Details of the Drug

General Information of Drug (ID: DMCE08M)

Drug Name
AT7519
Synonyms LZE; AT 7519, AT7519; AT-7519; 4-[(2,6-dichlorobenzoyl)amino]-N-(4-piperidyl)-2H-pyrazole-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 382.2
Logarithm of the Partition Coefficient (xlogp) 2.6
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C16H17Cl2N5O2
IUPAC Name
4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide
Canonical SMILES
C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl
InChI
InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)
InChIKey
OVPNQJVDAFNBDN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11338033
ChEBI ID
CHEBI:91326
CAS Number
844442-38-2
UNII
X1BF92PW9T
DrugBank ID
DB08142
TTD ID
D07DTV
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Gene/Protein Processing [3]
Forkhead box protein O4 (FOXO4) OT90X9LN FOXO4_HUMAN Gene/Protein Processing [3]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Gene/Protein Processing [3]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Gene/Protein Processing [3]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [3]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) OTVT4YA1 ATG7_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cyclin-dependent kinase 2 (CDK2) DTT CDK2 2.28E-06 0.12 0.19
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 0.6849 3.441 0.4174 34.9289
MHH-ES-1 GDSC1 -2.062 -0.8797 -2.0621 67.6724
ES5 GDSC1 -2.0394 1.4493 -2.1422 64.5798
ES7 GDSC1 -1.8534 0.0856 -1.8583 64.6925
HuO9 GDSC1 -1.6137 -0.2147 -1.6143 62.0587
EW-1 GDSC1 -1.5585 0.941 -1.5884 60.7074
ES6 GDSC1 -1.5035 0.7053 -1.5193 60.3038
ES8 GDSC1 -1.3565 0.7172 -1.3692 58.6308
EW-18 GDSC1 -1.2939 1.3609 -1.3443 57.5282
EW-13 GDSC1 -1.2196 2.1109 -1.361 56.2186
EW-7 GDSC1 -1.1062 0.8023 -1.1163 55.659
EW-11 GDSC1 -1.0055 1.6165 -1.0657 54.2105
NOS-1 [Human HNSCC] GDSC1 -0.6056 5.4677 -1.6837 49.704
ES1 GDSC1 -0.2976 5.0241 -1.1849 47.0673
SJSA-1 GDSC1 0.176 4.4775 -0.4744 42.1502
EW-16 GDSC1 0.3248 3.9303 -0.1249 39.9248
A-673 GDSC1 0.3813 3.7298 0.0004 39.0229
TC-71 GDSC1 0.5287 2.1206 0.5001 35.5163
CHSA0108 GDSC1 0.5472 4.1285 0.0497 37.6312
SK-ES-1 GDSC1 0.7786 4.4158 0.1964 35.409
CHSA0011 GDSC1 0.9495 4.128 0.4848 32.8453
HuO-3N1 GDSC1 1.1619 3.2469 0.9904 28.522
SK-PN-DW GDSC1 1.3375 3.9809 0.9557 27.7039
CHSA8926 GDSC1 1.3886 5.1493 0.5486 29.8609
ES4 GDSC1 1.4219 7.2236 -0.3568 33.9709
EW-3 GDSC1 1.4531 6.178 0.159 31.5419
NY GDSC1 2.3195 7.498 0.3685 26.1097
CADO-ES1 GDSC1 3.1631 8.8776 0.4329 22.1864
H-EMC-SS GDSC1 3.1736 6.1942 1.7822 13.032
CAL-78 GDSC1 4.2956 9.0577 1.2454 13.1039
EW-24 GDSC1 4.5344 6.2001 2.7545 1.8169
G-292 clone A141B1 GDSC1 5.0504 15.3113 -1.2749 23.9297
SaOS-2 GDSC1 5.1519 7.7288 2.4228 2.8671
HOS GDSC1 5.5701 6.8791 2.936 0.179
U2OS GDSC1 5.5843 8.0854 2.4895 1.8777
MG-63 GDSC1 5.6222 8.1697 2.4732 1.9176
CAL-72 GDSC1 5.9138 7.5308 2.8347 0.2804
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -1.8229 0.4385 -1.8363 64.0176
Loucy GDSC1 -5.0907 -3.3001 -5.0908 95.3541
SUP-M2 GDSC1 -4.3677 -2.2603 -4.3683 89.8438
ST486 GDSC1 -3.9202 -2.9611 -3.9202 90.0023
VL51 GDSC1 -3.9069 -2.3119 -3.9069 87.9829
SU-DHL-6 GDSC1 -3.6275 -2.3126 -3.6275 86.0383
PL-21 GDSC1 -3.4956 -1.6802 -3.496 83.3519
NB4 GDSC1 -3.469 -1.9534 -3.4691 83.8725
NKM-1 GDSC1 -3.434 -1.3061 -3.4357 81.8357
Karpas-45 GDSC1 -3.4051 0.7894 -3.5126 75.1645
SU-DHL-8 GDSC1 -3.3934 -1.8324 -3.3935 82.9605
Ku812 GDSC1 -3.3275 -2.1169 -3.3275 82.9417
DND-41 GDSC1 -3.3235 2.2113 -3.6559 70.9993
BL-41 GDSC1 -3.2788 -2.5687 -3.2788 82.878
KE-37 GDSC1 -3.2558 -1.4386 -3.2564 80.8836
697 GDSC1 -3.2002 -1.8007 -3.2002 81.1689
ALL-SIL GDSC1 -3.1897 -1.7173 -3.1898 80.918
MOLM-13 GDSC1 -3.1765 -1.3585 -3.1771 80.04
WIL2 NS GDSC1 -3.1266 -1.7828 -3.1267 80.4205
EB2 GDSC1 -3.0833 -1.0879 -3.0848 78.63
ATN-1 GDSC1 -3.0715 -1.6344 -3.0716 79.6386
Ramos.2G6.4C10 GDSC1 -3.0584 -2.1892 -3.0584 80.0925
HH [Human lymphoma] GDSC1 -3.0478 -0.7629 -3.0522 77.5402
MOLP-8 GDSC1 -3.0293 -2.0111 -3.0293 79.6427
CA46 GDSC1 -3.0109 -0.1653 -3.0297 75.6668
RPMI-8402 GDSC1 -2.9857 -1.6582 -2.9857 78.8025
Farage GDSC1 -2.9802 -1.41 -2.9804 78.3743
LC4-1 GDSC1 -2.913 -0.9945 -2.9143 76.9643
SU-DHL-5 GDSC1 -2.8943 -2.1891 -2.8943 78.1134
SR GDSC1 -2.8917 0.1043 -2.9193 74.1088
Mono-Mac-6 GDSC1 -2.8903 0.8941 -2.9796 72.0055
PF-382 GDSC1 -2.8809 -1.172 -2.8814 77.0078
NALM-6 GDSC1 -2.8636 -1.6857 -2.8636 77.5089
RS4;11 GDSC1 -2.8336 -1.6146 -2.8336 77.1113
SU-DHL-10 GDSC1 -2.761 -1.9575 -2.761 76.4376
NU-DUL-1 GDSC1 -2.7427 -1.2575 -2.7429 75.7443
BC-1 GDSC1 -2.7003 -0.4952 -2.7051 74.0455
TUR GDSC1 -2.6943 -1.5321 -2.6943 75.4667
Karpas-299 GDSC1 -2.6685 -1.6949 -2.6685 75.244
RL GDSC1 -2.648 4.4398 -3.5214 63.5042
MV4-11 GDSC1 -2.6396 -1.5765 -2.6396 74.8516
SIG-M5 GDSC1 -2.621 -1.5769 -2.621 74.6313
Reh GDSC1 -2.616 -1.2706 -2.616 74.378
P30/OHK GDSC1 -2.6124 -1.2158 -2.6125 74.2892
OCI-Ly19 GDSC1 -2.5526 -1.1743 -2.5527 73.5855
MLMA GDSC1 -2.5494 0.8991 -2.6207 69.6845
DB GDSC1 -2.5067 -0.885 -2.5073 72.793
Karpas-620 GDSC1 -2.4675 -0.4651 -2.4705 71.8136
SUP-T1 GDSC1 -2.4564 -1.0834 -2.4565 72.4252
HC-1 GDSC1 -2.4548 -0.17 -2.4625 71.1909
MY-M12 GDSC1 -2.4481 -1.2716 -2.4481 72.4433
DEL GDSC1 -2.4415 -1.6612 -2.4415 72.4618
ML-2 GDSC1 -2.3323 -1.4532 -2.3323 71.0905
