Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAH59S)

Drug Name
Amonafide Drug Info
Synonyms Quinamed (TN)
Cross-matching ID
PubChem CID
50515
ChEBI ID
CHEMBL428676
CAS Number
CAS 69408-81-7
TTD Drug ID
D0HR7P

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.23 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;SESN1;...
Histidine metabolism 2.11 5.31e-3 16/22 (72.73%) HAL;ALDH3A2;AOC1;...
Proteasome 2.02 3.54e-3 44/46 (95.65%) PSMB8;PSMB9;PSMD14;...
Viral protein interaction with cytokine and cytokine re... 2.00 2.66e-3 84/100 (84%) CXCL14;CXCL2;TNFRSF10B;...
Type I diabetes mellitus 1.96 2.13e-3 38/43 (88.37%) CPE;FAS;HLA-F;...
Graft-versus-host disease 1.92 3.54e-3 32/42 (76.19%) FAS;HLA-F;HLA-B;...
Epstein-Barr virus infection 1.90 3.04e-3 189/202 (93.56%) CDKN1A;DDB2;FAS;...
Allograft rejection 1.86 7.97e-3 32/38 (84.21%) FAS;HLA-F;HLA-B;...
Parkinson disease 1.77 2.36e-2 176/249 (70.68%) TUBB2A;CALML3;TP53;...
Collecting duct acid secretion 1.75 2.98e-2 22/27 (81.48%) ATP6V1D;CA2;SLC12A7;...
Colorectal cancer 1.74 2.90e-2 84/86 (97.67%) CDKN1A;DDB2;EREG;...
Arginine and proline metabolism 1.72 3.37e-2 39/50 (78%) ARG2;GOT1;GATM;...
Cytokine-cytokine receptor interaction 1.72 3.11e-2 246/295 (83.39%) CXCL14;CXCL2;FAS;...
Phenylalanine metabolism 1.71 3.26e-2 14/17 (82.35%) GOT1;HPD;PAH;...
Tyrosine metabolism 1.69 3.76e-2 30/36 (83.33%) ADH5;TYRP1;GOT1;...
Viral myocarditis 1.69 3.59e-2 53/60 (88.33%) CXADR;HLA-F;HLA-B;...
Prion disease 1.68 3.63e-2 209/273 (76.56%) TUBB2A;PPIF;KIF5C;...
Melanoma 1.68 3.54e-2 68/72 (94.44%) CDKN1A;DDB2;TP53;...
Autoimmune thyroid disease 1.67 3.75e-2 46/53 (86.79%) FAS;HLA-F;HLA-B;...
Basal cell carcinoma 1.66 4.04e-2 41/63 (65.08%) CDKN1A;DDB2;TP53;...
Kaposi sarcoma-associated herpesvirus infection 1.66 3.85e-2 172/193 (89.12%) CDKN1A;CXCL2;FAS;...
Epithelial cell signaling in Helicobacter pylori infect... 1.66 3.67e-2 62/70 (88.57%) CXCL2;ATP6V1D;JAM2;...
Alzheimer disease 1.64 4.11e-2 279/369 (75.61%) TUBB2A;FAS;CALML3;...
Pancreatic cancer 1.62 4.30e-2 75/76 (98.68%) CDKN1A;DDB2;TP53;...
Pathways of neurodegeneration 1.61 4.95e-2 354/475 (74.53%) TUBB2A;FAS;CALML3;...
Carbohydrate digestion and absorption -1.83 1.23e-2 37/47 (78.72%) AKT2;ATP1B2;G6PC3;...
Sulfur metabolism -1.83 1.85e-2 9/10 (90%) MPST;ETHE1;SELENBP1
Porphyrin and chlorophyll metabolism -1.85 3.70e-2 23/43 (53.49%) BLVRB;FECH;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H