Details of the Drug

General Information of Drug (ID: DMAWTG3)

Drug Name
LY2109761
Synonyms LY-2109761; LY 2109761
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 441.5
Logarithm of the Partition Coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C26H27N5O2
IUPAC Name
4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
Canonical SMILES
C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
InChI
InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
InChIKey
IHLVSLOZUHKNMQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11655119
CAS Number
700874-71-1
TTD ID
D06KKN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Inhibitor [1]
TGF-beta receptor type II (TGFBR2) TTZE3P7 TGFR2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [2]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [2]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Gene/Protein Processing [2]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Gene/Protein Processing [2]
Mothers against decapentaplegic homolog 1 (SMAD1) OTQSHR25 SMAD1_HUMAN Gene/Protein Processing [2]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Gene/Protein Processing [2]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TGF-beta receptor type I (TGFBR1) DTT TGFBR1 2.62E-01 0.27 1.01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.6095 7.8996 2.543 1.1043
EW-12 GDSC2 3.5606 5.5751 1.5748 2.119
U-CH2 GDSC2 3.8489 6.8586 1.1645 3.896
TC-71 GDSC2 3.9092 6.0112 2.4297 4.1532
ES7 GDSC2 4.3152 8.9445 1.2893 10.1373
CHSA0108 GDSC2 4.3496 6.6837 1.5097 1.4736
EW-22 GDSC2 4.6543 8.7161 1.6382 7.3113
MG-63 GDSC2 4.8272 6.6841 2.6678 1.3201
CHSA0011 GDSC2 4.9074 8.0727 1.2084 2.2198
HOS GDSC2 4.9172 6.4701 2.796 0.7059
EW-11 GDSC2 5.0062 8.3249 2.0457 4.2916
A-673 GDSC2 5.2066 6.6602 2.8445 0.3738
CHSA8926 GDSC2 5.2465 8.768 1.9863 4.2219
EW-24 GDSC2 5.2662 6.7035 2.852 0.3277
CAL-78 GDSC2 5.3272 7.6646 2.5067 1.5089
CADO-ES1 GDSC2 5.3606 6.9412 2.8025 0.4123
EW-1 GDSC2 5.4766 7.5353 2.6266 0.8986
HuO9 GDSC2 5.4954 9.6421 1.7368 5.1718
SaOS-2 GDSC2 5.6946 7.5388 2.7157 0.4844
EW-7 GDSC2 5.7262 7.5615 2.7198 0.4584
G-292 clone A141B1 GDSC2 5.7282 8.6174 2.309 1.9624
CAL-72 GDSC2 5.7378 7.7077 2.6707 0.5883
EW-16 GDSC2 5.7477 8.8622 2.2168 2.3597
NOS-1 [Human HNSCC] GDSC2 5.772 19.129 -2.6443 23.7805
ES8 GDSC2 5.8732 8.0708 2.5904 0.7541
NY GDSC2 5.8748 17.8161 -1.9234 21.2901
ES5 GDSC2 5.932 9.3353 2.1109 2.4008
SK-PN-DW GDSC2 5.955 7.8057 2.7198 0.3631
HuO-3N1 GDSC2 5.9711 14.2203 -0.1088 13.8333
MHH-ES-1 GDSC2 6.0071 8.121 2.626 0.5224
ES4 GDSC2 6.0315 8.0254 2.6703 0.4486
H-EMC-SS GDSC2 6.0807 8.1797 2.6335 0.5195
SK-ES-1 GDSC2 6.1102 7.6352 2.8346 0.1243
EW-18 GDSC2 6.1256 7.9041 2.7483 0.2504
EW-13 GDSC2 6.1885 8.0414 2.7234 0.278
U2OS GDSC2 6.2214 8.2696 2.6553 0.3708
ES6 GDSC2 6.3329 8.576 2.5879 0.5229
EW-3 GDSC2 6.4842 21.7384 -3.4022 24.421
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 3.4486 6.9493 0.8665 6.3932
SU-DHL-1 GDSC2 -4.2928 90.9537 -47.6202 50.9402
HT GDSC2 -1.1778 455.5931 -227.2367 49.8217
MC116 GDSC2 0.041 44.9507 -20.9218 46.7165
OCI-AML-5 GDSC2 1.7011 2.7933 1.6644 16.4525
RCH-ACV GDSC2 2.8803 5.0997 1.3664 4.6061
SIG-M5 GDSC2 3.009 6.0453 0.9971 6.5831
NK-92MI GDSC2 3.2649 6.6942 0.863 6.8146
JVM-3 GDSC2 3.4688 4.985 2.6094 4.1022
Ku812 GDSC2 3.6785 5.7364 2.3974 4.8952
JeKo-1 GDSC2 3.6811 5.5251 1.661 1.5212
MOLM-16 GDSC2 3.7132 5.8997 1.5163 2.2048
BC-1 GDSC2 3.7238 5.4601 2.5664 3.7342
NB4 GDSC2 3.7486 4.859 1.9568 0.2928
QIMR-WIL GDSC2 3.8155 8.488 0.3773 8.4903
RS4;11 GDSC2 3.878 5.8523 2.4849 3.8847
MEG-01 GDSC2 3.8781 5.803 2.5088 3.7384
DEL GDSC2 3.8786 5.8215 2.5002 3.79
LAMA-84 GDSC2 3.9497 6.2329 2.3506 4.5462
KMS-11 GDSC2 4.0087 9.6379 -0.0436 10.4549
CTB-1 GDSC2 4.01 28.4503 -9.3635 35.6602
EoL-1 GDSC2 4.0334 5.9064 2.5637 3.0834
Hs 445 GDSC2 4.0789 8.6052 1.2816 10.7647
HEL GDSC2 4.0872 5.5008 2.7848 1.5593
SU-DHL-16 GDSC2 4.1053 5.5447 1.8467 0.4185
GDM-1 GDSC2 4.11 6.5436 2.3111 4.4385
MHH-CALL-4 GDSC2 4.1559 6.076 1.6642 1.0143
Karpas-299 GDSC2 4.1832 5.9921 2.6181 2.4871
CESS GDSC2 4.2246 6.1721 2.5604 2.7424
SU-DHL-5 GDSC2 4.2314 5.3237 2.939 0.7425
SU-DHL-4 GDSC2 4.2361 5.9512 1.7479 0.6471
IM-9 GDSC2 4.2647 6.2608 2.5441 2.7645
SU-DHL-6 GDSC2 4.2771 6.1689 2.5937 2.4624
MM1.S GDSC2 4.2827 7.9127 1.7696 7.3395
MY-M12 GDSC2 4.3346 7.2281 1.2736 2.5926
BC-3 GDSC2 4.337 6.0743 1.7436 0.5973
NU-DUL-1 GDSC2 4.3407 5.8172 1.8397 0.3263
BONNA-12 GDSC2 4.3523 7.0622 1.3535 2.1812
OCI-Ly19 GDSC2 4.4009 6.1329 1.7478 0.5466
RPMI-8866 GDSC2 4.4149 7.3892 2.1112 5.0059
OCI-Ly7 GDSC2 4.4624 5.8473 1.8746 0.2084
ME1 GDSC2 4.4756 7.1848 2.2464 4.0939
P30/OHK GDSC2 4.4796 8.7305 1.5111 8.4433
U266B1 GDSC2 4.5121 7.4389 2.1507 4.5823
Karpas-231 GDSC2 4.5147 5.8718 2.8506 0.8391
MHH-CALL-2 GDSC2 4.5417 6.3723 2.6533 1.7396
A4/Fukuda GDSC2 4.5424 6.7262 2.4972 2.5619
Jiyoye GDSC2 4.5488 6.9356 2.4062 3.0529
CRO-AP2 GDSC2 4.5825 6.3854 1.7275 0.5078
SU-DHL-10 GDSC2 4.5898 5.8882 2.8787 0.6561
VL51 GDSC2 4.6019 6.7832 2.5057 2.4239