SUP-HD1 GDSC1 -2.3223 0.0822 -2.3345 69.5083
SU-DHL-4 GDSC1 -2.3213 -1.5984 -2.3213 70.9648
CTV-1 GDSC1 -2.3034 4.4133 -3.1383 61.7251
MHH-PREB-1 GDSC1 -2.2931 -1.3186 -2.2931 70.5881
BE-13 GDSC1 -2.2902 -0.6182 -2.2911 70.1626
BC-3 GDSC1 -2.2897 -0.9691 -2.2898 70.425
BV-173 GDSC1 -2.287 -1.0253 -2.287 70.4218
SUP-B15 GDSC1 -2.262 -0.5371 -2.2632 69.7731
Namalwa GDSC1 -2.2268 -0.7607 -2.2271 69.5688
RPMI-6666 GDSC1 -2.2201 -0.7252 -2.2204 69.4671
Sc-1 GDSC1 -2.2032 -1.1879 -2.2032 69.4622
P12-Ichikawa GDSC1 -2.1312 -0.4673 -2.1323 68.2623
L-363 GDSC1 -2.1202 -0.9137 -2.1202 68.3856
NOMO-1 GDSC1 -2.1146 -0.5202 -2.1154 68.1154
Kasumi-1 GDSC1 -2.0637 0.2879 -2.0771 66.6825
Hs 445 GDSC1 -2.0553 -0.2382 -2.0577 67.2159
SCC-3 GDSC1 -2.0449 -0.9488 -2.0449 67.4795
MOLT-4 GDSC1 -2.038 -0.6695 -2.0382 67.3106
ALL-PO GDSC1 -2.0206 -0.6114 -2.0209 67.0776
SU-DHL-1 GDSC1 -2.0088 -0.9826 -2.0088 67.0407
KCL-22 GDSC1 -2.0043 0.7021 -2.0357 65.4951
CESS GDSC1 -1.9282 0.3174 -1.9398 65.2609
MC116 GDSC1 -1.9203 -1.4759 -1.9203 65.9561
GR-ST GDSC1 -1.9072 0.8142 -1.9421 64.3993
KOPN-8 GDSC1 -1.8998 -0.2975 -1.9009 65.4966
A3/Kawakami GDSC1 -1.88 -0.0373 -1.8833 65.0911
EM-2 GDSC1 -1.8515 1.6971 -1.9752 62.5853
KMS-12-BM GDSC1 -1.8384 -0.4115 -1.8389 64.8276
RPMI-8866 GDSC1 -1.7762 0.8386 -1.8077 63.0729
RPMI-8226 GDSC1 -1.7589 -0.2713 -1.7596 63.8235
CCRF-CEM GDSC1 -1.7323 -0.3451 -1.7327 63.5296
Jiyoye GDSC1 -1.6782 -0.4596 -1.6783 62.8973
AMO1 GDSC1 -1.6737 0.082 -1.6767 62.6519
BALL-1 GDSC1 -1.6651 0.1859 -1.6694 62.49
ARH-77 GDSC1 -1.633 0.685 -1.6515 61.7417
JSC-1 GDSC1 -1.506 3.9671 -2.1287 57.1342
OCI-AML-3 GDSC1 -1.4641 -0.2961 -1.4642 60.2372
GDM-1 GDSC1 -1.4457 1.637 -1.5344 58.8772
HDLM-2 GDSC1 -1.4274 0.8105 -1.4458 59.3801
QIMR-WIL GDSC1 -1.3121 0.9738 -1.3352 57.9799
Karpas-422 GDSC1 -1.3068 -0.8321 -1.3068 58.287
MOLT-16 GDSC1 -1.2155 0.7413 -1.226 56.977
Raji GDSC1 -1.1778 0.134 -1.1784 56.6557
HT GDSC1 -1.1766 -0.327 -1.1766 56.6581
MOLT-13 GDSC1 -1.1716 0.4685 -1.175 56.5295
OCI-AML-2 GDSC1 -1.1365 -0.1736 -1.1365 56.1558
OPM-2 GDSC1 -1.1251 0.2158 -1.1259 55.997
SU-DHL-16 GDSC1 -1.0857 -0.5414 -1.0857 55.5228
LP-1 GDSC1 -1.0779 0.656 -1.0836 55.3546
VAL GDSC1 -1.0008 1.5448 -1.0535 54.1835
OCI-M1 GDSC1 -0.9165 1.0899 -0.9333 53.3226
DG-75 GDSC1 -0.8895 3.5189 -1.3227 52.333
HL-60 GDSC1 -0.8743 0.5362 -0.8761 52.8692
P32/ISH GDSC1 -0.839 1.5383 -0.8829 52.3203
Granta-519 GDSC1 -0.8168 1.0525 -0.8293 52.123
U-698-M GDSC1 -0.8113 3.3555 -1.1917 51.6397
KMOE-2 GDSC1 -0.775 1.1167 -0.7891 51.6083
OCI-AML-5 GDSC1 -0.6739 0.4389 -0.6743 50.3756
MN-60 GDSC1 -0.6312 2.4915 -0.7934 49.8596
EoL-1 GDSC1 -0.4646 7.2155 -2.2578 48.8416
THP-1 GDSC1 -0.4095 3.0762 -0.6805 47.508
L-540 GDSC1 -0.1412 2.4271 -0.253 44.1249
JURL-MK1 GDSC1 0.0394 4.9562 -0.7986 43.9312
K-562 GDSC1 0.2454 2.7369 0.1082 39.579
KM-H2 GDSC1 0.4633 2.1417 0.4295 36.362
H9 GDSC1 0.5274 3.2557 0.2959 36.6346
EJM GDSC1 0.5798 2.1401 0.5519 34.8743
A4/Fukuda GDSC1 0.7314 8.6557 -1.7065 41.415
KY821 GDSC1 0.932 3.2855 0.7296 31.5532
JJN-3 GDSC1 0.9962 3.0575 0.8557 30.3817
JVM-3 GDSC1 1.2969 5.5083 0.2991 31.7235
RC-K8 GDSC1 1.4481 4.6228 0.8299 27.8597
KMS-11 GDSC1 1.4958 2.5584 1.4756 23.3816
MEG-01 GDSC1 1.6442 5.2904 0.7512 27.2588
Daudi GDSC1 1.8486 2.4373 1.8466 18.8568
WSU-DLCL2 GDSC1 1.8729 14.753 -3.6212 39.8042
JVM-2 GDSC1 2.1222 9.7679 -0.9284 32.7257
SK-MM-2 GDSC1 2.1907 5.3064 1.2961 20.8842
LAMA-84 GDSC1 2.259 5.5318 1.2585 20.8183
WSU-NHL GDSC1 2.3234 6.1509 1.0264 22.095
KG-1 GDSC1 2.3842 5.0234 1.6193 17.6356
YT GDSC1 2.6048 4.5164 2.0728 13.2149
TK [Human B-cell lymphoma] GDSC1 2.6137 3.7633 2.4073 10.6972
CTB-1 GDSC1 2.783 18.3345 -4.6159 38.4167
L-1236 GDSC1 2.8847 4.869 2.1781 11.1495
L-428 GDSC1 2.9391 4.2028 2.5496 8.0515
P31/FUJ GDSC1 3.0114 5.3593 2.0545 11.5756
U266B1 GDSC1 3.0275 3.6991 2.8684 5.23
HEL GDSC1 3.1345 3.7696 2.9446 4.1492
ROS-50 GDSC1 3.2715 4.9595 2.4829 7.1994
NK-92MI GDSC1 3.291 4.2164 2.8706 4.0715
HAL-01 GDSC1 3.4725 6.8123 1.724 12.366
ME1 GDSC1 4.277 5.8801 2.7538 2.2733
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 -3.3993 1.9071 -3.6772 72.0922
ESO-26 GDSC1 -1.2448 1.073 -1.2714 57.164
FLO-1 GDSC1 -1.1461 2.8194 -1.4218 55.0323
OACP4 C GDSC1 -1.1407 0.2347 -1.1416 56.1874
KYSE-50 GDSC1 0.0778 2.2662 0.0063 41.3256
ESO-51 GDSC1 0.1196 5.4243 -0.8967 43.5436
KYAE-1 GDSC1 0.1973 18.2726 -6.8744 47.4951
KYSE-220 GDSC1 1.097 6.3625 -0.2837 35.4822
SK-GT-4 GDSC1 1.9609 6.8135 0.3613 27.8566
TE-12 GDSC1 3.0743 10.2159 -0.3114 26.3466
HCE-4 GDSC1 3.5454 5.8825 2.247 8.0796
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -0.5467 3.6452 -0.9854 49.051
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 -0.6388 0.5865 -0.6397 49.9375
MHH-NB-11 GDSC1 -0.2414 2.6378 -0.3998 45.4297
GI-ME-N GDSC1 -0.1506 3.7081 -0.5725 44.9924
IMR-5 GDSC1 -0.1104 2.7159 -0.2734 43.9157
KP-N-YS GDSC1 -0.0654 3.317 -0.3672 43.7892
SJNB-7 GDSC1 -0.0153 1.2427 -0.0185 42.1606
SK-N-AS GDSC1 0.9382 4.7931 0.2221 34.2618
SJNB-6 GDSC1 1.5265 4.7357 0.8663 27.194
SJNB-12 GDSC1 1.6746 3.6199 1.4428 22.5535
CHP-134 GDSC1 1.838 9.5158 -1.0652 34.4378
NB69 GDSC1 2.4192 4.8241 1.7461 16.5342
GOTO GDSC1 2.5951 10.6445 -0.9402 30.7997
TGW GDSC1 2.7453 6.4282 1.2855 18.4324
Kelly GDSC1 2.8097 4.766 2.1565 11.6433
NB(TU)1 GDSC1 2.9436 7.8272 0.7682 21.0552
