Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMC1BXV)

Drug Name
AZD-3514 Drug Info
Cross-matching ID
PubChem CID
46893585
ChEBI ID
CHEMBL2346976
CAS Number
CAS 1240299-33-5
TTD Drug ID
D08AAV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fatty acid degradation 2.29 0.00e+0 40/43 (93.02%) ALDH2;ALDH7A1;ACAT1;...
Mismatch repair 2.26 0.00e+0 22/23 (95.65%) POLD4;LIG1;RPA3;...
DNA replication 2.21 0.00e+0 34/36 (94.44%) POLD4;LIG1;RNASEH2A;...
Valine, leucine and isoleucine degradation 2.12 0.00e+0 42/48 (87.5%) ALDH2;ALDH7A1;ALDH6A1;...
Metabolism of xenobiotics by cytochrome P450 2.11 0.00e+0 49/77 (63.64%) AKR7A2;AKR7A3;GSTP1;...
Drug metabolism 2.01 3.79e-3 78/151 (51.66%) RRM1;MAOB;GSTP1;...
Mineral absorption 2.01 3.25e-3 48/60 (80%) MT1E;MT1G;MT1F;...
Biosynthesis of unsaturated fatty acids 1.88 8.53e-3 21/27 (77.78%) HSD17B12;HACD1;HACD2;...
beta-Alanine metabolism 1.88 7.58e-3 25/30 (83.33%) ALDH2;ALDH7A1;ALDH6A1;...
p53 signaling pathway 1.87 9.10e-3 63/73 (86.3%) TP53I3;CCNE2;SERPINE1;...
Steroid biosynthesis 1.85 1.14e-2 19/20 (95%) TM7SF2;SC5D;MSMO1;...
Glutathione metabolism 1.83 1.52e-2 43/57 (75.44%) ANPEP;GPX1;RRM1;...
Nucleotide excision repair 1.83 1.40e-2 40/47 (85.11%) POLD4;LIG1;CETN2;...
Folate biosynthesis 1.80 1.63e-2 23/26 (88.46%) QDPR;DHFR;AKR1C3;...
Nicotinate and nicotinamide metabolism 1.78 1.90e-2 25/35 (71.43%) SIRT3;ENPP1;NT5E;...
Homologous recombination 1.78 1.92e-2 35/41 (85.37%) RAD51C;POLD4;BRCA1;...
Fanconi anemia pathway 1.77 1.81e-2 36/54 (66.67%) RAD51C;BRCA1;RPA3;...
Tryptophan metabolism 1.74 2.40e-2 35/42 (83.33%) ALDH2;ALDH7A1;MAOB;...
Rheumatoid arthritis 1.74 2.28e-2 78/93 (83.87%) CXCL2;ATP6V1D;CXCL8;...
Sulfur metabolism 1.71 2.84e-2 9/10 (90%) PAPSS2;PAPSS1;TST;...
Fatty acid elongation 1.71 2.76e-2 19/27 (70.37%) HSD17B12;HACD1;HADH;...
Other glycan degradation 1.67 3.72e-2 13/18 (72.22%) AGA;NEU1;FUCA1;...
Butanoate metabolism 1.67 3.61e-2 23/28 (82.14%) OXCT1;BDH2;ACAT1;...
Lysosome 1.66 3.84e-2 115/128 (89.84%) GALC;AGA;NPC2;...
Propanoate metabolism 1.65 4.14e-2 30/34 (88.24%) ALDH6A1;ACAT1;HIBCH;...
Oocyte meiosis 1.64 4.38e-2 90/129 (69.77%) PPP3CA;CCNE2;PRKACB;...
Spliceosome -2.03 0.00e+0 101/150 (67.33%) SF3A1;DHX38;RBM8A;...
Notch signaling pathway -2.05 0.00e+0 49/59 (83.05%) PSEN2;JAG1;DVL2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H