Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBLHGP)

Drug Name
Saracatinib Drug Info
Synonyms H8H; AZD-0530; Saracatinib, AZD-0530, AZD0530; N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
10302451
ChEBI ID
CHEMBL217092
CAS Number
CAS 379231-04-6
TTD Drug ID
D0M0XB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.58 0.00e+0 19/20 (95%) DHCR24;MSMO1;SQLE;...
PPAR signaling pathway 2.23 0.00e+0 66/74 (89.19%) HMGCS1;SCD;DBI;...
Valine, leucine and isoleucine degradation 2.12 0.00e+0 42/48 (87.5%) HMGCS1;ACAT2;AACS;...
Terpenoid backbone biosynthesis 2.11 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Oxidative phosphorylation 2.09 1.53e-3 93/133 (69.92%) ATP6V1A;NDUFS6;ATP6V0D1;...
Fatty acid degradation 2.06 1.27e-3 40/43 (93.02%) ACAT2;ACSL3;ACSL1;...
Peroxisome 2.03 2.18e-3 72/82 (87.8%) IDH1;CAT;AMACR;...
Tyrosine metabolism 2.02 1.91e-3 30/36 (83.33%) MAOA;ALDH3A1;COMT;...
Steroid hormone biosynthesis 2.01 1.70e-3 43/61 (70.49%) AKR1C3;HSD17B7;AKR1C1;...
Butanoate metabolism 2.00 1.53e-3 23/28 (82.14%) HMGCS1;ACAT2;BDH1;...
Metabolism of xenobiotics by cytochrome P450 1.98 1.39e-3 49/77 (63.64%) EPHX1;AKR1C1;UGT2B28;...
Glyoxylate and dicarboxylate metabolism 1.97 1.91e-3 23/30 (76.67%) ACAT2;CAT;GLUL;...
Propanoate metabolism 1.91 2.35e-3 30/34 (88.24%) ACAT2;ACACA;SUCLA2;...
Fatty acid biosynthesis 1.91 2.18e-3 16/18 (88.89%) FASN;ACSL3;ACSL1;...
Staphylococcus aureus infection 1.91 2.04e-3 72/95 (75.79%) CFI;KRT15;CFB;...
Histidine metabolism 1.86 3.34e-3 16/22 (72.73%) MAOA;HNMT;ALDH3A1;...
Lysosome 1.85 3.15e-3 115/128 (89.84%) CTSK;CTSC;LIPA;...
Primary bile acid biosynthesis 1.85 2.97e-3 15/17 (88.24%) AMACR;HSD17B4;CYP39A1;...
Tryptophan metabolism 1.83 3.62e-3 35/42 (83.33%) ACAT2;MAOA;CAT;...
Phenylalanine metabolism 1.80 5.73e-3 14/17 (82.35%) MAOA;ALDH3A1;PAH;...
Drug metabolism 1.78 5.46e-3 78/151 (51.66%) MAOA;UGT2B28;GUSB;...
Renin-angiotensin system 1.76 6.95e-3 20/23 (86.96%) CPA3;MME;AGT;...
beta-Alanine metabolism 1.76 6.65e-3 25/30 (83.33%) ALDH3A1;CNDP2;DPYS;...
Biosynthesis of unsaturated fatty acids 1.74 9.24e-3 21/27 (77.78%) SCD;ELOVL6;FADS2;...
Synthesis and degradation of ketone bodies 1.72 1.28e-2 9/10 (90%) HMGCS1;ACAT2;BDH1
Ascorbate and aldarate metabolism 1.72 1.23e-2 15/30 (50%) UGT2B28;GUSB;UGT2B4;...
Complement and coagulation cascades 1.67 1.98e-2 76/85 (89.41%) CLU;CFI;TFPI;...
Nitrogen metabolism 1.65 2.70e-2 16/17 (94.12%) CA12;GLUL;GLUD1;...
Pyruvate metabolism 1.64 2.69e-2 41/47 (87.23%) ACAT2;ACACA;ADH1B;...
