 4.8122 8.5563 3.6564 12.6965
DV-90 CTRP2 4.9486 8.1333 3.9888 11.0167
LK2 CTRP2 5.0792 6.4008 4.876 7.1642
DMS 273 CTRP2 5.0941 9.3326 3.5539 12.4507
EBC-1 CTRP2 5.2069 7.8258 4.3864 8.7741
COLO 668 CTRP2 5.6269 10.5255 3.4471 11.7295
NCI-H446 CTRP2 5.6371 9.5585 3.9374 9.6722
NCI-H69 CTRP2 5.669 11.8958 2.8003 14.2708
HCC1588 CTRP2 5.7508 10.7128 3.4613 11.4158
NCI-H211 CTRP2 5.8318 10.1471 3.8133 9.7896
NCI-H889 CTRP2 5.864 12.1829 2.8235 13.7807
NCI-H1092 CTRP2 5.8829 9.0661 4.3969 7.2427
NCI-H1755 CTRP2 5.9382 15.0173 1.4692 18.7001
NCI-H810 CTRP2 5.9618 9.3295 4.3325 7.3562
NCI-H23 CTRP2 6.044 10.7597 3.6865 9.8988
NCI-H1944 CTRP2 6.0492 10.0473 4.047 8.3834
NCI-H1373 CTRP2 6.1735 9.5827 4.3817 6.7432
NCI-H2106 CTRP2 6.1762 12.2828 3.0343 12.3208
NCI-H1155 CTRP2 6.1835 10.8702 3.7464 9.3823
NCI-H838 CTRP2 6.2549 9.0193 4.7285 5.1381
SW1271 CTRP2 6.29 13.2937 2.6223 13.7409
LCLC-97TM1 CTRP2 6.3073 8.7063 4.9257 4.2186
HCC15 CTRP2 6.3249 11.4043 3.5945 9.7483
LXF 289 CTRP2 6.3883 12.1411 3.2776 10.9333
NCI-H2087 CTRP2 6.435 12.5673 3.1025 11.5578
HCC2279 CTRP2 6.4872 17.1933 0.8346 19.7252
RERF-LC-Ad1 CTRP2 6.566 8.1715 5.3779 1.9404
NCI-H1105 CTRP2 6.5782 12.9299 3.0358 11.5642
NCI-H522 CTRP2 6.5868 11.3807 3.8137 8.3686
COR-L105 CTRP2 6.6093 12.2323 3.4077 10.0007
SHP-77 CTRP2 6.6135 10.6026 4.2205 6.6337
NCI-H1694 CTRP2 6.6211 11.0903 3.9845 7.6011
SK-MES-1 CTRP2 6.6231 11.581 3.7424 8.6003
NCI-H2342 CTRP2 6.6726 11.3188 3.9107 7.8183
NCI-H1915 CTRP2 6.696 10.2467 4.4585 5.5086
NCI-H2081 CTRP2 6.7228 18.5351 0.355 20.7525
T3M-10 CTRP2 6.7667 14.5101 2.3974 13.7225
VMRC-LCD CTRP2 6.7823 11.0793 4.1123 6.7992
PC-14 CTRP2 6.8028 11.3373 4.0004 7.2278
COR-L95 CTRP2 6.8074 13.3464 3.0082 11.2647
NCI-H1651 CTRP2 6.8728 11.4203 4.0117 7.0657
NCI-H2110 CTRP2 6.9341 10.1364 4.684 4.2119
COLO 699 CTRP2 6.9885 15.185 2.235 13.9375
HCC95 CTRP2 7.0032 10.867 4.3779 5.3555
NCI-H358 CTRP2 7.0612 14.15 2.8047 11.628
NCI-H226 CTRP2 7.1095 8.9066 5.3732 1.3105
NCI-H322 CTRP2 7.1478 9.331 5.2042 1.8845
DMS 79 CTRP2 7.1536 12.9552 3.4642 8.8444
NCI-H727 CTRP2 7.155 12.475 3.7012 7.8811
NCI-H841 CTRP2 7.1916 9.9723 4.9344 2.8605
Sq-1 CTRP2 7.2154 17.5447 1.2386 17.0639
NCI-H1339 CTRP2 7.219 12.3041 3.8312 7.2518
RERF-LC-MS CTRP2 7.2443 11.3739 4.3012 5.3073
HOP-62 CTRP2 7.2511 22.9173 -1.4087 24.4249
KNS-62 CTRP2 7.2707 10.333 4.8157 3.2219
CAL-12T CTRP2 7.275 10.8811 4.5587 4.2302
Calu-3 CTRP2 7.3464 10.3883 4.8379 3.0403
NCI-H650 CTRP2 7.3685 10.5394 4.7813 3.2315
NCI-H1573 CTRP2 7.3846 15.1513 2.5539 12.0499
NCI-H520 CTRP2 7.3911 10.692 4.7241 3.4248
