Details of the Drug

General Information of Drug (ID: DMAN0DE)

Drug Name

Sorbitol

Synonyms

D-Sorbitol; sorbitol; D-Glucitol; 50-70-4; glucitol; L-Gulitol; (-)-Sorbitol; Glucarine; Sorbilande; Diakarmon; Sorbostyl; Multitol; Nivitin; Karion; Esasorb; Neosorb; D-(-)-Sorbitol; Sorbol; Cholaxine; Sorbite; Sionit; Sionite; Siosan; Sionon; Karion instant; Sorbitol F; Sorbitol FP; Sorbex Rp; Sorbitol syrup C; Sorbex X; Sorbex R; Sorbex M; Sorbex S; Sionit K; D-Sorbol; Hexahydric alcohol; Sorbicolan; Sorvilande; Neosorb P 60; D-Sorbite; Foodol D 70; Neosorb 20/60DC; Neosorb 70/70; Neosorb 70/02; Neosorb P 20/60; d-Sorbit; Karion (carbohydrate)

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]
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Affected Organisms

Humans and other mammals

ATC Code

A06AD18: Sorbitol

A06AD: Osmotically acting laxatives

A06A: DRUGS FOR CONSTIPATION

A06: DRUGS FOR CONSTIPATION

A: ALIMENTARY TRACT AND METABOLISM

A06AG07: Sorbitol

A06AG: Enemas

A06A: DRUGS FOR CONSTIPATION

A06: DRUGS FOR CONSTIPATION

A: ALIMENTARY TRACT AND METABOLISM

B05CX02: Sorbitol

B05CX: Other irrigating solutions

B05C: IRRIGATING SOLUTIONS

B05: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

B: BLOOD AND BLOOD FORMING ORGANS

V04CC01: Sorbitol

V04CC: Tests for bile duct patency

V04C: OTHER DIAGNOSTIC AGENTS

V04: DIAGNOSTIC AGENTS

V: VARIOUS

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 2

Molecular Weight (mw)

182.17

Logarithm of the Partition Coefficient (xlogp)

-3.1

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C6H14O6
IUPAC Name: (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol
Canonical SMILES: C([C@H]([C@H]([C@@H]([C@H](CO)O)O)O)O)O
InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey: FBPFZTCFMRRESA-JGWLITMVSA-N

Cross-matching ID

PubChem CID: 5780
ChEBI ID: CHEBI:17924
CAS Number: 50-70-4
UNII: 506T60A25R
DrugBank ID: DB01638
TTD ID: D09MXS
INTEDE ID: DR1933

Combinatorial Drugs (CBD)

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Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sorbitol dehydrogenase (SORD)_{Main DME}	DEWU03P	DHSO_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Regulation of Drug Effects	[3]
Fragile X messenger ribonucleoprotein 1 (FMR1)	OTWEV0T5	FMR1_HUMAN	Regulation of Drug Effects	[4]
MAP kinase-activated protein kinase 2 (MAPKAPK2)	OT460SBO	MAPK2_HUMAN	Gene/Protein Processing	[5]
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)	OTGBRJDQ	MKNK1_HUMAN	Gene/Protein Processing	[5]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Gene/Protein Processing	[6]
Mitogen-activated protein kinase 12 (MAPK12)	OTTCKE27	MK12_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Post-Translational Modifications	[8]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Post-Translational Modifications	[8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Protein Interaction/Cellular Processes	[9]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Plasma concentration of iditol dehydrogenase (sorbitol dehydrogenase) in ponies treated with aflatoxin B1. Am J Vet Res. 1980 Jun;41(6):925-7.
3	Aldose reductase expression as a risk factor for cataract. Chem Biol Interact. 2015 Jun 5;234:247-53. doi: 10.1016/j.cbi.2014.12.017. Epub 2014 Dec 22.
4	Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. Mol Med. 2016 Oct;22:548-559. doi: 10.2119/molmed.2016.00122. Epub 2016 Jun 30.
5	The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem. 1998 Apr 17;273(16):9373-7. doi: 10.1074/jbc.273.16.9373.
6	Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis. J Biol Chem. 1999 Oct 29;274(44):31150-4. doi: 10.1074/jbc.274.44.31150.
7	A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
8	Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
9	Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell. 2006 Sep;17(9):4002-13. doi: 10.1091/mbc.e06-05-0380. Epub 2006 Jun 28.