Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCU74R)

Drug Name
Daporinad Drug Info
Synonyms APO-866; FK-866; WK-175
Cross-matching ID
PubChem CID
6914657
ChEBI ID
CHEMBL94671
CAS Number
CAS 658084-64-1
TTD Drug ID
D0H9SX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oocyte meiosis 2.10 0.00e+0 90/129 (69.77%) CDC20;PLK1;PPP2R5E;...
Progesterone-mediated oocyte maturation 2.07 0.00e+0 75/100 (75%) CCNA2;PLK1;BUB1;...
Spliceosome 2.06 0.00e+0 101/150 (67.33%) SRSF1;SRSF7;PRPF8;...
DNA replication 2.04 0.00e+0 34/36 (94.44%) MCM3;PCNA;POLE2;...
RNA transport 2.02 0.00e+0 128/186 (68.82%) EIF4G1;FUS;NUP205;...
Cell cycle 1.99 0.00e+0 110/124 (88.71%) CDC20;CCNA2;PLK1;...
mRNA surveillance pathway 1.94 0.00e+0 71/98 (72.45%) PPP2R5E;GSPT1;FUS;...
Ribosome biogenesis in eukaryotes 1.82 1.68e-2 52/108 (48.15%) NOP56;NOL6;HEATR1;...
Amoebiasis 1.81 1.49e-2 99/102 (97.06%) RAB5C;TGFB1;SERPINB3;...
GnRH secretion 1.80 1.34e-2 60/64 (93.75%) AKT1;PLCB4;MAP2K1;...
Bacterial invasion of epithelial cells 1.79 1.47e-2 59/77 (76.62%) MET;PXN;RHOA;...
Relaxin signaling pathway 1.78 1.57e-2 114/129 (88.37%) JUN;TGFB1;COL1A2;...
Thyroid hormone signaling pathway 1.78 1.45e-2 112/121 (92.56%) CCND1;PFKP;MED1;...
Mismatch repair 1.77 1.63e-2 22/23 (95.65%) PCNA;MSH6;RFC2;...
Yersinia infection 1.77 1.52e-2 120/137 (87.59%) JUN;PXN;ITGA4;...
GnRH signaling pathway 1.75 1.85e-2 80/93 (86.02%) JUN;PRKACA;EGR1;...
Non-homologous end-joining 1.72 2.37e-2 11/13 (84.62%) FEN1;LIG4;PRKDC;...
Human T-cell leukemia virus 1 infection 1.72 2.24e-2 197/219 (89.95%) CDC20;NRP1;CCNA2;...
Gastric acid secretion 1.68 3.54e-2 63/76 (82.89%) CA2;PRKACA;ATP1A1;...
Dilated cardiomyopathy 1.65 4.23e-2 86/96 (89.58%) ITGA6;TGFB1;ITGA4;...
Vibrio cholerae infection 1.65 4.29e-2 44/50 (88%) PRKACA;KDELR1;CFTR;...
AGE-RAGE signaling pathway in diabetic complications 1.64 4.46e-2 97/100 (97%) JUN;CCND1;TGFB1;...
IL-17 signaling pathway 1.63 4.62e-2 84/94 (89.36%) SRSF1;JUN;ELAVL1;...
Tight junction 1.62 4.87e-2 130/169 (76.92%) JUN;CCND1;ACTN1;...
Nicotinate and nicotinamide metabolism -1.60 4.81e-2 25/35 (71.43%) SIRT2;NMRK1;NMNAT2;...
Phenylalanine metabolism -1.61 4.59e-2 14/17 (82.35%) HPD;PAH;GOT1;...
Sphingolipid metabolism -1.65 3.07e-2 32/49 (65.31%) SMPD2;PLPP2;CERS4;...
Ovarian steroidogenesis -1.69 2.45e-2 41/51 (80.39%) HSD17B2;ADCY3;CYP11A1;...
Fatty acid degradation -1.75 1.30e-2 40/43 (93.02%) GCDH;ACOX1;ACAA1;...
Valine, leucine and isoleucine degradation -1.78 1.14e-2 42/48 (87.5%) ACAA1;EHHADH;MMUT;...
Arginine biosynthesis -1.79 9.48e-3 17/22 (77.27%) GLUL;ARG2;ARG1;...
Butanoate metabolism -1.81 6.64e-3 23/28 (82.14%) EHHADH;GAD1;HADH;...
Arachidonic acid metabolism -1.81 6.59e-3 48/61 (78.69%) CYP4F3;GGT1;PLA2G4A;...
Ferroptosis -1.84 2.17e-3 36/41 (87.8%) SLC3A2;ACSL3;SLC39A14;...
Complement and coagulation cascades -1.88 1.61e-3 76/85 (89.41%) C5AR1;FGA;C5;...
Synthesis and degradation of ketone bodies -1.88 1.81e-3 9/10 (90%) HMGCL;ACAT1;BDH2;...
Tyrosine metabolism -1.90 2.07e-3 30/36 (83.33%) FAH;TYRP1;ADH1B;...
Glycine, serine and threonine metabolism -1.95 0.00e+0 31/40 (77.5%) SHMT2;AGXT;GCAT;...
PPAR signaling pathway -1.97 0.00e+0 66/74 (89.19%) PLTP;ACOX1;ACAA1;...
Alanine, aspartate and glutamate metabolism -2.02 0.00e+0 27/37 (72.97%) GLUL;GAD1;DDO;...
Metabolism of xenobiotics by cytochrome P450 -2.12 0.00e+0 49/77 (63.64%) GSTA4;ADH1B;CYP3A4;...
Steroid biosynthesis -2.33 0.00e+0 19/20 (95%) DHCR7;SQLE;EBP;...
Mineral absorption -2.37 0.00e+0 48/60 (80%) VDR;ATOX1;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.08uM - 0.3uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.08uM - 0.3uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.08uM - 0.3uM 6H
MDST8 CVCL_1400 Homo sapiens 0.08uM - 0.3uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.08uM - 0.3uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.08uM - 0.3uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.08uM - 0.3uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.08uM - 0.3uM 6H
SW480 CVCL_0546 Homo sapiens 0.08uM - 0.3uM 6H
SW620 CVCL_0547 Homo sapiens 0.08uM - 0.3uM 6H
SW948 CVCL_0550 Homo sapiens 0.08uM - 0.3uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.08uM - 0.3uM 6H
HT115 CVCL_1294 Homo sapiens 0.08uM - 0.3uM 6H
RKO CVCL_0504 Homo sapiens 0.08uM - 0.3uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM - 0.3uM 6H
SNG-M CVCL_1707 Homo sapiens 0.08uM - 0.3uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.08uM - 0.3uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 0.08uM - 0.3uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.08uM - 0.3uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.08uM - 0.3uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.08uM - 0.3uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.08uM - 0.3uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.08uM - 0.3uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.08uM - 0.3uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.08uM - 0.3uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.08uM - 0.3uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.08uM - 0.3uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.08uM - 0.3uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.08uM - 0.3uM 6H
OV7 CVCL_1623 Homo sapiens 0.08uM - 0.3uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.08uM - 0.3uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.08uM - 0.3uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.08uM - 0.3uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.08uM - 0.3uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.08uM - 0.3uM 6H
PL-21 CVCL_2161 Homo sapiens 0.08uM - 0.3uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.08uM - 0.3uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.08uM - 0.3uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.08uM - 0.3uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.08uM - 0.3uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.08uM - 0.3uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM - 0.3uM 6H