SJNB-5 GDSC1 3.1142 5.5192 2.0669 11.0677
NH-12 GDSC1 3.1616 5.1329 2.3008 9.0537
CHP-212 GDSC1 3.1791 5.0992 2.333 8.7328
SJNB-10 GDSC1 3.4349 5.7083 2.245 8.4767
SJNB-14 GDSC1 3.4361 8.2695 0.9658 17.8747
SJNB-13 GDSC1 3.4483 6.5961 1.8123 11.7827
SiMa GDSC1 3.4651 6.4632 1.8925 11.1104
SK-N-BE(2)-M17 GDSC1 3.5211 10.0896 0.1259 22.5265
SK-N-SH GDSC1 3.7984 6.9165 1.9298 9.6996
SK-N-DZ GDSC1 3.8425 5.6399 2.5898 4.4928
SK-N-FI GDSC1 3.9064 6.9 2.0193 8.6783
LA-N-6 GDSC1 4.0551 7.6412 1.7645 10.1383
SJNB-17 GDSC1 4.2691 6.7874 2.3287 5.3261
KP-N-YN GDSC1 5.3598 7.7128 2.5345 1.9157
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -0.3224 2.8504 -0.5325 46.4591
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC70 GDSC1 -2.3939 -1.1453 -2.3939 71.7413
HCC1599 GDSC1 -2.1545 -0.7891 -2.1547 68.7438
HCC1954 GDSC1 -2.1502 0.2229 -2.1633 67.6323
HCC1187 GDSC1 -1.866 -0.0446 -1.869 64.9384
DU4475 GDSC1 -1.8016 0.5818 -1.8201 63.6353
HCC202 GDSC1 -1.4937 5.5543 -2.6655 55.8567
AU565 GDSC1 -1.1301 0.7334 -1.1386 55.9648
OCUB-M GDSC1 -1.1288 0.0127 -1.129 56.0559
HCC1806 GDSC1 -0.8882 0.5591 -0.8903 53.0395
BT-20 GDSC1 -0.821 1.9434 -0.9088 52.0368
HCC2218 GDSC1 -0.7506 5.5343 -1.864 50.8057
HCC1500 GDSC1 -0.5692 2.0725 -0.6577 49.1317
CAL-85-1 GDSC1 -0.4692 4.4611 -1.1652 48.446
MDA-MB-468 GDSC1 -0.4572 1.7073 -0.4974 47.746
BT-549 GDSC1 -0.2402 2.1061 -0.3114 45.1929
MDA-MB-330 GDSC1 -0.0621 4.0069 -0.5703 44.2494
Evsa-T GDSC1 0.0663 1.8813 0.0361 41.279
HCC1419 GDSC1 0.3066 6.4588 -1.1343 42.756
HCC1569 GDSC1 0.4046 4.681 -0.3037 39.9682
MDA-MB-231 GDSC1 0.4443 2.979 0.2729 37.335
HCC2157 GDSC1 0.6219 4.7411 -0.0942 37.7072
UACC-893 GDSC1 1.0186 4.298 0.4977 32.3425
ZR-75-30 GDSC1 1.0379 5.7542 -0.0746 34.9854
HCC1937 GDSC1 1.4124 6.0805 0.1624 31.7501
HCC38 GDSC1 1.4197 7.0838 -0.2934 33.73
COLO 824 GDSC1 1.7033 7.1531 -0.0493 31.1999
EFM-19 GDSC1 1.7886 5.3489 0.8724 25.7407
MDA-MB-415 GDSC1 1.7886 5.8194 0.659 27.0463
CAMA-1 GDSC1 1.8256 6.9109 0.1843 29.4562
MDA-MB-453 GDSC1 1.8483 8.5419 -0.5801 32.7019
JIMT-1 GDSC1 2.0582 5.2407 1.1938 22.2447
CAL-51 GDSC1 2.107 6.8238 0.4963 26.3953
EFM-192A GDSC1 2.1219 5.3258 1.2187 21.7585
MDA-MB-157 GDSC1 2.1302 4.2365 1.706 18.2562
HDQ-P1 GDSC1 2.1369 4.9116 1.4219 20.2603
T-47D GDSC1 2.4142 6.9475 0.7256 23.6003
MDA-MB-436 GDSC1 2.4424 6.229 1.1018 21.0406
UACC-812 GDSC1 2.5748 8.0354 0.3372 25.1423
HCC1395 GDSC1 2.7436 9.205 -0.0932 26.6402
CAL-120 GDSC1 2.8354 5.2229 1.9598 13.0413
BT-483 GDSC1 3.0107 6.1081 1.6826 14.428
MRK-nu-1 GDSC1 3.409 4.4067 2.8742 3.614
BT-474 GDSC1 3.4338 11.9432 -0.8729 27.4046
MFM-223 GDSC1 3.498 4.8831 2.7074 4.6251
CAL-148 GDSC1 3.6419 8.6736 0.9316 17.3535
MDA-MB-175-VII GDSC1 3.721 12.9804 -1.1554 27.5003
MCF-7 GDSC1 4.2251 7.5015 1.9554 8.2205
Hs 578T GDSC1 4.8873 9.3922 1.499 9.697
HCC1428 GDSC1 4.9679 13.1577 -0.2748 19.8945
MDA-MB-361 GDSC1 5.2148 10.308 1.2804 10.3274
YMB-1-E GDSC1 5.5517 12.7589 0.3348 15.1603
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1 -2.0423 -0.3095 -2.044 67.1333
PFSK-1 GDSC1 -1.9112 -0.6167 -1.9113 65.7718
SK-MG-1 GDSC1 -1.5634 2.7502 -1.8602 58.7773
KALS-1 GDSC1 -1.4007 1.7019 -1.4947 58.3663
D-336MG GDSC1 -1.3025 0.6547 -1.3119 58.0334
U-251MG GDSC1 -1.0692 0.3882 -1.0709 55.2899
SF268 GDSC1 -1.039 2.5598 -1.2488 54.1433
8-MG-BA GDSC1 -0.9263 0.6019 -0.9292 53.5073
GI-1 GDSC1 -0.8283 1.1572 -0.8458 52.251
MOG-G-UVW GDSC1 -0.7435 0.5967 -0.745 51.2425
SF539 GDSC1 -0.2587 0.7007 -0.2589 45.187
SNB-75 GDSC1 0.1023 3.1308 -0.136 41.6846
D-423MG GDSC1 0.1561 2.2901 0.0867 40.3557
GaMG GDSC1 0.1709 2.3428 0.0951 40.2037
Onda 10 GDSC1 0.1726 1.7876 0.1535 39.9017
D-392MG GDSC1 0.2533 2.3713 0.1791 39.1834
D-566MG GDSC1 0.7014 2.0427 0.6858 33.2808
YKG-1 GDSC1 0.9517 4.1611 0.4753 32.883
Hs 683 GDSC1 0.9855 3.17 0.8174 30.6847
Daoy GDSC1 0.9868 3.0819 0.8398 30.5389
NMC-G1 GDSC1 1.2062 4.2242 0.7264 29.8931
KS-1 [Human Krukenberg tumour] GDSC1 1.2472 3.6754 0.9601 28.206
LN-405 GDSC1 1.3516 5.5046 0.357 31.1111
YH-13 GDSC1 1.6039 3.8472 1.2904 23.9842
MOG-G-CCM GDSC1 1.6375 4.6837 1.0042 25.7035
M059J GDSC1 1.6457 4.5126 1.0831 25.142
Onda 11 GDSC1 1.9855 5.2811 1.1023 23.2302
DK-MG GDSC1 2.749 3.5928 2.6166 8.488
AM-38 GDSC1 2.8384 4.6246 2.2517 10.7851
H4 GDSC1 2.954 4.1154 2.6052 7.5599
DBTRG-05MG GDSC1 2.9657 9.1657 0.1199 24.6715
D-263MG GDSC1 3.0299 5.6611 1.9217 12.5282
SF295 GDSC1 3.0802 4.2952 2.6407 6.7285
SF126 GDSC1 3.2073 3.9941 2.9059 4.1293
CAS-1 GDSC1 3.2308 9.6823 0.088 23.8029
LN-18 GDSC1 3.3284 4.0559 2.9829 3.046
Becker GDSC1 3.4193 8.6211 0.7761 19.1545
U-87MG ATCC GDSC1 3.4626 7.1469 1.5487 13.7076
KINGS-1 GDSC1 3.4632 9.2265 0.5097 20.6061
GB-1 GDSC1 3.5 4.7924 2.7541 4.2521
KNS-42 GDSC1 3.5837 4.9733 2.7285 4.1851
T98G GDSC1 3.6583 9.0634 0.7502 18.449
SW1088 GDSC1 3.7179 5.3528 2.6409 4.4578
LNZTA3WT4 GDSC1 3.8129 5.3751 2.6973 3.7562
D-502MG GDSC1 3.8146 6.1164 2.3369 6.5185
KNS-81-FD GDSC1 4.2867 10.913 0.3225 18.8583
42-MG-BA GDSC1 4.3555 13.4953 -0.9066 24.5128
SW1783 GDSC1 4.4592 7.4955 2.1178 6.3961
LN-229 GDSC1 4.8255 8.2473 1.9997 6.3556
D-542MG GDSC1 4.8885 6.9404 2.6225 2.0675
A-172 GDSC1 4.995 7.6444 2.3747 3.4409
D283 Med GDSC1 5.1609 6.7995 2.8068 0.7939
D-247MG GDSC1 5.4163 7.6859 2.5722 1.6465
U-118MG GDSC1 5.8204 7.3096 2.8775 0.2204
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -0.0373 2.669 -0.1847 43.0054
