Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB8MNU)

Drug Name
CHIR-99021 Drug Info
Synonyms CHIR99021; CHIR 99021; CT-99021; CT99021
Cross-matching ID
PubChem CID
9956119
ChEBI ID
CHEMBL91091
CAS Number
CAS 252917-06-9
TTD Drug ID
D0YK9D

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.57 0.00e+0 52/108 (48.15%) DKC1;NOP56;GTPBP4;...
RNA transport 2.37 0.00e+0 128/186 (68.82%) NXT1;EIF4G1;NDC1;...
DNA replication 2.14 0.00e+0 34/36 (94.44%) POLE3;FEN1;RNASEH1;...
Spliceosome 2.10 0.00e+0 101/150 (67.33%) CHERP;LSM5;PUF60;...
Asthma 2.09 0.00e+0 25/31 (80.65%) HLA-DQA1;HLA-DRB1;FCER1A;...
Ribosome 2.03 0.00e+0 113/158 (71.52%) MRPS2;MRPL3;MRPL15;...
Proteasome 1.93 0.00e+0 44/46 (95.65%) PSME3;PSMD12;PSMB5;...
RNA polymerase 1.77 1.49e-2 23/31 (74.19%) POLR1C;POLR1E;POLR2D;...
Collecting duct acid secretion 1.76 1.52e-2 22/27 (81.48%) CA2;ATP6V1D;ATP6V0A2;...
Protein export 1.69 3.50e-2 17/23 (73.91%) SRPRB;SRP72;HSPA5;...
IL-17 signaling pathway 1.68 3.49e-2 84/94 (89.36%) FOSL1;CXCL8;CXCL1;...
Systemic lupus erythematosus 1.63 4.63e-2 45/135 (33.33%) SNRPD1;HLA-DQA1;ELANE;...
Ovarian steroidogenesis -1.78 3.86e-2 41/51 (80.39%) ADCY1;CYP11A1;BMP6;...
Mineral absorption -1.81 4.05e-2 48/60 (80%) ATP1B1;ATP2B1;ATP2B4;...
Mitophagy -1.92 3.31e-2 56/68 (82.35%) SQSTM1;FOXO3;JUN;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 2.22uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H