Details of the Drug Pharmacogenomic Perturbation Atlas

SU11274 Drug Info

Met kinase Inhibitor; SU-11274

Cross-matching ID

PubChem CID

9549297

ChEBI ID

CHEMBL261641

CAS Number

CAS 658084-23-2

TTD Drug ID

D0E1QI

General Information of Drug (ID: DMASP9Z)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.58	0.00e+0	19/20 (95%)	MSMO1;DHCR7;LSS;...
Terpenoid backbone biosynthesis	2.40	0.00e+0	18/22 (81.82%)	HMGCS1;ACAT2;IDI1;...
Biosynthesis of unsaturated fatty acids	2.23	0.00e+0	21/27 (77.78%)	SCD;FADS2;ELOVL6;...
PPAR signaling pathway	2.17	0.00e+0	66/74 (89.19%)	SCD;HMGCS1;FADS2;...
Mineral absorption	2.12	0.00e+0	48/60 (80%)	MT1X;MT1H;SLC30A1;...
Fat digestion and absorption	2.12	0.00e+0	35/43 (81.4%)	ACAT2;APOB;CD36;...
Synthesis and degradation of ketone bodies	2.01	1.27e-3	9/10 (90%)	HMGCS1;ACAT2
Fatty acid elongation	1.97	2.23e-3	19/27 (70.37%)	ELOVL6;HACD1;HSD17B12;...
Fatty acid biosynthesis	1.85	5.95e-3	16/18 (88.89%)	ACSL1;FASN;ACACA;...
Cholesterol metabolism	1.74	2.77e-2	44/50 (88%)	LDLR;LIPG;APOB;...
Peroxisome	1.72	3.24e-2	72/82 (87.8%)	PHYH;ACSL1;ACOX2;...
Glycerolipid metabolism	1.68	4.98e-2	44/61 (72.13%)	LIPG;LPIN1;MGLL;...
Renin-angiotensin system	1.68	4.60e-2	20/23 (86.96%)	MME;AGT;ACE2;...
Butanoate metabolism	1.67	4.40e-2	23/28 (82.14%)	HMGCS1;ACAT2;ALDH5A1;...
Fructose and mannose metabolism	1.67	4.22e-2	30/33 (90.91%)	ALDOB;ALDOC;SORD;...
Fatty acid degradation	1.66	4.24e-2	40/43 (93.02%)	ACAT2;ACSL1;ALDH7A1;...
Glutathione metabolism	1.66	3.99e-2	43/57 (75.44%)	GSTM3;GSTK1;IDH1;...
Tryptophan metabolism	1.64	4.61e-2	35/42 (83.33%)	ACAT2;DLST;ALDH7A1;...
alpha-Linolenic acid metabolism	1.63	4.74e-2	17/25 (68%)	FADS2;ACAA1;PLAAT3;...
Antigen processing and presentation	-1.87	4.44e-2	60/78 (76.92%)	NFYC;KLRD1;HSPA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast carcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.04uM - 10uM	6H, 24H

Normal (Transformed)

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H

Normal (Fibroblast)

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	6H, 24H