NCI-H647 CTRP2 7.4692 13.1359 3.6045 7.7813
NCI-H2023 CTRP2 7.4745 11.7572 4.274 5.0889
HCC2935 CTRP2 7.4874 11.4066 4.4494 4.3759
NCI-H1793 CTRP2 7.4898 11.7788 4.2739 5.0683
SBC-5 CTRP2 7.4901 8.4075 5.7485 0.0859
LUDLU-1 CTRP2 7.5212 10.0375 5.1029 1.8558
DMS 114 CTRP2 7.533 10.5596 4.8737 2.6814
MOR/CPR CTRP2 7.54 8.2924 5.8049 0.0287
ChaGo-K-1 CTRP2 7.5449 12.3005 4.0612 5.839
NCI-H1838 CTRP2 7.625 13.7887 3.3974 8.3704
NCI-H292 CTRP2 7.6398 13.342 3.6244 7.4454
NCI-H2444 CTRP2 7.6588 8.7185 5.7017 0.1111
NCI-H2170 CTRP2 7.6659 10.8061 4.8407 2.6544
Lu-99 CTRP2 7.7052 12.8049 3.928 6.1432
NCI-H1734 CTRP2 7.735 14.6429 3.0596 9.5317
NCI-H1355 CTRP2 7.7602 13.6606 3.554 7.5481
BEN CTRP2 7.7749 8.7423 5.7349 0.057
IA-LM CTRP2 7.8048 10.4038 5.098 1.6043
NCI-H196 CTRP2 7.8109 14.5349 3.166 9.0003
NCI-H1869 CTRP2 7.8512 11.7019 4.542 3.5607
NCI-H460 CTRP2 7.9138 10.2887 5.2033 1.1759
LCLC-103H CTRP2 7.9631 9.0855 5.6844 0.0786
HCC4006 CTRP2 7.9698 9.7042 5.4636 0.4398
HCC366 CTRP2 7.9938 18.0737 1.5669 14.6272
NCI-H2126 CTRP2 8.0422 9.3185 5.6325 0.1222
NCI-H2172 CTRP2 8.0452 9.3621 5.6184 0.1393
NCI-H1435 CTRP2 8.0646 9.3842 5.6178 0.1361
HARA [Human squamous cell lung carcinoma] CTRP2 8.0659 15.8749 2.695 10.4276
NCI-H2196 CTRP2 8.0908 10.2014 5.3232 0.7183
NCI-H1975 CTRP2 8.1675 10.4078 5.276 0.7979
NCI-H1666 CTRP2 8.1744 16.7984 2.3225 11.651
LC-1/sq-SF CTRP2 8.2002 9.4322 5.6498 0.079
HCC1195 CTRP2 8.2015 10.1616 5.3872 0.5072
NCI-H2228 CTRP2 8.2307 14.7397 3.3561 7.652
HCC78 CTRP2 8.2581 10.2049 5.3945 0.4664
SK-LU-1 CTRP2 8.2588 13.819 3.8113 5.8553
RERF-LC-A1 CTRP2 8.3357 11.8743 4.7448 2.3169
RERF-LC-Ad2 CTRP2 8.3567 13.4235 4.0576 4.793
NCI-H526 CTRP2 8.3678 18.625 1.5696 14.0215
A-549 CTRP2 8.4193 15.6085 3.0675 8.4962
NCI-H2009 CTRP2 8.4332 11.2353 5.066 1.2143
HOP-92 CTRP2 8.4594 20.9859 0.4783 17.3815
NCI-H2291 CTRP2 8.4652 10.6249 5.3221 0.5354
NCI-H2122 CTRP2 8.4818 9.8262 5.6146 0.0752
NCI-H1184 CTRP2 8.4937 10.1449 5.5092 0.1887
NCI-H2085 CTRP2 8.6349 10.6821 5.3701 0.3735
NCI-H1299 CTRP2 8.6633 13.2641 4.3129 3.509
NCI-H2030 CTRP2 8.6746 11.2532 5.1701 0.7901
EPLC-272H CTRP2 8.6959 10.3603 5.508 0.1501
NCI-H1623 CTRP2 8.7088 10.8922 5.3222 0.4384
Lu-65 CTRP2 8.7105 24.9333 -1.2806 21.7157
NCI-H661 CTRP2 8.8464 10.7103 5.4409 0.2041
Calu-1 CTRP2 8.8578 17.2109 2.596 9.6476
NCI-H2405 CTRP2 8.9111 15.9389 3.2334 7.2132
NCI-H1650 CTRP2 8.9734 19.4362 1.6045 12.9848
DMS 454 CTRP2 9.1814 18.9149 1.9985 11.3329
HCC1438 CTRP2 9.4131 17.9668 2.6024 8.8813
HCC827 CTRP2 9.7634 19.8157 1.9568 10.6854
NCI-H1563 CTRP2 10.4618 24.7717 0.0574 15.6655
