Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBO28J)

Drug Name
CI-976 Drug Info
Synonyms
CI 976; 114289-47-3; 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide; CI-976; PD 128042; BRN 5831010; CHEMBL22373; UNII-8653IQ20EA; 8653IQ20EA; Dodecanamide,2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-; Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-; 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide; C23H39NO4; ACMC-1CUXF; AC1L3UE4; SCHEMBL691688; CTK4A8660; CHEBI:95040; DTXSID00150690; MolPort-002-018-232; HMS3268D10; HMS3262L19; ZINC8022586; Tox21_500859; BN0150; BDBM50005944; AKOS022180044; LP00859; CCG-222163
Cross-matching ID
PubChem CID
122327
ChEBI ID
CHEMBL22373
CAS Number
CAS 114289-47-3
TTD Drug ID
D0D1XG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.32 0.00e+0 34/36 (94.44%) POLE2;RFC4;POLD2;...
IL-17 signaling pathway 2.20 0.00e+0 84/94 (89.36%) CXCL8;PTGS2;CXCL1;...
Mismatch repair 2.09 0.00e+0 22/23 (95.65%) RFC4;POLD2;MLH1;...
Pyrimidine metabolism 2.09 0.00e+0 40/56 (71.43%) ENPP1;NT5E;CAD;...
Fanconi anemia pathway 2.00 0.00e+0 36/54 (66.67%) MLH1;BRCA1;MUS81;...
Homologous recombination 1.97 1.90e-3 35/41 (85.37%) POLD2;BRCA1;POLD1;...
Intestinal immune network for IgA production 1.95 3.27e-3 38/48 (79.17%) CXCL12;CD40;HLA-DRB1;...
Base excision repair 1.94 2.86e-3 29/33 (87.88%) PARP2;POLE2;POLD2;...
One carbon pool by folate 1.86 1.14e-2 15/20 (75%) TYMS;MTHFD2;MTR;...
Mucin type O-glycan biosynthesis 1.85 1.14e-2 20/36 (55.56%) GALNT1;GALNT14;GALNT6;...
Rheumatoid arthritis 1.84 1.14e-2 78/93 (83.87%) CXCL8;CXCL1;JUN;...
Purine metabolism 1.83 1.05e-2 102/129 (79.07%) PKM;ENPP1;NT5E;...
Cell cycle 1.83 1.06e-2 110/124 (88.71%) CCNA2;CDC20;CDC45;...
Aminoacyl-tRNA biosynthesis 1.81 1.14e-2 15/66 (22.73%) QRSL1;TARS2;FARSA;...
Nucleotide excision repair 1.78 1.30e-2 40/47 (85.11%) POLE2;RFC4;POLD2;...
Leishmaniasis 1.73 2.21e-2 67/77 (87.01%) PTGS2;JUN;IL1B;...
Inflammatory bowel disease 1.73 2.08e-2 58/65 (89.23%) JUN;IL1B;IFNG;...
Asthma 1.72 1.97e-2 25/31 (80.65%) CD40;HLA-DRB1;HLA-DQB1;...
Galactose metabolism 1.65 4.33e-2 26/31 (83.87%) PFKP;PFKL;GALE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 80uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.03uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 80uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.03uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 80uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 80uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
PL-21 CVCL_2161 Homo sapiens 80uM 6H
SKM-1 CVCL_0010 Homo sapiens 80uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H