Details of the Drug

General Information of Drug (ID: DMCBGLW)

Drug Name
GSK2636771
Synonyms
GSK2636771; 1372540-25-4; GSK-2636771; 2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid; UNII-DW94IAT0LS; DW94IAT0LS; GSK 2636771; 2-Methyl-1-((2-methyl-3-(trifluoromethyl)phenyl)methyl)-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid; 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid; lic acid; XTKLTGBKIDQGQL-UHFFFAOYSA-N
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 433.4
Logarithm of the Partition Coefficient (xlogp) 4
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C22H22F3N3O3
IUPAC Name
2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid
Canonical SMILES
CC1=C(C=CC=C1C(F)(F)F)CN2C(=NC3=C(C=C(C=C32)N4CCOCC4)C(=O)O)C
InChI
InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
InChIKey
XTKLTGBKIDQGQL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
56949517
CAS Number
1372540-25-4
UNII
DW94IAT0LS
DrugBank ID
DB11795
TTD ID
D0G3MN
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase beta (PIK3CB) TTTHBCA PK3CB_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Prostate cancer
ICD Disease Classification 2C82.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase beta (PIK3CB) DTT PIK3CB 8.82E-15 0.24 0.54
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 110 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 6.9941 9.7316 4.9195 3.1787
JK1 CTRP2 7.6607 11.1156 4.6957 3.2035
JM1 CTRP2 6.566 10.8595 3.2862 5.2637
SU-DHL-6 CTRP2 1.6454 6.0165 1.2513 30.6207
Pfeiffer CTRP2 2.6081 8.1814 1.5526 26.5967
Karpas-422 CTRP2 2.9037 11.6157 0.3467 29.4999
GA-10 CTRP2 2.9628 9.8754 1.2004 26.7448
Ri-1 CTRP2 3.0205 9.7932 1.2958 26.2677
OCI-Ly10 CTRP2 3.1 15.1481 -1.1457 32.5933
NU-DUL-1 CTRP2 3.4553 5.7882 3.2845 17.8406
EoL-1 CTRP2 4.2913 7.1374 3.7517 13.6624
RS4;11 CTRP2 4.5173 6.0926 4.3644 10.7101
EB1 CTRP2 4.5661 12.9458 1.2956 22.2893
L-540 CTRP2 4.855 6.2488 4.6853 8.527
ME1 CTRP2 4.943 9.9858 3.0944 14.6676
MOLT-16 CTRP2 5.0086 6.1932 4.8702 7.3912
Daudi CTRP2 5.2711 9.0037 3.8795 10.7084
L-428 CTRP2 5.4414 8.9566 4.0596 9.5835
697 CTRP2 5.5029 7.923 4.6228 7.1098
A3/Kawakami CTRP2 5.5612 6.1849 5.4729 3.5361
RCH-ACV CTRP2 5.589 12.2267 2.566 15.3622
SET-2 CTRP2 5.6195 6.53 5.3954 3.6769
NU-DHL-1 CTRP2 5.743 10.556 3.5328 11.1361
ST486 CTRP2 5.7556 8.8441 3.6997 4.7336
Ci-1 CTRP2 5.8106 6.6924 4.7375 0.3959
SUP-M2 CTRP2 5.8408 7.3959 5.1923 3.9952
MOLT-3 CTRP2 5.8499 6.9601 5.4159 3.0428
HuT 78 CTRP2 5.8967 8.0901 4.896 5.1201
Namalwa CTRP2 5.9626 7.6635 5.1658 3.8541
MOLM-6 CTRP2 6.1494 7.8883 5.2085 3.3162
RL CTRP2 6.2143 9.2914 3.7988 3.6009
DB CTRP2 6.2785 7.7755 5.3653 2.4332
CA46 CTRP2 6.3165 7.9785 5.2937 2.6678
SK-MM-2 CTRP2 6.3208 8.4109 5.0829 3.5385
JeKo-1 CTRP2 6.3361 10.1496 3.4715 4.8138
SEM CTRP2 6.3978 8.0877 5.3003 2.5082
MOTN-1 CTRP2 6.5003 10.4573 3.4339 4.7343
OPM-2 CTRP2 6.6232 10.2323 4.4111 5.825
SUP-B15 CTRP2 6.6597 12.8966 2.3694 9.0059
OCI-AML-3 CTRP2 6.702 8.1692 5.4672 1.4118
HD-MY-Z CTRP2 7.0417 12.9494 3.3837 9.3537
Raji CTRP2 7.0687 8.8731 5.3649 1.3818
RPMI-6666 CTRP2 7.1 9.4241 5.1323 2.2114
NB4 CTRP2 7.1099 10.0003 4.8683 3.2254
KMS-12-BM CTRP2 7.1127 10.7202 4.5258 4.5914
SU-DHL-4 CTRP2 7.1745 9.6148 5.0901 2.2831
SU-DHL-10 CTRP2 7.175 8.1921 5.7038 0.2572
HL-60 CTRP2 7.214 9.3696 5.2257 1.7328
HuNS1 CTRP2 7.2181 14.7075 2.6479 11.9696
SUP-T11 CTRP2 7.2521 12.972 3.5283 8.4268
BL-70 CTRP2 7.2788 15.0283 2.5351 12.2994
SIG-M5 CTRP2 7.3139 8.2733 5.73 0.1547
OCI-AML-2 CTRP2 7.3145 9.2148 5.3507 1.1939
KMS-20 CTRP2 7.32 10.4473 4.7936 3.245