TGBC24TKB GDSC1 2.2264 9.9807 -0.939 32.3148
TGBC1TKB GDSC1 4.4997 6.4217 2.6388 2.618
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1 0.5768 3.4329 0.3017 36.262
MFE-319 GDSC1 1.2201 3.8743 0.8654 28.9623
KLE GDSC1 1.4562 5.1282 0.6278 29.0265
AN3-CA GDSC1 1.9444 5.4927 0.9646 24.3466
RL95-2 GDSC1 2.3456 4.4629 1.8338 16.2413
ESS-1 GDSC1 3.3596 10.1089 -0.0173 23.8563
MFE-280 GDSC1 3.6657 9.0533 0.7613 18.3538
MFE-296 GDSC1 3.9496 8.5668 1.2274 14.3222
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-195 GDSC1 -2.606 -0.8005 -2.6072 73.7082
RXF 393L GDSC1 -0.5941 4.3902 -1.2758 49.5602
786-O GDSC1 -0.2969 2.0096 -0.3597 45.8546
LB1047-RCC GDSC1 0.2779 3.9375 -0.1783 40.4669
769-P GDSC1 0.6706 2.9752 0.5199 34.4623
VMRC-RCZ GDSC1 1.2679 4.0927 0.8407 28.8329
TK-10 GDSC1 1.2772 4.0457 0.8676 28.6109
OS-RC-2 GDSC1 1.2811 4.5341 0.6883 29.6762
KTCTL-140 GDSC1 1.414 3.0075 1.3207 24.8766
BB65-RCC GDSC1 1.4176 3.5204 1.1936 25.6922
KTCTL-21 GDSC1 1.8124 3.5329 1.6201 20.5696
HA7-RCC GDSC1 1.8516 4.6651 1.2357 23.0143
BFTC-909 GDSC1 2.0428 6.0638 0.7966 24.9219
UO-31 GDSC1 2.0741 4.1124 1.6966 18.6151
KTCTL-1M GDSC1 2.0936 4.4455 1.5807 19.3433
ACHN GDSC1 2.1304 4.9123 1.415 20.3418
LB996-RCC GDSC1 2.6493 6.4639 1.18 19.5835
SW13 GDSC1 2.7438 4.822 2.0664 12.6258
Caki-1 GDSC1 3.1666 7.5012 1.1237 17.8392
VMRC-RCW GDSC1 3.1728 5.452 2.1518 10.1768
RCC10RGB GDSC1 3.3444 4.9686 2.54 6.4789
KMRC-1 GDSC1 3.3647 5.7486 2.1671 9.3381
SW156 GDSC1 3.365 5.0553 2.5139 6.6104
CAL-54 GDSC1 3.402 5.0215 2.5614 6.1038
SN12C GDSC1 3.4301 5.269 2.4607 6.7983
KMRC-20 GDSC1 3.6795 6.1679 2.2098 7.9261
A-704 GDSC1 3.7669 5.298 2.7026 3.8436
KTCTL-13 GDSC1 3.7734 7.951 1.3965 13.7261
KTCTL-26A GDSC1 4.5036 7.1544 2.3069 4.9182
A-498 GDSC1 4.5513 8.7597 1.5739 10.0759
NCC021 GDSC1 4.9266 7.0609 2.5909 2.1983
LB2241-RCC GDSC1 5.581 7.7105 2.6367 1.1622
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1 -1.775 -0.1985 -1.7761 63.9831
LS411N GDSC1 -1.7639 0.417 -1.7753 63.4085
SNU-1040 GDSC1 -1.4279 5.0466 -2.4075 55.7667
RKO GDSC1 -1.403 0.3186 -1.4066 59.3561
HCC2998 GDSC1 -1.3902 0.9088 -1.4124 58.8978
NCI-H747 GDSC1 -0.839 2.9754 -1.1241 51.9957
KM12 GDSC1 -0.8116 7.6905 -2.8218 50.9966
SNU-175 GDSC1 -0.5935 0.9836 -0.5994 49.3756
SW620 GDSC1 -0.4689 2.0307 -0.5452 47.9401
SNU-61 GDSC1 -0.3702 8.0872 -2.5453 48.3674
SNU-81 GDSC1 -0.3557 17.7224 -7.1144 49.1414
SNU-C2B GDSC1 -0.3107 5.8561 -1.5254 47.4521
HT-29 GDSC1 -0.037 3.8528 -0.4936 43.8696
LS180 GDSC1 0.1467 4.8465 -0.6422 42.7951
SW626 GDSC1 0.4878 5.5388 -0.5554 40.1799
COLO205 GDSC1 0.9634 3.9675 0.5556 32.3669
GP5d GDSC1 1.0355 3.562 0.7645 30.6991
CaR-1 GDSC1 1.2902 5.8535 0.1404 32.5435
LS123 GDSC1 1.3991 5.7066 0.3165 31.053
NCI-H716 GDSC1 1.4969 5.5485 0.4865 29.5997
SW837 GDSC1 2.4689 6.4633 1.0128 21.5168
SW1417 GDSC1 2.6693 6.044 1.4043 17.9126
SNU-407 GDSC1 2.7 6.4038 1.256 18.8348
SNU-C5 GDSC1 2.7173 6.0007 1.4699 17.2284
CCK-81 GDSC1 2.7763 6.111 1.47 16.9755
T84 GDSC1 2.8323 5.5222 1.8106 14.1946
SNU-C1 GDSC1 2.9651 10.2956 -0.4446 27.3637
LS1034 GDSC1 3.3098 5.3017 2.3444 8.147
COLO 320HSR GDSC1 3.3545 5.8707 2.0975 9.9192
SW1463 GDSC1 3.6321 4.8101 2.8444 3.1399
LS513 GDSC1 3.7567 11.5198 -0.3968 24.2615
COLO 678 GDSC1 4.3509 9.4236 1.1062 13.8703
SW48 GDSC1 4.548 14.5835 -1.2978 25.4466
SW948 GDSC1 4.578 7.8743 2.0162 6.8354
LoVo GDSC1 4.5814 6.9949 2.4281 3.8892
C2BBe1 GDSC1 4.666 8.2811 1.8811 7.5856
HT-55 GDSC1 4.6746 7.4221 2.2886 4.6635
RCM-1 [Human ESC] GDSC1 4.9179 9.7048 1.3701 10.4923
HT115 GDSC1 4.9296 6.3795 2.869 0.727
HCT 15 GDSC1 4.9618 6.4604 2.8517 0.7736
SW1116 GDSC1 5.2369 6.8349 2.8251 0.6602
MDST8 GDSC1 5.574 15.0537 -0.7631 20.4545
CL-11 GDSC1 5.6117 8.4322 2.3602 2.5486
CW-2 GDSC1 6.3267 8.0215 2.8133 0.2028
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.6863 1.8636 -0.7555 50.4982
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-423 GDSC1 -0.9284 1.5434 -0.9772 53.357
SNU-398 GDSC1 -0.4816 0.9555 -0.4853 47.9812
SNU-387 GDSC1 0.0218 3.0126 -0.195 42.5449
JHH-1 GDSC1 0.2187 2.4668 0.1275 39.6911
SNU-475 GDSC1 1.0748 3.9594 0.679 30.9667
HLE GDSC1 1.5401 3.2859 1.393 23.6585
JHH-7 GDSC1 2.2075 5.0224 1.4432 19.761
JHH-2 GDSC1 2.4341 7.157 0.6416 24.0198
JHH-4 GDSC1 3.3103 5.5592 2.2161 9.1529
JHH-6 GDSC1 3.3685 6.0272 2.0309 10.3866
Huh-7 GDSC1 3.4029 4.3507 2.8973 3.4528
Hep-G2/C3A GDSC1 4.0824 5.9863 2.5859 3.8929
SNU-449 GDSC1 4.1376 6.8435 2.2129 6.5364
HuH-1 GDSC1 4.1915 5.8899 2.6992 2.8228
Hep 3B2.1-7 GDSC1 4.3197 6.3675 2.5576 3.5442
SK-HEP-1 GDSC1 4.9547 6.1275 2.973 0.3258
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L311 GDSC1 -5.8385 -1.9751 -5.8573 91.1049
SBC-3 GDSC1 -3.3459 -1.4348 -3.3467 81.5753
NCI-H748 GDSC1 -3.0481 2.8774 -3.5083 68.2051
LCLC-97TM1 GDSC1 -2.7977 1.767 -3.0021 69.2873
CAL-12T GDSC1 -2.2605 0.6535 -2.2984 67.904
EPLC-272H GDSC1 -2.2471 -1.0995 -2.2471 69.9743
NCI-H209 GDSC1 -2.1086 2.0421 -2.3072 64.1014
NCI-H1437 GDSC1 -2.0183 -0.6876 -2.0184 67.0826
NCI-H211 GDSC1 -1.999 0.6821 -2.0289 65.4741
NCI-H64 GDSC1 -1.9933 -1.1927 -1.9933 66.8649
COR-L321 GDSC1 -1.9862 0.0053 -1.9912 66.2228
COR-L303 GDSC1 -1.9557 6.3097 -3.449 57.9191
COR-L23 GDSC1 -1.9538 -0.0457 -1.9576 65.9187
HCC44 GDSC1 -1.9032 0.2349 -1.9119 65.0892
NCI-H810 GDSC1 -1.9019 0.7749 -1.934 64.4027
