Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBUI2A)

Drug Name
BETULINIC ACID Drug Info
Synonyms
betulinic acid; 472-15-1; Mairin; Betulic acid; NSC 113090; CCRIS 6748; 3-Hydroxylup-20(29)-en-28-oic acid; UNII-4G6A18707N; 3beta-Hydroxy-20(29)-lupaene-28-oic acid; EINECS 207-448-8; NSC677578; als-357; NSC 677578; CHEMBL269277; CHEBI:3087; 3beta-Hydroxy-lup-20(29)-en-28-oic acid; 4G6A18707N; Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-; AK-72848; Lupatic Acid; SMR000445624
Cross-matching ID
PubChem CID
64971
ChEBI ID
CHEMBL269277
CAS Number
CAS 472-15-1
TTD Drug ID
D0R9YR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.13 0.00e+0 34/36 (94.44%) PRIM1;MCM3;POLE2;...
Pyrimidine metabolism 1.94 6.89e-3 40/56 (71.43%) TYMS;CAD;UPP1;...
Mismatch repair 1.86 1.84e-2 22/23 (95.65%) MSH2;RPA3;EXO1;...
Cell cycle 1.84 1.72e-2 110/124 (88.71%) CCNE2;MCM3;PLK1;...
Progesterone-mediated oocyte maturation 1.81 1.93e-2 75/100 (75%) STK10;GNAI1;PLK1;...
Oocyte meiosis 1.80 1.84e-2 90/129 (69.77%) CCNE2;PLK1;RBX1;...
Homologous recombination 1.75 3.15e-2 35/41 (85.37%) RAD51;RPA3;RAD54B;...
RNA transport 1.73 3.45e-2 128/186 (68.82%) NUP85;NXT2;NUP155;...
Ribosome 1.70 3.75e-2 113/158 (71.52%) MRPS16;MRPL13;MRPS7;...
Fanconi anemia pathway 1.70 3.79e-2 36/54 (66.67%) FANCG;RAD51;RPA3;...
Metabolism of xenobiotics by cytochrome P450 -1.60 4.88e-2 49/77 (63.64%) UGT2B17;HSD11B1;CYP2D6;...
Glycosaminoglycan degradation -1.63 4.01e-2 19/19 (100%) GNS;GUSB;GALNS;...
Mitophagy -1.63 3.92e-2 56/68 (82.35%) CSNK2A2;ATF4;JUN;...
Synthesis and degradation of ketone bodies -1.64 3.73e-2 9/10 (90%) ACAT1;BDH2;ACAT2;...
C-type lectin receptor signaling pathway -1.64 3.77e-2 93/104 (89.42%) IL10;STAT2;PIK3R2;...
Retinol metabolism -1.65 3.66e-2 41/68 (60.29%) CYP3A7;RDH5;CYP3A4;...
Leishmaniasis -1.65 3.54e-2 67/77 (87.01%) HLA-DQA1;MAPK11;JUN;...
Pancreatic cancer -1.67 3.24e-2 75/76 (98.68%) BCL2L1;PIK3CD;GADD45B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.68 3.09e-2 62/70 (88.57%) CXCR2;ATP6AP1;ATP6V1A;...
Tryptophan metabolism -1.68 3.17e-2 35/42 (83.33%) CYP1A1;TDO2;ALDH8A1;...
Kaposi sarcoma-associated herpesvirus infection -1.69 2.94e-2 172/193 (89.12%) MAPK11;PIK3R1;TYK2;...
Apoptosis -1.69 2.96e-2 126/168 (75%) PARP3;PIK3R3;ENDOG;...
Collecting duct acid secretion -1.71 2.54e-2 22/27 (81.48%) SLC4A1;ATP4A;ATP6V0A2;...
Autophagy -1.73 2.00e-2 113/169 (66.86%) RRAGB;CTSB;STK11;...
Glyoxylate and dicarboxylate metabolism -1.75 1.96e-2 23/30 (76.67%) HAO2;ACAT1;GRHPR;...
Glycolysis / Gluconeogenesis -1.75 2.00e-2 56/67 (83.58%) HK2;ALDH3A1;ADH6;...
Synaptic vesicle cycle -1.79 1.31e-2 63/78 (80.77%) ATP6V1A;CACNA1A;DNM2;...
Primary bile acid biosynthesis -1.80 1.41e-2 15/17 (88.24%) CYP7A1;BAAT;AKR1D1;...
Butanoate metabolism -1.80 1.53e-2 23/28 (82.14%) ACSM5;ACAT1;AACS;...
Phosphatidylinositol signaling system -1.81 1.43e-2 82/97 (84.54%) MTMR6;INPP5D;ITPKC;...
Osteoclast differentiation -1.82 1.05e-2 117/127 (92.13%) MAPK11;PIK3R1;TYK2;...
Inositol phosphate metabolism -1.86 5.81e-3 66/73 (90.41%) INPP1;SACM1L;PIK3C2B;...
Vibrio cholerae infection -1.95 1.63e-3 44/50 (88%) ATP6V0A1;ATP6V1H;ARF1;...
Rheumatoid arthritis -1.97 0.00e+0 78/93 (83.87%) ATP6AP1;ATP6V1A;HLA-DQA1;...
Phagosome -1.99 0.00e+0 118/152 (77.63%) ATP6V0A1;RAB7A;ATP6V1H;...
NF-kappa B signaling pathway -2.09 0.00e+0 90/104 (86.54%) ATM;GADD45G;TRADD;...
B cell receptor signaling pathway -2.16 0.00e+0 71/81 (87.65%) PIK3CD;NFKBIA;FOS;...
Other glycan degradation -2.17 0.00e+0 13/18 (72.22%) MAN2B2;MAN2B1;MANBA;...
Steroid biosynthesis -2.19 0.00e+0 19/20 (95%) EBP;HSD17B7;LSS;...
Lysosome -2.31 0.00e+0 115/128 (89.84%) GALNS;CTSB;CLN3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 3.33uM 24H