THP-1 CTRP2 7.3391 14.3203 2.9296 10.6712
MOLM-16 CTRP2 7.3531 11.9955 4.0763 6.0556
OCI-AML-5 CTRP2 7.3686 8.7699 5.5636 0.5019
MHH-CALL-3 CTRP2 7.3776 11.1358 4.5057 4.3009
MM1.S CTRP2 7.3824 9.7812 5.1381 1.8722
MOLP-8 CTRP2 7.3956 14.1249 3.0674 10.0371
CMK CTRP2 7.4823 8.6322 5.6651 0.2166
KMS-11 CTRP2 7.504 10.4311 4.9151 2.5598
MC116 CTRP2 7.5295 8.601 5.6949 0.151
SU-DHL-8 CTRP2 7.5598 8.8011 5.6338 0.249
MOLP-2 CTRP2 7.5832 9.6566 5.3022 1.1241
AML-193 CTRP2 7.588 9.0664 5.5449 0.4307
Reh CTRP2 7.5881 10.2135 5.0624 1.9322
KO52 CTRP2 7.6029 10.564 4.9134 2.4557
A4/Fukuda CTRP2 7.6709 9.4667 5.4239 0.6976
OCI-M1 CTRP2 7.6806 8.6349 5.7384 0.0661
MHH-CALL-4 CTRP2 7.7285 9.715 5.3501 0.8692
U266B1 CTRP2 7.7315 10.0275 5.221 1.2633
MOLT-13 CTRP2 7.7522 11.74 4.4629 3.9826
AMO1 CTRP2 7.7577 8.8751 5.6832 0.1147
TF-1 CTRP2 7.7675 9.0263 5.6333 0.184
HEL 92.1.7 CTRP2 7.7692 8.9485 5.6617 0.141
U-937 CTRP2 7.7871 9.2064 5.5753 0.2805
NOMO-1 CTRP2 7.8104 12.4675 4.1584 5.0914
Hs 611.T CTRP2 7.8453 17.6222 1.6792 14.4814
KYO-1 CTRP2 7.855 9.7178 5.4081 0.6309
SUP-T1 CTRP2 7.9406 9.9127 5.3696 0.6826
P3HR-1 CTRP2 7.9646 9.6268 5.4907 0.3833
Mono-Mac-1 CTRP2 7.9785 15.2507 2.9365 9.6379
SKM-1 CTRP2 7.9809 9.7958 5.4332 0.504
Karpas-620 CTRP2 7.9874 9.409 5.5801 0.2088
L-363 CTRP2 7.9914 9.238 5.642 0.1203
RPMI-8226 CTRP2 8.0183 9.7449 5.4685 0.4083
HPB-ALL CTRP2 8.0647 9.9972 5.3916 0.5615
SUP-HD1 CTRP2 8.0658 12.6459 4.2377 4.4605
PL21 CTRP2 8.0748 9.7279 5.498 0.3264
LP-1 CTRP2 8.1019 9.5802 5.5624 0.2058
Karpas-299 CTRP2 8.1147 9.7132 5.5193 0.2736
K-562 CTRP2 8.1265 9.5449 5.5843 0.1676
GDM-1 CTRP2 8.1401 14.3915 3.4617 7.3687
KMS-34 CTRP2 8.144 9.4756 5.6149 0.1244
Kasumi-1 CTRP2 8.1813 10.041 5.4245 0.4343
JJN-3 CTRP2 8.2033 9.6017 5.5926 0.1403
BV-173 CTRP2 8.3767 10.1344 5.4685 0.2812
SR CTRP2 8.5456 9.8475 5.6293 0.0575
Granta-519 CTRP2 8.5573 18.5718 1.7313 13.1734
REC-1 CTRP2 8.6926 10.7125 5.3818 0.3343
TALL-1 [Human adult T-ALL] CTRP2 9.0137 18.4496 2.1079 11.1856
EJM CTRP2 9.0538 20.0214 1.3772 13.6269
KMS-18 CTRP2 9.1859 16.9096 2.9536 7.8986
OCI-Ly3 CTRP2 9.2668 21.5462 0.7872 15.2003
Kasumi-2 CTRP2 9.401 29.2156 -2.8766 24.1298
M-07e CTRP2 9.526 18.3191 2.5093 9.0683
OCI-Ly19 CTRP2 9.9466 20.1119 1.9362 10.5163
Mono-Mac-6 CTRP2 10.332 32.8314 -3.9655 24.8415
F-36P CTRP2 12.7764 27.1007 0.4574 11.7093
⏷ Show the Full List of 110 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.2305 7.9237 5.255 2.976
TE8 CTRP2 6.9559 9.1777 5.1566 2.2955
OE21 CTRP2 6.0841 7.2566 5.471 2.3346
TE-5 CTRP2 6.199 7.2822 5.5491 1.8018
TE-6 CTRP2 6.3165 7.8318 5.3661 2.3672
TE-4 CTRP2 6.4325 8.2066 5.2672 2.5895
KYSE-410 CTRP2 6.6585 8.6705 5.2012 2.5197
TE-1 CTRP2 7.5641 9.5663 5.3306 1.0494
KYSE-450 CTRP2 7.6983 8.8403 5.6735 0.1408
KYSE-150 CTRP2 7.7568 10.0281 5.2337 1.2025
EC-GI-10 CTRP2 8.2261 9.9469 5.4777 0.3123
OE19 CTRP2 8.2556 9.4896 5.6497 0.0723
KYSE-510 CTRP2 8.2708 9.8689 5.5234 0.2218
TE-11 CTRP2 8.3495 9.973 5.5161 0.2128
KYSE-30 CTRP2 8.4629 9.8556 5.5981 0.092
TE-14 CTRP2 8.5515 10.8435 5.2752 0.6015
KYSE-520 CTRP2 8.6378 10.6077 5.3984 0.3223
KYSE-70 CTRP2 9.0588 10.5514 5.5695 0.0532
OE33 CTRP2 11.8453 31.3373 -2.1549 19.3421
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.5654 10.0923 5.5536 0.1214
PaTu 8988s CTRP2 6.2022 7.8836 5.2527 3.0355
SW1990 CTRP2 6.3824 7.8853 5.3882 2.1704
Capan-1 CTRP2 6.4514 8.3884 5.1918 2.8704
SU.86.86 CTRP2 6.717 8.2592 5.4347 1.5182
PSN1 CTRP2 6.9289 9.5233 4.9754 3.0456
Panc 04.03 CTRP2 6.9958 8.886 5.3164 1.6384
PANC-1 CTRP2 7.2091 11.1978 4.362 5.1133
L3.3 CTRP2 7.2948 9.3382 5.2858 1.4352
