| Complement and coagulation cascades |
1.93 |
8.29e-2 |
76/85 (89.41%) |
A2M;PLAT;TFPI;...
|
| NF-kappa B signaling pathway |
1.80 |
8.29e-2 |
90/104 (86.54%) |
CXCL2;CXCL8;LYN;...
|
| Neutrophil extracellular trap formation |
1.79 |
7.60e-2 |
101/189 (53.44%) |
SRC;PIK3R1;FGG;...
|
| Tryptophan metabolism |
1.77 |
7.77e-2 |
35/42 (83.33%) |
AOC1;MAOB;CYP1A2;...
|
| Drug metabolism |
1.76 |
6.84e-2 |
78/151 (51.66%) |
FMO2;ADH1C;MAOB;...
|
| Tyrosine metabolism |
1.75 |
5.87e-2 |
30/36 (83.33%) |
TYRP1;ADH1C;MAOB;...
|
| Viral protein interaction with cytokine and cytokine re... |
1.75 |
5.03e-2 |
84/100 (84%) |
CXCL2;CXCL8;CXCL12;...
|
| Histidine metabolism |
1.72 |
6.35e-2 |
16/22 (72.73%) |
HNMT;AOC1;MAOB;...
|
| Retinol metabolism |
1.72 |
5.76e-2 |
41/68 (60.29%) |
ADH1C;ALDH1A3;CYP1A2;...
|
| IL-17 signaling pathway |
1.72 |
5.39e-2 |
84/94 (89.36%) |
CXCL2;CXCL8;S100A8;...
|
| Chemokine signaling pathway |
1.69 |
6.03e-2 |
163/192 (84.9%) |
CXCL2;CXCL8;LYN;...
|
| Mineral absorption |
1.69 |
5.87e-2 |
48/60 (80%) |
MT1F;MT1X;MT1H;...
|
| Propanoate metabolism |
1.66 |
7.18e-2 |
30/34 (88.24%) |
SUCLG2;ALDH6A1;ACAT2;...
|
| Platelet activation |
1.64 |
7.92e-2 |
106/124 (85.48%) |
MYLK;LYN;GNAS;...
|
| Proximal tubule bicarbonate reclamation |
1.63 |
8.15e-2 |
21/23 (91.3%) |
SLC4A4;ATP1A1;CA4;...
|
| Fc gamma R-mediated phagocytosis |
1.61 |
9.26e-2 |
79/97 (81.44%) |
LYN;MARCKSL1;PLPP3;...
|
| Pyruvate metabolism |
1.60 |
9.27e-2 |
41/47 (87.23%) |
ADH1C;ADH1B;ME2;...
|
| Peroxisome |
1.58 |
1.04e-1 |
72/82 (87.8%) |
FAR2;SLC27A2;PEX11A;...
|
| Glyoxylate and dicarboxylate metabolism |
1.58 |
9.98e-2 |
23/30 (76.67%) |
GLUL;GLDC;ACAT2;...
|
| PPAR signaling pathway |
1.56 |
1.05e-1 |
66/74 (89.19%) |
FABP7;LPL;SLC27A2;...
|
| Primary bile acid biosynthesis |
1.56 |
1.06e-1 |
15/17 (88.24%) |
ACOX2;CYP27A1;AMACR;...
|
| Gastric acid secretion |
1.55 |
1.08e-1 |
63/76 (82.89%) |
MYLK;GNAS;GNAQ;...
|
| PD-L1 expression and PD-1 checkpoint pathway in cancer |
1.54 |
1.20e-1 |
79/89 (88.76%) |
PRKCQ;PIK3R1;PTEN;...
|
| Fatty acid degradation |
1.53 |
1.21e-1 |
40/43 (93.02%) |
ADH1C;ADH1B;ACAT2;...
|
| Cholesterol metabolism |
1.52 |
1.31e-1 |
44/50 (88%) |
LPL;ABCA1;STAR;...
|
| Phenylalanine metabolism |
1.51 |
1.34e-1 |
14/17 (82.35%) |
MAOB;ALDH3B1;GLYAT;...
|
| Synthesis and degradation of ketone bodies |
1.51 |
1.29e-1 |
9/10 (90%) |
ACAT2;HMGCS2;BDH2;...
|
| Vascular smooth muscle contraction |
1.51 |
1.27e-1 |
113/133 (84.96%) |
MYLK;ACTA2;MYH11;...
|
| Nitrogen metabolism |
1.50 |
1.29e-1 |
16/17 (94.12%) |
GLUL;CPS1;CA4;...
|
| Chagas disease |
1.47 |
1.52e-1 |
93/102 (91.18%) |
CXCL8;GNAS;GNAQ;...