JVM-2 GDSC2 4.6119 11.176 0.4112 14.3159
RPMI-8226 GDSC2 4.6237 9.6054 1.1879 10.0064
MHH-PREB-1 GDSC2 4.6459 7.0696 2.4026 2.9132
JSC-1 GDSC2 4.6541 8.506 1.7384 6.7221
SUP-B8 GDSC2 4.6639 6.4028 1.7531 0.4016
THP-1 GDSC2 4.6661 6.6071 1.6791 0.6031
MLMA GDSC2 4.6693 7.7541 2.1028 4.5641
A3/Kawakami GDSC2 4.6849 5.7887 2.9573 0.3238
Raji GDSC2 4.7239 6.8139 2.5595 1.9684
CTV-1 GDSC2 4.7919 6.512 2.7216 1.1179
MOLT-13 GDSC2 4.8345 6.786 2.6289 1.4913
Karpas-45 GDSC2 4.8762 7.4466 2.3656 2.7575
SUP-HD1 GDSC2 4.9245 7.9302 2.1767 3.7025
Loucy GDSC2 4.9338 6.4699 2.8033 0.6668
KE-37 GDSC2 4.9426 6.2583 2.8872 0.3883
JURL-MK1 GDSC2 4.9508 15.8618 -1.6477 22.4296
TALL-1 [Human adult T-ALL] GDSC2 4.9568 7.8235 1.3338 1.6307
Karpas-422 GDSC2 4.9606 6.5554 2.7818 0.7246
MOLP-8 GDSC2 4.9671 6.4976 2.8071 0.6295
DoHH2 GDSC2 4.974 6.2866 2.8893 0.3326
Jurkat GDSC2 4.9768 7.5716 2.3662 2.6086
SKM-1 GDSC2 4.9826 6.1614 2.938 0.2166
Daudi GDSC2 4.9876 6.615 2.7704 0.7458
HL-60 GDSC2 5.0177 6.453 2.8452 0.4716
PL-21 GDSC2 5.0215 7.7357 1.3981 1.3204
SCC-3 GDSC2 5.0232 6.4336 2.8547 0.4396
SUP-M2 GDSC2 5.0302 6.3876 2.8746 0.3786
OCI-AML-3 GDSC2 5.0381 6.3377 2.8959 0.3175
BL-41 GDSC2 5.0452 6.5052 2.837 0.4808
AMO1 GDSC2 5.0457 6.4568 2.8552 0.4256
GA-10 GDSC2 5.0938 6.252 2.9475 0.1804
SU-DHL-8 GDSC2 5.1209 6.3835 2.9112 0.2466
P32/ISH GDSC2 5.1513 6.1999 2.986 0.1025
OCI-AML-2 GDSC2 5.1577 6.3423 2.9394 0.1767
MOLT-4 GDSC2 5.1641 6.5759 2.8585 0.3566
Ramos.2G6.4C10 GDSC2 5.17 6.3828 2.9297 0.1913
SK-MM-2 GDSC2 5.2024 6.9092 2.7497 0.6636
L-1236 GDSC2 5.2146 7.7612 2.4106 2.0747
LP-1 GDSC2 5.2169 6.7504 2.8154 0.408
CML-T1 GDSC2 5.2409 6.8954 2.7711 0.5689
L-363 GDSC2 5.254 6.6895 2.8523 0.3321
ATN-1 GDSC2 5.2603 7.442 2.5656 1.3227
P12-Ichikawa GDSC2 5.281 6.6924 2.8616 0.2983
HAL-01 GDSC2 5.2818 7.7443 2.4516 1.8039
OCI-M1 GDSC2 5.2879 6.3806 2.9725 0.0949
ST486 GDSC2 5.296 7.0271 2.7443 0.6203
L-428 GDSC2 5.2965 7.1207 2.7088 0.7386
MOLT-16 GDSC2 5.2989 6.4607 2.9492 0.1247
ALL-SIL GDSC2 5.3086 7.244 2.6664 0.8811
ROS-50 GDSC2 5.309 7.1878 1.7163 0.257
EJM GDSC2 5.3204 7.0462 2.7472 0.5959
TK [Human B-cell lymphoma] GDSC2 5.3259 6.9123 2.7994 0.4379
WSU-NHL GDSC2 5.3286 6.9396 2.7903 0.4618
DB GDSC2 5.3311 6.9959 2.7705 0.5181
ARH-77 GDSC2 5.3565 6.9704 2.7901 0.4481
RC-K8 GDSC2 5.3614 6.6888 2.893 0.2037
KMS-12-BM GDSC2 5.3782 6.9107 2.8205 0.3576
Karpas-620 GDSC2 5.3923 6.6972 2.9013 0.1797
EM-2 GDSC2 5.4081 6.9716 2.81 0.3708
CCRF-CEM GDSC2 5.4099 6.9684 2.8119 0.3653
VAL GDSC2 5.4102 7.4873 2.6161 0.9884
WIL2 NS GDSC2 5.4137 7.097 2.7664 0.4855
L-540 GDSC2 5.4347 7.0967 2.7748 0.451
OPM-2 GDSC2 5.4468 6.7137 2.9151 0.1434
Granta-519 GDSC2 5.4633 7.0114 2.8169 0.3306
EB2 GDSC2 5.4723 6.9236 2.8515 0.2508
Namalwa GDSC2 5.5018 7.1075 2.7971 0.3623
SUP-B15 GDSC2 5.5206 7.4062 2.6946 0.6401
Farage GDSC2 5.5232 7.3622 2.7122 0.5312
KY821 GDSC2 5.5264 7.0824 2.8155 0.3091
RPMI-6666 GDSC2 5.5428 7.1221 2.8075 0.321
DND-41 GDSC2 5.5468 7.1835 2.7871 0.3678
Karpas-1106P GDSC2 5.5585 7.2811 2.7562 0.4412
KG-1 GDSC2 5.5824 7.3593 2.737 0.4813
Kasumi-1 GDSC2 5.5854 13.3423 0.0496 12.8717
TUR GDSC2 5.5884 7.0421 2.8526 0.2126
ALL-PO GDSC2 5.6235 8.8537 2.1568 2.7961
LC4-1 GDSC2 5.6489 7.7966 2.6002 0.8677
NCI-H929 GDSC2 5.6576 7.3693 2.7628 0.3804
K-562 GDSC2 5.6632 7.2982 2.7903 0.3145
DG-75 GDSC2 5.6655 8.1363 2.4746 1.3231
SR GDSC2 5.7106 7.2271 2.8328 0.2142
697 GDSC2 5.7153 7.21 2.8404 0.1994
NOMO-1 GDSC2 5.7336 7.2566 2.8309 0.2112
SUP-T1 GDSC2 5.7535 7.8059 2.6405 0.6695
BE-13 GDSC2 5.7572 7.4598 2.7683 0.3285
RL GDSC2 5.7666 29.724 -8.6249 31.8578
ML-2 GDSC2 5.7813 7.2177 2.8612 0.1507
KM-H2 GDSC2 5.7881 7.2766 2.8435 0.1761
MN-60 GDSC2 5.8003 7.4756 2.7788 0.291
H9 GDSC2 5.8309 7.319 2.8442 0.1652
KOPN-8 GDSC2 5.8334 7.3436 2.8367 0.1763
PF-382 GDSC2 5.8613 7.6171 2.7516 0.3274
MOLM-13 GDSC2 5.89 7.5446 2.7876 0.2455
KCL-22 GDSC2 5.9026 7.7146 2.7325 0.3544
CA46 GDSC2 5.9182 7.8366 2.6947 0.4368
JJN-3 GDSC2 5.9222 7.4989 2.815 0.1897
NALM-6 GDSC2 5.9249 7.7496 2.7284 0.355
Reh GDSC2 5.9259 7.6076 2.7788 0.2515
HC-1 GDSC2 5.9628 7.6738 2.7692 0.2587
BALL-1 GDSC2 6.0271 7.7103 2.7798 0.2217
HH [Human lymphoma] GDSC2 6.0295 8.2659 2.5814 0.6905
HDLM-2 GDSC2 6.1405 8.1218 2.6773 0.3887
KMOE-2 GDSC2 6.1975 8.2507 2.6529 0.4225
U-698-M GDSC2 6.228 7.8921 2.7888 0.1621
GR-ST GDSC2 6.5299 8.8906 2.5504 0.5311
⏷ Show the Full List of 157 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC2 4.3086 9.8048 0.0784 9.1503
KYSE-220 GDSC2 4.3804 7.0818 2.234 4.3488
OACM5.1 C GDSC2 4.4602 7.2665 2.1984 4.4028
FLO-1 GDSC2 5.2345 10.4438 1.201 8.6216
OACP4 C GDSC2 5.3093 9.6479 1.6218 6.1266
KYSE-50 GDSC2 5.3366 7.8759 2.424 1.8692
TE-12 GDSC2 5.7091 12.5214 0.5272 10.3807
KYAE-1 GDSC2 5.8863 7.6544 2.7477 0.3268
ESO-51 GDSC2 5.8926 7.8692 2.6729 0.5039
SK-GT-4 GDSC2 5.9815 8.7967 2.3559 1.5189
ESO-26 GDSC2 6.2995 22.7402 -4.0313 26.325
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 5.307 7.789 2.4455 1.8036
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-126 GDSC2 3.8304 6.389 1.3654 2.8272
