Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBE24Y)

Drug Name
PF750 Drug Info
Synonyms PF-750; PF 750
Cross-matching ID
PubChem CID
25154868
ChEBI ID
CHEMBL560590
CAS Number
CAS 959151-50-9
TTD Drug ID
D0W0SE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.14 0.00e+0 34/36 (94.44%) RNASEH1;MCM2;POLD1;...
Tryptophan metabolism 1.96 1.43e-2 35/42 (83.33%) DLD;IDO1;DHTKD1;...
Retinol metabolism 1.96 9.52e-3 41/68 (60.29%) ALDH1A3;ALDH1A1;ADH1B;...
Base excision repair 1.94 1.19e-2 29/33 (87.88%) APEX1;POLD1;POLD4;...
Selenocompound metabolism 1.92 1.14e-2 11/17 (64.71%) SEPHS1;PAPSS1;PAPSS2;...
One carbon pool by folate 1.91 9.52e-3 15/20 (75%) SHMT2;MTHFD2;MTHFD1;...
Alanine, aspartate and glutamate metabolism 1.89 1.22e-2 27/37 (72.97%) ASNS;ALDH5A1;ALDH4A1;...
Cysteine and methionine metabolism 1.87 1.43e-2 43/50 (86%) PHGDH;PSAT1;CBS;...
Metabolism of xenobiotics by cytochrome P450 1.86 1.27e-2 49/77 (63.64%) AKR7A3;ADH1B;HSD11B1;...
Glycine, serine and threonine metabolism 1.84 1.33e-2 31/40 (77.5%) PHGDH;SHMT2;DLD;...
Glycerolipid metabolism 1.83 1.30e-2 44/61 (72.13%) PLPP3;MGLL;AGK;...
Glutathione metabolism 1.81 1.35e-2 43/57 (75.44%) LAP3;IDH1;RRM2;...
Drug metabolism 1.79 1.68e-2 78/151 (51.66%) ADH1B;ADH5;UPP1;...
Glycolysis / Gluconeogenesis 1.79 1.56e-2 56/67 (83.58%) PCK2;DLD;ADH1B;...
Porphyrin and chlorophyll metabolism 1.78 1.71e-2 23/43 (53.49%) FXN;ALAS2;FECH;...
Mismatch repair 1.75 2.02e-2 22/23 (95.65%) POLD1;POLD4;RFC5;...
Fructose and mannose metabolism 1.74 1.96e-2 30/33 (90.91%) GMDS;PFKP;AKR1B1;...
Pentose and glucuronate interconversions 1.73 1.90e-2 17/34 (50%) AKR1B1;UGT2B28;UGP2;...
Fatty acid degradation 1.72 2.20e-2 40/43 (93.02%) ADH1B;ADH5;ADH1C;...
Pyrimidine metabolism 1.71 2.24e-2 40/56 (71.43%) UPP1;UCK2;RRM2;...
Pentose phosphate pathway 1.67 2.99e-2 25/30 (83.33%) PFKP;PGM1;PFKL;...
Phagosome -2.03 0.00e+0 118/152 (77.63%) CD14;OLR1;HLA-A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 80uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 80uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 80uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 80uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H