Details of the Drug

General Information of Drug (ID: DMDSK9N)

Drug Name
GSK2801
Synonyms KB-146016
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 371.5
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C20H21NO4S
IUPAC Name
1-[1-(2-methylsulfonylphenyl)-7-propoxyindolizin-3-yl]ethanone
Canonical SMILES
CCCOC1=CC2=C(C=C(N2C=C1)C(=O)C)C3=CC=CC=C3S(=O)(=O)C
InChI
InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
InChIKey
KHWCPNJRJCNVRI-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
73010930
TTD ID
D0T3WL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain adjacent to zinc finger 2A (BAZ2A) TT2MV0R BAZ2A_HUMAN Inhibitor [2]
Bromodomain adjacent to zinc finger 2B (BAZ2B) TT6K8YG BAZ2B_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.3396 7.9064 2.4127 1.9181
SK-PN-DW GDSC2 4.0665 6.2691 2.4131 3.9149
CADO-ES1 GDSC2 4.5312 7.354 2.2025 4.2441
CAL-72 GDSC2 4.5481 6.6825 2.52 2.4295
EW-1 GDSC2 4.6116 7.1587 2.342 3.3055
EW-24 GDSC2 4.7981 6.7615 2.6208 1.5723
CAL-78 GDSC2 4.8114 7.5463 2.284 3.2971
EW-3 GDSC2 4.8241 8.9748 1.628 7.0194
CHSA8926 GDSC2 4.9504 12.8166 -0.1461 16.2701
HuO9 GDSC2 4.958 8.166 2.0894 4.1301
SaOS-2 GDSC2 4.9617 7.2558 2.4949 1.9793
EW-18 GDSC2 5.0143 7.514 2.4116 2.3251
HOS GDSC2 5.0418 8.3167 2.0706 4.0942
MG-63 GDSC2 5.2199 11.3957 0.7363 11.1946
ES4 GDSC2 5.2261 9.1054 1.8209 5.1654
U2OS GDSC2 5.2317 12.2997 0.3078 13.3997
G-292 clone A141B1 GDSC2 5.382 13.4389 -0.1395 15.2426
NOS-1 [Human HNSCC] GDSC2 5.4452 8.1352 2.3697 1.9968
A-673 GDSC2 5.5302 7.3365 2.7246 0.5438
H-EMC-SS GDSC2 5.5472 12.7996 0.2849 12.8268
EW-22 GDSC2 5.6025 11.4591 0.9608 9.2049
EW-7 GDSC2 5.6282 7.2012 2.8115 0.2811
TC-71 GDSC2 5.6637 12.2977 0.6036 10.9647
ES8 GDSC2 5.6847 8.1005 2.4975 1.2168
NY GDSC2 5.7839 18.0267 -2.0932 22.0487
MHH-ES-1 GDSC2 5.8428 14.7076 -0.4315 15.566
EW-13 GDSC2 5.9647 8.0018 2.6529 0.5229
HuO-3N1 GDSC2 5.9755 8.1971 2.5851 0.7098
ES6 GDSC2 5.9905 8.1515 2.6081 0.6338
SK-ES-1 GDSC2 6.0328 7.5961 2.8209 0.1564
EW-16 GDSC2 6.1566 12.1221 0.9998 7.9742
ES5 GDSC2 6.2151 8.6844 2.5009 0.828
ES7 GDSC2 6.2248 8.3768 2.6181 0.4946
EW-11 GDSC2 6.4701 9.617 2.2518 1.5114
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 4.4505 7.0919 2.2739 3.9812
FLO-1 GDSC2 4.4977 7.9968 1.8768 6.2285
ESO-51 GDSC2 5.1256 7.6194 2.4249 2.1151
KYAE-1 GDSC2 5.264 7.2892 2.6286 1.0614
OACP4 C GDSC2 5.3957 8.185 2.3238 2.271
KYSE-50 GDSC2 5.5214 16.2139 -1.3955 20.1963
ESO-26 GDSC2 5.6866 10.6507 1.3905 6.7259
OACM5.1 C GDSC2 5.8076 8.8816 2.2385 2.1928
TE-12 GDSC2 6.0887 15.0448 -0.4247 15.0205
SK-GT-4 GDSC2 6.3276 18.0159 -1.6958 19.5548
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.2282 7.3217 2.0177 5.959
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-YN GDSC2 3.7717 8.0273 1.3328 11.2561
NB(TU)1 GDSC2 3.9189 5.9378 2.4718 3.8743
NB69 GDSC2 3.9386 15.0553 -2.0391 26.2797
Kelly GDSC2 4.2305 5.9853 2.6496 2.2285
CHP-212 GDSC2 4.4516 9.5224 1.1053 10.8832
SK-N-DZ GDSC2 5.0476 6.6809 2.7711 0.6983
SJNB-14 GDSC2 5.1627 7.2963 2.5785 1.3639
CHP-134 GDSC2 5.2876 6.8215 2.8175 0.4072
TGW GDSC2 5.4102 6.8047 2.8703 0.2329
NH-12 GDSC2 5.4302 8.299 2.2931 2.3759
SJNB-10 GDSC2 5.456 7.58 2.6001 1.012
SK-N-BE(2)-M17 GDSC2 5.4885 7.1455 2.7782 0.4161
SJNB-7 GDSC2 5.6712 7.1171 2.8566 0.1834
IMR-5 GDSC2 5.7586 7.8698 2.6186 0.7347
SiMa GDSC2 5.8103 8.854 2.2513 2.1322
SJNB-13 GDSC2 5.8513 7.6743 2.7274 0.3858
GOTO GDSC2 6.168 8.1306 2.6845 0.363
GI-ME-N GDSC2 6.6097 9.0488 2.5241 0.5618
SK-N-AS GDSC2 7.0391 19.8203 -2.0725 19.4344
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 5.426 7.4437 2.6401 0.8878
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1937 GDSC2 4.0888 6.3004 2.4131 3.869
BT-20 GDSC2 4.3801 13.3128 -0.8214 20.6893
JIMT-1 GDSC2 4.3884 6.176 2.6551 1.9487
CAL-120 GDSC2 4.4405 8.271 1.7062 7.3687
MDA-MB-453 GDSC2 4.4771 9.0946 1.3325 9.5023
MDA-MB-468 GDSC2 4.5219 8.1087 1.8396 6.3989
CAMA-1 GDSC2 4.6236 15.3864 -1.6628 23.2771
BT-474 GDSC2 4.6841 6.1488 2.818 0.8152
HCC1806 GDSC2 4.7238 13.1642 -0.4853 18.375