SJNB-17 GDSC2 3.8402 19.1246 -4.8501 28.9286
SK-N-MC-IXC GDSC2 3.841 5.2515 1.8475 0.5777
SJNB-13 GDSC2 4.1187 6.9147 2.1384 5.4667
MHH-NB-11 GDSC2 4.2482 6.1233 1.6869 0.8522
KP-N-YN GDSC2 4.2977 7.3836 2.0355 5.7012
SK-N-DZ GDSC2 4.3099 11.3917 0.0779 16.7769
SJNB-6 GDSC2 4.324 5.8838 1.809 0.4124
KP-N-YS GDSC2 4.4043 6.9678 1.4193 1.8158
TGW GDSC2 4.533 6.337 2.6639 1.6972
LA-N-6 GDSC2 4.7602 6.629 1.7085 0.4722
IMR-5 GDSC2 4.8336 7.2085 2.4469 2.3935
CHP-212 GDSC2 4.9529 6.5608 2.7763 0.7509
SJNB-5 GDSC2 5.0247 12.9613 -0.9488 12.9725
NB(TU)1 GDSC2 5.0449 6.7007 2.7622 0.732
CHP-134 GDSC2 5.0823 6.7418 2.7626 0.7033
KP-N-RT-BM-1 GDSC2 5.1296 7.3912 1.5754 0.6539
SK-N-AS GDSC2 5.1507 6.9133 2.7259 0.7841
Kelly GDSC2 5.1575 6.5877 2.8516 0.3782
SJNB-14 GDSC2 5.2887 6.8684 2.8007 0.4533
NH-12 GDSC2 5.4558 7.3022 2.7069 0.6405
SJNB-7 GDSC2 5.4607 7.0828 2.7901 0.3979
SJNB-10 GDSC2 5.473 11.2188 0.9901 9.3019
GOTO GDSC2 5.5214 7.542 2.6434 0.8077
SiMa GDSC2 5.6443 14.4669 -0.4538 16.0932
SK-N-BE(2)-M17 GDSC2 5.7297 7.5788 2.7149 0.4697
NB69 GDSC2 5.9718 17.7423 -1.8168 20.7197
GI-ME-N GDSC2 6.3461 8.6713 2.5585 0.5927
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.5193 9.4927 1.1685 10.3587
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1599 GDSC2 3.5265 6.1095 1.313 3.6171
Evsa-T GDSC2 3.954 5.9668 2.482 3.7371
DU4475 GDSC2 4.1278 9.1475 1.0505 11.9973
HCC2218 GDSC2 4.2822 6.2341 1.6586 0.931
JIMT-1 GDSC2 4.4133 7.2865 2.1587 4.7281
HCC1187 GDSC2 4.5701 7.9712 1.9371 5.7224
CAL-120 GDSC2 4.6046 6.6145 2.5817 2.0193
HCC1937 GDSC2 4.705 8.2932 1.8728 5.831
UACC-893 GDSC2 4.7353 13.9217 -1.6105 16.5776
YMB-1-E GDSC2 4.8363 7.1486 1.5453 0.9264
BT-474 GDSC2 4.9254 6.2954 2.8664 0.4607
MDA-MB-330 GDSC2 5.0295 8.3844 2.0324 3.9345
MDA-MB-157 GDSC2 5.0977 7.268 2.5587 1.5194
Hs 578T GDSC2 5.1674 7.3039 2.5777 1.3626
HCC1806 GDSC2 5.1797 10.5736 1.103 9.2785
HCC1419 GDSC2 5.2105 14.1883 -0.629 17.8367
CAMA-1 GDSC2 5.2562 6.8742 2.7854 0.5159
HCC1428 GDSC2 5.3311 6.8241 2.8335 0.3456
HCC38 GDSC2 5.4871 7.4791 2.6528 0.799
HCC1500 GDSC2 5.4888 7.4299 2.6724 0.7317
EFM-192A GDSC2 5.5622 7.9728 2.4925 1.3432
T-47D GDSC2 5.5647 15.9804 -1.2494 19.5485
HCC70 GDSC2 5.5753 7.2996 2.7561 0.4337
CAL-51 GDSC2 5.5831 7.3675 2.7343 0.4884
HDQ-P1 GDSC2 5.6236 7.2876 2.7791 0.3553
HCC2157 GDSC2 5.6318 7.1421 2.8337 0.2354
AU565 GDSC2 5.6351 12.1291 0.6648 10.7053
BT-20 GDSC2 5.6455 7.2179 2.8121 0.274
OCUB-M GDSC2 5.6536 7.3009 2.7857 0.3283
MDA-MB-231 GDSC2 5.663 7.6909 2.6464 0.7053
MDA-MB-436 GDSC2 5.6912 7.9967 2.5412 1.047
MRK-nu-1 GDSC2 5.6954 7.179 2.8439 0.1986
MDA-MB-361 GDSC2 5.7173 9.3374 1.9978 3.4629
MFM-223 GDSC2 5.7435 7.1902 2.8573 0.165
MDA-MB-453 GDSC2 5.7551 7.6733 2.6903 0.5237
COLO 824 GDSC2 5.9165 7.8059 2.7051 0.4123
MDA-MB-415 GDSC2 5.9463 14.6906 -0.3518 14.9928
BT-549 GDSC2 5.9616 7.7051 2.7578 0.281
MDA-MB-468 GDSC2 6.0676 7.7709 2.7735 0.2221
HCC1569 GDSC2 6.0769 8.6001 2.475 0.9102
HCC1954 GDSC2 6.0771 7.8641 2.7446 0.2712
EFM-19 GDSC2 6.1061 8.2196 2.629 0.5198
ZR-75-30 GDSC2 6.1652 7.8207 2.791 0.1717
MCF-7 GDSC2 6.1837 8.7166 2.4757 0.9278
HCC1143 GDSC2 6.2297 9.6936 2.1092 2.3178
CAL-85-1 GDSC2 6.579 10.1769 2.0786 2.1022
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YKG-1 GDSC2 2.9343 4.8115 1.5431 3.4093
Onda 10 GDSC2 3.1187 6.6819 0.7651 7.747
D283 Med GDSC2 3.3361 10.7503 -0.3804 21.6847
NMC-G1 GDSC2 3.4403 9.1205 -0.1963 12.6183
D-502MG GDSC2 3.4745 6.1788 1.2485 4.0839
D-566MG GDSC2 3.5453 5.549 1.5778 2.1252
D-542MG GDSC2 3.5853 7.4463 0.7208 6.9698
SF126 GDSC2 3.6871 6.4919 1.235 3.7777
SNB-75 GDSC2 3.7407 7.286 0.8992 5.6075
KNS-42 GDSC2 3.9653 6.1178 1.5554 1.6837
KS-1 [Human Krukenberg tumour] GDSC2 3.9766 9.638 0.6915 14.4297
KNS-81-FD GDSC2 4.038 9.8694 -0.1351 10.8939
Hs 683 GDSC2 4.1717 5.5586 1.8678 0.3294
GaMG GDSC2 4.2015 11.5869 -0.1023 17.9412
SF295 GDSC2 4.21 5.5991 1.868 0.3123
D-423MG GDSC2 4.2381 8.9857 0.4195 7.3917
Onda 11 GDSC2 4.4123 7.8594 1.0401 3.679
D-247MG GDSC2 4.4535 6.4455 1.6513 0.8278
D-245MG GDSC2 4.4557 7.6078 1.174 2.9296
CAS-1 GDSC2 4.4595 6.9896 2.3272 3.6566
SF268 GDSC2 4.5559 7.1167 2.3277 3.482
GB-1 GDSC2 4.5674 8.5387 1.6643 7.3422
42-MG-BA GDSC2 4.7178 9.8482 1.1362 10.0891
8-MG-BA GDSC2 4.7918 6.5517 2.7052 1.1902
SF539 GDSC2 5.0211 7.4396 2.4473 2.1379
U-251MG GDSC2 5.0454 6.4428 2.8603 0.4111
M059J GDSC2 5.0675 7.4813 2.4537 2.0475
DK-MG GDSC2 5.1546 6.8643 2.7465 0.7077
GI-1 GDSC2 5.1613 7.3676 2.5486 1.4967
LN-405 GDSC2 5.217 6.7352 2.8211 0.4327
U-87MG ATCC GDSC2 5.3428 6.7861 2.8517 0.2972
D-263MG GDSC2 5.3604 7.1753 2.7151 0.6745
T98G GDSC2 5.3817 8.5956 2.1393 3.2076
A-172 GDSC2 5.3903 7.4229 2.6325 0.9428
D-336MG GDSC2 5.4092 7.6146 1.6033 0.4544
AM-38 GDSC2 5.4761 7.3273 2.7059 0.6315
LN-18 GDSC2 5.4995 6.6471 2.9559 0.0805
U-118MG GDSC2 5.6096 7.1375 2.8271 0.2552
D-392MG GDSC2 5.7237 8.151 2.4951 1.1938
SW1088 GDSC2 5.7446 10.3615 1.5575 5.7276
DBTRG-05MG GDSC2 5.79 12.7232 0.4849 11.3171