NCI-H2087 GDSC1 -1.8467 -0.2577 -1.8478 64.8553
NCI-H1568 GDSC1 -1.812 -0.737 -1.812 64.5835
NCI-H526 GDSC1 -1.7177 -0.1578 -1.7188 63.2875
RERF-LC-KJ GDSC1 -1.6209 -0.2613 -1.6213 62.1574
HARA [Human squamous cell lung carcinoma] GDSC1 -1.5538 0.1653 -1.5567 61.2061
PC-14 GDSC1 -1.5357 0.2152 -1.5391 60.9698
HCC78 GDSC1 -1.4813 0.6886 -1.4959 60.0675
NCI-H647 GDSC1 -1.3888 1.0238 -1.4176 58.8028
LCLC-103H GDSC1 -1.3249 0.6368 -1.3343 58.3037
NCI-H82 GDSC1 -1.1923 1.0613 -1.2163 56.5713
HOP-62 GDSC1 -1.1173 2.415 -1.3049 54.9999
Lu-139 GDSC1 -1.0393 5.6671 -2.2232 52.8409
NCI-H2030 GDSC1 -1.0012 1.1454 -1.0236 54.3176
NCI-H1648 GDSC1 -0.9438 1.0147 -0.958 53.6643
NCI-H3122 GDSC1 -0.9067 2.6056 -1.1147 52.7868
NCI-H187 GDSC1 -0.8961 3.55 -1.3388 52.3847
NCI-H358 GDSC1 -0.8251 4.0921 -1.4272 51.615
NCI-H2122 GDSC1 -0.6309 11.2219 -4.2475 49.9424
IST-SL1 GDSC1 -0.6271 4.2634 -1.2686 49.8503
NCI-H2110 GDSC1 -0.5792 1.3177 -0.5971 49.2076
NCI-H522 GDSC1 -0.5299 1.6762 -0.571 48.6281
NCI-H596 GDSC1 -0.4761 2.0603 -0.5567 48.0311
LXF 289 GDSC1 -0.4708 1.1696 -0.4796 47.8568
ChaGo-K-1 GDSC1 -0.4237 1.975 -0.4901 47.3865
NCI-H520 GDSC1 -0.4202 2.6463 -0.5952 47.5062
NCI-H1975 GDSC1 -0.3968 5.0217 -1.2903 47.9316
LC-2/ad GDSC1 -0.395 4.0039 -0.9312 47.6337
NCI-H1876 GDSC1 -0.3127 2.6297 -0.4754 46.2618
NCI-H2135 GDSC1 -0.2001 2.3732 -0.3074 44.8134
NCI-H1048 GDSC1 -0.1673 1.1434 -0.1705 44.0592
Lu-134-A GDSC1 -0.1051 3.7069 -0.5226 44.5016
NCI-H524 GDSC1 -0.0665 2.8246 -0.2485 43.4602
ABC-1 GDSC1 0.0186 2.9802 -0.1909 42.5577
NCI-H1563 GDSC1 0.0209 1.5733 0.0084 41.7568
CPC-N GDSC1 0.0348 5.7158 -1.1042 44.5126
HCC33 GDSC1 0.1082 7.0059 -1.5773 44.7251
NCI-H650 GDSC1 0.1261 3.1423 -0.1129 41.4104
NCI-H838 GDSC1 0.2753 3.0844 0.064 39.5486
NCI-H727 GDSC1 0.3198 4.3907 -0.2882 40.5273
Lu-65 GDSC1 0.3266 5.0828 -0.5416 41.2409
NCI-H446 GDSC1 0.329 9.367 -2.4351 44.533
NCI-H1836 GDSC1 0.4004 4.8537 -0.3739 40.2254
NCI-H2227 GDSC1 0.4405 11.7688 -3.4727 45.0067
NCI-H1993 GDSC1 0.4719 3.2896 0.2264 37.3667
NCI-H292 GDSC1 0.4834 93.7899 -44.2764 49.3369
PaCa-3 GDSC1 0.4911 4.1506 -0.0186 38.309
COR-L95 GDSC1 0.527 6.981 -1.1391 41.408
NCI-H23 GDSC1 0.5326 2.3069 0.4851 35.5793
IST-SL2 GDSC1 0.5676 3.7694 0.1908 36.8611
Lu-99A GDSC1 0.588 4.4214 -0.0105 37.6008
SK-MES-1 GDSC1 0.6577 3.4523 0.3844 35.2863
NCI-H2029 GDSC1 0.6615 4.0028 0.2165 36.0954
NCI-H1944 GDSC1 0.7126 5.4658 -0.2896 37.8443
UMC-11 GDSC1 0.771 3.4227 0.5165 33.8198
A-427 GDSC1 0.9113 3.6027 0.6168 32.3481
NCI-H1688 GDSC1 0.9183 4.0266 0.4865 33.0336
NCI-H661 GDSC1 0.9216 7.193 -0.8379 38.3505
COR-L88 GDSC1 0.9312 6.4939 -0.5106 37.2705
NCI-H2085 GDSC1 0.9463 5.2616 0.0401 35.0495
NCI-H1092 GDSC1 0.9718 8.572 -1.4324 39.6081
EMC-BAC-1 GDSC1 0.9917 5.4468 0.0096 34.9032
NCI-H1792 GDSC1 0.9932 3.1024 0.842 30.4848
NCI-H2170 GDSC1 1.0536 6.6313 -0.4489 36.3457
COLO 668 GDSC1 1.0845 4.3344 0.5549 31.6202
SBC-1 GDSC1 1.0887 6.0102 -0.1348 34.9354
NCI-H2196 GDSC1 1.2298 4.0449 0.8167 29.2059
NCI-H1915 GDSC1 1.2452 9.0904 -1.4163 38.2068
EBC-1 GDSC1 1.2482 4.6534 0.6062 30.3467
NCI-H2141 GDSC1 1.2484 4.1465 0.8002 29.1967
LB647-SCLC GDSC1 1.2721 3.8749 0.9216 28.3029
SK-LU-1 GDSC1 1.3525 5.1486 0.5114 30.2749
LC-1/sq GDSC1 1.3771 4.2302 0.9076 27.78
LK-2 GDSC1 1.4972 5.0817 0.6902 28.4305
NCI-H1703 GDSC1 1.5329 3.5808 1.3008 24.3157
NCI-H2869 GDSC1 1.5834 5.5385 0.5791 28.604
COR-L105 GDSC1 1.6599 5.26 0.7806 26.9946
NCI-H2795 GDSC1 1.6659 3.6882 1.4113 22.8168
NCI-H1869 GDSC1 1.6743 6.3303 0.3093 29.5947
HCC827 GDSC1 1.7632 7.147 0.0115 30.6132
EMC-BAC-2 GDSC1 1.7789 2.9106 1.7328 20.0098
NCI-H2347 GDSC1 1.878 7.2412 0.0769 29.7252
NCI-H69 GDSC1 1.9057 8.4022 -0.4584 31.9557
IA-LM GDSC1 2.0251 4.3996 1.5284 20.0681
NCI-H441 GDSC1 2.0738 8.8193 -0.506 31.3669
NCI-H2228 GDSC1 2.1148 6.9957 0.4208 26.7815
Lu-165 GDSC1 2.1602 8.5741 -0.3061 30.1423
NCI-H2081 GDSC1 2.1764 6.5258 0.7058 24.83
NCI-H1694 GDSC1 2.2045 5.2174 1.3509 20.4318
DMS 273 GDSC1 2.22 6.7524 0.6381 25.0302
NCI-H847 GDSC1 2.2314 3.5143 2.0821 15.0517
NCI-H3255 GDSC1 2.2423 7.9867 0.0578 28.0832
NCI-H2369 GDSC1 2.2457 3.9958 1.9248 16.0853
NCI-H460 GDSC1 2.2817 6.1976 0.9642 22.7009
NCI-H2595 GDSC1 2.3522 6.6911 0.7926 23.4691
NCI-H1693 GDSC1 2.4478 8.7343 -0.123 28.0355
NCI-H1581 GDSC1 2.5368 4.288 2.1067 13.2866
Lu-135 GDSC1 2.5417 4.6806 1.9343 14.5521
A-549 GDSC1 2.5525 5.7171 1.4536 18.0723
RERF-LC-MS GDSC1 2.5651 4.2335 2.1596 12.7559
NCI-H1734 GDSC1 2.5824 9.4504 -0.3576 28.5255
NCI-H226 GDSC1 2.5828 6.8991 0.9051 21.7138
NCI-H1436 GDSC1 2.6033 7.6295 0.5636 23.732
SW1271 GDSC1 2.6275 5.1231 1.8105 15.0902
NCI-H2804 GDSC1 2.6638 5.4917 1.6679 15.9985
NCI-H841 GDSC1 2.783 3.5065 2.684 7.8291
Ms-1 GDSC1 2.7912 3.4078 2.7247 7.5019
NCI-H1651 GDSC1 2.8122 4.4138 2.3261 10.3346
NCI-H2171 GDSC1 2.8185 4.0434 2.5026 8.9715
NCI-H290 GDSC1 2.9126 4.2611 2.4962 8.58
NCI-H196 GDSC1 2.9175 10.9275 -0.801 29.0156
NCI-H1304 GDSC1 2.9418 9.6756 -0.1552 26.1354
NCI-H1793 GDSC1 3.0079 4.2138 2.6112 7.2714
NCI-H2342 GDSC1 3.1648 7.7984 0.9736 18.8528
NCI-H2818 GDSC1 3.1956 5.5302 2.1326 10.2389
NCI-H510A GDSC1 3.3172 6.4783 1.7624 12.6399
SBC-5 GDSC1 3.3263 5.2348 2.3918 7.7133
BEN GDSC1 3.3536 4.6574 2.7034 5.1574
RERF-LC-Sq1 GDSC1 3.3564 10.9043 -0.4177 25.7711
DMS 114 GDSC1 3.3804 7.0404 1.5342 14.1136
