Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDIPW8)

Drug Name
JNJ-38877605 Drug Info
Synonyms C-met inhibitor, Ortho Biotech Oncology Research & Development; C-met inhibitor (solid tumors), ORD/J&J PRD
Cross-matching ID
PubChem CID
46911863
ChEBI ID
CHEMBL91417
CAS Number
CAS 943540-75-8
TTD Drug ID
D0YT8P

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.24 0.00e+0 34/36 (94.44%) RFC2;RFC4;PRIM1;...
Propanoate metabolism 2.08 0.00e+0 30/34 (88.24%) EHHADH;PCCA;HIBCH;...
beta-Alanine metabolism 1.94 6.28e-3 25/30 (83.33%) ALDH3A1;ALDH2;EHHADH;...
Fanconi anemia pathway 1.92 9.42e-3 36/54 (66.67%) BLM;FANCI;BRCA1;...
Mismatch repair 1.90 1.13e-2 22/23 (95.65%) RFC2;RFC4;LIG1;...
Homologous recombination 1.88 9.42e-3 35/41 (85.37%) BLM;RAD54B;BRCA1;...
Glycolysis / Gluconeogenesis 1.86 1.21e-2 56/67 (83.58%) ALDH3A1;PGAM1;ALDH2;...
Primary bile acid biosynthesis 1.83 1.53e-2 15/17 (88.24%) AMACR;SLC27A5;HSD17B4;...
Retinol metabolism 1.78 2.30e-2 41/68 (60.29%) DHRS3;ALDH1A3;ADH1C;...
Peroxisome 1.76 2.73e-2 72/82 (87.8%) IDH2;AMACR;PECR;...
Drug metabolism 1.75 2.48e-2 78/151 (51.66%) ALDH3A1;NME4;IMPDH2;...
Tryptophan metabolism 1.75 2.36e-2 35/42 (83.33%) CYP1B1;AOC1;DHTKD1;...
Nucleotide excision repair 1.74 2.32e-2 40/47 (85.11%) RFC2;RFC4;LIG1;...
Parkinson disease 1.70 3.50e-2 176/249 (70.68%) UCHL1;DAXX;TUBB2A;...
Cell cycle 1.69 3.52e-2 110/124 (88.71%) TFDP2;CCNE2;CHEK2;...
Tyrosine metabolism 1.69 3.42e-2 30/36 (83.33%) ALDH3A1;TYRP1;TYR;...
Proteasome 1.64 4.43e-2 44/46 (95.65%) PSME1;SEM1;PSMA7;...
ECM-receptor interaction -2.08 0.00e+0 80/88 (90.91%) ITGA3;CD44;THBS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H