Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEM2SW)

Drug Name
CYCLOPAMINE Drug Info
Synonyms
CYCLOPAMINE; 11-Deoxojervine; 4449-51-8; UNII-ZH658AJ192; CHEMBL254129; CHEBI:4021; 11-Deoxyjervine; ZH658AJ192; HSDB 3505; Jervine, 11-deoxo-; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- (9CI); (3beta,22S,23R)-17,23-epoxyveratraman-3-ol; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; CY8; [3H]-Cyclopamine; AC1L9DRQ; DSSTox_CID_23709; DSSTox_RID_80067; SCHEMBL29153
Cross-matching ID
PubChem CID
442972
ChEBI ID
CHEMBL254129
CAS Number
CAS 4449-51-8
TTD Drug ID
D05UKJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.35 0.00e+0 19/20 (95%) DHCR24;MSMO1;SQLE;...
Retinol metabolism 2.14 0.00e+0 41/68 (60.29%) ALDH1A1;ADH1B;UGT2B4;...
Terpenoid backbone biosynthesis 1.99 7.06e-3 18/22 (81.82%) HMGCS1;FDPS;IDI1;...
PPAR signaling pathway 1.90 1.32e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Pentose and glucuronate interconversions 1.88 1.48e-2 17/34 (50%) UGT2B4;SORD;UGT2B28;...
IL-17 signaling pathway 1.87 1.24e-2 84/94 (89.36%) CCL20;MMP3;LCN2;...
Tyrosine metabolism 1.87 1.21e-2 30/36 (83.33%) MAOA;AOC3;ADH1B;...
Malaria 1.87 1.06e-2 44/50 (88%) COMP;CXCL8;ICAM1;...
Biosynthesis of unsaturated fatty acids 1.86 1.06e-2 21/27 (77.78%) SCD;FADS2;FADS1;...
Steroid hormone biosynthesis 1.86 1.06e-2 43/61 (70.49%) UGT2B4;UGT2B28;COMT;...
Folate biosynthesis 1.85 9.62e-3 23/26 (88.46%) AKR1B10;QDPR;GGH;...
Ascorbate and aldarate metabolism 1.81 1.85e-2 15/30 (50%) UGT2B4;UGT2B28;UGT2A3;...
Arachidonic acid metabolism 1.79 1.95e-2 48/61 (78.69%) ALOX5;ALOX15B;PLA2G2A;...
DNA replication 1.78 1.89e-2 34/36 (94.44%) RFC5;RFC3;LIG1;...
Rheumatoid arthritis 1.78 1.83e-2 78/93 (83.87%) CCL20;MMP3;CXCL8;...
Pentose phosphate pathway 1.69 4.23e-2 25/30 (83.33%) ALDOC;PGD;RPIA;...
Legionellosis 1.68 4.05e-2 51/57 (89.47%) CXCL8;CXCL1;HSPA2;...
Necroptosis 1.68 3.94e-2 113/159 (71.07%) TNFAIP3;STAT6;BID;...
Synthesis and degradation of ketone bodies 1.68 3.79e-2 9/10 (90%) HMGCS1;ACAT2
NF-kappa B signaling pathway 1.67 4.08e-2 90/104 (86.54%) CXCL8;TNFAIP3;ICAM1;...
Phenylalanine metabolism 1.67 3.93e-2 14/17 (82.35%) MAOA;AOC3;ALDH3A1;...
Fatty acid elongation 1.65 4.33e-2 19/27 (70.37%) ELOVL5;HACD2;ELOVL2;...
Antigen processing and presentation -1.90 3.73e-2 60/78 (76.92%) KIR3DL1;CREB1;HSPA6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H