KP-2 CTRP2 7.3418 8.7583 4.5885 0.1286
AsPC-1 CTRP2 7.453 10.5144 4.8458 2.8804
TCC-Pan2 CTRP2 7.5679 8.9667 5.5747 0.3707
PK-59 CTRP2 7.6123 10.1367 5.1099 1.7413
PaTu 8988t CTRP2 7.6717 9.15 5.5487 0.3823
Capan-2 CTRP2 7.7198 9.9557 5.2454 1.1948
PaTu 8902 CTRP2 7.7451 8.9677 5.6457 0.1705
DAN-G CTRP2 7.8629 9.2174 5.6011 0.2096
SNU-410 CTRP2 7.8811 10.6704 5.0233 1.7871
Panc 10.05 CTRP2 8.0241 11.8885 4.5609 3.2917
Panc 05.04 CTRP2 8.0329 20.1214 0.5866 17.7461
YAPC CTRP2 8.0375 9.1545 5.687 0.0665
MIA PaCa-2 CTRP2 8.111 9.4174 5.6231 0.1207
Panc 08.13 CTRP2 8.2443 10.7227 5.185 0.9993
Panc 02.03 CTRP2 8.439 10.0699 5.5153 0.1926
HPAC CTRP2 8.5524 10.0393 5.5671 0.1095
HuP-T3 CTRP2 8.8493 16.708 2.83 8.7966
HuP-T4 CTRP2 8.8608 18.6642 1.8995 12.1367
Panc 03.27 CTRP2 9.0322 16.0213 3.2717 6.9185
PK-45H CTRP2 10.9628 25.3079 0.1389 14.7726
Hs 766T CTRP2 11.1461 61.893 -17.7505 36.7907
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 9.1497 24.433 -0.7078 19.6155
SK-MEL-3 CTRP2 6.0496 9.4023 3.6356 4.5416
CJM [Human melanoma] CTRP2 6.393 15.3031 0.991 14.9997
WM115 CTRP2 6.6131 35.2354 -8.08 35.3503
IGR-37 CTRP2 6.9713 10.3423 4.6103 4.4564
SK-MEL-28 CTRP2 7.038 10.5185 4.5715 4.5156
Hs 852.T CTRP2 7.2127 12.5408 3.7109 7.7503
A-375 CTRP2 7.2399 11.0733 4.443 4.7426
SK-MEL-5 CTRP2 7.2688 9.9041 5.0144 2.4585
Hs 688(A).T CTRP2 7.4474 8.5289 5.6892 0.1844
IPC-298 CTRP2 7.4897 10.043 5.0824 1.9611
HMCB CTRP2 7.5016 8.4551 5.7361 0.099
Hs 936.T CTRP2 7.5657 11.6008 4.4087 4.4321
SK-MEL-2 CTRP2 7.5671 8.5189 5.7377 0.0846
A2058 CTRP2 7.6554 8.5525 5.7575 0.0521
IGR-1 CTRP2 7.7041 9.8717 5.2729 1.1208
A101D CTRP2 7.7094 9.2877 5.5119 0.4495
Hs 940.T CTRP2 7.7865 13.2307 3.7789 6.6195
SK-MEL-30 CTRP2 7.8391 9.2538 5.5786 0.2564
SK-MEL-31 CTRP2 7.8884 9.3689 5.5559 0.2817
COLO 829 CTRP2 7.9816 10.5532 5.1264 1.3633
G-361 CTRP2 8.1222 13.3856 3.9273 5.5842
LOX-IMVI CTRP2 8.224 9.7757 5.539 0.2101
COLO 800 CTRP2 8.3013 14.1148 3.6994 6.231
WM1799 CTRP2 8.3136 13.1928 4.1377 4.5418
Malme-3M CTRP2 8.3843 16.0778 2.8184 9.4898
WM793 CTRP2 8.4791 14.1837 3.7807 5.6936
Mel JuSo CTRP2 8.5701 17.9903 2.0229 12.1325
SK-MEL-24 CTRP2 8.7055 18.1253 2.0522 11.8275
MeWo CTRP2 8.9264 17.6623 2.4262 10.1701
Hs 944.T CTRP2 9.0383 18.4252 2.1364 11.05
Hs 839.T CTRP2 9.5648 18.6755 2.3665 9.524
WM88 CTRP2 9.6159 20.2961 1.6303 11.9869
Hs 895.T CTRP2 9.8978 21.3504 1.3157 12.6351
RVH-421 CTRP2 9.9973 24.4651 -0.1159 16.7904
WM266-4 CTRP2 10.1536 29.5654 -2.492 22.2875
MDA-MB-435S CTRP2 10.4159 18.6811 2.8904 6.6762
COLO 792 CTRP2 10.5477 22.2526 1.3158 11.7801
WM983B CTRP2 10.5833 18.8235 2.9239 6.383
UACC-257 CTRP2 10.6634 18.9834 2.8983 6.3859
HT-144 CTRP2 10.6886 20.1627 2.3776 8.1205
K029AX CTRP2 11.8487 22.8726 1.8341 8.616
UACC-62 CTRP2 12.1295 22.3749 2.2194 7.1186
WT2-iPS CTRP2 12.9158 27.4171 0.3969 11.7259
IGR-39 CTRP2 13.66 27.2051 0.9347 9.4483
Hs 294T CTRP2 16.3146 36.8815 -1.8885 13.909
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 6.4533 18.2242 0.2918 21.45
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 CTRP2 5.9835 8.4799 4.7755 5.4523
CHP-126 CTRP2 6.1027 7.9642 5.1327 3.7213
SK-N-FI CTRP2 6.436 11.417 3.6771 9.2033
SK-N-AS CTRP2 6.439 8.1052 5.3215 2.3565
SK-N-DZ CTRP2 6.5964 8.3026 5.3356 2.067
SK-N-BE(2) CTRP2 6.7466 10.8641 4.1918 6.5293
NH-6 CTRP2 7.1553 9.3209 5.2133 1.8425
Kelly CTRP2 7.3342 11.6156 4.2467 5.3968
KP-N-YN CTRP2 7.5066 9.2023 4.4938 0.2221
IMR-32 CTRP2 7.7125 9.0228 5.6131 0.2351
KP-N-SI9s CTRP2 7.8771 10.9298 4.907 2.1933
SK-N-SH CTRP2 8.3767 15.7441 2.9736 8.9133
NB1 CTRP2 10.8462 19.461 2.7893 6.5628