YH-13 GDSC2 5.8161 7.5113 2.7721 0.2995
Daoy GDSC2 5.8247 7.4129 2.8097 0.2239
PFSK-1 GDSC2 5.8873 7.7113 2.7279 0.3705
LN-229 GDSC2 5.9119 12.8036 0.5268 10.8621
KALS-1 GDSC2 5.9267 8.329 2.5148 0.9687
ONS-76 GDSC2 5.9609 7.4786 2.8356 0.1502
Becker GDSC2 5.9746 7.4558 2.8481 0.131
SK-MG-1 GDSC2 6.0938 7.8368 2.7601 0.2382
H4 GDSC2 6.1911 15.5619 -0.6034 15.5854
KINGS-1 GDSC2 6.1973 8.2833 2.6412 0.4501
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 5.677 8.1913 2.4579 1.3798
TGBC24TKB GDSC2 6.0471 7.9671 2.6971 0.3794
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC2 4.3766 6.0968 2.6836 1.8154
MFE-296 GDSC2 4.9039 8.563 1.8732 5.4481
RL95-2 GDSC2 4.9799 6.6804 2.7413 0.8621
KLE GDSC2 5.1045 7.7753 2.3467 2.5315
ESS-1 GDSC2 5.1921 6.662 2.8381 0.398
MFE-319 GDSC2 5.8783 7.5521 2.7807 0.2621
AN3-CA GDSC2 5.9282 8.0789 2.6099 0.6624
MFE-280 GDSC2 6.2356 8.814 2.4605 0.9443
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC2 3.5856 8.6282 0.1498 10.3127
NCC021 GDSC2 3.6679 6.9147 1.027 5.0052
UO-31 GDSC2 4.0908 7.3068 1.1037 3.8335
LB2241-RCC GDSC2 4.101 6.4522 1.4833 1.8646
KTCTL-140 GDSC2 4.2354 7.5415 1.0816 3.726
KTCTL-26A GDSC2 4.2557 8.2771 0.76 5.4521
VMRC-RCW GDSC2 4.4189 6.4429 1.6373 0.9032
KTCTL-195 GDSC2 4.4871 7.9091 1.9116 6.0435
BB65-RCC GDSC2 4.6381 7.6661 1.244 2.36
OS-RC-2 GDSC2 4.7279 10.713 0.7225 12.3756
SW156 GDSC2 4.7634 6.8933 1.6117 0.7537
A-704 GDSC2 4.8148 6.8598 2.5876 1.7114
KTCTL-1M GDSC2 4.8573 7.2309 1.5227 0.9902
A-498 GDSC2 4.9874 6.4049 2.8508 0.472
769-P GDSC2 5.0482 19.779 -3.5159 27.6869
ACHN GDSC2 5.1386 9.1979 1.7246 5.86
KTCTL-13 GDSC2 5.1494 7.2617 1.6305 0.4964
SN12C GDSC2 5.2554 7.369 2.5928 1.2139
RCC10RGB GDSC2 5.2641 6.9774 2.7498 0.6229
Caki-1 GDSC2 5.3483 12.9047 -0.71 11.1943
BFTC-909 GDSC2 5.3816 7.1205 2.7446 0.5676
CAL-54 GDSC2 5.4035 14.5766 -0.679 17.6077
LB1047-RCC GDSC2 5.4116 7.8099 1.5336 0.6276
786-O GDSC2 5.4498 7.1551 2.7593 0.4866
KMRC-20 GDSC2 5.4976 7.4256 2.6777 0.7085
SW13 GDSC2 5.5829 7.1245 2.8218 0.2752
LB996-RCC GDSC2 5.7018 7.6144 2.6908 0.5497
VMRC-RCZ GDSC2 5.7085 7.4393 2.7571 0.3731
HA7-RCC GDSC2 5.8109 8.4389 2.4205 1.2826
TK-10 GDSC2 6.0458 8.1958 2.6139 0.5889
RXF 393L GDSC2 6.1183 8.5991 2.4929 0.8307
NCC010 GDSC2 6.5201 8.6215 2.6423 0.3025
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H508 GDSC2 3.8129 6.9499 1.1009 4.3153
KM12 GDSC2 4.273 11.625 -0.0661 17.5786
SNU-283 GDSC2 4.4249 6.1331 1.7575 0.5049
LS513 GDSC2 4.44 6.2813 2.6374 1.9663
LS411N GDSC2 4.6982 6.398 2.723 1.211
SNU-175 GDSC2 4.7017 6.5146 2.676 1.4252
HCC2998 GDSC2 4.7949 7.2479 2.408 2.6535
SNU-1040 GDSC2 4.8054 6.3924 2.7764 0.8744
MDST8 GDSC2 4.8126 6.0668 2.9057 0.4058
SNU-61 GDSC2 4.8327 7.0828 2.5012 2.1166
SW1116 GDSC2 4.9077 6.8885 2.6226 1.4375
DiFi GDSC2 4.9109 7.3999 2.4053 2.4993
SNU-C1 GDSC2 4.9339 6.7876 2.6769 1.1683
SNU-81 GDSC2 5.0772 6.7673 2.7505 0.6818
COLO 678 GDSC2 5.1655 12.8521 -0.0078 15.1075
COLO205 GDSC2 5.1742 6.8281 2.7687 0.6187
LoVo GDSC2 5.1937 8.2098 2.2053 3.1342
SW948 GDSC2 5.2004 6.5717 2.8741 0.3014
HCT 15 GDSC2 5.3175 7.1238 2.7166 0.6979
SNU-C5 GDSC2 5.328 7.2907 2.6567 0.9019
SW48 GDSC2 5.3371 20.2893 -3.5465 27.1332
CaR-1 GDSC2 5.3648 7.065 2.7584 0.5352
SW837 GDSC2 5.3972 7.7294 2.5136 1.4099
T84 GDSC2 5.3984 8.6354 2.131 3.2268
SW1463 GDSC2 5.4006 7.0866 2.7649 0.4965
LS1034 GDSC2 5.4284 6.9792 2.8151 0.3493
SK-CO-1 GDSC2 5.4542 7.5122 2.6258 0.9183
CCK-81 GDSC2 5.4948 7.5694 2.6213 0.9042
COLO 320HSR GDSC2 5.5067 7.2736 2.7384 0.5163
HT-29 GDSC2 5.5172 6.9615 2.8548 0.2088
HT-55 GDSC2 5.5716 7.5106 2.6764 0.6663
RCM-1 [Human ESC] GDSC2 5.6113 7.0541 2.8568 0.1986
HCT 116 GDSC2 5.612 7.109 2.838 0.2331
HT115 GDSC2 5.6277 6.8758 2.9233 0.0886
SW620 GDSC2 5.6601 13.007 0.2622 11.7368
CL-11 GDSC2 5.6983 8.9229 2.1661 2.6577
GP5d GDSC2 5.7673 7.4188 2.7866 0.286
SW1417 GDSC2 5.8227 7.4831 2.7844 0.2722
NCI-H716 GDSC2 5.8875 8.1304 2.5739 0.7977
NCI-H747 GDSC2 5.8959 7.9494 2.6448 0.5788
C2BBe1 GDSC2 5.9584 8.3738 2.5111 0.9593
SNU-407 GDSC2 5.9718 8.7899 2.3541 1.5345
SW626 GDSC2 6.0007 7.9996 2.6677 0.4682
LS180 GDSC2 6.0804 7.7106 2.7987 0.1787
RKO GDSC2 6.1401 8.0834 2.6908 0.3594
LS123 GDSC2 6.2788 7.9723 2.7794 0.1651
CW-2 GDSC2 6.388 8.2318 2.7295 0.2152
SNU-C2B GDSC2 7.2065 9.5164 2.5803 0.2589
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.2151 6.7957 2.7979 0.5015
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-1 GDSC2 4.0322 6.294 2.3781 4.199
JHH-6 GDSC2 4.5737 5.8827 2.8736 0.69
JHH-4 GDSC2 4.6808 6.9011 2.4977 2.3483
JHH-7 GDSC2 5.0473 6.7301 2.7518 0.7681
Hep 3B2.1-7 GDSC2 5.086 6.5619 2.8324 0.428
Huh-7 GDSC2 5.3158 7.1064 2.7225 0.6791
SK-HEP-1 GDSC2 5.3607 6.6728 2.8982 0.194
HLE GDSC2 5.4371 7.7795 2.5121 1.3783
SNU-449 GDSC2 5.4595 7.8558 2.4918 1.4421
Hep-G2/C3A GDSC2 5.5289 7.0857 2.8153 0.3087
SNU-423 GDSC2 5.5648 7.3689 2.7265 0.5198
SNU-398 GDSC2 5.6841 13.7443 -0.0762 14.2833
SNU-387 GDSC2 5.7844 7.3038 2.8329 0.1944
JHH-1 GDSC2 5.8599 7.2765 2.8688 0.125
JHH-2 GDSC2 6.7157 22.6036 -3.6576 24.6265