NCI-H1755 GDSC1 3.4626 6.3892 1.9274 10.8504
NCI-H1355 GDSC1 3.4671 4.981 2.6342 5.3044
NCI-H1666 GDSC1 3.4915 7.6944 1.2988 15.4046
NCI-H1155 GDSC1 3.5445 5.987 2.1942 8.4954
SHP-77 GDSC1 3.5775 4.8053 2.8067 3.5948
NCI-H1573 GDSC1 3.5831 8.7834 0.8293 18.2205
NCI-H1299 GDSC1 3.7144 6.7822 1.9318 9.9573
Calu-3 GDSC1 3.759 6.5027 2.1047 8.4847
NCI-H2461 GDSC1 3.8112 8.3932 1.206 14.9312
NCI-H1650 GDSC1 3.8347 9.8869 0.4805 19.4545
HOP-92 GDSC1 3.8439 9.8531 0.5046 19.2825
EKVX GDSC1 3.8708 8.1686 1.3643 13.6289
NCI-H2405 GDSC1 3.9233 8.9459 1.0187 15.8145
NCI-H345 GDSC1 4.0165 7.5679 1.7721 10.201
Calu-6 GDSC1 4.1043 9.8661 0.7017 17.2314
NCI-H2803 GDSC1 4.1197 6.2253 2.4971 4.4562
NCI-H1781 GDSC1 4.1584 6.3247 2.4754 4.5195
NCI-H2591 GDSC1 4.1658 10.6998 0.3354 19.1749
NCI-H2722 GDSC1 4.17 6.2723 2.5077 4.253
DMS 79 GDSC1 4.2334 13.3924 -0.9509 25.0687
NCI-H1623 GDSC1 4.2442 8.0465 1.7036 10.0207
LOU-NH91 GDSC1 4.2838 5.9387 2.7315 2.4104
SW1573 GDSC1 4.3319 9.7606 0.9263 15.1005
NCI-H1435 GDSC1 4.5268 11.3193 0.3031 18.2172
NCI-H2444 GDSC1 4.5422 8.1236 1.8737 7.957
NCI-H2291 GDSC1 5.0501 12.3663 0.1729 17.3903
NCI-H1770 GDSC1 5.0563 12.085 0.3147 16.6037
NCI-H1838 GDSC1 5.0607 10.8627 0.9109 13.0898
NCI-H322M GDSC1 5.0841 11.7659 0.4898 15.5423
NCI-H2731 GDSC1 5.0888 7.0246 2.6859 1.442
NCI-H720 GDSC1 5.2024 6.3765 2.9774 0.2077
NCI-H2373 GDSC1 5.357 7.3987 2.6596 1.2756
HCC15 GDSC1 5.3578 17.2804 -2.0164 25.6835
NCI-H2023 GDSC1 5.6032 11.642 0.9029 11.7469
NCI-H513 GDSC1 5.8014 12.0112 0.8573 11.5453
DMS 53 GDSC1 5.964 7.7758 2.7673 0.4272
NCI-H2172 GDSC1 5.9909 11.5742 1.1801 9.1599
NCI-H2009 GDSC1 6.115 7.784 2.8196 0.248
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -2.3707 1.9553 -2.5745 66.1494
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 -0.6556 0.7627 -0.6581 50.1456
KYSE-140 GDSC1 -0.423 1.8718 -0.4776 47.3572
KYSE-180 GDSC1 -0.2923 2.8431 -0.498 46.1117
TE-15 GDSC1 1.1053 7.1435 -0.632 36.6836
KYSE-270 GDSC1 1.2273 2.8224 1.1538 27.0787
TE-6 GDSC1 1.7001 6.8051 0.1124 30.453
KYSE-410 GDSC1 1.734 6.6102 0.2373 29.6554
TE-4 GDSC1 1.9258 4.6463 1.3208 22.0411
COLO 680N GDSC1 2.1025 8.8399 -0.4897 31.1714
KYSE-520 GDSC1 2.1031 7.5198 0.1559 28.242
KYSE-70 GDSC1 2.2144 5.1376 1.3975 20.0539
OE21 GDSC1 2.4649 5.063 1.6806 16.8049
TE-5 GDSC1 2.6715 8.5655 0.161 25.669
T.T GDSC1 2.8173 3.7514 2.6274 8.0542
KYSE-150 GDSC1 3.3809 8.2642 0.9227 18.3611
TE-1 GDSC1 3.5325 7.444 1.4572 14.1256
TE-10 GDSC1 3.5738 8.5504 0.9381 17.554
EC-GI-10 GDSC1 3.6447 4.9394 2.7902 3.5205
KYSE-510 GDSC1 4.2309 8.6123 1.4166 12.1158
OE33 GDSC1 4.5551 16.8716 -2.4302 29.0638
TE-8 GDSC1 5.2969 11.078 0.9683 12.1111
OE19 GDSC1 5.5575 6.8436 2.9437 0.1682
TE-9 GDSC1 5.5655 7.2226 2.8135 0.4907
TE-11 GDSC1 5.582 11.5407 0.937 11.5912
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 -1.7331 -0.008 -1.7355 63.3922
TOV-21G GDSC1 -1.6904 2.0488 -1.8574 60.6969
TOV-112D GDSC1 -1.6819 0.0388 -1.6844 62.7707
IGROV-1 GDSC1 -1.5082 5.8422 -2.7908 55.7633
OVISE GDSC1 -0.5176 0.8999 -0.5208 48.4285
OC 314 GDSC1 -0.4389 1.7129 -0.4787 47.5236
ES-2 GDSC1 -0.1012 1.6637 -0.1226 43.3162
OVCAR-8 GDSC1 0.3176 3.5504 -0.0149 39.5569
EFO-21 GDSC1 0.3549 5.7818 -0.7957 41.705
SK-OV-3 GDSC1 0.3569 5.4098 -0.6402 41.2983
OV-90 GDSC1 0.5495 6.328 -0.8273 40.5291
OVCAR-5 GDSC1 0.6297 6.5127 -0.8261 40.03
Caov-4 GDSC1 0.769 4.6061 0.1146 35.8478
OV56 GDSC1 0.9079 3.7603 0.5639 32.671
OVCAR-4 GDSC1 1.0868 4.8898 0.3406 32.7541
Kuramochi GDSC1 1.1214 5.4278 0.1524 33.4711
EFO-27 GDSC1 1.4077 7.0455 -0.2873 33.7701
RMG-I GDSC1 1.6177 4.5686 1.0308 25.6384
FU-OV-1 GDSC1 1.8647 7.0773 0.1427 29.4683
Caov-3 GDSC1 1.9377 5.9832 0.7312 25.8485
OVTOKO GDSC1 2.7143 5.0737 1.9175 13.892
OAW28 GDSC1 2.764 4.9771 2.0115 12.9556
OVKATE GDSC1 2.8925 8.8714 0.2032 24.5299
JHOS-2 GDSC1 3.3611 4.9644 2.5561 6.2915
OVK18 GDSC1 3.4062 5.1927 2.4792 6.7362
OAW42 GDSC1 3.5558 6.154 2.1199 9.036
DOV13 GDSC1 4.9324 7.9293 2.2113 4.6517
OVCAR-3 GDSC1 5.3405 7.0765 2.7771 0.7705
TYK-nu GDSC1 6.1277 13.7595 0.2433 14.2289
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -2.0431 -0.7562 -2.0433 67.406
HuP-T4 GDSC1 -1.9884 -0.6842 -1.9885 66.7232
BxPC-3 GDSC1 -1.773 0.0893 -1.7769 63.7865
MZ-PC-1 GDSC1 -1.4839 0.7286 -1.5003 60.0692
KP-1N GDSC1 -1.0912 0.5014 -1.0943 55.5443
KP-2 GDSC1 -0.8066 0.8568 -0.8128 52.0135
Panc 08.13 GDSC1 -0.7833 3.2353 -1.129 51.3914
PaTu 8988t GDSC1 -0.7549 2.008 -0.8471 51.2774
HPAC GDSC1 -0.7026 2.8658 -0.9497 50.6194
Panc 10.05 GDSC1 -0.6891 2.4315 -0.8448 50.5016
Capan-1 GDSC1 -0.366 3.293 -0.6888 47.105
HPAF-II GDSC1 -0.026 3.2552 -0.3079 43.2929
DAN-G GDSC1 0.2043 1.3518 0.2018 39.4133
PaTu 8902 GDSC1 0.3703 3.4896 0.0602 38.855
QGP-1 GDSC1 0.3876 7.6013 -1.5599 43.0322
SU.86.86 GDSC1 0.4451 4.32 -0.1278 39.0607
Panc 03.27 GDSC1 0.5683 4.8683 -0.2005 38.4734
Panc 02.03 GDSC1 0.6416 4.1716 0.1368 36.5992
HuP-T3 GDSC1 0.8408 3.6905 0.513 33.385
KP-3 GDSC1 0.9118 4.4873 0.3124 33.9849
KP-4 GDSC1 1.0214 2.2463 1.0048 29.2886
CFPAC-1 GDSC1 1.7332 5.2342 0.867 26.0671
MIA PaCa-2 GDSC1 1.7581 6.9291 0.1102 30.1664
SW1990 GDSC1 2.0279 6.6919 0.4838 26.8505
SUIT-2 GDSC1 2.2417 4.3617 1.7702 17.224
PL4 GDSC1 2.6012 9.4221 -0.3269 28.3121
YAPC GDSC1 2.7741 10.249 -0.5866 28.717
Panc 04.03 GDSC1 2.9344 12.1921 -1.418 31.1406
Hs 766T GDSC1 3.5023 6.8409 1.734 12.1848