HCC1833 CTRP2 10.4907 23.0483 0.9013 13.1473
NCI-H441 CTRP2 10.5062 20.8643 1.9407 9.7986
HCC1171 CTRP2 10.6169 22.7745 1.1142 12.326
SW1573 CTRP2 10.8854 22.6418 1.3498 11.2499
NCI-H2286 CTRP2 11.1948 23.1232 1.3205 10.9668
HCC2108 CTRP2 11.8006 21.979 2.209 7.4793
LOU-NH91 CTRP2 11.8709 25.8021 0.4964 12.6301
NCI-H1792 CTRP2 11.9512 23.8073 1.4694 9.6398
Hs 888.Lu CTRP2 5.5244 10.3755 3.4316 12.0084
⏷ Show the Full List of 136 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.0073 14.0624 2.0044 16.6454
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.8051 18.2946 0.5412 20.0386
A2780 CTRP2 4.1877 7.1828 3.6239 14.4397
COV434 CTRP2 5.1272 10.5077 3.0089 14.5959
DOV13 CTRP2 5.5047 7.6606 4.7518 6.5732
FU-OV-1 CTRP2 5.8215 9.7028 4.0263 8.9203
SNU-840 CTRP2 5.8633 15.2419 1.2939 19.4525
HEY A8 CTRP2 6.3905 11.2208 3.7387 9.0304
ONCO-DG-1 CTRP2 6.4066 11.3683 3.6779 9.2532
TYK-nu CTRP2 6.5844 10.4051 4.2961 6.3687
OVK18 CTRP2 6.7031 11.3969 3.8954 7.8296
JHOM-1 CTRP2 6.7958 9.2216 5.03 3.0132
ES2 CTRP2 6.8479 9.8973 4.7395 4.1144
EFO-27 CTRP2 6.938 10.4933 4.5135 4.9006
SNU-119 CTRP2 6.9747 10.0477 4.755 3.8656
OVISE CTRP2 7.0556 9.6495 4.9988 2.7833
OVCAR-8 CTRP2 7.0933 11.5703 4.0994 6.3547
RMG-I CTRP2 7.1577 15.8351 2.0431 14.3492
TOV-112D CTRP2 7.2012 10.9596 4.4713 4.6839
OV-90 CTRP2 7.3854 10.2448 4.9287 2.6458
OAW42 CTRP2 7.4074 8.6866 5.6135 0.3564
COV644 CTRP2 7.4837 17.8197 1.309 16.3585
TOV-21G CTRP2 7.4946 10.765 4.7554 3.1753
Kuramochi CTRP2 7.5215 17.0664 1.7108 14.913
JHOS-2 CTRP2 7.6152 13.4449 3.5574 7.7491
MCAS CTRP2 7.8062 10.5559 5.0325 1.8247
OAW28 CTRP2 7.8778 15.0143 2.9803 9.6213
COV362 CTRP2 7.9147 9.8437 5.3852 0.6565
OV56 CTRP2 7.935 11.6298 4.6257 3.151
SNU-8 CTRP2 7.9427 13.026 3.9805 5.6122
OC 314 CTRP2 7.9821 12.1774 4.4029 3.9325
OVCAR-4 CTRP2 8.0004 16.1255 2.5264 11.1631
OVCAR-5 CTRP2 8.0874 15.054 3.1076 8.8167
EFO-21 CTRP2 8.2256 11.0057 5.0593 1.3834
JHOC-5 CTRP2 8.3184 9.8145 5.5605 0.158
SK-OV-3 CTRP2 8.4725 10.2944 5.4478 0.2879
IGROV-1 CTRP2 8.5137 10.9625 5.2127 0.7687
OVSAHO CTRP2 8.7192 14.8425 3.6245 5.9872
Caov-3 CTRP2 8.947 17.5747 2.482 9.9394
OV7 CTRP2 9.1388 18.6092 2.1162 10.9805
OVTOKO CTRP2 9.4579 17.694 2.7593 8.2602
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.8316 12.511 3.4414 9.4746
Aska-SS CTRP2 7.7292 13.3337 3.6903 7.0526
Rh41 CTRP2 3.418 4.9748 3.384 17.6121
G-402 CTRP2 5.4387 9.7898 3.6457 11.307
KYM-1 CTRP2 5.4819 9.8383 3.6605 11.1527
G-401 CTRP2 5.5008 10.4105 3.3933 12.2164
A-204 CTRP2 5.835 9.6996 4.0395 8.8376
GCT CTRP2 5.8853 14.4323 1.7171 17.9353