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 166 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2081 GDSC2 3.1612 6.6058 0.8328 7.2346
NCI-H460 GDSC2 3.1804 4.4963 1.8394 1.2854
NCI-H2444 GDSC2 3.3702 5.207 1.631 2.106
IST-SL1 GDSC2 3.556 5.7448 1.4967 2.5431
Lu-99A GDSC2 3.5797 9.3856 0.5021 16.57
NCI-H2291 GDSC2 3.6208 6.2632 1.2997 3.5271
BEN GDSC2 3.6233 12.4855 -1.7202 19.645
NCI-H290 GDSC2 3.6676 6.4275 1.2527 3.7116
NCI-H2171 GDSC2 3.6933 5.4146 1.7137 1.2589
NCI-H838 GDSC2 3.8293 12.106 -1.3778 17.6336
NCI-H1770 GDSC2 3.8413 9.0926 0.1039 9.9972
NCI-H748 GDSC2 3.9862 6.6195 1.3504 2.6772
NCI-H2172 GDSC2 3.9931 5.3528 1.8725 0.4037
SBC-3 GDSC2 4.0622 6.6194 2.2419 4.9607
NCI-H1836 GDSC2 4.0977 5.6751 1.7947 0.5831
SBC-1 GDSC2 4.1074 5.9972 1.6734 1.02
LB647-SCLC GDSC2 4.1665 6.5483 1.476 1.8222
HCC33 GDSC2 4.2195 6.0273 1.7117 0.784
NCI-H526 GDSC2 4.2843 9.7421 0.8743 12.6096
HOP-62 GDSC2 4.2855 7.2556 2.0886 5.4073
Calu-3 GDSC2 4.2913 7.2296 2.105 5.2968
COR-L32 GDSC2 4.3261 6.7191 1.4838 1.6104
SBC-5 GDSC2 4.341 5.5418 2.9023 0.7901
NCI-H2029 GDSC2 4.3614 7.5548 1.9965 5.2743
Lu-165 GDSC2 4.3674 6.7008 2.4039 3.3828
NCI-H647 GDSC2 4.3744 6.8981 1.4334 1.7844
NCI-H1105 GDSC2 4.3963 6.3705 1.6555 0.8544
NCI-H1734 GDSC2 4.4238 6.3617 1.6708 0.781
HOP-92 GDSC2 4.4645 7.7853 1.9557 5.8284
LC-2/ad GDSC2 4.4709 6.7147 1.5537 1.1788
NCI-H146 GDSC2 4.474 6.1371 1.7756 0.4299
NCI-H1436 GDSC2 4.482 5.9428 1.8483 0.254
NCI-H513 GDSC2 4.499 7.2704 2.2212 4.196
NCI-H345 GDSC2 4.5097 5.3133 3.0614 0.1271
NCI-H2196 GDSC2 4.5545 6.0427 1.84 0.2471
COR-L303 GDSC2 4.5635 6.0203 1.8512 0.2225
NCI-H1563 GDSC2 4.6348 12.86 -0.402 18.2231
NCI-H740 GDSC2 4.6449 7.9408 1.1307 2.8967
NCI-H2461 GDSC2 4.7022 8.9081 1.5786 7.5601
IA-LM GDSC2 4.7322 6.773 2.5816 1.8464
NCI-H510A GDSC2 4.7759 6.5511 1.7428 0.3798
PC-14 GDSC2 4.7761 8.1819 1.9705 4.6642
COR-L321 GDSC2 4.7802 6.4729 1.7723 0.3116
CPC-N GDSC2 4.7859 6.8543 2.5749 1.8098
NCI-H1781 GDSC2 4.7885 6.7942 2.602 1.6743
NCI-H1694 GDSC2 4.8087 6.1356 2.8781 0.4959
NCI-H2122 GDSC2 4.8148 7.1362 2.4683 2.3096
COR-L311 GDSC2 4.8309 10.561 0.8699 11.3292
NCI-H2135 GDSC2 4.8533 8.4728 1.8834 4.9904
COLO 668 GDSC2 4.8831 8.469 1.9039 5.3107
LCLC-103H GDSC2 4.9076 6.0106 2.9634 0.2096
KNS-62 GDSC2 4.9095 8.4278 1.9396 5.0586
EPLC-272H GDSC2 4.9173 7.1085 2.5348 1.8405
EBC-1 GDSC2 4.9385 7.2908 2.4677 2.1442
NCI-H2030 GDSC2 4.9603 7.1106 1.6111 0.6412
NCI-H3255 GDSC2 5.0117 7.3172 2.4947 1.7431
NCI-H196 GDSC2 5.0258 6.3485 2.8871 0.3463
UMC-11 GDSC2 5.0561 7.3023 2.5236 1.7271
NCI-H292 GDSC2 5.0601 6.7622 1.7738 0.2235
HCC827 GDSC2 5.0656 7.9716 2.2391 3.145
NCI-H209 GDSC2 5.073 9.3465 1.614 6.6094
NCI-H1437 GDSC2 5.0904 6.6531 1.8217 0.1441
NCI-H2810 GDSC2 5.1405 9.7932 1.4474 6.7752
CAL-12T GDSC2 5.1427 15.823 -2.2468 18.2892
NCI-H1568 GDSC2 5.1451 8.3149 2.1313 3.5988
Lu-134-A GDSC2 5.1494 7.4813 1.55 0.7171
Lu-65 GDSC2 5.1587 6.9116 2.73 0.7633
NCI-H1963 GDSC2 5.1678 8.0206 2.2741 2.8149
LC-1/sq GDSC2 5.1732 8.5808 2.0281 4.1128
NCI-H1581 GDSC2 5.1922 7.4041 2.5485 1.4645
NCI-H2369 GDSC2 5.2051 6.7081 2.8263 0.4242
NCI-H1299 GDSC2 5.2209 7.8885 2.3596 2.3145
NCI-H1693 GDSC2 5.2279 7.9562 2.3342 2.4303
NCI-H2731 GDSC2 5.2299 9.8599 1.4733 7.1054
NCI-H1915 GDSC2 5.252 7.0025 2.7351 0.6794
RERF-LC-MS GDSC2 5.2673 6.8205 1.8265 0.1091
NCI-H2110 GDSC2 5.2699 7.1841 1.7034 0.2916
EMC-BAC-2 GDSC2 5.2806 7.474 2.5622 1.3175
DMS 79 GDSC2 5.2913 7.009 2.7492 0.5522
NCI-H720 GDSC2 5.2953 6.4882 2.9385 0.1419
Lu-135 GDSC2 5.3159 7.1343 2.7119 0.7147
ChaGo-K-1 GDSC2 5.3199 15.4904 -1.9622 16.8079
COR-L23 GDSC2 5.3604 6.7533 2.8699 0.2503
VMRC-LCD GDSC2 5.3655 6.867 2.8313 0.3363
NCI-H23 GDSC2 5.3717 7.3068 2.6695 0.8227
NCI-H82 GDSC2 5.3725 6.6333 2.9162 0.1594
NCI-H522 GDSC2 5.4049 7.1021 2.7609 0.5057
LOU-NH91 GDSC2 5.4218 7.1632 2.7451 0.5431
RERF-LC-KJ GDSC2 5.4279 6.6888 2.9169 0.1449
SHP-77 GDSC2 5.4454 7.4015 2.6648 0.7867
DMS 114 GDSC2 5.4617 7.0177 2.814 0.3381
NCI-H650 GDSC2 5.4747 7.3256 2.7059 0.6321
NCI-H322M GDSC2 5.4748 8.2723 2.3272 2.1607
NCI-H226 GDSC2 5.4841 6.8636 2.8768 0.1981
NCI-H1155 GDSC2 5.4867 7.6373 2.5913 1.0206
NCI-H1651 GDSC2 5.4871 7.6241 2.5966 1.0004
SW1271 GDSC2 5.4878 8.7865 2.1136 3.1912
NCI-H2141 GDSC2 5.4945 7.0814 2.8037 0.3494
NCI-H1435 GDSC2 5.5002 7.2182 2.7562 0.4695
HARA [Human squamous cell lung carcinoma] GDSC2 5.501 7.43 2.6775 0.707
DMS 53 GDSC2 5.5033 7.3805 2.6971 0.6426
NCI-H1793 GDSC2 5.505 14.0583 -0.3536 15.9527
NCI-H2227 GDSC2 5.507 7.0437 2.822 0.2744
NCI-H2722 GDSC2 5.5111 10.5694 1.3196 7.4297
NCI-H810 GDSC2 5.5275 6.897 2.8809 0.1791
NCI-H446 GDSC2 5.5303 7.3182 2.7314 0.524
NCI-H520 GDSC2 5.5683 7.4705 2.6901 0.6256
NCI-H1876 GDSC2 5.5741 7.3273 2.7455 0.4624
NCI-H524 GDSC2 5.5756 7.5112 2.6778 0.6594
NCI-H727 GDSC2 5.5829 7.1499 2.8128 0.2944
NCI-H1975 GDSC2 5.5898 7.4929 2.6905 0.6118
NCI-H2818 GDSC2 5.615 13.3704 0.0566 13.8
NCI-H841 GDSC2 5.6362 7.4644 2.7198 0.5019
HCC15 GDSC2 5.6385 8.1735 2.4472 1.4584
NCI-H2228 GDSC2 5.6437 8.3524 2.3771 1.7507