Hs 578T GDSC2 4.9017 6.8667 2.6287 1.4164
HCC1500 GDSC2 4.9273 8.0489 2.1244 3.9869
OCUB-M GDSC2 5.0463 7.369 2.4905 1.8958
HCC2157 GDSC2 5.1763 6.9109 2.7379 0.7223
MFM-223 GDSC2 5.198 11.0222 0.9008 10.3532
HCC1419 GDSC2 5.2681 14.8497 -0.9115 18.8875
MDA-MB-361 GDSC2 5.3211 7.7535 2.4672 1.69
HDQ-P1 GDSC2 5.3307 7.2754 2.6638 0.8736
CAL-51 GDSC2 5.3322 7.8812 2.4196 1.8945
HCC38 GDSC2 5.4169 7.9099 2.4493 1.6681
Evsa-T GDSC2 5.4338 6.94 2.8312 0.3089
MCF-7 GDSC2 5.4869 17.237 -1.9241 22.1419
ZR-75-30 GDSC2 5.492 16.6769 -1.6446 21.1667
T-47D GDSC2 5.5176 7.9704 2.4727 1.4666
HCC70 GDSC2 5.5479 7.1241 2.8087 0.3163
MRK-nu-1 GDSC2 5.561 6.8799 2.8987 0.1428
CAL-85-1 GDSC2 5.6078 10.6017 1.3648 7.0057
HCC1428 GDSC2 5.6367 7.4254 2.7343 0.4624
DU4475 GDSC2 5.7207 6.9871 2.9179 0.0894
MDA-MB-231 GDSC2 5.7241 7.7039 2.6666 0.6077
COLO 824 GDSC2 5.756 7.5801 2.7246 0.4326
HCC1569 GDSC2 5.8111 8.5566 2.3734 1.6028
MDA-MB-436 GDSC2 5.8217 7.8533 2.6506 0.6015
MDA-MB-157 GDSC2 5.8242 8.6681 2.3344 1.754
HCC1187 GDSC2 5.853 7.5113 2.7857 0.2603
MDA-MB-330 GDSC2 5.9518 9.7375 1.9499 3.3885
EFM-19 GDSC2 5.9657 7.9771 2.6623 0.4978
EFM-192A GDSC2 6.0389 12.8911 0.5679 10.4077
HCC1143 GDSC2 6.0402 15.4036 -0.631 16.0154
MDA-MB-415 GDSC2 6.0707 7.7306 2.7884 0.1967
BT-549 GDSC2 6.1606 8.1613 2.6708 0.3958
HCC1954 GDSC2 6.3567 8.2252 2.7206 0.2373
AU565 GDSC2 6.589 9.023 2.5254 0.5675
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LN-18 GDSC2 4.2397 14.15 -1.3476 23.1198
8-MG-BA GDSC2 4.6135 7.9944 1.9544 5.5343
42-MG-BA GDSC2 4.6184 15.335 -1.6413 23.2149
LN-405 GDSC2 4.7521 8.5216 1.7955 6.1891
U-87MG ATCC GDSC2 4.8114 9.4635 1.3863 8.4472
KINGS-1 GDSC2 4.9816 9.7579 1.3599 8.2414
U-251MG GDSC2 4.9907 6.4973 2.8172 0.5784
U-118MG GDSC2 5.067 6.8296 2.7216 0.8659
ONS-76 GDSC2 5.1011 7.4681 2.4766 1.8961
SK-MG-1 GDSC2 5.1933 7.6889 2.4303 2.0063
DK-MG GDSC2 5.2911 6.6912 2.8659 0.2844
AM-38 GDSC2 5.2956 8.4496 2.1561 3.2436
D-263MG GDSC2 5.3102 7.0616 2.7372 0.6345
CAS-1 GDSC2 5.3141 6.8782 2.8072 0.4222
LN-229 GDSC2 5.388 14.0177 -0.4172 16.5003
D-392MG GDSC2 5.4227 11.6114 0.7702 10.5852
D283 Med GDSC2 5.4547 6.8225 2.8804 0.2
YH-13 GDSC2 5.7191 7.4236 2.7668 0.3464
GI-1 GDSC2 5.7333 7.3494 2.7984 0.2731
GB-1 GDSC2 5.7534 7.8829 2.6115 0.7608
SF268 GDSC2 5.7568 7.3811 2.7959 0.2704
SW1088 GDSC2 5.7767 7.4896 2.765 0.3286
GaMG GDSC2 5.7885 7.5047 2.7641 0.3263
SF539 GDSC2 5.8096 16.0224 -1.0934 18.4034
A-172 GDSC2 5.8749 7.7311 2.716 0.4032
PFSK-1 GDSC2 5.9124 7.8097 2.7022 0.421
M059J GDSC2 5.9508 7.6924 2.7583 0.2834
H4 GDSC2 5.9721 17.2458 -1.574 19.864
Daoy GDSC2 5.9845 7.4963 2.8379 0.1426
DBTRG-05MG GDSC2 5.9936 7.5823 2.8118 0.178
T98G GDSC2 6.03 9.3398 2.1579 2.3138
Becker GDSC2 6.2334 7.9404 2.7743 0.1816
KS-1 [Human Krukenberg tumour] GDSC2 6.304 8.397 2.6411 0.4088
KALS-1 GDSC2 6.4801 8.6537 2.6161 0.3996
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 4.5194 11.3085 0.2774 15.2367
ETK-1 GDSC2 5.0633 9.0684 1.7378 5.9237
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC2 4.8057 8.4521 1.8629 5.6929
MFE-280 GDSC2 5.2762 8.3086 2.2072 3.0067
MFE-296 GDSC2 5.6532 8.7456 2.2181 2.4644
ESS-1 GDSC2 5.6555 7.3968 2.752 0.4079
KLE GDSC2 5.8801 8.2637 2.5198 0.9839
AN3-CA GDSC2 5.9284 12.0164 0.9074 8.8673
RL95-2 GDSC2 6.709 17.4711 -1.1677 16.8386
EN GDSC2 7.1418 19.0037 -1.6092 17.6473
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 128 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUP-HD1 GDSC2 1.9431 14.4501 -3.4292 35.5123
OCI-AML-3 GDSC2 3.5039 10.1595 0.0536 19.1218
DEL GDSC2 3.687 5.13 2.7011 2.9876
Ku812 GDSC2 3.7614 5.7144 2.4693 4.2471
KMS-12-BM GDSC2 3.9711 8.8621 1.0725 12.2741
NCI-H929 GDSC2 3.9734 6.2489 2.3593 4.4406
ALL-PO GDSC2 3.9784 9.1144 0.9529 12.9479
OCI-AML-5 GDSC2 4.0178 8.1968 1.4373 9.9855
Karpas-45 GDSC2 4.0422 5.8918 2.5762 2.9922
P12-Ichikawa GDSC2 4.0584 9.214 0.9649 12.6695
P30/OHK GDSC2 4.1027 6.1366 2.4999 3.324
MM1.S GDSC2 4.1504 7.6295 1.8134 7.3775
Raji GDSC2 4.1716 7.4314 1.925 6.6483
L-1236 GDSC2 4.1766 12.123 -0.3882 19.3429