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 6.5242 8.1719 5.3491 2.1161
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC71 CTRP2 5.8219 9.0029 3.6697 4.7556
A-673 CTRP2 5.9293 8.3596 4.7895 5.501
SK-ES-1 CTRP2 6.1819 8.2917 5.0332 3.9923
SJSA-1 CTRP2 6.4289 8.0416 5.3452 2.2746
MG-63 CTRP2 7.1383 13.7696 2.2794 8.6262
Hs 822.T CTRP2 7.3227 8.507 5.6462 0.3204
SK-N-MC CTRP2 7.5959 13.2971 3.6156 7.5459
HOS CTRP2 8.0308 9.9434 5.3977 0.5636
SaOS-2 CTRP2 8.1747 15.6535 2.8785 9.5675
CAL-78 CTRP2 8.2818 9.7775 5.56 0.1664
Hs 888.T CTRP2 8.7025 17.8907 2.1635 11.4356
G-292 clone A141B1 CTRP2 9.0455 14.3932 4.0263 4.1367
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 5.4579 6.1579 5.3701 4.2197
ZR-75-30 CTRP2 6.4592 10.933 3.9366 8.0841
HCC1419 CTRP2 6.8778 11.1577 4.1447 6.5098
CAL-51 CTRP2 7.0172 9.2829 5.1463 2.2587
Hs 578Bst CTRP2 7.1308 9.2726 5.2207 1.8425
EFM-192A CTRP2 7.2088 9.1781 4.384 0.5476
BT-20 CTRP2 7.3411 8.8816 5.5053 0.6824
MDA-MB-453 CTRP2 7.3893 10.4148 4.8525 2.9314
HCC1428 CTRP2 7.4974 9.329 5.3967 0.8955
SK-BR-3 CTRP2 7.5761 12.958 3.7659 6.9745
ZR-75-1 CTRP2 7.7811 18.1637 1.3642 15.6674
BT-474 CTRP2 7.9322 9.4387 5.5476 0.2821
MDA-MB-231 CTRP2 7.9331 23.6547 -1.2405 22.8705
AU565 CTRP2 7.9793 11.1723 4.8569 2.2688
MDA-MB-415 CTRP2 7.996 24.2471 -1.4861 23.3432
HCC1500 CTRP2 8.0451 14.0641 3.5544 7.1395
Hs 578T CTRP2 8.0716 10.1792 5.3233 0.7288
MDA-MB-361 CTRP2 8.1143 10.1294 5.3619 1.3058
CAL-85-1 CTRP2 8.23 17.0178 2.2553 11.8117
HCC202 CTRP2 8.3461 10.8372 5.1864 0.9319
HCC38 CTRP2 8.3847 10.5013 5.3351 0.5418
HCC1143 CTRP2 8.7108 11.2285 5.1955 0.7109
MDA-MB-157 CTRP2 8.8606 10.7339 5.4379 0.2051
MDA-MB-468 CTRP2 9.2703 22.4363 0.3565 16.4949
BT-549 CTRP2 10.9404 29.4694 -1.8812 19.9012
T-47D CTRP2 11.2791 22.7316 1.555 10.1307
BT 482 CTRP2 6.9724 8.8198 5.3326 1.6043
BT 239 CTRP2 7.0426 10.8747 4.4021 5.1968
BT 228 CTRP2 7.0639 8.6667 5.4538 1.0735
BT 145 CTRP2 7.1857 10.2168 4.8154 3.3335
BT 320 CTRP2 7.2907 8.9285 5.4608 0.8549
BT 112 CTRP2 7.2981 10.2486 4.8726 2.9661
BT 504 CTRP2 7.3208 8.8461 5.5101 0.6825
BT 245 CTRP2 7.3451 9.0302 5.4455 0.8603
BT147 CTRP2 7.3604 9.5911 5.2105 1.6356
BT 248 CTRP2 7.3737 11.4791 4.3391 4.9698
BT 286 CTRP2 7.4906 9.7102 5.2302 1.4418
BT164 CTRP2 7.5414 8.8469 5.6091 0.3064
BT 422 CTRP2 7.5607 9.1323 5.5069 0.5402
BT 440 CTRP2 7.5718 16.3998 2.078 13.5134
BT 271 CTRP2 7.592 9.8313 5.2321 1.3447
BT 131 CTRP2 7.6211 9.0984 5.5469 0.41
BT 498 CTRP2 7.6395 25.1921 -2.2348 25.5679
BT 444 CTRP2 7.6712 8.7955 5.6792 0.139
BT 340 CTRP2 7.6905 9.0426 5.597 0.2733
BT 216 CTRP2 7.7099 9.4796 5.4367 0.6389
BT 416 CTRP2 7.7231 9.044 5.6095 0.2382
BT 231 CTRP2 7.7458 10.5108 5.0191 1.9288
BT 159 CTRP2 7.7794 9.2965 5.5384 0.3584
BT 359 CTRP2 7.8175 9.2637 5.5663 0.287
BT 328 CTRP2 7.8187 9.0909 5.6297 0.1759
BT 330 CTRP2 7.9186 9.1774 5.6365 0.1422
BT 179 CTRP2 7.9417 11.0018 4.9113 2.1151
BT 232 CTRP2 7.969 9.1841 5.6526 0.1118
BT 333 CTRP2 8.0517 9.2628 5.6552 0.095
BT 428 CTRP2 8.0521 9.4705 5.5827 0.1876
BT 172 CTRP2 8.084 9.4951 5.586 0.1751
BT 187 CTRP2 8.0988 10.4952 5.2085 1.0283
BT 224 CTRP2 8.1731 13.083 4.1014 4.8496
BT 139 CTRP2 10.2103 17.4794 3.3122 5.4405
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA CTRP2 1.0394 165.3271 -77.8053 49.1649
KNS-60 CTRP2 6.7625 8.6142 5.2973 1.9945
KNS-42 CTRP2 6.9011 8.5627 5.4072 1.407
KNS-81 CTRP2 7.0808 8.4363 5.5618 0.7024
U-251MG CTRP2 7.4345 9.687 5.2095 1.566
D283 Med CTRP2 7.4393 14.6715 2.8309 10.8924
DK-MG CTRP2 7.5235 8.9524 5.561 0.4243
CCF-STTG1 CTRP2 7.5649 8.8561 5.6154 0.2838
SW1783 CTRP2 7.6697 18.9486 0.1403 15.8056