EKVX GDSC2 5.6486 8.9468 2.1301 2.6328
NCI-H1792 GDSC2 5.6689 7.5822 2.6894 0.571
SK-LU-1 GDSC2 5.6726 8.1524 2.4714 1.3295
Ms-1 GDSC2 5.6783 7.3997 2.7598 0.3792
NCI-H250 GDSC2 5.6869 7.4078 2.7602 0.3405
NCI-H1755 GDSC2 5.6911 7.2451 2.8194 0.2447
NCI-H1650 GDSC2 5.694 7.3559 2.7814 0.3227
LCLC-97TM1 GDSC2 5.7061 7.7995 2.6233 0.7526
NCI-H2023 GDSC2 5.7095 7.4133 2.7668 0.35
NCI-H1666 GDSC2 5.71 8.2197 2.4617 1.3356
NCI-H1355 GDSC2 5.7181 7.77 2.6394 0.6939
Lu-139 GDSC2 5.7255 7.7209 2.6608 0.6241
DMS 273 GDSC2 5.7299 7.2144 2.8441 0.1893
HCC78 GDSC2 5.7331 7.5781 2.7165 0.464
NCI-H661 GDSC2 5.7544 7.5425 2.7376 0.401
NCI-H596 GDSC2 5.7606 7.5385 2.7414 0.3892
NCI-H441 GDSC2 5.779 7.624 2.7177 0.4401
EMC-BAC-1 GDSC2 5.8034 8.202 1.543 0.4423
NCI-H2405 GDSC2 5.8392 11.0117 1.3173 6.8539
HCC366 GDSC2 5.8418 7.7144 2.7093 0.394
NCI-H2595 GDSC2 5.8534 7.8273 2.6728 0.523
IST-SL2 GDSC2 5.8638 8.137 2.5614 0.7759
SK-MES-1 GDSC2 5.8676 7.8323 2.6766 0.506
NCI-H2170 GDSC2 5.9148 7.6903 2.7457 0.3212
NCI-H1092 GDSC2 5.917 7.7265 2.7336 0.3465
COR-L105 GDSC2 5.9192 10.0392 1.8011 4.18
LK-2 GDSC2 5.938 7.7633 2.7285 0.3501
LXF 289 GDSC2 5.9402 8.044 2.6277 0.6044
NCI-H2803 GDSC2 6.0194 7.7093 2.7774 0.2072
NCI-H2085 GDSC2 6.0231 8.0337 2.664 0.4677
NCI-H2591 GDSC2 6.0363 8.1601 2.6232 0.568
NCI-H1944 GDSC2 6.0581 8.4808 2.5125 0.8884
Calu-6 GDSC2 6.0597 7.6432 2.8144 0.1602
NCI-H2795 GDSC2 6.0664 27.7666 -6.6953 31.7141
NCI-H358 GDSC2 6.0862 8.0292 2.6898 0.3812
NCI-H2869 GDSC2 6.1241 9.5525 2.116 2.183
NCI-H1623 GDSC2 6.1537 7.8467 2.7781 0.1936
RERF-LC-Sq1 GDSC2 6.163 9.7747 2.0428 2.6892
NCI-H3122 GDSC2 6.1702 8.5986 2.5147 0.8121
NCI-H211 GDSC2 6.1831 7.8206 2.7974 0.1592
NCI-H1993 GDSC2 6.1888 7.8402 2.7927 0.1645
NCI-H2087 GDSC2 6.192 9.0131 2.3651 1.3085
NCI-H2373 GDSC2 6.239 8.167 2.6981 0.3114
HCC44 GDSC2 6.2937 8.3379 2.6582 0.3751
NCI-H1869 GDSC2 6.3039 8.1838 2.7159 0.2592
ABC-1 GDSC2 6.3623 15.6224 -0.5162 13.8645
A-427 GDSC2 6.4371 10.2609 1.9761 2.4458
NCI-H2804 GDSC2 6.4793 8.7314 2.5882 0.4198
SW1573 GDSC2 6.5622 8.8407 2.5806 0.4475
NCI-H1048 GDSC2 7.5057 24.9191 -4.2197 24.5395
A-549 GDSC2 8.3321 20.1971 -1.3953 14.7722
⏷ Show the Full List of 166 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.5903 7.1847 2.3173 3.4811
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC2 4.1668 6.4942 2.3726 3.9519
COLO 680N GDSC2 4.5046 6.4493 2.5992 2.0724
OE33 GDSC2 4.5948 6.9983 2.405 2.9833
OE21 GDSC2 4.7233 9.3674 1.3724 8.7171
KYSE-520 GDSC2 4.778 13.0236 -0.3754 17.748
TE-1 GDSC2 4.838 10.3311 0.9863 10.6655
TE-6 GDSC2 4.9748 7.2539 2.5025 1.9257
EC-GI-10 GDSC2 5.0923 6.7545 2.762 0.6981
KYSE-450 GDSC2 5.3894 7.1567 2.7342 0.595
TE-15 GDSC2 5.4293 8.3589 2.2671 2.503
TE-9 GDSC2 5.4299 6.7331 2.9024 0.1679
TE-4 GDSC2 5.7251 7.2769 2.8207 0.2321
KYSE-140 GDSC2 5.7592 9.4931 1.9527 3.6335
TE-5 GDSC2 5.7676 7.442 2.7785 0.3028
TE-10 GDSC2 5.7677 7.8589 1.6496 0.2523
KYSE-180 GDSC2 5.7789 15.9739 -1.0917 18.4635
KYSE-270 GDSC2 5.8941 18.3474 -2.1699 22.0605
KYSE-70 GDSC2 6.0044 7.7899 2.7438 0.2951
TE-8 GDSC2 6.1115 8.1881 2.6425 0.4831
TE-11 GDSC2 6.3723 22.6769 -4.7094 23.5432
KYSE-410 GDSC2 6.3877 8.2759 2.7142 0.24
KYSE-510 GDSC2 10.8518 28.4115 -3.6405 17.1192
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-2 GDSC2 3.1281 6.0819 1.064 5.8993
Caov-3 GDSC2 3.6502 5.7972 1.5266 2.2414
JHOS-4 GDSC2 4.3322 8.975 0.4843 6.8513
A2780 GDSC2 4.4706 6.5544 2.5329 2.4811
ES-2 GDSC2 4.5733 7.3809 2.2163 4.0867
OVCAR-3 GDSC2 4.5819 8.4375 1.7226 6.9662
OVISE GDSC2 4.6809 8.4055 1.8039 6.2827
OVCAR-8 GDSC2 4.7169 12.0049 0.081 15.7369
OVK18 GDSC2 5.112 6.5049 2.8639 0.3336
OAW42 GDSC2 5.1406 6.4963 2.8783 0.3166
OV56 GDSC2 5.2808 6.3891 2.9671 0.1031
TOV-112D GDSC2 5.3671 7.0955 2.748 0.5656
TOV-21G GDSC2 5.4311 6.6089 2.9452 0.1041
TYK-nu GDSC2 5.5426 7.7997 2.5524 1.1233
SK-OV-3 GDSC2 5.6611 7.1347 2.8469 0.2026
DOV13 GDSC2 5.7447 7.0748 2.8968 0.11
OVTOKO GDSC2 5.8697 8.0663 2.5906 0.7553
OAW28 GDSC2 5.9495 7.9368 2.6706 0.4837
IGROV-1 GDSC2 6.1886 8.0387 2.7244 0.2762
OVCAR-5 GDSC2 6.2217 7.7723 2.827 0.1154
OVCAR-4 GDSC2 6.2228 16.819 -1.1886 17.8987
EFO-21 GDSC2 6.2478 7.7763 2.8346 0.1033
OV-90 GDSC2 6.2584 8.0331 2.7515 0.211
Kuramochi GDSC2 6.2863 8.5076 2.5946 0.5265
EFO-27 GDSC2 7.3064 17.6014 -0.833 13.4786
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC GDSC2 3.6593 5.4637 2.5176 4.1918
MZ-PC-1 GDSC2 3.7176 7.0189 1.0097 5.0113
KP-4 GDSC2 4.2908 5.9143 2.7164 1.7694
SU.86.86 GDSC2 4.4835 8.6867 1.535 8.2925
PaTu 8902 GDSC2 4.7017 6.4724 2.6937 1.3419
HPAF-II GDSC2 4.8362 7.9263 2.1259 4.1337
MIA PaCa-2 GDSC2 4.8912 7.3437 2.4192 2.4556
PaTu 8988t GDSC2 4.9372 14.9731 -1.2183 20.8837
DAN-G GDSC2 5.2482 14.3787 -0.6948 18.0307
Capan-1 GDSC2 5.2879 7.0178 2.7444 0.6252
PSN1 GDSC2 5.3067 7.7922 2.444 1.8108
BxPC-3 GDSC2 5.3454 8.0325 2.3626 2.1461
KP-2 GDSC2 5.3741 6.5549 2.9436 0.1171
PL4 GDSC2 5.401 7.2093 2.7192 0.6354
HuP-T4 GDSC2 5.434 7.5963 2.5839 1.092
KP-3 GDSC2 5.5125 8.8145 2.1148 3.1514
