Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD8JIC)

• Drug Name: P22077 Drug Info
• Synonyms: 1247819-59-5; P 22077; 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone; CHEMBL2159498; 1-[5-(2,4-difluorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone; 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone; 1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone; P-22077; 1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone; 1-{5-[(2,4-Difluorophenyl)sulfanyl]-4-nitrothiophen-2-yl}ethan-1-one; C12H7F2NO3S2; SCHEMBL2680945; DTXSID40677376; HMS3653G09; BCP07858; EX-A1445; 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one; 2624AH; BDBM50393440; MFCD22580421; s7133; ZINC91696068; AKOS024458186; CCG-267643; CS-1860; QC-8199; AC-32695; AK313221; AS-55923; DA-46729; HY-13865; AB0003913; FT-0707469; SW219709-1; EC-000.2542; J3.502.624J; Z1646327284; 1-[5-(2,4-difluorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone; 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanon; 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl) ethanone
• Cross-matching ID:
  PubChem CID: 46931953
  ChEBI ID: CHEMBL2159498
  CAS Number: CAS 1247819-59-5
  TTD Drug ID: D2K6DU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
PPAR signaling pathway	1.94	3.53e-2	66/74 (89.19%)	SCD;PLTP;APOA2;...
ECM-receptor interaction	1.90	4.70e-2	80/88 (90.91%)	THBS4;LAMC2;THBS2;...
p53 signaling pathway	1.87	4.70e-2	63/73 (86.3%)	CCNB1;IGFBP3;THBS1;...
Vibrio cholerae infection	1.85	4.70e-2	44/50 (88%)	SEC61G;TJP2;ERO1A;...
Proximal tubule bicarbonate reclamation	-1.88	2.33e-2	21/23 (91.3%)	GLUD2;ATP1B1;GLUD1;...
Asthma	-1.95	2.33e-2	25/31 (80.65%)	HLA-DOA;FCER1A;HLA-DRA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