Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEK4TJ)

Drug Name
PI-103 Drug Info
Synonyms
PI-103; 371935-74-9; PI103; 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol; UNII-YQX02F616F; PI 103; PIK-103; Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-; YQX02F616F; CHEBI:90524; AK163162; 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol; 3-(4-Morpholin-4-Ylpyrido[3',2':4,5]furo[3,2-D]pyrimidin-2-Yl)phenol; Phenol, 3-(4-(4-morpholinyl)pyrido(3',2':4,5)furo(3,2-d)pyrimidin-2-yl)-; 3-(4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
9884685
ChEBI ID
CHEMBL573339
CAS Number
CAS 371935-74-9
TTD Drug ID
D0W8XH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.11 0.00e+0 80/88 (90.91%) ITGB5;LAMA4;THBS3;...
Notch signaling pathway 2.00 0.00e+0 49/59 (83.05%) RBPJ;ATXN1;TLE1;...
Wnt signaling pathway 1.83 8.18e-3 124/166 (74.7%) MYC;FRAT1;PLCB4;...
Fatty acid elongation -1.66 4.31e-2 19/27 (70.37%) HACD2;ACOT7;HSD17B12;...
Ferroptosis -1.67 4.13e-2 36/41 (87.8%) FTL;ACSL3;SLC39A8;...
Steroid biosynthesis -1.67 4.10e-2 19/20 (95%) CYP27B1;SOAT2;LIPA;...
Glycolysis / Gluconeogenesis -1.68 3.76e-2 56/67 (83.58%) GPI;ALDH2;GCK;...
Citrate cycle (TCA cycle) -1.70 3.38e-2 30/30 (100%) PCK1;PDHA1;MDH1;...
Amyotrophic lateral sclerosis -1.76 1.58e-2 267/364 (73.35%) NDUFA8;ANXA7;DCTN5;...
Thiamine metabolism -1.76 1.68e-2 12/15 (80%) TPK1;ALPP;ACP1;...
Biosynthesis of unsaturated fatty acids -1.76 1.80e-2 21/27 (77.78%) HSD17B4;ACOX3;ELOVL1;...
Legionellosis -1.78 1.67e-2 51/57 (89.47%) CASP7;BNIP3;CXCL2;...
Alanine, aspartate and glutamate metabolism -1.80 1.08e-2 27/37 (72.97%) GLS;GFPT2;ASPA;...
Protein export -1.83 9.76e-3 17/23 (73.91%) SPCS1;SEC63;SEC61G;...
Fructose and mannose metabolism -1.83 1.06e-2 30/33 (90.91%) KHK;FPGT;FBP1;...
Cysteine and methionine metabolism -1.86 9.37e-3 43/50 (86%) BHMT2;AMD1;ADI1;...
Glutathione metabolism -1.87 7.81e-3 43/57 (75.44%) G6PD;RRM2;GSTA1;...
Parkinson disease -1.91 2.93e-3 176/249 (70.68%) NDUFC1;NDUFA4L2;MFN1;...
Ribosome biogenesis in eukaryotes -1.94 0.00e+0 52/108 (48.15%) PWP2;NMD3;MPHOSPH10;...
Prion disease -1.95 0.00e+0 209/273 (76.56%) HSPA8;NDUFB2;ATP5F1C;...
Folate biosynthesis -1.95 0.00e+0 23/26 (88.46%) ALPP;SPR;GGH;...
Arginine and proline metabolism -2.00 0.00e+0 39/50 (78%) PYCR3;GOT2;CKM;...
Glycine, serine and threonine metabolism -2.02 0.00e+0 31/40 (77.5%) DLD;SRR;ALAS1;...
Proteasome -2.31 0.00e+0 44/46 (95.65%) ADRM1;PSMB6;PSMD2;...
Protein processing in endoplasmic reticulum -2.45 0.00e+0 127/171 (74.27%) HSPA8;YOD1;ERO1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 12uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 12uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 12uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 12uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 12uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 12uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 12uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 12uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 12uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H