YKG-1 CTRP2 7.6769 11.2035 4.6651 3.3005
SF268 CTRP2 7.7785 18.0727 1.4072 15.5269
Hs 683 CTRP2 8.0431 16.9805 2.1394 12.5246
U-118MG CTRP2 8.072 9.6723 5.5174 0.291
SW1088 CTRP2 8.1039 23.764 -1.163 22.4029
SF539 CTRP2 8.2134 16.4522 2.5186 10.8663
8-MG-BA CTRP2 8.6595 10.3979 5.4816 0.1899
GaMG CTRP2 8.699 15.1312 3.4769 6.5687
KALS-1 CTRP2 8.8106 16.8376 2.7426 9.173
TM-31 CTRP2 8.9269 15.3945 3.4975 6.2084
Becker CTRP2 9.2693 16.693 3.1076 7.2298
YH-13 CTRP2 9.7441 21.7368 1.0264 13.7688
GMS-10 CTRP2 10.2188 17.2396 3.4238 5.049
SNB-75 CTRP2 10.8475 23.1772 1.0739 12.1584
M059K CTRP2 10.9429 19.2663 2.9316 5.9884
DBTRG-05MG CTRP2 11.7793 25.7393 0.4676 12.8217
T98G CTRP2 13.3547 25.108 1.6948 7.5483
GOS-3 CTRP2 14.6921 26.3212 1.883 5.8849
A-172 CTRP2 14.8155 33.2473 -1.1283 13.6442
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFE-184 CTRP2 5.3582 7.9771 4.4599 8.1146
AN3-CA CTRP2 6.4141 8.4914 5.1137 3.2536
JHUEM-1 CTRP2 6.6358 7.7904 5.6011 0.984
JHUEM-3 CTRP2 6.6466 15.2598 1.9284 15.6912
HEC-1-A CTRP2 7.3461 9.016 5.452 0.8396
HEC-151 CTRP2 7.5126 8.9888 5.542 0.4769
EN CTRP2 7.6378 8.7033 5.6993 0.1187
MFE-319 CTRP2 7.9789 9.5177 5.5372 0.2858
HEC-50B CTRP2 7.9828 11.103 4.8895 2.1515
JHUEM-7 CTRP2 8.1058 9.8214 5.4758 0.3585
MFE-296 CTRP2 8.2093 11.6468 4.7753 2.3308
ESS-1 CTRP2 10.7977 19.3796 2.7978 6.5846
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 5.2307 37.3925 -10.3128 38.9945
KMRC-3 CTRP2 6.0093 14.3937 1.8405 17.241
CAL-54 CTRP2 6.1207 15.511 1.3745 18.66
TUHR10TKB CTRP2 6.5097 9.4018 4.7359 4.6646
A-498 CTRP2 6.5646 15.0058 1.9895 15.621
VMRC-RCW CTRP2 7.8893 12.511 4.1889 4.8697
TUHR14TKB CTRP2 8.0175 19.5501 0.8571 26.7461
RCC10RGB CTRP2 8.5577 14.6351 3.6193 6.2079
786-O CTRP2 9.1281 16.581 3.0708 7.5411
KMRC-1 CTRP2 10.7315 22.4857 1.3247 11.5201
ACHN CTRP2 11.5044 21.5502 2.2304 7.7163
KMRC-2 CTRP2 12.704 32.9873 -2.3626 18.7463
Caki-1 CTRP2 12.8056 31.0172 -1.3568 16.3685
VMRC-RCZ CTRP2 13.6438 34.1694 -2.3009 17.536
Caki-2 CTRP2 15.2304 29.0876 0.9778 7.905
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo CTRP2 3.1227 13.3375 -0.2525 30.4866
COLO 320 CTRP2 4.3279 9.1496 2.9024 16.9078
LS1034 CTRP2 4.3629 6.6818 4.0029 12.5031
SNU-C1 CTRP2 5.6484 8.0838 4.6784 6.5549
CL-11 CTRP2 5.7247 7.7918 4.8918 5.4993
HCT 8 CTRP2 6.1596 8.5305 4.896 4.6092
SW1417 CTRP2 6.3529 8.476 4.2573 1.5839
SW948 CTRP2 6.3622 8.9017 4.8712 4.351
HCC-56 CTRP2 6.5258 7.8551 5.502 1.5009
COLO 678 CTRP2 6.7327 10.761 3.4407 4.3834
SNU-503 CTRP2 6.7606 12.9961 3.1459 10.7956
T84 CTRP2 7.1187 14.4835 2.6833 12.002
NCI-H747 CTRP2 7.1983 13.8149 3.0739 10.3349
SNU-C5 CTRP2 7.6595 18.2099 1.2496 16.2563
HT-55 CTRP2 7.6937 9.3858 5.4667 0.5698
C2BBe1 CTRP2 7.7853 18.4318 1.2349 16.0927
CW-2 CTRP2 7.8355 12.5883 4.1177 5.2177
LS123 CTRP2 7.8445 9.1092 5.6329 0.1645
NCI-H508 CTRP2 7.8477 9.829 5.3603 0.7627
SNU-C4 CTRP2 7.8905 9.1298 5.6428 0.1398
COLO201 CTRP2 8.1354 9.4146 5.6329 0.1054
CCK-81 CTRP2 8.1361 10.0388 5.4063 0.4936
NCI-H716 CTRP2 8.2566 10.1537 5.4132 0.4275
SNU-407 CTRP2 8.2937 10.3637 5.3491 0.5515
HCT 15 CTRP2 8.3071 11.3105 4.9722 1.5921
KM12 CTRP2 8.3119 9.7801 5.5701 0.1471
SNU-61 CTRP2 8.4248 10.2039 5.462 0.2779
RCM-1 [Human ESC] CTRP2 8.658 9.9855 5.6216 0.0529
RKO CTRP2 8.6609 10.1656 5.5622 0.0989
SW620 CTRP2 8.6867 10.436 5.4783 0.1886
MDST8 CTRP2 8.9111 18.6417 1.9452 11.9041
SNU-1033 CTRP2 9.0059 10.9282 5.4233 0.1942
GP2d CTRP2 10.177 24.3312 0.0739 16.0086
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-761 CTRP2 4.8041 6.4083 4.5765 9.0798
SNU-449 CTRP2 5.9392 10.7087 3.624 10.3634