Ferroptosis 1.62 3.06e-2 36/41 (87.8%) CP;TF;SLC39A8;...
T cell receptor signaling pathway -1.61 3.77e-2 93/104 (89.42%) CD3E;CD28;ZAP70;...
Hematopoietic cell lineage -1.62 3.49e-2 90/99 (90.91%) CD33;IL5RA;CD14;...
Rap1 signaling pathway -1.62 3.52e-2 184/210 (87.62%) FGFR4;AKT1;PLCE1;...
Yersinia infection -1.62 3.65e-2 120/137 (87.59%) RPS6KA1;ZAP70;RPS6KA2;...
Colorectal cancer -1.63 3.59e-2 84/86 (97.67%) RALA;RHOA;TGFBR1;...
Salmonella infection -1.63 3.47e-2 198/249 (79.52%) RAF1;IRAK1;MAP2K3;...
MAPK signaling pathway -1.64 3.34e-2 272/294 (92.52%) RAF1;IRAK1;MAP2K3;...
Malaria -1.64 3.37e-2 44/50 (88%) KLRB1;ITGB2;ITGAL;...
PI3K-Akt signaling pathway -1.66 2.93e-2 317/354 (89.55%) ITGA3;PCK1;CHUK;...
Bacterial invasion of epithelial cells -1.66 3.07e-2 59/77 (76.62%) CTNNB1;ARPC5L;SRC;...
Signaling pathways regulating pluripotency of stem cell... -1.67 2.83e-2 110/143 (76.92%) BMI1;FGFR4;WNT7A;...
RNA transport -1.68 2.63e-2 128/186 (68.82%) EEF1A2;NUP155;THOC7;...
Bladder cancer -1.68 2.78e-2 40/41 (97.56%) RAF1;HRAS;CXCL8;...
Arrhythmogenic right ventricular cardiomyopathy -1.70 2.32e-2 70/77 (90.91%) DSC2;CTNNB1;ITGA3;...
TNF signaling pathway -1.71 2.38e-2 103/112 (91.96%) TRAF3;CSF1;TAB2;...
Th1 and Th2 cell differentiation -1.73 2.28e-2 80/92 (86.96%) CD3E;ZAP70;MAPK9;...
Ribosome -1.73 2.44e-2 113/158 (71.52%) RPL17;RPS7;MRPL3;...
ECM-receptor interaction -1.77 1.52e-2 80/88 (90.91%) ITGB6;COL4A5;FN1;...
Apelin signaling pathway -1.78 1.53e-2 117/137 (85.4%) AKT1;GNB2;GNB3;...
Tight junction -1.80 9.56e-3 130/169 (76.92%) ROCK1;MYL12B;NF2;...
Inflammatory bowel disease -1.81 1.05e-2 58/65 (89.23%) IL4R;IL21R;HLA-DQA1;...
AGE-RAGE signaling pathway in diabetic complications -1.84 7.30e-3 97/100 (97%) COL4A5;FN1;MAPK1;...
Proteoglycans in cancer -1.85 8.22e-3 172/205 (83.9%) PTK2;RHOA;MMP9;...
Regulation of actin cytoskeleton -1.89 5.63e-3 185/218 (84.86%) PPP1CA;RAF1;ROCK1;...
Hippo signaling pathway -1.92 4.38e-3 120/186 (64.52%) PPP1CA;SMAD3;TEAD1;...
Dilated cardiomyopathy -2.07 0.00e+0 86/96 (89.58%) ITGB1;DES;MYL2;...
Ribosome biogenesis in eukaryotes -2.14 0.00e+0 52/108 (48.15%) NHP2;RPP30;GNL3L;...
TGF-beta signaling pathway -2.15 0.00e+0 81/94 (86.17%) TGIF1;GREM2;IFNG;...
Hypertrophic cardiomyopathy -2.19 0.00e+0 81/90 (90%) ITGB1;DES;MYL2;...
Focal adhesion -2.20 0.00e+0 180/201 (89.55%) PPP1CA;RAF1;ROCK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H