AsPC-1 GDSC1 5.0141 13.9215 -0.6165 21.3393
Capan-2 GDSC1 5.9078 13.0784 0.4218 13.7913
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 2.8403 4.168 2.468 9.1277
NCI-H2452 GDSC1 3.643 6.3823 2.075 9.0917
MPP 89 GDSC1 3.7621 5.4217 2.639 4.3441
IST-Mes1 GDSC1 4.3713 9.2318 1.2154 13.0777
NCI-H28 GDSC1 4.4098 6.5221 2.5413 3.4635
NCI-H2052 GDSC1 5.9924 11.4647 1.2314 8.8409
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 -0.6218 5.5228 -1.7224 49.8311
PC-3 GDSC1 0.3504 3.464 0.0458 39.0634
VCaP GDSC1 0.641 1.8396 0.6335 33.9857
22Rv1 GDSC1 1.5665 5.2298 0.6979 28.0019
DU145 GDSC1 4.3159 6.5501 2.4705 4.1759
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -0.2896 2.5434 -0.4338 45.9573
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-431 GDSC1 -2.3172 -1.2226 -2.3172 70.8592
Mel JuSo GDSC1 -1.3782 0.4378 -1.3836 59.0161
Mel Ho GDSC1 -1.1283 0.4704 -1.1314 56.0029
RPMI-7951 GDSC1 -0.9791 1.2778 -1.0089 54.0211
IGR-1 GDSC1 -0.7858 1.47 -0.8215 51.7037
SK-MEL-30 GDSC1 -0.7509 2.3848 -0.9031 51.1849
WM793 GDSC1 -0.5156 5.2817 -1.516 48.9742
SK-MEL-2 GDSC1 -0.3842 2.351 -0.5018 47.0066
MZ-MEL-2 GDSC1 -0.3798 0.9366 -0.3821 46.7077
MZ-MEL-7 GDSC1 -0.3392 1.1335 -0.3446 46.2124
IST-MEL1 GDSC1 0.1155 5.1794 -0.8038 43.3836
A101D GDSC1 0.3844 1.7679 0.3733 37.2141
WM35 GDSC1 0.4297 2.8716 0.2805 37.4001
HMV-II GDSC1 0.5221 3.5392 0.2114 37.0822
COLO 679 GDSC1 0.6406 2.3769 0.5914 34.2442
IPC-298 GDSC1 0.6526 3.2417 0.4361 35.0456
COLO 800 GDSC1 0.6899 4.2807 0.1502 36.2114
LB2518-MEL GDSC1 0.803 2.0995 0.7876 32.0108
WM1552C GDSC1 0.8196 2.8289 0.712 32.3699
RVH-421 GDSC1 0.8281 4.6479 0.1617 35.2488
A-388 GDSC1 0.8986 3.7294 0.5636 32.7318
A-375 GDSC1 0.9874 3.2261 0.8054 30.7475
G-mel GDSC1 1.1241 4.5746 0.5055 31.6525
G-361 GDSC1 1.129 3.4733 0.8926 29.3389
WM115 GDSC1 1.1812 3.4939 0.9436 28.7039
M14 GDSC1 1.3149 4.4458 0.7587 29.0589
UACC-257 GDSC1 1.4414 3.4434 1.242 25.2345
CHL-1 GDSC1 1.4547 3.3219 1.2903 24.8365
DJM-1 GDSC1 1.4643 3.9506 1.1033 26.0193
SK-MEL-3 GDSC1 1.6215 3.9269 1.2814 23.9472
IGR-37 GDSC1 1.8015 4.4214 1.2844 22.9461
HT-144 GDSC1 1.8795 9.182 -0.8633 33.5811
WM278 GDSC1 1.8818 5.53 0.8848 25.1784
LOX-IMVI GDSC1 1.9705 7.2094 0.1806 28.7555
MeWo GDSC1 2.0183 5.7502 0.9194 24.2675
A2058 GDSC1 2.0736 4.9745 1.3294 21.2288
MMAc-SF GDSC1 2.1395 4.0528 1.7895 17.6094
COLO 783 GDSC1 2.1485 3.4762 2.0036 16.0554
COLO 792 GDSC1 2.4151 4.0725 2.0727 14.1433
SK-MEL-24 GDSC1 2.4577 6.0075 1.2234 20.1368
LB373-MEL-D GDSC1 2.4653 3.5177 2.3355 12.0013
Hs 938.T GDSC1 2.516 5.4296 1.5568 17.4829
451Lu GDSC1 2.5374 5.062 1.7521 15.9377
WT2-iPS GDSC1 2.6605 6.5365 1.1546 19.7101
SK-MEL-5 GDSC1 2.6646 4.2506 2.2535 11.574
CP50-MEL-B GDSC1 2.8143 3.3768 2.759 7.137
CP66-MEL GDSC1 2.8369 3.4324 2.767 6.9559
COLO 829 GDSC1 3.0995 5.0667 2.2786 9.4735
Hs 940.T GDSC1 3.2096 6.5106 1.6552 13.8544
VMRC-MELG GDSC1 3.3443 5.6442 2.2022 9.1376
GAK GDSC1 3.3615 4.8467 2.6153 5.8236
UACC-62 GDSC1 3.4998 4.4177 2.9398 2.7988
SH-4 GDSC1 3.7309 7.3607 1.657 11.9739
SK-MEL-28 GDSC1 3.7901 5.1506 2.7897 3.1186
SK-MEL-1 GDSC1 4.0525 6.036 2.5427 4.2879
EquiPSC Line K2 GDSC1 1.5521 5.4755 0.5752 28.7972
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 2.5023 3.6071 2.3455 11.7294
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC1 -2.1216 -0.5895 -2.1221 68.2439
STS-0421 GDSC1 -2.0772 -0.3582 -2.0787 67.565
G-402 GDSC1 -1.4275 0.4171 -1.4331 59.6054
G-401 GDSC1 -0.9402 2.3679 -1.1044 53.2157
EW-8 GDSC1 -0.9129 0.7522 -0.9183 53.3279
Rh18 GDSC1 -0.8702 3.7368 -1.3655 52.0971
Rh30 GDSC1 -0.2776 1.8394 -0.3209 45.5664
RKN GDSC1 -0.0475 3.7423 -0.4706 43.9009
SK-LMS-1 GDSC1 0.1673 2.1078 0.1208 40.1073
A-204 GDSC1 0.3769 3.9457 -0.0733 39.3464
Hs 633.T GDSC1 1.1388 3.0373 1.0153 28.5029
SK-UT-1 GDSC1 1.2049 4 0.8057 29.4216
MES-SA GDSC1 1.2228 3.0916 1.0945 27.4886
RD GDSC1 2.016 5.2189 1.1611 22.6793
HT-1080 GDSC1 2.4302 6.1467 1.1301 20.9039
GCT GDSC1 2.5235 5.9447 1.3161 19.1882
Rh41 GDSC1 2.7788 3.7861 2.5727 8.6489
VA-ES-BJ GDSC1 3.1515 4.9703 2.3728 8.5288
MFH-ino GDSC1 3.7287 8.1483 1.263 14.819
SW872 GDSC1 3.7927 5.7182 2.5162 5.1997
SW684 GDSC1 4.6068 6.0834 2.84 1.2141
KYM-1 GDSC1 5.5591 6.7498 2.9759 0.1153
SW982 GDSC1 5.5654 7.2486 2.8041 0.5209
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IM95 GDSC1 -1.7201 2.4714 -1.9697 60.401
HGC-27 GDSC1 -1.2782 3.1524 -1.6473 55.9905
RF-48 GDSC1 -0.8544 1.2932 -0.8804 52.545
SNU-1 GDSC1 -0.4311 2.0596 -0.5086 47.4924
AGS GDSC1 -0.3205 2.455 -0.4511 46.2886
RERF-GC-1B GDSC1 -0.2567 3.6208 -0.662 46.0747
SNU-16 GDSC1 0.4812 3.4077 0.2044 37.4053
HSC-39 GDSC1 0.5065 6.0369 -0.7458 40.5876
Fu97 GDSC1 1.0943 3.2314 0.9206 29.3739
ECC10 GDSC1 1.1714 5.6364 0.1141 33.3554
MKN1 GDSC1 1.2441 6.0984 -0.0159 33.526
TMK-1 GDSC1 1.3394 6.188 0.04 32.735
MKN45 GDSC1 1.6341 9.488 -1.2412 35.8997
TGBC11TKB GDSC1 1.8674 5.3546 0.9498 24.8366
Hs 746.T GDSC1 2.0113 10.7944 -1.5357 35.0844
NUGC-3 GDSC1 2.0487 6.715 0.4928 26.6977
OCUM-1 GDSC1 2.4396 8.5008 -0.015 27.555
23132/87 GDSC1 2.5834 8.8273 -0.0474 27.0903
SCH GDSC1 3.7329 9.5411 0.5718 19.2717
MKN28 GDSC1 3.8507 12.5172 -0.8191 25.767
MKN7 GDSC1 4.2715 7.9432 1.7735 9.4309
SNU-5 GDSC1 4.4969 9.2935 1.2761 12.2942
NUGC-4 GDSC1 4.6354 9.1689 1.4345 10.8158
GCIY GDSC1 5.0077 6.9669 2.6707 1.6242
NCI-N87 GDSC1 6.0029 7.8139 2.7684 0.4071