CFPAC-1 GDSC2 5.7242 7.2891 2.8161 0.241
AsPC-1 GDSC2 5.7552 9.3794 2 3.4004
QGP-1 GDSC2 5.8173 13.2852 0.2351 11.5646
Panc 10.05 GDSC2 5.8722 8.0778 2.5873 0.7642
SUIT-2 GDSC2 5.8749 7.2292 2.8898 0.0976
KP-1N GDSC2 5.9446 7.802 2.7172 0.3728
HuP-T3 GDSC2 6.0348 7.895 2.7181 0.3379
Panc 02.03 GDSC2 6.0696 18.0834 -1.913 20.8412
Capan-2 GDSC2 6.2587 8.3121 2.6542 0.3964
Panc 08.13 GDSC2 6.3578 8.265 2.7072 0.2598
YAPC GDSC2 7.0663 24.4109 -4.2882 25.479
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 5.1265 8.9823 1.8169 5.3621
MSTO-211H GDSC2 5.3294 10.5675 1.2044 8.4133
IST-Mes1 GDSC2 5.3565 7.0943 2.7441 0.584
NCI-H28 GDSC2 5.9421 8.2175 2.5637 0.7963
NCI-H2052 GDSC2 6.4402 8.4937 2.6576 0.3277
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 4.2548 6.0691 1.7108 0.7615
LNCaP clone FGC GDSC2 4.7974 7.6071 2.2483 3.5162
VCaP GDSC2 4.8455 6.636 2.6966 1.1725
DU145 GDSC2 5.8143 7.579 2.7474 0.354
PC-3 GDSC2 5.9245 8.3221 2.5164 0.9645
22Rv1 GDSC2 6.0865 8.077 2.6728 0.42
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.9691 9.44 1.5027 7.45
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 GDSC2 2.7881 9.122 -0.6978 17.0409
MZ-MEL-2 GDSC2 2.9564 6.9032 0.5362 9.5415
Mel Ho GDSC2 3.5021 7.112 0.8247 6.5289
COLO 800 GDSC2 3.5307 7.3538 0.7282 7.0419
Hs 938.T GDSC2 3.6575 6.6311 1.1526 4.2992
IPC-298 GDSC2 3.6868 8.2123 0.422 8.5082
DJM-1 GDSC2 3.7411 7.7699 0.6705 6.9413
MMAc-SF GDSC2 3.746 6.885 1.0897 4.4987
LB2518-MEL GDSC2 3.7516 5.1193 1.8599 0.5986
RPMI-7951 GDSC2 4.0151 5.7635 2.6192 2.7913
SK-MEL-3 GDSC2 4.0906 5.6202 1.8125 0.5301
COLO 783 GDSC2 4.0937 5.6083 1.8182 0.5101
Hs 940.T GDSC2 4.1219 6.4647 1.4886 1.8147
A-431 GDSC2 4.1829 6.1061 1.6645 0.9899
LB373-MEL-D GDSC2 4.2351 5.5125 1.9082 0.2132
SK-MEL-2 GDSC2 4.3232 10.4419 0.5581 14.2559
UACC-62 GDSC2 4.3269 6.0857 2.6604 2.0141
A2058 GDSC2 4.3621 6.4725 2.506 2.8106
VMRC-MELG GDSC2 4.4202 6.0842 1.7737 0.4615
RVH-421 GDSC2 4.4347 12.7349 -1.2462 15.6201
SK-MEL-31 GDSC2 4.4569 14.9528 -2.3146 20.0386
SK-MEL-30 GDSC2 4.4797 6.1749 1.764 0.4585
CP50-MEL-B GDSC2 4.4839 6.265 1.7324 0.5463
GAK GDSC2 4.5314 7.5874 2.0932 4.8812
SH-4 GDSC2 4.5758 7.0686 2.3617 3.256
MZ-MEL-7 GDSC2 4.6156 6.3845 1.7409 0.4547
451Lu GDSC2 4.6598 9.8351 0.2889 7.3247
A-388 GDSC2 4.6883 6.8444 1.5987 0.8457
M14 GDSC2 4.9164 7.237 2.4792 2.1159
G-mel GDSC2 4.9302 6.7833 2.6769 1.0652
WM115 GDSC2 4.9318 6.5312 2.7786 0.7592
WM793 GDSC2 4.9566 7.2924 2.4766 2.0764
COLO 679 GDSC2 5.0037 10.0804 1.2207 8.9863
A101D GDSC2 5.0896 6.4162 2.8875 0.3159
UACC-257 GDSC2 5.1034 6.8678 2.7228 0.8321
SK-MEL-24 GDSC2 5.2451 6.8951 2.773 0.5606
A-375 GDSC2 5.358 10.6873 1.1664 7.8384
HT-144 GDSC2 5.3611 11.8218 0.6278 11.4674
Mel JuSo GDSC2 5.4526 7.2166 2.7377 0.5479
WT2-iPS GDSC2 5.458 6.6814 2.93 0.1084
CP66-MEL GDSC2 5.6347 6.8524 2.9335 0.0773
G-361 GDSC2 5.6982 7.5383 2.7173 0.4784
WM1552C GDSC2 5.7339 7.2478 2.834 0.2056
LOX-IMVI GDSC2 5.7834 7.4399 2.7851 0.2836
CHL-1 GDSC2 5.7875 7.4287 2.7905 0.2713
IGR-1 GDSC2 5.8294 7.7165 2.7037 0.453
WM35 GDSC2 5.8644 8.2637 2.5131 1.019
HMV-II GDSC2 5.8986 8.4349 2.4615 1.1805
COLO 829 GDSC2 6.0174 7.9825 2.6803 0.4302
IGR-37 GDSC2 6.4137 15.7898 -0.5617 14.957
WM278 GDSC2 6.7547 20.6564 -2.6778 21.8795
SK-MEL-5 GDSC2 7.7102 18.2259 -0.8675 12.9479
COLO 792 GDSC2 7.774 24.1069 -3.6347 22.642
EquiPSC Line K2 GDSC2 3.5787 7.1326 0.8662 6.124
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 5.4625 7.3581 2.6885 0.6322
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC2 4.2017 5.6332 1.8524 0.3552
HT-1080 GDSC2 4.2363 5.8087 2.7325 1.7653
KYM-1 GDSC2 4.277 6.9712 2.2187 4.6457
EW-8 GDSC2 4.3517 7.4706 2.0304 5.6175
Rh30 GDSC2 4.7701 7.0902 2.4639 2.3959
SW982 GDSC2 4.8396 6.5607 2.7245 1.058
MES-SA GDSC2 4.8867 6.0413 2.9445 0.2618
A-204 GDSC2 5.0326 8.4694 1.9955 4.5261
SW684 GDSC2 5.2758 6.4138 2.957 0.1182
RKN GDSC2 5.422 6.5598 2.9585 0.0893
SW872 GDSC2 5.4865 15.1398 -0.8945 18.3197
VA-ES-BJ GDSC2 5.4901 7.2719 2.7323 0.5429
G-402 GDSC2 5.6746 18.1584 -2.2386 22.7528
STS-0421 GDSC2 5.676 7.792 1.6397 0.2924
GCT GDSC2 5.7474 13.2067 0.2256 12.6989
Rh41 GDSC2 5.7871 7.4573 2.7803 0.2922
SK-UT-1 GDSC2 6.1082 8.3839 2.5695 0.6823
RD GDSC2 6.1357 7.9511 2.7356 0.2707
SK-LMS-1 GDSC2 6.3924 8.1407 2.762 0.1667
G-401 GDSC2 6.6818 20.7314 -2.7664 22.2821
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN7 GDSC2 3.7615 10.2312 -0.5066 13.5242
KATO III GDSC2 3.9262 5.8331 2.5272 3.5223
ECC12 GDSC2 3.9885 5.2608 1.9045 0.318
SCH GDSC2 4.0239 5.5889 1.7963 0.6269
NUGC-4 GDSC2 4.3249 8.8678 1.3339 9.8507
TMK-1 GDSC2 4.4514 6.6895 1.5548 1.1912
SNU-5 GDSC2 4.4896 6.7872 2.4386 2.9716
MKN45 GDSC2 4.4994 6.4573 2.5927 2.1147
OCUM-1 GDSC2 5.0696 7.2046 2.5711 1.4936
IM95 GDSC2 5.0784 13.0605 -0.1724 16.0922
MKN1 GDSC2 5.1291 6.9242 2.7121 0.8516
AGS GDSC2 5.335 6.8343 2.8313 0.3493
23132/87 GDSC2 5.5414 7.0187 2.8436 0.2441
RF-48 GDSC2 5.6758 8.3872 2.3782 1.7135
NCI-N87 GDSC2 5.7151 8.655 2.2871 2.0745
Hs 746.T GDSC2 5.7844 7.9153 2.6122 0.7393
MKN28 GDSC2 5.8151 7.8115 2.6634 0.5684
