Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB1IU4)

Drug Name
Lenvatinib Drug Info
Synonyms E 7080; E-7080, E7080; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
Cross-matching ID
PubChem CID
9823820
ChEBI ID
CHEMBL1289601
CAS Number
CAS 417716-92-8
TTD Drug ID
D0R0FO
VARIDT Drug ID
DR00265

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Platelet activation 1.86 4.21e-2 106/124 (85.48%) GNAS;TLN1;GNAI1;...
Cholesterol metabolism 1.83 4.42e-2 44/50 (88%) APOA1;MYLIP;APOA2;...
Regulation of actin cytoskeleton 1.82 3.53e-2 185/218 (84.86%) PDGFC;FGFR3;PXN;...
Salivary secretion 1.82 3.15e-2 76/93 (81.72%) GNAS;ATP2B4;CST3;...
Melanogenesis 1.80 2.70e-2 74/101 (73.27%) GNAS;LEF1;CREB1;...
Focal adhesion 1.79 2.52e-2 180/201 (89.55%) PDGFC;PXN;COL4A5;...
Fc gamma R-mediated phagocytosis 1.78 2.80e-2 79/97 (81.44%) PRKCB;ARPC1B;INPPL1;...
Gap junction 1.76 3.03e-2 72/88 (81.82%) PDGFC;GNAS;GNAI1;...
Glucagon signaling pathway 1.76 3.10e-2 89/107 (83.18%) PFKP;GNAS;CREB1;...
Growth hormone synthesis, secretion and action 1.75 2.94e-2 108/119 (90.76%) GNAS;CREB1;GNAI1;...
ECM-receptor interaction 1.74 3.20e-2 80/88 (90.91%) COL4A5;ITGA4;COL9A2;...
Inositol phosphate metabolism 1.74 3.25e-2 66/73 (90.41%) INPP5A;INPPL1;ALDH6A1;...
Adipocytokine signaling pathway 1.72 3.45e-2 64/69 (92.75%) RXRA;ACSL3;NPY;...
Neutrophil extracellular trap formation 1.69 4.57e-2 101/189 (53.44%) CLEC7A;ITGAL;PRKCB;...
Cholinergic synapse 1.68 4.45e-2 99/113 (87.61%) GNG11;CREB1;GNAI1;...
Yersinia infection 1.67 4.98e-2 120/137 (87.59%) PXN;ITGA4;SKAP2;...
Long-term depression 1.66 4.86e-2 55/60 (91.67%) GNAS;GNAI1;PRKCB;...
Choline metabolism in cancer 1.66 4.81e-2 84/98 (85.71%) PDGFC;PRKCB;DGKD;...
Circadian entrainment 1.65 4.93e-2 85/97 (87.63%) GNAS;GNG11;CREB1;...
Vitamin digestion and absorption 1.65 4.77e-2 17/24 (70.83%) APOA1;ABCC1;SLC19A1;...
T cell receptor signaling pathway 1.65 4.63e-2 93/104 (89.42%) NFATC3;ITK;CD3D;...
Relaxin signaling pathway 1.64 4.69e-2 114/129 (88.37%) GNAS;GNG11;CREB1;...
Glycolysis / Gluconeogenesis 1.62 4.96e-2 56/67 (83.58%) PFKP;ENO2;GPI;...
Mineral absorption -1.70 4.77e-2 48/60 (80%) ATP1B3;ATP1B2;HMOX2;...
Parkinson disease -1.75 3.35e-2 176/249 (70.68%) SLC25A5;SLC25A31;NDUFS3;...
Protein export -1.77 3.14e-2 17/23 (73.91%) HSPA5;SRPRB;SEC62;...
Oxidative phosphorylation -1.87 9.30e-3 93/133 (69.92%) COX6B1;COX7A2L;COX11;...
Ribosome -1.94 1.05e-2 113/158 (71.52%) RPS4X;RPL29;MRPS12;...
Legionellosis -2.05 0.00e+0 51/57 (89.47%) IL12B;RAB1A;CXCL3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H