TTC-709 CTRP2 6.1492 14.4108 1.9482 16.5706
TE 441.T CTRP2 6.2769 9.7698 4.3717 6.5941
SK-LMS-1 CTRP2 6.5268 9.8539 4.5252 5.5127
MES-SA CTRP2 6.9574 9.6558 4.9312 3.1825
BT-12 CTRP2 7.0595 8.1921 5.6524 0.4485
HT-1080 CTRP2 7.1041 9.9863 4.8712 3.2217
TE 617.T CTRP2 7.1756 12.6371 3.6367 8.1101
SW982 CTRP2 7.3743 8.7479 5.5749 0.4688
Rh18 CTRP2 7.4677 13.9371 3.2122 9.3492
Tm87-16 CTRP2 7.4955 12.0283 4.1583 5.521
RD CTRP2 7.5407 15.7403 2.3799 12.4485
BT-16 CTRP2 7.961 10.6144 5.0898 1.4971
RKN CTRP2 8.2696 9.5322 5.6401 0.0789
SK-UT-1 CTRP2 8.73 17.4945 2.3735 10.6393
Hs 729.T CTRP2 8.8546 13.6131 4.266 3.4809
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.3384 8.3559 5.7095 0.1831
P-STS CTRP2 7.5255 16.3894 2.0484 13.6985
SYO-1 CTRP2 8.4548 15.0352 3.3642 7.3153
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 3.0024 7.943 2.0654 23.6374
NCI-H2452 CTRP2 5.7894 12.6392 2.5321 15.081
NCI-H28 CTRP2 6.8408 10.2668 4.5545 4.882
JL-1 CTRP2 6.9322 8.4446 5.4785 1.1151
ACC-MESO-1 CTRP2 7.136 10.9955 4.4089 5.0303
IST-Mes1 CTRP2 7.7275 11.194 4.7003 3.1082
NCI-H2052 CTRP2 8.2152 15.3236 3.0656 8.7931
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 4.7975 7.8844 3.9536 11.5332
22Rv1 CTRP2 5.2577 10.9731 2.8973 14.7565
VCaP CTRP2 5.4204 9.2887 3.8768 10.3881
PaCa-3 CTRP2 7.0496 8.9903 5.3009 1.6357
DU145 CTRP2 7.6566 10.8871 4.7983 2.8226
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.4954 14.6045 2.9051 10.5125
A-253 CTRP2 7.7797 11.5168 4.5836 3.4878
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GSS CTRP2 3.842 7.4569 3.1484 17.22
SNU-16 CTRP2 3.915 6.4441 3.6002 15.3064
HGC-27 CTRP2 4.2722 6.5986 3.935 13.0191
IM95 CTRP2 4.7829 8.3614 3.7189 12.5149
SNU-1 CTRP2 4.8254 8.6713 3.615 12.8321
SNU-620 CTRP2 4.8467 7.4522 4.1979 10.4325
SNU-5 CTRP2 4.9619 9.0032 3.5883 12.6158
HuG1-N CTRP2 5.0147 9.2339 3.5272 12.7426
NCI-N87 CTRP2 5.7703 11.5202 3.0748 12.959
MKN74 CTRP2 6.1408 10.8098 3.7415 9.4838
ECC10 CTRP2 6.5687 11.5434 3.7187 8.794
OCUM-1 CTRP2 6.616 13.84 2.6121 24.2018
SNU-601 CTRP2 6.6231 10.4347 4.3109 6.2418
GSU CTRP2 6.9032 7.4447 5.8698 0.0496
SNU-216 CTRP2 6.9079 13.3617 3.0781 10.8105
MKN45 CTRP2 7.087 8.1392 5.686 0.3427
ECC12 CTRP2 7.1203 9.8878 4.9284 2.9754
NUGC-4 CTRP2 7.1553 17.07 1.4279 16.5315
MKN1 CTRP2 7.4887 9.3818 5.3702 0.9842
SNU-668 CTRP2 7.5881 8.9478 5.5904 0.3269
MKN7 CTRP2 7.874 15.3336 2.8221 10.2366
LMSU CTRP2 7.9243 12.1341 4.3872 4.0619
23132/87 CTRP2 7.9959 9.9164 5.3929 0.5933
SH-10-TC CTRP2 8.0809 10.5586 5.1737 1.1429
Fu97 CTRP2 8.1715 13.1303 4.0784 4.9397
NUGC-3 CTRP2 8.2395 10.0887 5.4306 0.3985
