General Information of Drug (ID: DMDSK9N)

Drug Name
GSK2801 Drug Info
Synonyms KB-146016
Cross-matching ID
PubChem CID
73010930
ChEBI ID
CHEMBL3739699
TTD Drug ID
D0T3WL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Proximal tubule bicarbonate reclamation 2.00 0.00e+0 21/23 (91.3%) CA2;ATP1A2;ATP1B3;...
Ribosome biogenesis in eukaryotes 1.99 0.00e+0 52/108 (48.15%) CSNK2A1;PWP2;GNL3;...
Citrate cycle (TCA cycle) 1.94 0.00e+0 30/30 (100%) DLD;IDH3B;PCK1;...
Cardiac muscle contraction 1.87 1.35e-2 64/87 (73.56%) ATP1A2;CACNA1D;ATP1B3;...
Olfactory transduction 1.83 1.95e-2 69/440 (15.68%) CALML3;NCALD;GRK2;...
Aldosterone-regulated sodium reabsorption 1.76 4.15e-2 34/37 (91.89%) ATP1A2;ATP1B3;MAPK1;...
Sphingolipid metabolism -1.69 4.38e-2 32/49 (65.31%) PSAP;SGPL1;ASAH1;...
Phagosome -1.72 3.73e-2 118/152 (77.63%) M6PR;HLA-DMB;CLEC7A;...
Metabolism of xenobiotics by cytochrome P450 -1.74 3.61e-2 49/77 (63.64%) HPGDS;CYP2B6;CYP2A13;...
Primary bile acid biosynthesis -1.75 4.00e-2 15/17 (88.24%) SCP2;HSD17B4;CYP7A1;...
Lysosome -1.76 3.57e-2 115/128 (89.84%) IDS;TCIRG1;ARSA;...
Ferroptosis -1.76 3.73e-2 36/41 (87.8%) GCLC;SAT1;GSS;...
Mucin type O-glycan biosynthesis -1.79 3.03e-2 20/36 (55.56%) GALNT10;C1GALT1;GALNT2;...
Biosynthesis of unsaturated fatty acids -1.81 3.42e-2 21/27 (77.78%) ELOVL1;SCP2;FADS2;...
Complement and coagulation cascades -1.85 4.66e-2 76/85 (89.41%) CFHR4;C4BPA;SERPINA1;...
Steroid biosynthesis -1.96 2.80e-2 19/20 (95%) NSDHL;HSD17B7;LSS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H