NUGC-3 GDSC2 5.8847 7.4937 2.8034 0.2187
HGC-27 GDSC2 5.8882 7.288 2.8747 0.1129
ECC10 GDSC2 5.9454 7.5215 2.8155 0.1834
SNU-1 GDSC2 6.0373 8.3663 2.5471 0.7907
GCIY GDSC2 6.1154 8.0442 2.6954 0.3581
RERF-GC-1B GDSC2 6.186 8.6703 2.4942 0.867
SK-GT-2 GDSC2 6.3893 8.9264 2.4817 0.786
SNG-M GDSC2 6.2549 7.9722 2.771 0.1819
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] GDSC2 3.9089 6.4137 1.3983 2.5388
KMH-2 GDSC2 4.0386 5.9314 1.668 1.1048
TT2609-C02 GDSC2 4.2474 9.4057 1.0127 11.914
CAL-62 GDSC2 4.7655 7.1064 2.4542 2.4532
BHT-101 GDSC2 4.79 7.3453 2.3619 2.9078
K5 GDSC2 4.8962 9.252 1.5439 7.3602
IHH-4 GDSC2 4.9462 6.4996 2.7972 0.6795
8305C GDSC2 5.0393 7.3202 2.5076 1.8225
ASH-3 GDSC2 5.0995 6.5587 2.8391 0.4435
B-CPAP GDSC2 5.3012 6.6463 2.8856 0.2376
FTC-133 GDSC2 5.5837 6.852 2.9161 0.114
WRO GDSC2 5.7165 7.1311 2.8679 0.1548
HTC-C3 GDSC2 6.3597 8.1064 2.7622 0.1728
8505C GDSC2 6.3907 8.2185 2.735 0.2061
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KOSC-2 GDSC2 3.0804 9.8713 -0.8408 16.9745
PCI-15A GDSC2 3.4559 7.9869 0.3698 9.3318
JHU-011 GDSC2 3.5982 5.9619 1.4234 2.8763
KON GDSC2 3.6211 8.5764 0.2001 9.9418
BHY GDSC2 3.8548 5.9145 1.585 1.6751
BICR 31 GDSC2 3.8941 7.8183 0.7475 6.1893
BB30-HNC GDSC2 3.9874 12.9148 -1.6587 18.4905
DOK GDSC2 4.0949 10.3836 0.4128 15.6244
OSC-19 GDSC2 4.2753 6.6856 1.4728 1.7142
PCI-06A GDSC2 4.3281 10.0255 -0.0135 9.6144
HSC-3 GDSC2 4.4371 6.9375 2.3374 3.6385
JHU-029 GDSC2 4.5738 9.5798 0.3539 7.1271
SKN-3 GDSC2 4.6597 9.9724 1.0349 10.7976
CAL-33 GDSC2 4.7536 11.2186 0.4939 13.5405
SAT [Human HNSCC] GDSC2 4.8186 9.867 1.1971 9.5176
SAS GDSC2 4.9018 7.5975 2.313 2.9989
PCI-04B GDSC2 4.9334 8.4204 1.9577 4.4691
HSC-4 GDSC2 4.9769 6.8009 2.6918 1.0637
BICR 22 GDSC2 4.9773 6.4045 2.8468 0.4908
HSC-2 GDSC2 4.9909 10.0352 1.2337 8.9398
PE/CA-PJ15 GDSC2 5.0033 6.9724 1.6785 0.4404
SCC-25 GDSC2 5.1461 6.9114 1.7532 0.2363
Detroit 562 GDSC2 5.2617 7.9832 2.3404 2.3567
SCC-4 GDSC2 5.3212 7.361 2.626 1.0231
NCI-H3118 GDSC2 5.4424 8.901 2.0385 3.6433
BB49-HNC GDSC2 5.4515 15.4413 -1.0676 19.0951
CAL-27 GDSC2 5.4563 7.0729 2.792 0.3951
FaDu GDSC2 5.5085 6.9668 2.8497 0.2425
BICR 10 GDSC2 5.5786 14.267 -0.403 16.0118
SCC-15 GDSC2 5.6446 9.0535 2.082 3.1384
SCC-9 GDSC2 5.6531 7.6186 2.6695 0.6394
JHU-022 GDSC2 5.6673 16.7631 -1.5583 20.4682
HO-1-N-1 GDSC2 5.7561 7.4447 2.7732 0.3181
UPCI-SCC-090 GDSC2 5.8948 8.2617 2.5269 0.949
BICR 78 GDSC2 6.1859 8.0263 2.7278 0.2707
Ca9-22 GDSC2 6.2275 8.1286 2.7073 0.297
LB771-HNC GDSC2 6.3512 8.1149 2.7564 0.1828
OSC-20 GDSC2 6.4296 8.2934 2.7231 0.2155
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T24 GDSC2 4.2722 8.0861 0.8574 4.885
KU-19-19 GDSC2 4.7291 8.9141 1.5938 7.4148
CAL-29 GDSC2 4.7463 7.1481 2.425 2.6365
RT-112 GDSC2 4.9681 6.762 2.7034 1.0242
RT-4 GDSC2 5.1066 8.5415 2.0068 4.3385
BFTC-905 GDSC2 5.2709 6.6605 2.8692 0.2848
647V GDSC2 5.377 6.5897 2.9327 0.1322
TCCSUP GDSC2 5.3821 7.3472 2.6584 0.8547
639V GDSC2 5.3981 6.7419 2.8879 0.2025
HT-1197 GDSC2 5.6255 6.9954 2.8821 0.1535
J82 GDSC2 5.7736 7.4896 2.7638 0.3324
SW1710 GDSC2 5.8338 7.4307 2.8068 0.2266
5637 GDSC2 6.1207 8.1692 2.6528 0.4537
SW780 GDSC2 7.2779 22.8303 -3.3643 22.8219
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC2 2.8304 12.192 -1.5291 27.7796
SW962 GDSC2 3.7685 7.1838 0.9648 5.1746
JEG-3 GDSC2 3.7939 5.676 1.6546 1.4181
DSH1 GDSC2 3.8319 6.2637 2.2514 5.4308
OMC-1 [Human cervical carcinoma] GDSC2 4.0268 6.5855 1.3873 2.431
JAR GDSC2 4.1714 7.9368 0.8651 5.0139
HeLa GDSC2 4.2993 10.0006 0.758 13.2228
OVCA433 GDSC2 4.3856 9.2112 0.4076 7.178
MS751 GDSC2 4.6009 7.7534 2.0598 4.9424
SW954 GDSC2 4.6843 6.8515 1.5943 0.8635
HEY GDSC2 4.7223 10.0401 1.0462 10.5901
DoTc2 4510 GDSC2 4.84 8.1289 2.035 4.6413
SW756 GDSC2 4.9188 7.5188 2.3575 2.7376
PWR-1E GDSC2 4.9679 9.0121 1.7037 6.2983
JHOS-3 GDSC2 4.997 6.8859 1.7071 0.3758
SiHa GDSC2 5.0308 14.5004 -0.9149 19.4587
CAL-39 GDSC2 5.0548 13.7567 -0.5312 17.7765
HT-3 GDSC2 5.1082 7.4318 2.4955 1.7984
PA-1 GDSC2 5.1206 16.7591 -1.9629 23.1055
NEC8 GDSC2 5.1326 6.6163 2.8312 0.4487
UWB1.289 GDSC2 5.1913 7.5791 1.5306 0.7513
ACC-OV7 GDSC2 5.3447 7.608 1.5809 0.5354
OVCA420 GDSC2 5.3747 6.8531 2.8398 0.3121
C-4-I GDSC2 5.3933 7.2181 2.7127 0.6611
SiSo GDSC2 5.4801 8.074 2.4124 1.7653
OV17R GDSC2 5.5599 7.3186 1.7602 0.1393
SKG-IIIa GDSC2 5.7152 7.6652 2.6774 0.5811
OVMIU GDSC2 5.7225 8.2589 2.4518 1.3641
TC-YIK GDSC2 5.7272 7.6934 2.6717 0.591
HEC-1 GDSC2 5.7898 7.3874 2.8059 0.2409
SKN GDSC2 5.9251 8.3479 2.5068 0.9975
LB831-BLC GDSC2 6.0867 7.859 2.7499 0.2586
C-33 A GDSC2 6.1369 7.9531 2.7353 0.2709
PEO1 GDSC2 6.2627 8.1659 2.7071 0.2867
ME-180 GDSC2 6.504 9.0942 2.4658 0.7699
Ca Ski GDSC2 6.6172 8.9141 2.5752 0.4392
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

References

1 LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-40.
2 In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-. Toxicol Appl Pharmacol. 2018 Sep 15;355:127-137. doi: 10.1016/j.taap.2018.07.001. Epub 2018 Jul 3.