SUP-M2 GDSC2 4.1785 5.5196 2.8281 1.3462
OPM-2 GDSC2 4.2089 6.1564 2.558 2.7843
WSU-NHL GDSC2 4.253 15.854 -2.1861 25.9257
Karpas-422 GDSC2 4.2819 5.8558 2.7373 1.6713
A3/Kawakami GDSC2 4.2834 5.8062 2.76 1.5504
ML-2 GDSC2 4.3205 7.8404 1.8311 6.8836
Karpas-231 GDSC2 4.332 6.7639 2.3523 3.7484
OCI-AML-2 GDSC2 4.3588 12.1672 -0.2691 18.3168
RPMI-8226 GDSC2 4.3737 10.3577 0.6375 13.6981
KOPN-8 GDSC2 4.381 7.4325 2.0681 5.3309
JJN-3 GDSC2 4.3945 6.4428 2.5388 2.5719
U-698-M GDSC2 4.3947 6.2869 2.6093 2.1853
SU-DHL-6 GDSC2 4.4032 7.3547 2.1198 4.9782
CA46 GDSC2 4.4272 9.2146 1.2382 10.1703
A4/Fukuda GDSC2 4.4484 8.8314 1.4402 8.934
ST486 GDSC2 4.4563 8.0976 1.8005 6.7708
CML-T1 GDSC2 4.4688 15.436 -1.8078 24.1602
EoL-1 GDSC2 4.4718 6.7366 2.4511 2.9319
VL51 GDSC2 4.4777 7.3972 2.1482 4.6635
AMO1 GDSC2 4.492 9.9211 0.9394 11.7327
SU-DHL-5 GDSC2 4.5123 5.6282 2.9461 0.4669
SU-DHL-10 GDSC2 4.5271 5.51 2.997 0.2936
SCC-3 GDSC2 4.5426 5.8974 2.8533 0.8007
SR GDSC2 4.5583 7.1636 2.3076 3.5919
KE-37 GDSC2 4.5735 6.8134 2.476 2.6283
GA-10 GDSC2 4.6419 6.6189 2.6 1.8738
H9 GDSC2 4.6538 10.3416 0.8507 11.8449
NOMO-1 GDSC2 4.6708 6.441 2.6913 1.3889
LC4-1 GDSC2 4.6744 7.6805 2.1402 4.3398
Karpas-620 GDSC2 4.6918 15.1117 -1.4739 22.4363
MN-60 GDSC2 4.7098 7.0151 2.4635 2.4865
KCL-22 GDSC2 4.714 7.5022 2.2465 3.6667
Kasumi-1 GDSC2 4.7243 8.2156 1.9218 5.5083
ME1 GDSC2 4.7392 6.296 2.7845 0.9021
HAL-01 GDSC2 4.7684 7.9571 2.0702 4.5695
Karpas-1106P GDSC2 4.7893 6.4488 2.7462 1.0148
MEG-01 GDSC2 4.8279 10.19 1.0476 10.3447
BC-1 GDSC2 4.8285 7.5288 2.3018 3.173
HC-1 GDSC2 4.8387 7.0177 2.5325 1.9516
DB GDSC2 4.8728 7.4634 2.3562 2.8122
697 GDSC2 4.8754 6.4412 2.7888 0.7659
Loucy GDSC2 4.8756 7.4435 2.3666 2.7531
SKM-1 GDSC2 4.8829 6.314 2.8415 0.5695
Jurkat GDSC2 4.9105 6.6955 2.7033 1.0788
Daudi GDSC2 4.9206 6.2959 2.8642 0.4704
MHH-CALL-2 GDSC2 4.9441 6.81 2.6726 1.1767
LAMA-84 GDSC2 4.9543 13.3346 -0.3977 17.4215
VAL GDSC2 4.9628 7.7366 2.2856 3.0525
L-363 GDSC2 4.9646 17.8469 -2.6211 25.5044
SK-MM-2 GDSC2 4.9805 7.613 2.3501 2.6869
MOLT-13 GDSC2 4.9955 7.3812 2.4589 2.1136
Ramos.2G6.4C10 GDSC2 5.0158 11.5945 0.4982 12.9078
PF-382 GDSC2 5.0274 7.6961 2.3394 2.6756
Karpas-299 GDSC2 5.0405 6.8183 2.7141 0.917
SUP-T1 GDSC2 5.0528 6.9375 2.6722 1.0742
BL-41 GDSC2 5.0713 6.489 2.8536 0.4165
L-428 GDSC2 5.0891 14.6128 -0.927 19.3696
Farage GDSC2 5.0909 6.8035 2.7424 0.7695
DoHH2 GDSC2 5.0929 6.438 2.8809 0.3314
IM-9 GDSC2 5.1036 6.6008 2.8251 0.483
GDM-1 GDSC2 5.1115 16.0406 -1.6145 21.9327
HEL GDSC2 5.1205 6.2588 2.9548 0.1591
Namalwa GDSC2 5.1259 15.4764 -1.3252 20.8411
HL-60 GDSC2 5.1543 6.4905 2.8857 0.2927
KY821 GDSC2 5.1691 7.6458 2.4361 2.0075
MHH-PREB-1 GDSC2 5.2133 7.1164 2.6741 0.9276
TK [Human B-cell lymphoma] GDSC2 5.2199 6.9375 2.7464 0.6631
ARH-77 GDSC2 5.2313 6.9739 2.7373 0.686
LP-1 GDSC2 5.2537 6.7504 2.8301 0.3896
KM-H2 GDSC2 5.2565 6.8496 2.7947 0.4879
JVM-3 GDSC2 5.2648 12.9324 0.0239 14.7288
TUR GDSC2 5.2715 7.5316 2.5344 1.4449
MOLP-8 GDSC2 5.2867 7.3121 2.6299 1.0373
NALM-6 GDSC2 5.314 10.3578 1.2933 7.95
Hs 445 GDSC2 5.3238 7.1082 2.7252 0.6649
RPMI-8866 GDSC2 5.3334 7.6745 2.5056 1.5072
CCRF-CEM GDSC2 5.3344 13.6809 -0.2912 16.0525
BALL-1 GDSC2 5.3381 7.1095 2.7307 0.6378
ALL-SIL GDSC2 5.3724 6.9434 2.8063 0.3965
MOLT-16 GDSC2 5.3837 6.6782 2.9047 0.176
RS4;11 GDSC2 5.3884 7.4166 2.6341 0.9384
P32/ISH GDSC2 5.399 6.5341 2.9592 0.0922
RPMI-6666 GDSC2 5.428 18.1099 -2.3986 23.7932
Jiyoye GDSC2 5.4325 7.7697 2.5139 1.3749
SU-DHL-8 GDSC2 5.4491 6.8812 2.8578 0.2455
CESS GDSC2 5.4817 8.5462 2.2143 2.695
EJM GDSC2 5.4828 6.904 2.8622 0.2258
JVM-2 GDSC2 5.4931 8.2397 2.35 2.0336
K-562 GDSC2 5.5038 7.6809 2.5818 1.0428
U266B1 GDSC2 5.518 7.5243 2.6487 0.7917
BE-13 GDSC2 5.5274 7.4996 2.6621 0.7404
OCI-M1 GDSC2 5.5299 6.97 2.8564 0.2227
RC-K8 GDSC2 5.5654 7.0322 2.8477 0.2286
WIL2 NS GDSC2 5.5685 7.1633 2.8026 0.3224
Reh GDSC2 5.6581 7.2642 2.8005 0.2942
JSC-1 GDSC2 5.7149 7.3099 2.8054 0.2648
SUP-B15 GDSC2 5.7311 7.3665 2.7915 0.2879
ATN-1 GDSC2 5.7695 7.1956 2.8646 0.1482
