Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCE08M)

Drug Name
AT7519 Drug Info
Synonyms LZE; AT 7519, AT7519; AT-7519; 4-[(2,6-dichlorobenzoyl)amino]-N-(4-piperidyl)-2H-pyrazole-3-carboxamide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
11338033
ChEBI ID
CHEMBL445813
CAS Number
CAS 844442-38-2
TTD Drug ID
D07DTV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Lysosome 2.36 0.00e+0 115/128 (89.84%) LAPTM4B;ATP6AP1;TCIRG1;...
Rheumatoid arthritis 2.22 0.00e+0 78/93 (83.87%) CCL20;CXCL8;ATP6AP1;...
Ascorbate and aldarate metabolism 2.08 4.41e-3 15/30 (50%) ALDH7A1;UGT2B28;AKR1A1;...
Oxidative phosphorylation 2.05 3.31e-3 93/133 (69.92%) ATP6AP1;TCIRG1;ATP6V0B;...
Glycosaminoglycan degradation 2.05 2.65e-3 19/19 (100%) IDS;HEXA;ARSB;...
Type I diabetes mellitus 2.04 2.21e-3 38/43 (88.37%) CPE;HLA-DQA1;HLA-F;...
Glycolysis / Gluconeogenesis 2.03 1.89e-3 56/67 (83.58%) ENO2;PFKM;ADH1B;...
Epithelial cell signaling in Helicobacter pylori infect... 2.02 1.66e-3 62/70 (88.57%) CXCL8;ATP6AP1;TCIRG1;...
Cell adhesion molecules 2.00 1.47e-3 118/148 (79.73%) SDC2;CDH1;HLA-DQA1;...
Drug metabolism 2.00 1.32e-3 78/151 (51.66%) ADH1B;NME1;CES1;...
Phagosome 1.97 1.20e-3 118/152 (77.63%) ATP6AP1;C3;TCIRG1;...
Fatty acid degradation 1.95 1.10e-3 40/43 (93.02%) ADH1B;ACAT1;ALDH7A1;...
Tryptophan metabolism 1.91 3.06e-3 35/42 (83.33%) IDO1;ACAT1;ALDH7A1;...
Pyruvate metabolism 1.87 4.73e-3 41/47 (87.23%) ADH1B;ACAT1;PCK1;...
Viral myocarditis 1.86 5.30e-3 53/60 (88.33%) CXADR;HLA-DQA1;HLA-F;...
Graft-versus-host disease 1.85 4.97e-3 32/42 (76.19%) HLA-DQA1;HLA-F;HLA-B;...
Metabolism of xenobiotics by cytochrome P450 1.83 5.45e-3 49/77 (63.64%) ADH1B;EPHX1;UGT2B28;...
Fat digestion and absorption 1.83 5.15e-3 35/43 (81.4%) ACAT1;APOA1;SCARB1;...
Arginine and proline metabolism 1.82 5.58e-3 39/50 (78%) CKB;OAT;P4HA1;...
Citrate cycle (TCA cycle) 1.81 7.94e-3 30/30 (100%) PCK1;IDH2;OGDHL;...
Tyrosine metabolism 1.80 7.57e-3 30/36 (83.33%) ADH1B;ADH1C;GOT2;...
Retinol metabolism 1.80 7.22e-3 41/68 (60.29%) ADH1B;ALDH1A3;DGAT1;...
Staphylococcus aureus infection 1.78 9.79e-3 72/95 (75.79%) DEFA4;C3;HLA-DQA1;...
Allograft rejection 1.75 1.32e-2 32/38 (84.21%) HLA-DQA1;HLA-F;HLA-B;...
Complement and coagulation cascades 1.75 1.27e-2 76/85 (89.41%) CD59;C3;A2M;...
Systemic lupus erythematosus 1.73 1.38e-2 45/135 (33.33%) ACTN1;C3;HLA-DQA1;...
IL-17 signaling pathway 1.72 1.62e-2 84/94 (89.36%) MMP9;CCL20;CXCL8;...
ECM-receptor interaction 1.71 1.80e-2 80/88 (90.91%) COL6A2;COL4A6;THBS1;...
Pentose and glucuronate interconversions 1.69 2.10e-2 17/34 (50%) SORD;UGT2B28;AKR1A1;...
Cholesterol metabolism 1.66 3.00e-2 44/50 (88%) APOA2;LRPAP1;SORT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H