Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCBGLW)

Drug Name
GSK2636771 Drug Info
Synonyms
GSK2636771; 1372540-25-4; GSK-2636771; 2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid; UNII-DW94IAT0LS; DW94IAT0LS; GSK 2636771; 2-Methyl-1-((2-methyl-3-(trifluoromethyl)phenyl)methyl)-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid; 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid; lic acid; XTKLTGBKIDQGQL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
56949517
ChEBI ID
CHEMBL3188551
CAS Number
CAS 1372540-25-4
TTD Drug ID
D0G3MN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.03 0.00e+0 113/158 (71.52%) RPS5;RPS26;RPL14;...
Metabolism of xenobiotics by cytochrome P450 2.00 0.00e+0 49/77 (63.64%) UGT2B28;MGST3;CYP2E1;...
Valine, leucine and isoleucine degradation 2.00 0.00e+0 42/48 (87.5%) HMGCS2;ABAT;DLD;...
Primary bile acid biosynthesis 1.99 0.00e+0 15/17 (88.24%) ACOX2;AMACR;CYP27A1;...
Peroxisome 1.95 2.38e-3 72/82 (87.8%) FAR2;SLC27A2;ACOX2;...
Pentose and glucuronate interconversions 1.93 1.99e-3 17/34 (50%) AKR1A1;CRYL1;UGT2B28;...
Bile secretion 1.89 5.11e-3 68/90 (75.56%) ABCG2;SLC4A4;UGT2B28;...
Propanoate metabolism 1.79 2.68e-2 30/34 (88.24%) ABAT;DLD;ACAT1;...
Butanoate metabolism 1.74 4.11e-2 23/28 (82.14%) ALDH5A1;ACSM3;HMGCS2;...
Natural killer cell mediated cytotoxicity 1.71 4.77e-2 99/131 (75.57%) GZMB;RAC2;ICAM2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.70 4.77e-2 79/89 (88.76%) RASGRP1;PRKCQ;TLR4;...
Ribosome biogenesis in eukaryotes -2.01 0.00e+0 52/108 (48.15%) TCOF1;NOP10;GNL2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H