Hs 746.T CTRP2 8.4654 16.8772 2.4888 10.6014
AGS CTRP2 8.5764 9.9766 5.5967 0.0791
SNU-719 CTRP2 8.7136 10.2738 5.544 0.109
KE-39 CTRP2 9.2465 15.8905 3.4649 5.9494
SNU-685 CTRP2 6.9915 8.3684 5.5444 0.8323
SNG-M CTRP2 8.2333 10.2139 5.3807 0.5075
SNU-1077 CTRP2 8.9261 16.4851 2.986 8.1155
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C CTRP2 6.7105 11.4674 3.8661 7.9382
ML-1 [Human leukemia] CTRP2 6.8205 15.9719 1.7117 16.1485
CGTH-W-1 CTRP2 6.8826 11.272 4.092 6.7192
B-CPAP CTRP2 6.9146 11.2084 4.1469 6.4416
8505C CTRP2 6.9767 11.0741 4.2579 5.8873
TT CTRP2 7.0079 13.9833 2.8465 11.5556
FTC-238 CTRP2 7.1591 10.7873 4.5253 4.5267
SW579 CTRP2 7.1749 11.9372 3.9788 6.7201
TT2609-C02 CTRP2 7.3611 12.5304 3.8224 7.069
BHT-101 CTRP2 7.8789 10.2943 5.1834 1.2646
CAL-62 CTRP2 7.9531 9.2083 5.6384 0.1323
FTC-133 CTRP2 8.0111 12.7459 4.1565 4.84
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 3.2131 7.2843 2.5453 21.2692
SNU-1214 CTRP2 5.5541 11.1376 3.0784 13.3911
CAL-33 CTRP2 6.1091 9.7291 4.2557 7.3935
CAL-27 CTRP2 6.6085 9.8802 4.5739 5.1738
HSC-4 CTRP2 6.6622 12.7722 3.1805 10.8304
PE/CA-PJ15 CTRP2 6.845 9.9524 4.7107 4.2362
PE/CA-PJ34 (clone C12) CTRP2 6.9672 10.6163 4.4744 5.0162
BICR 18 CTRP2 7.0451 12.1741 3.7683 7.7843
PE/CA-PJ49 CTRP2 7.0902 10.7441 4.4987 4.7338
BHY CTRP2 7.1217 11.3007 4.251 5.6929
PE/CA-PJ41 (clone D2) CTRP2 7.1651 9.9332 4.9358 2.8887
HSC-2 CTRP2 7.2114 10.6416 4.6306 4.0316
FaDu CTRP2 7.3709 11.4316 4.36 4.8902
SCC-9 CTRP2 7.715 11.3663 4.6133 3.4517
BICR 6 CTRP2 7.7502 11.045 4.782 2.778
SCC-25 CTRP2 7.8161 10.5313 5.0487 1.7605
BICR 56 CTRP2 7.8346 9.2046 5.5948 0.2288
BICR 31 CTRP2 7.8924 11.4439 4.685 2.9792
SNU-1066 CTRP2 7.9881 9.8588 5.4119 0.5508
SNU-46 CTRP2 8.035 18.47 1.4024 15.1199
HSC-3 CTRP2 8.134 9.8295 5.4842 0.3318
SNU-899 CTRP2 8.162 9.671 5.5528 0.2049
SCC-4 CTRP2 8.1877 9.7032 5.5511 0.201
Detroit 562 CTRP2 8.2437 10.0712 5.4389 0.3803
BICR 22 CTRP2 8.5213 10.0425 5.5549 0.1271
BICR 16 CTRP2 9.0951 23.915 -0.4935 19.1375
YD-8 CTRP2 10.6291 30.424 -2.5678 21.7944
SNU-1041 CTRP2 11.4668 23.2434 1.434 10.2937
SNU-1076 CTRP2 11.6962 25.9579 0.3117 13.3657
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2 5.159 7.662 4.4162 8.7692
U-BLC1 CTRP2 5.4219 11.7865 2.6394 15.4269
SW1710 CTRP2 5.5533 8.7999 4.2387 8.5936
VM-CUB-1 CTRP2 5.6008 8.3744 4.4918 7.4359
253J-BV CTRP2 6.3952 9.3049 4.6964 5.024
HT-1197 CTRP2 6.5952 10.4285 4.2927 6.3643
CAL-29 CTRP2 6.5996 10.0879 4.4647 5.6419
253J CTRP2 7.178 11.9761 3.962 6.7836
SCaBER CTRP2 7.5605 10.908 4.73 3.1926
KU-19-19 CTRP2 7.5692 12.5403 3.9626 6.1985
