Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCQBFT)

Drug Name
Parthenolide Drug Info
Synonyms
parthenolide; 20554-84-1; (-)-Parthenolide; CHEBI:7939; Parthenolide, Tanacetum parthenium; 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone; partenolide; C15H20O3; 29552-41-8; Prestwick2_000550; Prestwick3_000550; Epitope ID:115014; SCHEMBL8220; BSPBio_001308; BSPBio_000599; MLS002153872; CHEMBL465158; BPBio1_000659; SCHEMBL13367522; BCBcMAP01_000041; Parthenolide, > MolPort-008-268-168; MolPort-003-959-089; HMS1361B10; HMS3402B10; HMS1989B10; HMS1791B10; HMS1569N21; HMS2096N21
Cross-matching ID
PubChem CID
7251185
ChEBI ID
CHEMBL7939
CAS Number
CAS 20554-84-1
TTD Drug ID
D0M4KE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.33 0.00e+0 127/171 (74.27%) HSPA1A;HSPA6;DNAJB1;...
Ferroptosis 2.17 0.00e+0 36/41 (87.8%) HMOX1;GCLM;FTH1;...
Glutathione metabolism 2.08 4.01e-3 43/57 (75.44%) GCLM;ODC1;G6PD;...
Antigen processing and presentation 2.01 1.20e-2 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Amino sugar and nucleotide sugar metabolism 1.88 4.33e-2 38/48 (79.17%) UGDH;NAGK;HK2;...
Fluid shear stress and atherosclerosis 1.85 3.81e-2 123/139 (88.49%) HMOX1;SQSTM1;NQO1;...
Amyotrophic lateral sclerosis 1.85 3.27e-2 267/364 (73.35%) SQSTM1;SOD1;PSMD11;...
Proteasome 1.83 4.82e-2 44/46 (95.65%) PSMD11;PSMA1;PSMD14;...
Folate biosynthesis 1.81 4.95e-2 23/26 (88.46%) AKR1B10;AKR1C3;CBR1;...
Spinocerebellar ataxia 1.77 4.91e-2 128/143 (89.51%) PSMD11;PSMA1;PSMD14;...
Prion disease 1.77 4.56e-2 209/273 (76.56%) HSPA1A;HSPA6;HSPA8;...
Estrogen signaling pathway 1.76 4.82e-2 119/137 (86.86%) HSPA1A;HSPA6;HSPA8;...
Lysosome 1.75 4.74e-2 115/128 (89.84%) GLA;NEU1;LAMP1;...
Porphyrin and chlorophyll metabolism 1.73 4.82e-2 23/43 (53.49%) HMOX1;BLVRB
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM - 20uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Normal (Stromal)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HS-27a CVCL_0313 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 20uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM - 20uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 20uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM - 20uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM - 20uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM - 20uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM - 20uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM - 20uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM - 20uM 6H
SW480 CVCL_0546 Homo sapiens 10uM - 20uM 6H
SW620 CVCL_0547 Homo sapiens 10uM - 20uM 6H
SW948 CVCL_0550 Homo sapiens 10uM - 20uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM - 20uM 6H
HT115 CVCL_1294 Homo sapiens 10uM - 20uM 6H
RKO CVCL_0504 Homo sapiens 10uM - 20uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM - 20uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM - 20uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM - 20uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 20uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 20uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM - 20uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM - 20uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM - 20uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM - 20uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM - 20uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM - 20uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM - 20uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM - 20uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM - 20uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM - 20uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM - 20uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM - 20uM 6H
OV7 CVCL_1623 Homo sapiens 10uM - 20uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM - 20uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM - 20uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM - 20uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM - 20uM 6H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 2.5uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 20uM 3H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM - 20uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM - 20uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM - 20uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM - 20uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 20uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 20uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM - 20uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM - 20uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM - 20uM 6H