KMOE-2 GDSC2 5.7989 7.5843 2.7396 0.378
HDLM-2 GDSC2 5.8239 7.864 2.6475 0.6092
DND-41 GDSC2 5.8449 13.6996 0.0553 13.321
HH [Human lymphoma] GDSC2 5.8517 7.9794 2.6158 0.6878
Granta-519 GDSC2 5.8665 7.4724 2.8042 0.2222
EM-2 GDSC2 5.933 7.5409 2.8045 0.2043
MOLM-13 GDSC2 6.0028 7.7487 2.7576 0.2686
KG-1 GDSC2 6.0212 8.0612 2.6534 0.4954
EB2 GDSC2 6.0231 7.9339 2.6999 0.3822
JURL-MK1 GDSC2 6.0871 7.5351 2.8602 0.0988
MOLT-4 GDSC2 6.1365 7.5985 2.8559 0.0965
DG-75 GDSC2 6.1967 8.1328 2.6944 0.3323
MLMA GDSC2 6.3533 7.9123 2.8252 0.0986
GR-ST GDSC2 6.3729 8.8407 2.5069 0.7214
L-540 GDSC2 6.4294 23.238 -4.1799 26.416
CTV-1 GDSC2 6.4743 20.146 -2.6296 22.2882
⏷ Show the Full List of 128 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-498 GDSC2 3.5945 12.148 -0.866 23.0147
A-704 GDSC2 3.9458 6.7699 2.0862 6.1825
786-O GDSC2 4.3507 7.5571 1.9882 5.8726
BFTC-909 GDSC2 4.9144 6.8905 2.6251 1.4185
KTCTL-195 GDSC2 4.9362 9.9436 1.2406 9.0161
SN12C GDSC2 5.051 9.9801 1.3001 8.4382
RCC10RGB GDSC2 5.0568 6.7157 2.7616 0.7253
RXF 393L GDSC2 5.2202 9.559 1.6077 6.3682
SW13 GDSC2 5.5035 6.9526 2.8529 0.2378
LB996-RCC GDSC2 5.5168 7.7581 2.5572 1.126
KMRC-20 GDSC2 5.5307 7.0411 2.8317 0.2721
ACHN GDSC2 5.5871 8.2134 2.4068 1.6791
769-P GDSC2 5.8027 7.5979 2.7362 0.3845
OS-RC-2 GDSC2 5.8041 7.4133 2.802 0.2438
CAL-54 GDSC2 5.9594 19.247 -2.5638 23.1453
NCC010 GDSC2 6.0134 8.4507 2.5051 0.9423
HA7-RCC GDSC2 6.1119 13.4048 0.3729 11.2414
VMRC-RCZ GDSC2 6.1785 11.3527 1.3633 6.049
TK-10 GDSC2 6.5135 9.0173 2.498 0.6745
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-55 GDSC2 4.0254 7.1964 1.9351 6.9259
SW48 GDSC2 4.1947 10.585 0.3897 15.4835
GP5d GDSC2 4.2566 6.9047 2.2368 4.5794
HT115 GDSC2 4.346 12.0995 -0.2453 18.2396
RCM-1 [Human ESC] GDSC2 4.3627 6.5854 2.4544 3.102
LS411N GDSC2 4.5835 5.9347 2.8574 0.7461
HCT 15 GDSC2 4.6105 9.2924 1.3305 9.2104
SW837 GDSC2 4.6309 15.4745 -1.7009 23.3917
CL-11 GDSC2 4.6994 8.6106 1.7187 6.7445
SW1463 GDSC2 4.8143 6.9008 2.5699 1.7986
SNU-61 GDSC2 4.8229 7.4784 2.3212 3.076
CCK-81 GDSC2 4.8576 6.8305 2.6218 1.4975
C2BBe1 GDSC2 4.8888 7.3583 2.4115 2.4989
SNU-C5 GDSC2 4.8986 8.6198 1.8434 5.6289
HT-29 GDSC2 4.9499 6.6105 2.7555 0.8325
COLO205 GDSC2 4.9588 6.9896 2.6058 1.4576
MDST8 GDSC2 5.0251 7.2878 2.514 1.8089
COLO 320HSR GDSC2 5.0808 7.3042 2.5353 1.6447
CaR-1 GDSC2 5.0811 7.0577 2.6369 1.1947
SW948 GDSC2 5.1104 6.4008 2.901 0.274
SW1116 GDSC2 5.1174 7.126 2.6263 1.2044
LS513 GDSC2 5.1203 6.6923 2.7976 0.5591
SNU-81 GDSC2 5.1567 6.8619 2.7483 0.6999
SNU-1040 GDSC2 5.1758 6.5685 2.8658 0.3326
KM12 GDSC2 5.1858 6.8362 2.7705 0.6053
RKO GDSC2 5.2569 11.151 0.8789 10.3475
COLO 678 GDSC2 5.2788 8.7397 2.0177 4.0011
LoVo GDSC2 5.281 10.0488 1.4173 7.322
LS1034 GDSC2 5.2846 6.6339 2.8838 0.2471
LS123 GDSC2 5.3078 6.8064 2.8309 0.3624
CW-2 GDSC2 5.3181 14.7881 -0.8446 18.4974
HCT 116 GDSC2 5.3185 7.1904 2.6915 0.7836
SNU-C1 GDSC2 5.3611 7.2768 2.6766 0.8054
HCC2998 GDSC2 5.3912 9.3447 1.8103 4.9444
DiFi GDSC2 5.4358 7.8573 2.4799 1.5157
SNU-175 GDSC2 5.4737 7.4539 2.6568 0.7948
SNU-407 GDSC2 5.5034 7.4185 2.6828 0.688
SK-CO-1 GDSC2 5.5554 7.1018 2.8195 0.2896
LS180 GDSC2 5.7831 7.2459 2.8523 0.1637
NCI-H716 GDSC2 5.9012 7.8393 2.6872 0.463
SW1417 GDSC2 5.92 7.8887 2.6766 0.4817
SW620 GDSC2 6.0704 17.3673 -1.5628 19.6152
NCI-H747 GDSC2 6.148 8.5735 2.5149 0.8247
T84 GDSC2 6.3578 8.3218 2.6875 0.2955
SNU-C2B GDSC2 6.4492 16.7612 -1.0039 16.7124
SW626 GDSC2 6.624 8.4299 2.7449 0.1471
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.3682 7.2753 2.6802 0.7876
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-1 GDSC2 4.4302 6.2378 2.6512 1.9079
JHH-6 GDSC2 4.5207 5.5965 2.9618 0.4074
Hep 3B2.1-7 GDSC2 4.5405 6.4873 2.6023 2.0038
JHH-7 GDSC2 4.6956 11.0687 0.5251 13.5137
SNU-398 GDSC2 4.7766 12.1867 0.0357 15.8144
JHH-1 GDSC2 4.9986 6.5111 2.8153 0.5797
HLE GDSC2 5.0973 10.7328 0.9713 10.1809
Hep-G2/C3A GDSC2 5.1418 6.863 2.7415 0.7346
JHH-2 GDSC2 5.1726 7.8217 2.3629 2.3601
Huh-7 GDSC2 5.4584 7.0204 2.8118 0.3448
SNU-449 GDSC2 5.7087 7.5296 2.7246 0.4541