647V CTRP2 7.6209 9.621 5.3363 0.9881
5637 CTRP2 7.6307 19.375 0.6505 18.2278
639V CTRP2 7.6444 8.5111 5.7676 0.0451
T24 CTRP2 7.7523 12.2086 4.243 4.8367
UM-UC-1 CTRP2 7.7645 11.5021 4.5811 3.5154
BFTC-905 CTRP2 7.8107 9.0505 5.641 0.1609
TCCSUP CTRP2 8.0939 12.9417 4.1175 4.8863
RT-112 CTRP2 8.1161 10.436 5.2408 0.9251
RT-4 CTRP2 8.2383 12.7097 4.3141 3.9676
HT-1376 CTRP2 8.303 10.5069 5.2977 0.6685
UM-UC-3 CTRP2 8.3255 13.9431 3.7958 5.8294
BC-3C CTRP2 8.5543 9.948 5.5987 0.08
KMBC-2 CTRP2 8.7454 15.8906 3.1493 7.7434
J82 CTRP2 11.8532 25.3237 0.7086 12.0364
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.6171 8.5048 5.7602 0.0543

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Vorapaxar (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Arn-509 DMT81LZ Major Increased metabolism of Vorapaxar caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [6]
Troleandomycin DMUZNIG Major Decreased metabolism of Vorapaxar caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [7]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Vorapaxar caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [8]
Tucatinib DMBESUA Major Decreased metabolism of Vorapaxar caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [7]
Intedanib DMSTA36 Moderate Increased risk of bleeding by the combination of Vorapaxar and Intedanib. Colorectal cancer [2B91] [9]
Lumacaftor DMCLWDJ Major Increased metabolism of Vorapaxar caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [10]
Vortioxetine DM6F1PU Moderate Increased risk of bleeding by the combination of Vorapaxar and Vortioxetine. Depression [6A70-6A7Z] [11]
Apigenin DMI3491 Minor Increased risk of bleeding by the combination of Vorapaxar and Apigenin. Discovery agent [N.A.] [12]
Tazemetostat DMWP1BH Major Increased risk of bleeding by the combination of Vorapaxar and Tazemetostat. Follicular lymphoma [2A80] [6]
Avapritinib DMK2GZX Major Increased risk of bleeding by the combination of Vorapaxar and Avapritinib. Gastrointestinal stromal tumour [2B5B] [13]
Cobicistat DM6L4H2 Major Decreased metabolism of Vorapaxar caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [7]
Ceritinib DMB920Z Major Decreased metabolism of Vorapaxar caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [7]
PF-06463922 DMKM7EW Moderate Increased metabolism of Vorapaxar caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [14]
Idelalisib DM602WT Major Decreased metabolism of Vorapaxar caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [7]
Acalabrutinib DM7GCVW Major Increased risk of bleeding by the combination of Vorapaxar and Acalabrutinib. Mature B-cell lymphoma [2A85] [15]