|
| Type II diabetes mellitus |
-1.28 |
3.48e-1 |
42/46 (91.3%) |
GCK;CACNA1C;PKLR;...
|
| Sulfur relay system |
-1.30 |
3.46e-1 |
5/8 (62.5%) |
MPST;TST
|
| Glycerophospholipid metabolism |
-1.33 |
3.28e-1 |
71/98 (72.45%) |
PLA2G6;GPD1;ETNK1;...
|
| Insulin signaling pathway |
-1.33 |
3.38e-1 |
121/137 (88.32%) |
PHKG1;INPP5A;HKDC1;...
|
| Autoimmune thyroid disease |
-1.35 |
3.38e-1 |
46/53 (86.79%) |
HLA-DMB;HLA-DPB1;HLA-DQB1;...
|
| Glutathione metabolism |
-1.36 |
3.27e-1 |
43/57 (75.44%) |
ODC1;GSTM3;GPX1;...
|
| Antigen processing and presentation |
-1.37 |
3.06e-1 |
60/78 (76.92%) |
RFXANK;RFX5;TAPBP;...
|
| Malaria |
-1.38 |
2.87e-1 |
44/50 (88%) |
IFNG;TLR4;THBS3;...
|
| Estrogen signaling pathway |
-1.39 |
2.90e-1 |
119/137 (86.86%) |
PIK3CA;RAF1;AKT1;...
|
| Bacterial invasion of epithelial cells |
-1.39 |
2.98e-1 |
59/77 (76.62%) |
CLTC;CLTCL1;CRKL;...
|
| ABC transporters |
-1.39 |
3.10e-1 |
37/45 (82.22%) |
ABCB6;ABCA6;ABCA4;...
|
| Cellular senescence |
-1.40 |
2.92e-1 |
139/156 (89.1%) |
HRAS;CALML5;ATM;...
|
| Maturity onset diabetes of the young |
-1.41 |
3.07e-1 |
21/26 (80.77%) |
HNF4A;HNF1A;PDX1;...
|
| Focal adhesion |
-1.41 |
3.20e-1 |
180/201 (89.55%) |
CRKL;COL4A2;MYL2;...
|
| Galactose metabolism |
-1.42 |
3.14e-1 |
26/31 (83.87%) |
HKDC1;PFKL;GALE;...
|
| SNARE interactions in vesicular transport |
-1.43 |
3.17e-1 |
19/33 (57.58%) |
STX4;SNAP29;STX7;...
|
| TGF-beta signaling pathway |
-1.47 |
2.60e-1 |
81/94 (86.17%) |
PITX2;E2F5;IFNG;...
|
| Phagosome |
-1.50 |
2.25e-1 |
118/152 (77.63%) |
ATP6V1E1;TLR6;HLA-DRB1;...
|
| Human papillomavirus infection |
-1.53 |
1.85e-1 |
284/331 (85.8%) |
HRAS;IKBKG;ATM;...
|
| Collecting duct acid secretion |
-1.56 |
1.58e-1 |
22/27 (81.48%) |
ATP6V1E1;ATP6V1F;ATP6V0A1;...
|
| Central carbon metabolism in cancer |
-1.57 |
1.58e-1 |
67/70 (95.71%) |
MYC;HKDC1;NTRK1;...
|
| Synaptic vesicle cycle |
-1.57 |
1.64e-1 |
63/78 (80.77%) |
STX3;SLC1A6;ATP6V1E1;...
|
| Small cell lung cancer |
-1.59 |
1.62e-1 |
90/92 (97.83%) |
GADD45G;COL4A5;LAMB1;...
|
| Toxoplasmosis |
-1.63 |
1.25e-1 |
103/112 (91.96%) |
LAMB1;TNFRSF1A;MYD88;...
|
| Viral myocarditis |
-1.65 |
1.32e-1 |
53/60 (88.33%) |
EIF4G3;HLA-DMB;HLA-DPB1;...
|
| ECM-receptor interaction |
-1.68 |
1.13e-1 |
80/88 (90.91%) |
ITGB4;COL1A2;LAMB3;...
|
| Graft-versus-host disease |
-1.70 |
1.22e-1 |
32/42 (76.19%) |
HLA-DMB;HLA-DPB1;HLA-DQB1;...
|
| Allograft rejection |
-1.73 |
1.14e-1 |
32/38 (84.21%) |
HLA-DMB;HLA-DPB1;HLA-DQB1;...
|
| Type I diabetes mellitus |
-1.78 |
1.00e-1 |
38/43 (88.37%) |
HLA-DMB;HLA-DPB1;HLA-DQB1;...
|
| Protein digestion and absorption |
-1.89 |
6.68e-2 |
78/103 (75.73%) |
PRSS3;CELA2A;COL4A5;...
|