SNU-423 GDSC2 5.9237 8.0229 2.6288 0.6097
SNU-387 GDSC2 5.9827 11.8528 1.0173 8.1913
SK-HEP-1 GDSC2 6.0331 14.1036 -0.0112 13.2499
JHH-4 GDSC2 6.6786 15.405 -0.2036 12.8723
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1793 GDSC2 3.8084 6.4554 2.1398 6.1815
NCI-H82 GDSC2 3.9331 6.9894 1.9692 6.9361
SHP-77 GDSC2 4.0553 9.8296 0.6573 14.4097
NCI-H2170 GDSC2 4.062 6.5422 2.279 4.7357
NCI-H1563 GDSC2 4.1625 10.959 0.1793 16.6543
Ms-1 GDSC2 4.1642 6.077 2.5671 2.8136
NCI-H522 GDSC2 4.2105 10.3161 0.535 14.6693
LOU-NH91 GDSC2 4.2903 9.4722 1.0118 11.8124
Calu-3 GDSC2 4.3106 12.8414 -0.6411 20.1075
NCI-H524 GDSC2 4.3591 7.1767 2.1753 4.7379
HCC78 GDSC2 4.3763 10.2477 0.6936 13.3852
NCI-H23 GDSC2 4.3999 9.9177 0.8737 12.3264
NCI-H196 GDSC2 4.4431 7.0517 2.288 3.9132
Lu-165 GDSC2 4.4465 10.6824 0.5317 14.0874
NCI-H810 GDSC2 4.497 6.2024 2.703 1.5488
COR-L311 GDSC2 4.5451 6.5749 2.5662 2.187
NCI-H345 GDSC2 4.6102 5.5584 3.012 0.2135
NCI-H1993 GDSC2 4.6296 7.2987 2.2888 3.5736
HCC366 GDSC2 4.6536 6.9735 2.4502 2.6424
NCI-H720 GDSC2 4.6665 6.7252 2.5671 2.0084
NCI-H1048 GDSC2 4.6915 9.2961 1.3849 8.7142
NCI-H526 GDSC2 4.7337 7.8074 2.1181 4.3586
SW1271 GDSC2 4.7637 10.1747 1.01 10.7003
VMRC-LCD GDSC2 4.7946 8.1581 1.9932 4.9627
COR-L23 GDSC2 4.8103 8.5283 1.83 5.8745
NCI-H2795 GDSC2 4.8841 20.1741 -3.8403 28.8097
NCI-H1755 GDSC2 4.9033 7.1191 2.523 1.9157
PC-14 GDSC2 4.9081 7.5783 2.325 2.9249
Lu-139 GDSC2 4.9082 6.7195 2.6924 1.1273
HOP-62 GDSC2 4.9216 6.9987 2.5835 1.603
NCI-H1694 GDSC2 4.9955 7.0326 2.606 1.4165
SBC-5 GDSC2 5.0411 5.9079 3.046 0.0504
NCI-H1963 GDSC2 5.047 8.5145 1.9836 4.568
NCI-H1915 GDSC2 5.0495 6.6604 2.7798 0.6661
NCI-H2228 GDSC2 5.0827 10.1123 1.2582 8.6099
DMS 273 GDSC2 5.0839 10.7809 0.9391 10.387
NCI-H2122 GDSC2 5.1034 6.6324 2.8132 0.52
NCI-H1666 GDSC2 5.1043 9.136 1.732 5.881
LCLC-103H GDSC2 5.1117 15.5875 -1.3906 21.1191
NCI-H2141 GDSC2 5.1132 6.6203 2.8218 0.4877
NCI-H1092 GDSC2 5.1349 7.4605 2.4969 1.7609
SW1573 GDSC2 5.1562 8.7658 1.9342 4.6565
UMC-11 GDSC2 5.1601 12.5951 0.1137 14.5292
NCI-H2085 GDSC2 5.216 14.315 -0.6871 18.0727
NCI-H513 GDSC2 5.2166 12.2385 0.3269 13.3371
COR-L105 GDSC2 5.2194 11.549 0.6622 11.5904
SBC-3 GDSC2 5.2277 7.317 2.6008 1.2064
NCI-H250 GDSC2 5.2336 7.6947 2.4483 1.874
NCI-H1651 GDSC2 5.2687 16.2421 -1.5962 21.5019
NCI-H226 GDSC2 5.2988 15.0194 -0.9723 19.0634
HCC44 GDSC2 5.3187 7.7536 2.466 1.6981
HOP-92 GDSC2 5.3388 13.8661 -0.3785 16.4383
NCI-H727 GDSC2 5.3582 11.6989 0.6849 11.173
NCI-H358 GDSC2 5.3844 7.9017 2.4368 1.7581
IST-SL2 GDSC2 5.3925 8.2706 2.2857 2.4591
NCI-H2227 GDSC2 5.4018 7.1836 2.7292 0.6031
LK-2 GDSC2 5.4311 12.6851 0.2602 13.1995
NCI-H1581 GDSC2 5.442 7.2565 2.7184 0.6128
NCI-H1944 GDSC2 5.446 11.6124 0.7853 10.457
NCI-H1693 GDSC2 5.4628 7.2688 2.7224 0.5883
NCI-H2369 GDSC2 5.4724 7.0292 2.814 0.3339
NCI-H2591 GDSC2 5.4735 15.11 -0.8893 18.3278
NCI-H1876 GDSC2 5.4922 7.1556 2.776 0.4203
LXF 289 GDSC2 5.5142 14.8953 -0.755 17.6796
NCI-H596 GDSC2 5.5176 7.4665 2.6706 0.719
NCI-H1155 GDSC2 5.5202 7.1055 2.8049 0.3361
NCI-H1781 GDSC2 5.5265 7.0189 2.838 0.2604
NCI-H2023 GDSC2 5.5354 9.2985 1.9145 4.156
Lu-65 GDSC2 5.5492 7.4692 2.6828 0.6599
NCI-H2135 GDSC2 5.5583 6.9636 2.869 0.1915
Lu-135 GDSC2 5.5764 7.3406 2.7415 0.472
KNS-62 GDSC2 5.5863 16.7552 -1.6137 20.8462
NCI-H1355 GDSC2 5.5929 14.1526 -0.3373 15.6852
IA-LM GDSC2 5.6218 6.9814 2.8855 0.1492
NCI-H3122 GDSC2 5.6508 8.5684 2.2913 2.1263
DMS 53 GDSC2 5.6567 8.9253 2.1435 2.8192
NCI-H441 GDSC2 5.6587 12.6509 0.4318 11.854
RERF-LC-KJ GDSC2 5.673 7.3154 2.7879 0.3162
NCI-H1623 GDSC2 5.6835 8.2108 2.4531 1.3934
NCI-H446 GDSC2 5.7013 8.1074 2.5023 1.1847
NCI-H2804 GDSC2 5.7041 7.9811 2.5528 0.9949
NCI-H1435 GDSC2 5.7181 7.2876 2.8145 0.246
Calu-6 GDSC2 5.7185 9.4975 1.9285 3.8139
NCI-H2803 GDSC2 5.7202 7.4913 2.7429 0.4027
NCI-H1650 GDSC2 5.7229 12.8419 0.3836 11.9646
NCI-H1975 GDSC2 5.7697 7.7221 2.6782 0.55
ABC-1 GDSC2 5.7757 7.8393 2.6371 0.667
NCI-H2810 GDSC2 5.7827 8.7039 2.2999 1.9456
NCI-H2373 GDSC2 5.7981 7.827 2.6508 0.6136