Ibrutinib DMHZCPO Major Increased risk of bleeding by the combination of Vorapaxar and Ibrutinib. Mature B-cell lymphoma [2A85] [16]
Fedratinib DM4ZBK6 Major Increased risk of bleeding by the combination of Vorapaxar and Fedratinib. Myeloproliferative neoplasm [2A20] [6]
MK-4827 DMLYGH4 Moderate Increased risk of bleeding by the combination of Vorapaxar and MK-4827. Ovarian cancer [2C73] [13]
Abametapir DM2RX0I Moderate Decreased metabolism of Vorapaxar caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [17]
Lefamulin DME6G97 Moderate Decreased metabolism of Vorapaxar caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [18]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Vorapaxar caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [13]
Larotrectinib DM26CQR Moderate Decreased metabolism of Vorapaxar caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [7]
Curcumin DMQPH29 Minor Increased risk of bleeding by the combination of Vorapaxar and Curcumin. Solid tumour/cancer [2A00-2F9Z] [19]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Vorapaxar caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [20]
Betrixaban DM2C4RF Major Increased risk of bleeding by the combination of Vorapaxar and Betrixaban. Venous thromboembolism [BD72] [6]
⏷ Show the Full List of 25 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Carmellose sodium E00625 Not Available Disintegrant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Vorapaxar Sulfate eq 2.08mg base tablet eq 2.08mg base Tablet Oral
Vorapaxar 2.08 mg tablet 2.08 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4047).
2 Vorapaxar FDA Label
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 In Process Citation. Pharm Unserer Zeit. 2009;38(4):320-8.
5 Vorapaxar: the missing link in antiplatelet therapy! J Anaesthesiol Clin Pharmacol. 2017 Apr-Jun;33(2):269-270.
6 Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
9 Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
10 Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
11 Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
12 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
13 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
15 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
16 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
17 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
18 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
19 Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
20 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.