General Information of Drug (ID: DMAWTG3)

Drug Name
LY2109761 Drug Info
Synonyms LY-2109761; LY 2109761
Cross-matching ID
PubChem CID
11655119
ChEBI ID
CHEMBL260015
CAS Number
CAS 700874-71-1
TTD Drug ID
D06KKN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.31 0.00e+0 52/108 (48.15%) NXT2;POP7;GNL3;...
Alanine, aspartate and glutamate metabolism 2.15 3.85e-3 27/37 (72.97%) ASNS;GOT1;ASPA;...
Glycine, serine and threonine metabolism 1.96 5.13e-3 31/40 (77.5%) MAOB;GATM;DLD;...
Citrate cycle (TCA cycle) 1.85 1.35e-2 30/30 (100%) IDH3A;DLD;DLAT;...
Folate biosynthesis 1.76 2.16e-2 23/26 (88.46%) GCH1;PTS;MOCOS;...
Glyoxylate and dicarboxylate metabolism 1.74 2.31e-2 23/30 (76.67%) PCCB;DLD;ACAT2;...
Propanoate metabolism 1.70 3.52e-2 30/34 (88.24%) PCCB;DLD;ACAT2;...
RNA transport 1.69 3.85e-2 128/186 (68.82%) EIF2S3;TARDBP;EIF2S1;...
Taurine and hypotaurine metabolism 1.69 3.51e-2 8/11 (72.73%) ADO;CDO1;GAD2;...
Nitrogen metabolism 1.67 3.70e-2 16/17 (94.12%) CA2;GLUD2;CPS1;...
Homologous recombination 1.65 4.27e-2 35/41 (85.37%) RAD51C;RAD51;RAD52;...
Non-homologous end-joining 1.64 4.56e-2 11/13 (84.62%) FEN1;DNTT;PRKDC;...
Pentose and glucuronate interconversions 1.64 4.32e-2 17/34 (50%) UGT2B15;DCXR;UGP2;...
Yersinia infection -1.65 4.93e-2 120/137 (87.59%) GNAQ;FYB1;PIP5K1C;...
HIF-1 signaling pathway -1.66 4.70e-2 105/109 (96.33%) EGF;PFKP;LDHA;...
Relaxin signaling pathway -1.66 4.65e-2 114/129 (88.37%) GNAI2;COL1A1;NOS2;...
Rap1 signaling pathway -1.66 4.85e-2 184/210 (87.62%) IGF1R;EFNA3;GNAI2;...
Sphingolipid metabolism -1.67 4.16e-2 32/49 (65.31%) SPTLC1;PLPP2;ARSA;...
Notch signaling pathway -1.68 4.30e-2 49/59 (83.05%) HEYL;DVL1;PSEN1;...
Complement and coagulation cascades -1.68 4.51e-2 76/85 (89.41%) F5;F3;ITGAM;...
Regulation of actin cytoskeleton -1.71 3.13e-2 185/218 (84.86%) PTK2;ITGA9;BAIAP2;...
Pathways in cancer -1.73 2.51e-2 474/531 (89.27%) MITF;PGF;CCND2;...
Proteoglycans in cancer -1.74 2.51e-2 172/205 (83.9%) FZD2;IGF1R;DROSHA;...
Bladder cancer -1.76 1.93e-2 40/41 (97.56%) CXCL8;MMP9;TP53;...
Pathogenic Escherichia coli infection -1.76 2.06e-2 152/197 (77.16%) CYFIP2;CLDN6;RAB1A;...
Transcriptional misregulation in cancer -1.77 1.95e-2 158/192 (82.29%) GADD45G;DDX5;REL;...
Pertussis -1.77 2.10e-2 64/76 (84.21%) MYD88;GNAI2;NOS2;...
Basal cell carcinoma -1.79 1.78e-2 41/63 (65.08%) GADD45G;BMP4;FZD2;...
Mucin type O-glycan biosynthesis -1.80 1.40e-2 20/36 (55.56%) GALNT1;GCNT1;B3GNT3;...
Arrhythmogenic right ventricular cardiomyopathy -1.81 1.31e-2 70/77 (90.91%) CACNB2;CDH2;TCF7;...
Human papillomavirus infection -1.85 9.24e-3 284/331 (85.8%) PPP2R5E;MAML1;TRADD;...
MicroRNAs in cancer -1.87 4.45e-3 146/310 (47.1%) CCND2;EFNA3;PDGFRA;...
Protein digestion and absorption -1.89 3.39e-3 78/103 (75.73%) COL13A1;COL6A1;COL9A2;...
PI3K-Akt signaling pathway -1.99 1.98e-3 317/354 (89.55%) IBSP;EIF4E2;GNG7;...
AGE-RAGE signaling pathway in diabetic complications -2.00 2.38e-3 97/100 (97%) PIM1;PRKCB;SMAD3;...
Small cell lung cancer -2.06 2.97e-3 90/92 (97.83%) CDKN1B;TRAF5;TP53;...
Amoebiasis -2.14 0.00e+0 99/102 (97.06%) LAMC3;RAB7A;COL1A1;...
Focal adhesion -2.30 0.00e+0 180/201 (89.55%) PDPK1;PTK2;ITGA9;...
ECM-receptor interaction -2.75 0.00e+0 80/88 (90.91%) CHAD;HSPG2;COL6A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H