NCI-H650 GDSC2 5.8013 10.1803 1.6722 5.0262
A-427 GDSC2 5.8054 8.2371 2.4976 1.1192
NCI-H841 GDSC2 5.8133 10.8595 1.3715 6.6086
HCC15 GDSC2 5.8151 9.3283 2.0538 3.0556
SK-LU-1 GDSC2 5.8188 7.6858 2.7107 0.4399
NCI-H2818 GDSC2 5.8189 7.9487 2.6139 0.7132
NCI-H2029 GDSC2 5.8228 7.1787 2.8889 0.1067
DMS 114 GDSC2 5.8377 7.6701 2.7237 0.4001
NCI-H209 GDSC2 5.8531 8.21 2.5289 0.9714
CPC-N GDSC2 5.8589 9.9619 1.8018 4.2634
HARA [Human squamous cell lung carcinoma] GDSC2 5.9026 7.4906 2.8109 0.2012
EPLC-272H GDSC2 5.9224 7.9891 2.6408 0.5766
NCI-H2722 GDSC2 5.9371 7.4852 2.825 0.1707
NCI-H1299 GDSC2 5.946 11.3802 1.2129 7.224
RERF-LC-Sq1 GDSC2 5.9614 9.6846 1.9777 3.2403
EMC-BAC-2 GDSC2 5.9723 7.9335 2.6806 0.4485
EBC-1 GDSC2 5.9752 7.6916 2.7675 0.2582
NCI-H520 GDSC2 6.0045 7.6969 2.7763 0.2339
LCLC-97TM1 GDSC2 6.0242 8.0584 2.6556 0.4885
NCI-H322M GDSC2 6.0391 14.3623 -0.1309 13.7958
SK-MES-1 GDSC2 6.0652 7.881 2.7343 0.2946
NCI-H2461 GDSC2 6.0686 8.2307 2.6102 0.5878
COLO 668 GDSC2 6.0743 7.9691 2.7066 0.3486
NCI-H211 GDSC2 6.0947 7.6969 2.8084 0.1615
HCC827 GDSC2 6.1726 13.9385 0.16 12.1586
NCI-H2087 GDSC2 6.1788 8.6394 2.5029 0.8439
NCI-H2595 GDSC2 6.1903 8.8866 2.4134 1.1351
NCI-H3255 GDSC2 6.2567 8.4057 2.62 0.4765
DMS 79 GDSC2 6.2772 8.1231 2.7272 0.2465
Lu-99A GDSC2 6.2789 8.5824 2.5645 0.6088
LC-1/sq GDSC2 6.3428 14.5733 -0.0292 12.7189
EKVX GDSC2 6.3599 13.2633 0.5973 9.6619
NCI-H1792 GDSC2 6.3745 8.6548 2.5755 0.5358
NCI-H661 GDSC2 6.459 8.2555 2.7464 0.175
NCI-H2731 GDSC2 6.4795 8.4474 2.688 0.2608
NCI-H2405 GDSC2 6.4852 8.6329 2.6254 0.3782
NCI-H2869 GDSC2 6.6894 9.2498 2.4823 0.6325
NCI-H1869 GDSC2 6.8276 17.5896 -1.1442 16.5171
NCI-H1568 GDSC2 7.1864 19.9465 -2.0318 19.0207
A-549 GDSC2 9.3676 23.9754 -2.5061 16.8329
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 5.6915 7.8986 2.5793 0.9104
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC2 3.7817 5.6899 2.4958 4.0354
TE-8 GDSC2 4.5493 7.6408 2.0796 4.9259
TE-6 GDSC2 4.5853 7.3001 2.2612 3.8084
KYSE-520 GDSC2 4.9919 8.2042 2.0922 4.0577
TE-4 GDSC2 5.1133 7.2713 2.5649 1.4748
TE-9 GDSC2 5.2434 6.688 2.8488 0.3457
KYSE-140 GDSC2 5.291 8.7309 2.0287 3.923
TE-1 GDSC2 5.3179 10.1722 1.383 7.4432
OE33 GDSC2 5.3244 7.5603 2.5479 1.3357
EC-GI-10 GDSC2 5.3291 7.5831 2.5408 1.361
TE-5 GDSC2 5.3579 7.9758 2.3928 1.9892
KYSE-450 GDSC2 5.6486 15.6617 -1.0328 18.516
COLO 680N GDSC2 5.6747 7.0224 2.8902 0.1314
KYSE-70 GDSC2 5.8327 7.9484 2.6196 0.6873
KYSE-180 GDSC2 5.834 7.8189 2.6682 0.5453
KYSE-410 GDSC2 5.9408 21.782 -3.8268 26.5541
TE-15 GDSC2 6.0123 8.575 2.4568 1.1109
KYSE-270 GDSC2 6.1545 10.7311 1.6267 4.7308
OE21 GDSC2 6.2153 8.1256 2.7039 0.3074
KYSE-510 GDSC2 8.8082 22.4668 -2.1557 16.6081
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 4.3406 7.0251 2.2349 4.4215
OAW42 GDSC2 4.4467 13.7483 -0.9862 21.1903
TOV-21G GDSC2 4.5389 7.2826 2.2406 4.0102
OVCAR-3 GDSC2 4.791 6.7689 2.614 1.6133
OVISE GDSC2 5.0073 6.2802 2.9048 0.3086
OV-90 GDSC2 5.0619 9.4214 1.5717 6.8716
DOV13 GDSC2 5.1966 6.7858 2.794 0.5241
OV56 GDSC2 5.2912 6.2771 3.0081 0.0556
Kuramochi GDSC2 5.3891 9.0398 1.9466 4.2104
EFO-27 GDSC2 5.5195 11.3566 0.9552 9.3981
ES-2 GDSC2 5.5856 6.8991 2.9008 0.1345
IGROV-1 GDSC2 5.6428 8.0409 2.5022 1.2339
EFO-21 GDSC2 5.7056 7.2806 2.8123 0.2541
OVCAR-5 GDSC2 5.746 17.0865 -1.6596 20.6574
OVK18 GDSC2 5.7844 7.327 2.8249 0.208
OAW28 GDSC2 5.8882 13.4221 0.2172 12.4501
SK-OV-3 GDSC2 5.9942 8.0325 2.6533 0.5081
TOV-112D GDSC2 6.0863 8.129 2.654 0.4652
TYK-nu GDSC2 6.1586 8.2233 2.6479 0.4499
OVTOKO GDSC2 6.266 8.1011 2.7308 0.2433
OVCAR-4 GDSC2 6.3254 8.0601 2.7659 0.1745
OVCAR-8 GDSC2 6.4788 8.0723 2.8146 0.0931
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-2 GDSC2 4.1564 12.0898 -0.3875 19.3934
PaTu 8988t GDSC2 4.4687 7.8417 1.9315 5.9632
AsPC-1 GDSC2 4.7358 7.179 2.4053 2.7575
HuP-T3 GDSC2 4.7877 9.114 1.5376 7.6201
YAPC GDSC2 4.8067 16.9866 -2.3159 24.9671
PaTu 8902 GDSC2 4.8663 6.2327 2.8655 0.5002
SU.86.86 GDSC2 4.9723 6.6026 2.7686 0.7645
Panc 10.05 GDSC2 4.9991 11.8244 0.3744 13.5879