JHH-5 CTRP2 5.9715 8.6675 4.6716 5.9125
JHH-6 CTRP2 6.681 7.8395 5.6055 0.9188
HuH-1 CTRP2 7.4961 9.2586 5.4253 0.8102
SNU-398 CTRP2 7.6139 14.3859 3.0983 9.5686
HLF CTRP2 7.8377 14.3491 3.2749 8.5336
Hep-G2 CTRP2 7.9196 9.2023 5.6281 0.1536
JHH-1 CTRP2 7.9337 9.2121 5.6299 0.1478
SNU-387 CTRP2 8.1766 17.5543 1.9552 12.9768
JHH-4 CTRP2 8.5337 14.3964 3.7158 5.872
HuH-6 CTRP2 9.0227 11.0846 5.3745 0.2563
PLC/PRF/5 CTRP2 9.0669 17.1534 2.7617 8.7566
SNU-423 CTRP2 9.37 22.2077 -0.2551 14.4934
JHH-2 CTRP2 9.6031 29.8437 -3.0353 24.1474
SNU-475 CTRP2 13.1317 31.6394 -1.4383 16.1842
SK-HEP-1 CTRP2 13.2308 24.7337 1.7911 7.379
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 98 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DMS 53 CTRP2 4.7 8.2155 3.7043 12.7789
COR-L279 CTRP2 5.151 15.7461 0.4302 23.7062
NCI-H1435 CTRP2 5.4685 13.8618 1.646 19.0555
DMS 454 CTRP2 5.5246 10.0604 3.5883 11.3609
SK-MES-1 CTRP2 5.7959 9.5938 4.0586 8.837
COLO 668 CTRP2 6.0158 10.6562 3.7146 9.8365
DV-90 CTRP2 6.1515 13.3571 2.4769 14.5737
LK2 CTRP2 6.1994 7.1155 5.6318 1.457
NCI-H1944 CTRP2 6.2052 10.8154 3.7915 9.1538
NCI-H889 CTRP2 6.2805 8.6412 4.9371 4.2181
LUDLU-1 CTRP2 6.3687 8.455 5.0976 3.396
NCI-H1105 CTRP2 6.373 11.3754 3.6475 9.4405
ChaGo-K-1 CTRP2 6.6059 11.9802 3.5305 9.5038
NCI-H810 CTRP2 6.6248 8.6034 5.2104 2.5313
LCLC-97TM1 CTRP2 6.6321 12.4807 3.3019 10.3916
NCI-H1355 CTRP2 6.6337 9.2283 4.9128 3.7324
NCI-H2171 CTRP2 6.6824 11.8862 3.6367 8.9328
NCI-H322 CTRP2 6.7051 8.495 5.3163 1.9955
NCI-H2170 CTRP2 6.773 8.7796 5.226 2.2618
NCI-H1915 CTRP2 6.7968 8.666 5.295 1.9591
KNS-62 CTRP2 6.9196 9.3943 5.0307 2.8382
HCC4006 CTRP2 6.9481 12.2937 3.6372 8.4791
Sq-1 CTRP2 6.9958 10.7904 4.4099 5.236
NCI-H1693 CTRP2 7.0071 13.0235 3.3211 9.6646
NCI-H2110 CTRP2 7.0726 9.61 5.0284 2.646
NCI-H2444 CTRP2 7.1172 8.135 5.701 0.2904
LOU-NH91 CTRP2 7.1369 10.7237 4.5407 4.4965
SW1271 CTRP2 7.1722 9.1271 5.3105 1.4703
NCI-H647 CTRP2 7.1958 14.88 2.5456 12.4004
HCC2935 CTRP2 7.1964 12.7937 3.5751 8.3266
Calu-6 CTRP2 7.2792 9.7274 5.1018 2.1179
NCI-H2029 CTRP2 7.2957 8.8383 5.5011 0.7273
NCI-H2126 CTRP2 7.3003 8.7698 5.5315 0.6341
COR-L51 CTRP2 7.3075 10.0308 4.9797 2.5445
NCI-H1395 CTRP2 7.3144 9.8302 4.1745 1.0544
NCI-H1092 CTRP2 7.373 10.8806 4.6237 3.8411
EKVX CTRP2 7.4676 15.3363 2.5246 12.0233
EBC-1 CTRP2 7.541 9.7841 5.2253 1.4125
PC-14 CTRP2 7.5676 9.4192 5.3938 0.8529
NCI-H1184 CTRP2 7.6552 17.681 1.5079 15.3907
NCI-H226 CTRP2 7.6799 9.0215 5.6006 0.2701
NCI-H661 CTRP2 7.7 10.4464 5.022 1.9635
RERF-LC-MS CTRP2 7.7044 13.1359 3.7686 6.7775
IA-LM CTRP2 7.7629 9.0214 5.6333 0.1853
NCI-H2228 CTRP2 7.7668 9.5494 5.4349 0.6109
NCI-H2196 CTRP2 7.7671 10.1126 5.2031 1.2915
NCI-H841 CTRP2 7.7883 9.2968 5.5419 0.3472
NCI-H1341 CTRP2 7.8138 13.7679 3.5393 7.528
NCI-H460 CTRP2 7.8557 9.7912 5.3792 0.7066
DMS 273 CTRP2 7.8954 25.7642 -2.3186 25.3203
COR-L95 CTRP2 7.9054 9.4929 5.5166 0.3531
NCI-H1755 CTRP2 7.918 22.3744 -0.6165 21.3396
HCC1438 CTRP2 7.9465 9.7197 5.4477 0.4865
NCI-H1651 CTRP2 7.9539 14.3596 3.3505 8.067
Calu-1 CTRP2 7.9778 14.5224 3.2885 8.2743
NCI-H2085 CTRP2 7.9868 12.7461 4.141 4.9307
NCI-H1694 CTRP2 8.0464 9.5451 5.5537 0.2352
NCI-H2023 CTRP2 8.0731 9.5086 5.577 0.1909
NCI-H1869 CTRP2 8.077 10.2065 5.3149 0.7478
NCI-H838 CTRP2 8.0833 9.3915 5.6221 0.1271
COR-L105 CTRP2 8.1457 16.0435 2.6694 10.4036
NCI-H1793 CTRP2 8.1531 9.9917 5.4314 0.4314
NCI-H520 CTRP2 8.1868 21.2731 0.1334 18.8379
NCI-H2122 CTRP2 8.1874 9.8356 5.5032 0.2792
LC-1/sq-SF CTRP2 8.2414 9.3478 5.6922 0.0425
VMRC-LCD CTRP2 8.3008 10.0515 5.469 0.3037