SNG-M GDSC1 -1.0247 0.9369 -1.0378 54.6503
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 -1.6194 -0.6707 -1.6194 62.1897
ASH-3 GDSC1 -0.1921 5.0332 -1.0755 46.1304
KMH-2 GDSC1 -0.0033 1.7544 -0.0269 42.1113
8505C GDSC1 0.1568 4.1292 -0.3733 42.0123
B-CPAP GDSC1 0.2773 3.4329 -0.0252 39.9013
CAL-62 GDSC1 1.116 4.5334 0.5129 31.6615
TT2609-C02 GDSC1 1.513 5.1252 0.6879 28.3566
ML-1 [Human leukemia] GDSC1 1.7211 4.4516 1.1873 24.0377
K5 GDSC1 2.224 4.5435 1.6736 18.0158
TT GDSC1 2.7677 3.5542 2.6508 8.1455
HTC-C3 GDSC1 2.8149 4.062 2.4906 9.0782
8305C GDSC1 2.8886 5.5656 1.8411 13.7256
BHT-101 GDSC1 3.3636 4.1582 2.9613 3.0872
CGTH-W-1 GDSC1 4.2531 7.9321 1.7658 9.5403
WRO GDSC1 5.4143 7.2214 2.753 0.8091
FTC-133 GDSC1 5.4355 6.8817 2.8861 0.3421
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHU-011 GDSC1 -1.8932 2.1997 -2.1033 62.1773
NCI-H3118 GDSC1 -1.7355 -0.6793 -1.7356 63.6319
PCI-04B GDSC1 -1.4892 -0.0058 -1.4903 60.4953
CAL-27 GDSC1 -1.3407 -0.0315 -1.3412 58.6845
SCC-9 GDSC1 -1.3165 0.7576 -1.3298 58.1491
HO-1-N-1 GDSC1 -1.0903 0.1707 -1.0908 55.5688
SCC-25 GDSC1 -1.0346 1.4623 -1.0813 54.5982
BB30-HNC GDSC1 -0.8995 0.296 -0.8999 53.1907
UPCI-SCC-090 GDSC1 -0.6852 2.244 -0.808 50.468
BHY GDSC1 -0.6793 1.8247 -0.7435 50.4176
PCI-38 GDSC1 -0.5997 2.0034 -0.6808 49.484
PCI-06A GDSC1 -0.5917 3.419 -0.9696 49.4792
SAS GDSC1 -0.5688 2.5124 -0.7299 49.1645
SAT [Human HNSCC] GDSC1 -0.5684 1.5409 -0.6001 49.0855
PCI-15A GDSC1 -0.4192 3.3136 -0.7524 47.6795
OSC-20 GDSC1 -0.0448 3.0602 -0.2789 43.3664
SCC-15 GDSC1 0.0535 2.7916 -0.1111 41.9907
HSC-4 GDSC1 0.1953 4.281 -0.3839 41.7499
BICR 22 GDSC1 0.2733 1.5176 0.2684 38.5653
HO-1-u-1 GDSC1 0.3439 3.8235 -0.0697 39.5758
Ca9-22 GDSC1 0.4749 3.3936 0.2014 37.4642
OSC-19 GDSC1 0.4792 3.6692 0.1257 37.7807
DOK GDSC1 0.6015 4.0918 0.1211 36.9439
HSC-3 GDSC1 0.7085 3.9937 0.2704 35.5195
SKN-3 GDSC1 0.8254 6.468 -0.6066 38.2108
LB771-HNC GDSC1 1.1658 3.4377 0.943 28.8002
CAL-33 GDSC1 1.9083 5.0264 1.1378 23.3847
FaDu GDSC1 2.2128 4.9113 1.4989 19.335
PE/CA-PJ15 GDSC1 2.2352 6.1875 0.9244 23.1794
BB49-HNC GDSC1 2.4161 6.4712 0.9595 22.1082
BICR 31 GDSC1 2.8433 6.5141 1.3317 17.691
BICR 78 GDSC1 3.5643 8.6015 0.9048 17.8044
HSC-2 GDSC1 3.8247 8.3736 1.2264 14.7453
PCI-30 GDSC1 4.1857 6.5345 2.3938 5.0554
BICR 10 GDSC1 4.2498 6.7813 2.3188 5.4479
JHU-022 GDSC1 4.5054 9.6003 1.1323 13.2339
SCC-4 GDSC1 4.7056 10.2353 0.966 13.7317
Detroit 562 GDSC1 4.9263 12.0421 0.2421 17.369
KON GDSC1 5.8177 12.4935 0.64 12.7798
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1 -1.9884 -0.1596 -1.9911 66.4046
RT-112 GDSC1 -1.0483 0.2403 -1.0489 55.0431
RT-4 GDSC1 -0.7015 0.8862 -0.7068 50.715
5637 GDSC1 0.3772 2.5063 0.2915 37.7161
KU-19-19 GDSC1 0.9588 5.1125 0.1149 34.6355
HT-1197 GDSC1 2.1565 7.5096 0.211 27.7076
HT-1376 GDSC1 2.2904 6.6478 0.7553 23.988
647V GDSC1 2.5603 6.315 1.1705 20.0406
T24 GDSC1 2.5712 8.397 0.155 26.1285
UM-UC-3 GDSC1 2.7678 4.0139 2.464 9.5043
SW1710 GDSC1 2.9279 5.4148 1.9513 12.7173
639V GDSC1 3.2414 10.4645 -0.294 25.633
CAL-29 GDSC1 3.442 6.7923 1.709 12.588
J82 GDSC1 3.6898 5.9074 2.3468 6.828
TCCSUP GDSC1 4.8877 7.626 2.3221 3.9909
SW780 GDSC1 5.2377 6.9158 2.7949 0.7799
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JAR GDSC1 -3.0372 0.079 -3.0681 75.1611
BPH-1 GDSC1 -2.9252 -1.1568 -2.9259 77.3974
PA-1 GDSC1 -2.6089 -1.2991 -2.6089 74.3217
Ca Ski GDSC1 -1.8805 0.6493 -1.9046 64.3595
NCC-IT GDSC1 -1.8328 0.3509 -1.8435 64.2151
SW954 GDSC1 -1.713 -0.7122 -1.713 63.3557
NEC8 GDSC1 -1.1968 13.902 -6.0659 51.9559
OVMIU GDSC1 -1.1238 4.3555 -1.8383 53.9839
LB831-BLC GDSC1 -0.3148 2.9958 -0.5577 46.4304
ACC-OV7 GDSC1 -0.255 1.4436 -0.2693 45.1961
JEG-3 GDSC1 -0.039 0.5575 -0.039 42.4389
ME-180 GDSC1 -0.0105 2.8995 -0.2041 42.8436
HT-3 GDSC1 0.0061 1.263 0.0029 41.8934
NT2-D1 GDSC1 0.0675 0.8062 0.0675 41.1083
DSH1 GDSC1 0.1295 1.9674 0.0949 40.5171
MS751 GDSC1 0.7965 3.1123 0.6253 33.0336
SKN GDSC1 0.9413 5.0955 0.1034 34.7967
KGN GDSC1 1.024 3.6303 0.7312 30.9703
PEO1 GDSC1 1.3779 7.7567 -0.6515 35.2892
DoTc2 4510 GDSC1 1.3801 3.8429 1.0495 26.854
HEY GDSC1 1.4688 5.3233 0.5566 29.3634
OMC-1 [Human cervical carcinoma] GDSC1 1.9474 6.5583 0.4698 27.3275
C-33 A GDSC1 2.3104 4.163 1.9255 15.7472
SiSo GDSC1 2.5208 6.4585 1.0637 20.9435
UWB1.289 GDSC1 2.9027 6.3128 1.4847 16.3385
CAL-39 GDSC1 2.9845 6.0439 1.6912 14.4693
HeLa GDSC1 3.0379 3.5814 2.9291 4.7324
JHOS-3 GDSC1 3.1584 7.1004 1.3168 16.5264
SiHa GDSC1 3.25 3.8652 3.0085 3.1519
C-4-I GDSC1 3.2687 4.567 2.6764 5.6863
SW962 GDSC1 3.4372 6.5989 1.8018 11.9024
OV17R GDSC1 4.038 6.128 2.489 4.7268
OVCA420 GDSC1 4.2101 7.8607 1.7699 9.6356
HEC-1 GDSC1 4.7258 9.5044 1.3351 11.246
OVCA433 GDSC1 5.2927 10.6235 1.1819 10.771
SKG-IIIa GDSC1 5.4611 7.3023 2.742 0.8168
SW756 GDSC1 5.4621 7.086 2.8228 0.5197
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT02503709) Onalespib and CDKI AT7519 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery in National Cancer Institute (NCI).
2 Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32.
3 CDK Blockade Using AT7519 Suppresses Acute Myeloid Leukemia Cell Survival through the Inhibition of Autophagy and Intensifies the Anti-leukemic Effect of Arsenic Trioxide. Iran J Pharm Res. 2019 Fall;18(Suppl1):119-131. doi: 10.22037/ijpr.2019.112560.13827.