KP-3 GDSC2 5.248 7.9366 2.3531 2.3116
CFPAC-1 GDSC2 5.2751 7.0609 2.7226 0.7062
Panc 02.03 GDSC2 5.2836 11.1438 0.9003 10.1754
KP-4 GDSC2 5.3272 6.8261 2.8313 0.3529
KP-1N GDSC2 5.4268 8.3464 2.2711 2.4866
MIA PaCa-2 GDSC2 5.4424 6.9867 2.8178 0.337
QGP-1 GDSC2 5.5022 7.4012 2.6889 0.6695
HuP-T4 GDSC2 5.6039 9.1477 2.0191 3.512
Panc 08.13 GDSC2 5.6292 8.9684 2.1105 3.0167
HPAC GDSC2 5.6687 13.7352 -0.0824 14.3459
PL4 GDSC2 5.6939 7.247 2.8198 0.2432
PSN1 GDSC2 5.6974 7.4087 2.7638 0.3617
Capan-1 GDSC2 5.9525 7.6719 2.7661 0.2677
BxPC-3 GDSC2 6.1248 15.4539 -0.5969 15.694
Capan-2 GDSC2 6.31 16.157 -0.8084 16.2026
HPAF-II GDSC2 6.3804 8.0097 2.802 0.1193
DAN-G GDSC2 6.464 18.2389 -1.708 19.32
SUIT-2 GDSC2 6.5564 17.6387 -1.353 17.8455
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 4.9174 14.123 -0.8135 19.3128
NCI-H28 GDSC2 5.0866 10.9552 0.857 10.8311
MSTO-211H GDSC2 5.6498 7.9184 2.5535 1.0337
IST-Mes1 GDSC2 5.7403 7.6686 2.6862 0.5428
NCI-H2052 GDSC2 6.3034 8.3256 2.6661 0.355
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 5.2365 11.8127 0.5468 12.1606
VCaP GDSC2 5.4931 7.5643 2.6226 0.9011
22Rv1 GDSC2 5.9873 8.0513 2.6437 0.5366
DU145 GDSC2 6.0101 7.7649 2.7547 0.2721
PC-3 GDSC2 6.0244 8.7027 2.4124 1.2644
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 6.0122 7.6794 2.7851 0.2166
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM115 GDSC2 3.91 5.9334 2.4678 3.9183
COLO 679 GDSC2 4.2218 10.6576 0.3744 15.4928
RPMI-7951 GDSC2 4.4174 6.8114 2.3837 3.4087
WT2-iPS GDSC2 4.6773 6.2252 2.784 0.9637
Mel JuSo GDSC2 4.7449 6.5393 2.6873 1.3224
SK-MEL-2 GDSC2 4.893 14.1367 -0.8385 19.4758
IGR-37 GDSC2 4.9357 6.6036 2.7518 0.8587
CP66-MEL GDSC2 5.0011 6.4517 2.8389 0.5012
IGR-1 GDSC2 5.0376 6.6025 2.7969 0.6154
A101D GDSC2 5.0727 6.3851 2.8922 0.3115
UACC-62 GDSC2 5.0908 6.3712 2.9042 0.2744
COLO 829 GDSC2 5.182 7.7391 2.4031 2.1507
UACC-257 GDSC2 5.1888 6.7365 2.8093 0.4823
G-361 GDSC2 5.1981 13.1783 -0.1436 15.6788
HT-144 GDSC2 5.202 14.8561 -0.9631 19.2507
WM793 GDSC2 5.2075 7.0665 2.6911 0.8682
WM1552C GDSC2 5.2142 8.8178 1.9449 4.5006
SK-MEL-24 GDSC2 5.2839 21.3488 -4.1132 28.5585
GAK GDSC2 5.3972 6.7111 2.8982 0.1838
WM278 GDSC2 5.4697 14.9837 -0.8303 18.0935
WM35 GDSC2 5.5468 15.4268 -0.9914 18.577
COLO 792 GDSC2 5.6534 7.204 2.8199 0.2556
CHL-1 GDSC2 5.6823 7.6386 2.6739 0.6093
LOX-IMVI GDSC2 5.7288 8.6794 2.2837 2.0751
A-375 GDSC2 5.8069 14.4983 -0.3553 15.3033
G-mel GDSC2 5.8373 7.4671 2.7954 0.2465
SH-4 GDSC2 5.8414 7.6759 2.7231 0.4001
HMV-II GDSC2 5.8642 8.0928 2.5783 0.7979
M14 GDSC2 5.8778 7.5793 2.771 0.2813
SK-MEL-5 GDSC2 5.9009 7.154 2.9235 0.0619
A2058 GDSC2 6.7623 18.0959 -1.4317 17.7309
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 4.4333 11.8468 -0.0534 17.1026
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC2 4.2697 7.9394 1.7475 7.503
HT-1080 GDSC2 4.7334 7.7203 2.1581 4.1317
SW982 GDSC2 4.9694 6.3476 2.8649 0.4396
MES-SA GDSC2 5.1025 6.367 2.9101 0.2559
VA-ES-BJ GDSC2 5.1031 6.7958 2.7507 0.7302
SW684 GDSC2 5.1099 6.5625 2.8419 0.4297
Rh41 GDSC2 5.1184 6.987 2.6825 0.9743
EW-8 GDSC2 5.3014 7.1572 2.6969 0.7767
A-204 GDSC2 5.3906 11.9066 0.6073 11.5125
RKN GDSC2 5.4435 6.7623 2.8972 0.1732
GCT GDSC2 5.4966 12.6328 0.3305 12.7062
G-401 GDSC2 5.5895 13.9398 -0.2365 15.2336
SK-UT-1 GDSC2 5.6708 7.6387 2.6692 0.6301
SW872 GDSC2 5.7121 15.0481 -0.6883 16.9606
Rh30 GDSC2 5.7383 7.2361 2.8397 0.1947
RD GDSC2 5.9818 11.3808 1.2343 7.0491
G-402 GDSC2 6.0162 13.0588 0.4741 10.9239
SK-LMS-1 GDSC2 6.0743 16.0143 -0.9026 17.075
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC2 4.2624 6.3386 2.5067 2.9826
SK-GT-2 GDSC2 4.2929 9.3064 1.0953 11.3247
NUGC-4 GDSC2 4.5675 9.4613 1.2181 9.9604
KATO III GDSC2 4.8823 7.5987 2.3013 3.0911
OCUM-1 GDSC2 4.8883 14.577 -1.0595 20.3822
MKN1 GDSC2 4.9128 8.0589 2.1113 4.0843
SNU-5 GDSC2 4.914 21.8344 -4.6433 30.4351
GCIY GDSC2 5.0494 7.4072 2.4759 1.9623
RF-48 GDSC2 5.1033 18.2652 -2.722 25.476
Hs 746.T GDSC2 5.1817 15.2092 -1.1519 20.0472
IM95 GDSC2 5.2128 9.169 1.7836 5.3959
23132/87 GDSC2 5.2569 6.8451 2.7965 0.4823
