Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBWUR0)

Drug Name
WZ-3146 Drug Info
Synonyms WZ-4002; WZ-8040; EGFR-T790M kinase inhibitors (lung cancer); EGFR-T790M kinase inhibitors (lung cancer), Gatekeeper Pharmaceuticals
Cross-matching ID
PubChem CID
44607360
ChEBI ID
CHEMBL1643976
CAS Number
CAS 1214265-56-1
TTD Drug ID
D0NJ3Q

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.42 0.00e+0 19/20 (95%) MSMO1;FDFT1;EBP;...
Lysosome 2.10 0.00e+0 115/128 (89.84%) TPP1;NEU1;ATP6V1H;...
Autophagy 2.09 0.00e+0 113/169 (66.86%) RRAGD;IRS2;RRAGC;...
Starch and sucrose metabolism 2.03 0.00e+0 25/36 (69.44%) GPI;GBE1;HK2;...
Porphyrin and chlorophyll metabolism 2.03 0.00e+0 23/43 (53.49%) HMOX1;BLVRB;FECH;...
Peroxisome 2.01 0.00e+0 72/82 (87.8%) IDH1;ACSL3;AMACR;...
Tryptophan metabolism 1.97 0.00e+0 35/42 (83.33%) KYNU;CYP1B1;ACAT2;...
mTOR signaling pathway 1.96 0.00e+0 114/154 (74.03%) RRAGD;ATP6V1C1;RRAGC;...
Terpenoid backbone biosynthesis 1.93 0.00e+0 18/22 (81.82%) HMGCS1;FDPS;PCYOX1;...
Metabolism of xenobiotics by cytochrome P450 1.85 5.68e-3 49/77 (63.64%) CBR3;ADH5;AKR1C1;...
Butanoate metabolism 1.84 6.89e-3 23/28 (82.14%) HMGCS1;ACAT2;ACSM3;...
Steroid hormone biosynthesis 1.84 6.31e-3 43/61 (70.49%) AKR1C3;AKR1C1;SRD5A1;...
Ferroptosis 1.81 8.74e-3 36/41 (87.8%) HMOX1;ACSL3;GPX4;...
Biosynthesis of unsaturated fatty acids 1.79 8.80e-3 21/27 (77.78%) SCD;FADS2;FADS1;...
Synthesis and degradation of ketone bodies 1.78 8.84e-3 9/10 (90%) HMGCS1;ACAT2;BDH2;...
PPAR signaling pathway 1.78 8.29e-3 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Tyrosine metabolism 1.77 1.00e-2 30/36 (83.33%) ADH5;MAOA;COMT;...
Carbohydrate digestion and absorption 1.73 2.10e-2 37/47 (78.72%) PLCB1;FXYD2;HK2;...
Phosphatidylinositol signaling system 1.72 1.99e-2 82/97 (84.54%) PLCB1;ITPKB;MTMR4;...
Collecting duct acid secretion 1.71 2.23e-2 22/27 (81.48%) ATP6V1C1;ATP6V1B2;ATP6V0C;...
Glyoxylate and dicarboxylate metabolism 1.68 2.53e-2 23/30 (76.67%) GLUL;ACAT2;MDH1;...
Cholesterol metabolism 1.65 3.44e-2 44/50 (88%) LDLR;MYLIP;STAR;...
Other glycan degradation 1.65 3.29e-2 13/18 (72.22%) NEU1;HEXA;GLB1;...
Pentose and glucuronate interconversions 1.64 3.35e-2 17/34 (50%) AKR1B10;GUSB;CRYL1;...
Inositol phosphate metabolism 1.64 3.30e-2 66/73 (90.41%) PLCB1;ALDH6A1;ITPKB;...
Insulin signaling pathway 1.63 3.32e-2 121/137 (88.32%) IRS2;SREBF1;KRAS;...
Nitrogen metabolism 1.63 3.23e-2 16/17 (94.12%) CPS1;GLUL;CA12;...
Valine, leucine and isoleucine degradation 1.62 3.21e-2 42/48 (87.5%) HMGCS1;ALDH6A1;ACAT2;...
Glycerolipid metabolism 1.62 3.36e-2 44/61 (72.13%) PLPP3;AKR1B10;MGLL;...
Synaptic vesicle cycle 1.61 3.41e-2 63/78 (80.77%) ATP6V1C1;SLC1A1;ATP6V1H;...
Base excision repair -1.63 4.81e-2 29/33 (87.88%) FEN1;POLD1;NEIL1;...
TNF signaling pathway -1.65 3.74e-2 103/112 (91.96%) VEGFC;FADD;JAG1;...
Hypertrophic cardiomyopathy -1.66 3.55e-2 81/90 (90%) CACNA1D;ITGB5;MYL3;...
Protein export -1.66 3.63e-2 17/23 (73.91%) SEC11A;SRP54;SRPRB;...
Viral myocarditis -1.68 3.41e-2 53/60 (88.33%) CD28;HLA-DPB1;RAC3;...
p53 signaling pathway -1.68 3.16e-2 63/73 (86.3%) CHEK2;CDK1;CASP3;...
Proteoglycans in cancer -1.70 2.67e-2 172/205 (83.9%) PTK2;CASP3;RRAS2;...
Hippo signaling pathway -1.72 2.56e-2 120/186 (64.52%) BMPR1B;TEAD4;PPP1CA;...
Focal adhesion -1.72 2.67e-2 180/201 (89.55%) COL1A2;RHOA;VEGFC;...
Pyrimidine metabolism -1.73 2.54e-2 40/56 (71.43%) CDA;DUT;UMPS;...
Cellular senescence -1.78 1.24e-2 139/156 (89.1%) ITPR2;CACNA1D;MAPKAPK2;...
RNA polymerase -1.79 1.26e-2 23/31 (74.19%) POLR3G;POLR2D;POLR3E;...
Graft-versus-host disease -1.87 5.85e-3 32/42 (76.19%) HLA-A;KLRD1;FAS;...
Type I diabetes mellitus -1.87 6.58e-3 38/43 (88.37%) INS;CD28;HLA-DPB1;...
Malaria -1.89 6.02e-3 44/50 (88%) TGFB3;THBS4;MET;...
Inflammatory bowel disease -1.99 1.76e-3 58/65 (89.23%) HLA-DRB1;STAT1;IL4R;...
Proteasome -2.01 2.11e-3 44/46 (95.65%) PSMA5;PSMB6;PSMC6;...
DNA replication -2.04 2.63e-3 34/36 (94.44%) RNASEH1;POLE;RPA4;...
TGF-beta signaling pathway -2.04 3.51e-3 81/94 (86.17%) E2F5;PITX2;CDKN2B;...
AGE-RAGE signaling pathway in diabetic complications -2.06 5.27e-3 97/100 (97%) MAPK13;TGFB3;NFATC1;...
Ribosome biogenesis in eukaryotes -2.06 1.05e-2 52/108 (48.15%) NHP2;GNL3;NAT10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H