Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCRXAM)

Drug Name
PF3845 Drug Info
Synonyms PF-3845; PF 3845
Cross-matching ID
PubChem CID
25154867
ChEBI ID
CHEMBL1651524
CAS Number
CAS 1196109-52-0
TTD Drug ID
D0E9UX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
AGE-RAGE signaling pathway in diabetic complications 2.05 2.50e-2 97/100 (97%) JUN;SMAD3;CCL2;...
Drug metabolism 1.90 3.12e-2 78/151 (51.66%) GSTO1;CYP3A5;GSTM3;...
Fluid shear stress and atherosclerosis 1.89 2.50e-2 123/139 (88.49%) JUN;PDGFA;GSTO1;...
Retinol metabolism 1.89 2.19e-2 41/68 (60.29%) CYP3A5;ALDH1A3;UGT2B15;...
DNA replication 1.87 2.50e-2 34/36 (94.44%) POLE2;PCNA;RPA2;...
Butanoate metabolism 1.83 3.54e-2 23/28 (82.14%) HMGCS2;ACAT2;HADH;...
Mucin type O-glycan biosynthesis 1.80 3.75e-2 20/36 (55.56%) GALNT12;GALNT7;GALNT3;...
Glutathione metabolism 1.79 3.75e-2 43/57 (75.44%) GSTO1;ANPEP;GSTM3;...
Malaria 1.79 3.33e-2 44/50 (88%) CCL2;MET;HBB;...
Steroid biosynthesis 1.79 3.00e-2 19/20 (95%) MSMO1;EBP;DHCR7;...
Bladder cancer 1.77 3.41e-2 40/41 (97.56%) FGFR3;CDH1;CXCL8;...
Mismatch repair 1.77 3.23e-2 22/23 (95.65%) PCNA;RPA2;POLD4;...
Bacterial invasion of epithelial cells 1.76 3.08e-2 59/77 (76.62%) CDH1;MET;CAV1;...
TNF signaling pathway 1.74 3.84e-2 103/112 (91.96%) JUN;CCL2;LIF;...
Metabolism of xenobiotics by cytochrome P450 1.72 3.92e-2 49/77 (63.64%) GSTO1;CYP3A5;GSTM3;...
Primary bile acid biosynthesis 1.72 3.67e-2 15/17 (88.24%) ACOX2;CH25H;SLC27A5
RNA polymerase 1.70 4.56e-2 23/31 (74.19%) POLR2H;POLR2L;POLR3G;...
Staphylococcus aureus infection -1.72 3.01e-2 72/95 (75.79%) KRT33A;ITGAL;FCGR2B;...
Systemic lupus erythematosus -1.74 2.93e-2 45/135 (33.33%) HLA-DPA1;HLA-DRB1;C1QB;...
Antigen processing and presentation -1.77 2.95e-2 60/78 (76.92%) HSP90AA1;CALR;NFYC;...
Asthma -1.91 3.51e-3 25/31 (80.65%) HLA-DPA1;HLA-DRB1;PRG2;...
Protein export -1.93 4.68e-3 17/23 (73.91%) SRP9;SEC62;SRP14;...
Phagosome -1.95 7.02e-3 118/152 (77.63%) ATP6V0B;SEC61A2;NCF4;...
Protein processing in endoplasmic reticulum -2.42 0.00e+0 127/171 (74.27%) EDEM3;SEC61A2;SSR2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H