Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB5A80)

Drug Name
SNX-2112 Drug Info
Synonyms
SNX-2112; 908112-43-6; SNX 2112; 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide; UNII-10C9P3FFOW; PF-04928473; 10C9P3FFOW; CHEMBL560895; SNX-2112 (PF-04928473); 945626-71-1; 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide; 4-[6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-2-[(cis-4-hydroxycyclohexyl)amino]benzamide
Cross-matching ID
PubChem CID
24772860
CAS Number
CAS 908112-43-6
TTD Drug ID
D0K0TJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.04 0.00e+0 127/171 (74.27%) HSPA1A;HSPA8;HSPH1;...
Nitrogen metabolism 1.98 3.48e-3 16/17 (94.12%) GLUL;GLUD1;GLUD2;...
Longevity regulating pathway 1.84 1.85e-2 90/151 (59.6%) HSPA1A;HSPA8;CRYAB;...
Chagas disease -1.65 4.89e-2 93/102 (91.18%) AKT1;TICAM1;PLCB1;...
Osteoclast differentiation -1.66 4.83e-2 117/127 (92.13%) LCP2;AKT1;LILRB2;...
TNF signaling pathway -1.66 4.93e-2 103/112 (91.96%) TNFAIP3;IRF1;RIPK1;...
Allograft rejection -1.72 2.32e-2 32/38 (84.21%) HLA-DQB1;HLA-DRB1;HLA-DOB;...
Pertussis -1.74 2.18e-2 64/76 (84.21%) CASP1;CALML4;IL6;...
Epstein-Barr virus infection -1.74 2.23e-2 189/202 (93.56%) TLR2;E2F2;PSMC5;...
Kaposi sarcoma-associated herpesvirus infection -1.75 2.15e-2 172/193 (89.12%) PIK3R5;IL6;GNG7;...
Rheumatoid arthritis -1.76 2.05e-2 78/93 (83.87%) FOS;TLR2;HLA-DQB1;...
Tuberculosis -1.77 1.95e-2 159/180 (88.33%) CALML4;IL18;FCGR2C;...
Intestinal immune network for IgA production -1.78 1.83e-2 38/48 (79.17%) HLA-DQB1;HLA-DRB1;IL15RA;...
Influenza A -1.79 1.60e-2 156/172 (90.7%) AKT1;CCND3;TICAM1;...
Amphetamine addiction -1.80 1.53e-2 57/69 (82.61%) ARC;PRKCB;PPP3CA;...
Homologous recombination -1.81 1.66e-2 35/41 (85.37%) MUS81;RPA3;RAD51D;...
Base excision repair -1.83 1.59e-2 29/33 (87.88%) POLD3;LIG1;POLE3;...
Asthma -1.85 1.12e-2 25/31 (80.65%) HLA-DQB1;HLA-DRB1;HLA-DOB;...
NF-kappa B signaling pathway -1.85 1.25e-2 90/104 (86.54%) GADD45A;CCL19;TNFRSF1A;...
Pyrimidine metabolism -1.87 1.09e-2 40/56 (71.43%) DTYMK;DCTD;ENPP1;...
Mismatch repair -1.89 8.91e-3 22/23 (95.65%) RFC3;POLD3;LIG1;...
IL-17 signaling pathway -1.89 1.04e-2 84/94 (89.36%) CCL20;S100A9;FADD;...
Complement and coagulation cascades -1.90 1.25e-2 76/85 (89.41%) CD55;SERPINA1;F12;...
Graft-versus-host disease -1.91 1.25e-2 32/42 (76.19%) HLA-DQB1;HLA-DRB1;HLA-DOB;...
Fanconi anemia pathway -1.96 4.16e-3 36/54 (66.67%) ATR;ERCC1;ERCC4;...
Leishmaniasis -2.08 0.00e+0 67/77 (87.01%) CYBA;ITGAM;FCGR2A;...
DNA replication -2.42 0.00e+0 34/36 (94.44%) RFC3;POLD3;LIG1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H