NCI-H2172 CTRP2 8.3973 13.0095 4.2724 3.9424
SK-LU-1 CTRP2 8.4009 10.1384 5.4764 0.261
NCI-H1573 CTRP2 8.4339 10.1576 5.4822 0.2428
NCI-H1623 CTRP2 8.6313 17.2234 2.4363 10.5526
NCI-H1568 CTRP2 8.6369 10.8994 5.29 0.532
NCI-H1339 CTRP2 8.7015 13.8861 4.0542 4.4068
NCI-H522 CTRP2 8.8339 20.2819 1.0952 14.8758
NCI-H1666 CTRP2 8.8435 21.3674 0.5719 16.4969
HOP-92 CTRP2 9.1565 20.8475 1.0487 23.0905
NCI-H1373 CTRP2 9.1858 16.5668 3.114 7.3099
EPLC-272H CTRP2 9.3233 31.7254 -4.1763 26.5832
NCI-H2087 CTRP2 9.488 22.6435 0.4101 16.0164
HOP-62 CTRP2 9.9743 26.0625 -0.9085 18.9171
NCI-H1650 CTRP2 10.1094 21.2278 1.5145 11.7072
NCI-H2286 CTRP2 10.306 25.7108 -0.5035 17.4071
NCI-H2342 CTRP2 10.3718 20.3053 2.1168 9.3722
NCI-H441 CTRP2 10.4707 19.8047 2.4098 8.2611
NCI-H446 CTRP2 10.6999 21.3203 1.8498 9.865
SW1573 CTRP2 10.7103 27.6464 -1.1585 18.518
NCI-H1563 CTRP2 10.7352 23.3343 0.9265 12.7534
LXF 289 CTRP2 10.8274 21.2692 1.9527 9.3753
NCI-H23 CTRP2 11.1131 26.8387 -0.4921 16.2951
NCI-H2081 CTRP2 11.1505 31.6579 -2.7967 21.5721
Lu-65 CTRP2 11.4553 23.0704 1.5069 10.0789
NCI-H1792 CTRP2 12.4826 26.5021 0.5533 11.764
NCI-H1703 CTRP2 12.6184 25.2197 1.2233 9.6682
T3M-10 CTRP2 12.8132 24.4788 1.67 8.1363
HCC1195 CTRP2 13.5457 25.8365 1.4795 7.9992
RERF-LC-Ad2 CTRP2 13.9127 26.2202 1.5134 7.5677
A-549 CTRP2 14.1547 28.1768 0.7831 9.3947
DMS 114 CTRP2 14.1759 32.9502 -1.3865 14.913
Hs 888.Lu CTRP2 10.4513 21.0658 0.9653 9.1291
⏷ Show the Full List of 98 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 6.9922 8.2967 5.5756 0.7298
Yamato-SS CTRP2 8.0832 9.7104 5.5078 0.3049
TE 441.T CTRP2 6.1154 9.5522 4.3493 6.9884
TE 617.T CTRP2 6.4022 8.1936 5.2514 2.7029
GCT CTRP2 6.539 8.4183 5.2401 2.537
A-204 CTRP2 6.8546 15.2494 2.0985 14.6851
MES-SA CTRP2 7.0602 9.3138 5.1587 2.1584
Hs 729.T CTRP2 7.194 9.7591 5.0353 2.4686
HT-1080 CTRP2 7.2257 8.7197 5.5157 0.7343
BT-12 CTRP2 7.2277 8.2365 5.709 0.224
BT-16 CTRP2 7.7449 8.9951 5.6359 0.1862
TTC-709 CTRP2 7.8921 9.7224 5.4228 0.5733
SW982 CTRP2 8.0115 9.263 5.6407 0.1182
Tm87-16 CTRP2 8.1739 9.66 5.5612 0.1894
RKN CTRP2 8.2342 9.372 5.6817 0.0499
Rh18 CTRP2 8.5979 10.3146 5.4881 0.1945
RD CTRP2 9.1379 17.1746 2.798 8.5304
G-401 CTRP2 9.8439 25.951 -1.7299 18.0204
SK-LMS-1 CTRP2 10.2283 25.5979 -0.5031 17.5139
G-402 CTRP2 10.7989 23.647 0.8201 12.9952
KYM-1 CTRP2 10.9993 20.9846 2.1884 8.401
SK-UT-1 CTRP2 11.6636 21.4672 2.3596 7.1363
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.1707 8.0492 5.7555 0.1546
SYO-1 CTRP2 11.895 26.8094 0.0389 13.8866
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 8.6016 20.2205 0.9581 15.6722
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 9.797 28.0827 -2.0253 21.7959
TOV-21G CTRP2 4.8624 5.9839 4.7705 8.1945
A2780 CTRP2 6.1566 9.0475 4.6353 5.7097
COV362 CTRP2 6.2091 9.7104 4.3468 6.8231
OAW42 CTRP2 6.3485 10.3771 4.126 7.4929
TOV-112D CTRP2 6.642 9.712 4.6817 4.6725
EFO-27 CTRP2 6.6718 9.1556 4.9756 3.4164
TYK-nu CTRP2 6.8275 8.8667 5.2203 2.2119
OVCAR-5 CTRP2 6.9327 11.8508 3.8441 7.6568
OC 314 CTRP2 6.9777 11.1026 4.2446 5.9402
SNU-840 CTRP2 7.2165 9.8081 5.0265 2.475
EFO-21 CTRP2 7.25 9.436 5.2167 1.7272
OVK18 CTRP2 7.4742 11.3144 4.4844 4.2554
SK-OV-3 CTRP2 8.0496 9.8516 5.4411 0.4544
OV56 CTRP2 8.1237 13.3916 3.9254 5.5894
HEY A8 CTRP2 8.1586 11.1828 4.9497 1.7873
FU-OV-1 CTRP2 8.2276 10.2956 5.3468 0.5881
JHOM-1 CTRP2 8.2543 17.0198 2.2716 11.7152
RMG-I CTRP2 8.2707 13.426 4.0029 5.1056
IGROV-1 CTRP2 8.2763 9.8255 5.541 0.1941
COV434 CTRP2 8.3421 10.972 5.1301 1.0912
MCAS CTRP2 8.3467 9.9818 5.5119 0.2198
OVCAR-4 CTRP2 8.4354 10.0918 5.5062 0.2063
