Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCJLD1)

Drug Name
SCH 727965 Drug Info
Synonyms Dinaciclib; SCH-727965
Cross-matching ID
PubChem CID
46926350
ChEBI ID
CHEMBL2103840
CAS Number
CAS 779353-01-4
TTD Drug ID
D0D3PX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.35 0.00e+0 76/85 (89.41%) SERPING1;CFI;CD59;...
Phagosome 2.28 0.00e+0 118/152 (77.63%) ATP6V0B;TCIRG1;ITGB5;...
Type I diabetes mellitus 2.27 0.00e+0 38/43 (88.37%) GAD1;CPE;HLA-DQA1;...
Oxidative phosphorylation 2.19 0.00e+0 93/133 (69.92%) ATP6V0B;NDUFB2;TCIRG1;...
ECM-receptor interaction 2.17 0.00e+0 80/88 (90.91%) COL1A2;COL4A5;COL6A2;...
Valine, leucine and isoleucine degradation 2.10 0.00e+0 42/48 (87.5%) OXCT1;ACADM;PCCB;...
Pyruvate metabolism 2.03 0.00e+0 41/47 (87.23%) ADH1B;ACYP2;GLO1;...
Lysosome 1.97 1.73e-3 115/128 (89.84%) CTSZ;ATP6V0B;CTSC;...
Rheumatoid arthritis 1.94 1.53e-3 78/93 (83.87%) ATP6V0B;FOS;TCIRG1;...
Tyrosine metabolism 1.92 2.76e-3 30/36 (83.33%) MAOA;ADH1B;AOC3;...
Graft-versus-host disease 1.92 2.51e-3 32/42 (76.19%) HLA-DQA1;GZMB;IL1A;...
Glycolysis / Gluconeogenesis 1.91 4.60e-3 56/67 (83.58%) ADH1B;ENO1;PFKL;...
Cell adhesion molecules 1.90 4.25e-3 118/148 (79.73%) ALCAM;VTCN1;SDC2;...
Hematopoietic cell lineage 1.86 6.91e-3 90/99 (90.91%) CD9;IL7R;CD59;...
Fatty acid degradation 1.80 1.75e-2 40/43 (93.02%) ADH1B;ACADM;ALDH7A1;...
Propanoate metabolism 1.77 1.81e-2 30/34 (88.24%) PCCB;ALDH6A1;SUCLG2;...
Fat digestion and absorption 1.77 1.71e-2 35/43 (81.4%) AGPAT1;SCARB1;CD36;...
Leukocyte transendothelial migration 1.76 1.61e-2 90/114 (78.95%) MMP9;CTNNB1;CTNNA1;...
Retrograde endocannabinoid signaling 1.74 1.96e-2 118/148 (79.73%) NDUFB2;GNG10;ADCY7;...
Glyoxylate and dicarboxylate metabolism 1.72 2.35e-2 23/30 (76.67%) GLUL;PCCB;ACAT1;...
Focal adhesion 1.72 2.24e-2 180/201 (89.55%) COL1A2;COL4A5;PDGFRA;...
Phenylalanine metabolism 1.71 2.45e-2 14/17 (82.35%) MAOA;AOC3;MIF;...
Viral myocarditis 1.70 2.34e-2 53/60 (88.33%) EIF4G1;CXADR;SGCB;...
Glycosaminoglycan degradation 1.70 2.24e-2 19/19 (100%) IDS;HEXA;GNS;...
Staphylococcus aureus infection 1.70 2.38e-2 72/95 (75.79%) CFI;CFD;CFH;...
Citrate cycle (TCA cycle) 1.69 2.44e-2 30/30 (100%) IDH2;SUCLG2;PCK1;...
Diabetic cardiomyopathy 1.68 2.46e-2 162/203 (79.8%) MMP9;COL1A2;NDUFB2;...
Metabolism of xenobiotics by cytochrome P450 1.68 2.42e-2 49/77 (63.64%) ADH1B;GSTO1;EPHX1;...
Proximal tubule bicarbonate reclamation 1.68 2.48e-2 21/23 (91.3%) GLUD2;CA4;GLUD1;...
Arginine and proline metabolism 1.67 2.47e-2 39/50 (78%) MAOA;CKB;P4HA1;...
MicroRNAs in cancer -1.70 4.33e-2 146/310 (47.1%) RAF1;APC;PLCG2;...
Phosphatidylinositol signaling system -1.73 3.87e-2 82/97 (84.54%) PPIP5K2;MTMR2;INPP4B;...
Autophagy -1.75 4.12e-2 113/169 (66.86%) MTMR14;RAF1;RUBCN;...
mRNA surveillance pathway -1.87 9.67e-3 71/98 (72.45%) CPSF1;CPSF7;PAPOLG;...
Spliceosome -1.87 1.07e-2 101/150 (67.33%) DHX15;SNRNP40;HNRNPU;...
Ribosome biogenesis in eukaryotes -2.01 3.22e-3 52/108 (48.15%) NXF3;NVL;EIF6;...
RNA transport -2.02 6.44e-3 128/186 (68.82%) EIF2S1;EIF2B2;NUP98;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 2.5uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.37uM - 1.11uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 2.5uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 4uM 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 2.5uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H