MKN28 GDSC2 5.5527 8.9334 2.0848 3.2485
ECC10 GDSC2 5.5922 7.3692 2.7373 0.4758
NCI-N87 GDSC2 5.6325 8.8526 2.162 2.7597
HGC-27 GDSC2 5.7799 7.3341 2.8208 0.2165
RERF-GC-1B GDSC2 6.0154 21.3129 -3.5393 25.7026
NUGC-3 GDSC2 6.0813 7.8282 2.7586 0.2443
SNU-1 GDSC2 6.1468 7.6451 2.8439 0.1078
AGS GDSC2 6.9226 18.5935 -1.5614 17.8929
SNG-M GDSC2 6.2344 7.8399 2.8087 0.135
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C GDSC2 3.8501 5.4496 2.6595 2.8841
ASH-3 GDSC2 4.6355 6.5083 2.6444 1.6597
B-CPAP GDSC2 4.6466 7.6417 2.1409 4.3866
WRO GDSC2 4.7365 8.5447 1.7744 6.3434
CAL-62 GDSC2 4.89 8.3554 1.961 4.9719
HTC-C3 GDSC2 5.364 8.5572 2.1464 3.1959
IHH-4 GDSC2 5.4769 6.8735 2.8707 0.2114
8505C GDSC2 5.5403 13.7379 -0.1731 15.0487
K5 GDSC2 5.7105 9.2616 2.0271 3.3247
FTC-133 GDSC2 5.7227 12.7157 0.4436 11.6626
TT2609-C02 GDSC2 5.8424 11.2766 1.1973 7.4891
BHT-101 GDSC2 6.278 18.3499 -1.8936 20.3417
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OSC-20 GDSC2 4.2371 6.6681 2.3363 4.0269
DOK GDSC2 4.339 13.9401 -1.1652 22.172
Detroit 562 GDSC2 4.5063 11.081 0.3798 14.7402
HO-1-N-1 GDSC2 4.7156 9.101 1.4952 8.0193
SAT [Human HNSCC] GDSC2 4.7358 9.878 1.1343 10.0593
FaDu GDSC2 4.7439 7.0202 2.4802 2.3484
PCI-04B GDSC2 4.9359 7.6253 2.3199 2.9107
SAS GDSC2 4.9572 7.5391 2.3697 2.6182
BICR 10 GDSC2 5.0309 11.4844 0.5623 12.5367
HSC-3 GDSC2 5.0326 6.9054 2.6757 1.0784
CAL-27 GDSC2 5.1301 9.9617 1.361 7.9336
SCC-9 GDSC2 5.1861 10.1178 1.3237 8.0321
HSC-2 GDSC2 5.3707 6.7568 2.8725 0.2414
BICR 22 GDSC2 5.5488 6.9638 2.8655 0.2004
HSC-4 GDSC2 5.6154 7.1514 2.8244 0.2589
SKN-3 GDSC2 5.6227 9.0437 2.0745 3.205
UPCI-SCC-090 GDSC2 5.6232 22.9608 -4.6517 28.9997
Ca9-22 GDSC2 5.6722 12.9045 0.3195 12.3905
NCI-H3118 GDSC2 5.6858 8.1298 2.4865 1.2588
CAL-33 GDSC2 5.7116 8.2463 2.4519 1.3734
JHU-022 GDSC2 5.8197 12.1829 0.76 9.8435
BB49-HNC GDSC2 5.8552 8.5367 2.4018 1.4471
SCC-15 GDSC2 5.9422 8.0606 2.6223 0.6186
BICR 78 GDSC2 6.0801 8.9706 2.3317 1.529
SCC-4 GDSC2 6.0851 15.1826 -0.4935 15.3293
LB771-HNC GDSC2 6.7272 20.1135 -2.433 21.1906
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
J82 GDSC2 4.5986 9.5108 1.2161 9.901
639V GDSC2 4.8073 6.2346 2.8395 0.6309
KU-19-19 GDSC2 4.9417 10.9234 0.7718 11.6159
BFTC-905 GDSC2 5.1169 6.707 2.7906 0.5838
HT-1197 GDSC2 5.1983 6.9323 2.7392 0.7025
647V GDSC2 5.2027 6.7502 2.8098 0.4729
TCCSUP GDSC2 5.5045 12.3767 0.459 12.0381
RT-4 GDSC2 5.5535 16.8237 -1.6715 21.1239
SW780 GDSC2 5.6154 18.668 -2.5337 23.7897
CAL-29 GDSC2 5.6335 7.07 2.8593 0.1884
SW1710 GDSC2 5.6359 7.6552 2.6486 0.7152
RT-112 GDSC2 5.7851 7.6652 2.7051 0.4696
5637 GDSC2 6.0396 8.0364 2.6695 0.4472
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DoTc2 4510 GDSC2 3.9541 9.8853 0.5511 15.2607
HeLa GDSC2 3.9891 12.6223 -0.7846 21.5747
PA-1 GDSC2 4.0002 6.5557 2.2295 5.175
CAL-39 GDSC2 4.0816 6.7252 2.2042 5.1476
OVCA420 GDSC2 4.4635 6.6457 2.4875 2.743
NEC8 GDSC2 4.6095 6.8036 2.501 2.4376
HT-3 GDSC2 4.6812 10.1192 0.9787 11.0656
HEC-1 GDSC2 4.7978 8.2425 1.9559 5.171
SKN GDSC2 4.8111 10.2133 1.0245 10.5117
MS751 GDSC2 4.9885 11.4603 0.5441 12.729
LB831-BLC GDSC2 5.143 8.2519 2.1582 3.4583
PWR-1E GDSC2 5.3266 7.1817 2.6983 0.754
BPH-1 GDSC2 5.3487 15.6016 -1.2216 19.9305
SiSo GDSC2 5.4623 9.4956 1.7838 4.9716
OVMIU GDSC2 5.4782 8.3679 2.2885 2.3395
Ca Ski GDSC2 5.5432 9.7466 1.7176 5.1971
SW756 GDSC2 5.5582 15.8713 -1.2007 19.3756
TC-YIK GDSC2 5.6095 7.8198 2.5742 0.9886
PEO1 GDSC2 5.6252 9.1497 2.0298 3.4279
DSH1 GDSC2 5.6256 7.2116 2.8069 0.2918
C-4-I GDSC2 5.6459 7.9018 2.5582 1.0193
SKG-IIIa GDSC2 6.011 19.1802 -2.493 22.8238
HEY GDSC2 6.0138 8.1531 2.6169 0.5968
ME-180 GDSC2 6.0674 8.7031 2.4311 1.1622
C-33 A GDSC2 6.4885 8.5546 2.6541 0.3198
SiHa GDSC2 6.8083 17.2205 -0.9805 15.9125
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

References

1 The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J. 2010 Jul 7;29(13):2135-46.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2721).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2722).