Caov-3 CTRP2 8.4502 15.0908 3.3348 7.4336
OV-90 CTRP2 8.5514 10.444 5.4242 0.3042
OVCAR-8 CTRP2 8.6366 13.5894 4.1506 4.1251
OAW28 CTRP2 10.6061 20.6178 2.1175 9.0891
OV7 CTRP2 11.2877 28.566 -1.2029 17.8636
JHOS-2 CTRP2 11.9788 23.2607 1.7348 8.7884
COV644 CTRP2 14.0235 35.4661 -2.6665 17.8842
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 7.002 8.9577 5.2873 1.7401
MSTO-211H CTRP2 7.0083 12.0578 3.7983 7.7213
NCI-H2452 CTRP2 7.8569 14.0465 3.4346 7.8779
JL-1 CTRP2 8.2699 9.7264 5.5735 0.1512
NCI-H2052 CTRP2 8.3146 16.1477 2.7368 9.8987
IST-Mes1 CTRP2 9.5996 19.0915 2.1926 10.088
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 3.9742 9.0512 2.595 19.0049
VCaP CTRP2 6.5184 8.0622 4.5155 0.5805
DU145 CTRP2 9.3055 19.1347 1.977 11.2348
PaCa-3 CTRP2 13.4305 27.3776 0.7234 10.2717
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 9.0499 17.9199 2.386 10.144
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 5.8335 6.8571 5.4512 2.9325
HGC-27 CTRP2 6.2048 7.8768 5.2581 3.0081
SH-10-TC CTRP2 7.0321 9.1262 5.2281 1.9279
KATO III CTRP2 7.1777 9.0286 5.3573 1.2992
SNU-1 CTRP2 7.1789 11.71 3.2778 4.4682
SNU-216 CTRP2 7.2811 21.4152 -0.6362 22.4849
KE-39 CTRP2 7.57 14.5729 2.9751 10.12
HuG1-N CTRP2 7.5986 9.1664 4.5399 0.1401
ECC10 CTRP2 7.7158 15.2758 2.7367 10.8115
Fu97 CTRP2 7.7669 15.7758 2.5289 11.5208
SNU-601 CTRP2 7.8648 9.3912 5.538 0.3252
NUGC-3 CTRP2 8.0696 10.944 5.0055 1.6803
Hs 746.T CTRP2 8.1124 21.2696 0.0791 19.1163
NCC-StC-K140 CTRP2 8.3778 22.9688 -0.5606 20.4381
MKN74 CTRP2 8.4401 11.598 4.9185 1.6561
MKN7 CTRP2 8.7101 20.1447 1.0735 15.1351
IM95 CTRP2 8.9131 10.6912 5.4719 0.1535
LMSU CTRP2 11.2121 20.7492 1.541 6.4062
SNU-685 CTRP2 8.4239 9.7826 5.6092 0.0869
SNG-M CTRP2 8.8161 10.1634 5.616 0.0442
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 6.6337 7.8082 5.5918 1.0212
ML-1 [Human leukemia] CTRP2 8.0086 9.7959 5.445 0.4639
FTC-133 CTRP2 8.1765 12.2899 4.4688 3.4631
FTC-238 CTRP2 8.9644 14.9684 3.7172 5.3497
TT2609-C02 CTRP2 10.0437 23.6477 0.3117 15.5128
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ15 CTRP2 6.2722 13.3296 2.5899 13.9015
PE/CA-PJ34 (clone C12) CTRP2 6.5633 7.92 5.4958 1.4758
FaDu CTRP2 6.6603 8.111 5.4682 1.4593
HSC-2 CTRP2 6.6617 8.246 5.4057 1.7006
HSC-4 CTRP2 6.7561 8.1113 5.5265 1.1266
PE/CA-PJ41 (clone D2) CTRP2 6.7635 15.5226 1.8904 15.6126
PE/CA-PJ49 CTRP2 6.8829 8.8734 5.2527 2.0147
BICR 18 CTRP2 6.8861 9.3363 4.1693 1.3964
BICR 31 CTRP2 7.1145 11.7456 3.2217 4.7781
BICR 22 CTRP2 7.2557 8.6972 4.5784 0.1583
SCC-25 CTRP2 7.5932 13.728 3.4044 8.3913
SCC-4 CTRP2 7.6591 10.4576 4.9939 2.1042
CAL-27 CTRP2 7.7679 9.1747 5.5793 0.2796
YD-8 CTRP2 7.7888 10.8698 4.8836 2.366
BICR 6 CTRP2 7.9301 9.2994 5.5975 0.1967
BICR 16 CTRP2 8.6386 9.9196 5.6369 0.0451
CAL-33 CTRP2 8.7383 10.2831 5.5495 0.1005
BICR 56 CTRP2 10.8275 20.6611 2.233 8.4469
SCC-9 CTRP2 10.9183 20.6013 2.315 8.0721
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BC-3C CTRP2 6.2472 7.9226 5.2685 2.8903
UM-UC-1 CTRP2 6.6668 8.202 5.4297 1.6003
U-BLC1 CTRP2 6.7897 9.1396 5.0652 2.8802
HT-1376 CTRP2 7.2733 9.5177 5.1935 1.787
HT-1197 CTRP2 7.4385 9.3993 5.3368 1.1318
647V CTRP2 7.5538 9.298 5.437 0.7363
RT-4 CTRP2 7.8572 9.8174 5.3694 0.732
RT-112 CTRP2 7.8742 9.1901 5.6154 0.1836
SCaBER CTRP2 8.2766 19.1687 1.2369 15.2822
T24 CTRP2 8.4757 17.328 2.2779 11.358
J82 CTRP2 10.4386 20.1793 2.2169 8.9533
KMBC-2 CTRP2 10.458 20.8379 1.9227 9.9174
UM-UC-3 CTRP2 11.559 25.3851 0.4929 13.0141
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.6709 8.6941 5.7146 0.0929

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7967).