Details of the Drug

General Information of Drug (ID: DMEM2SW)

Drug Name
CYCLOPAMINE
Synonyms
CYCLOPAMINE; 11-Deoxojervine; 4449-51-8; UNII-ZH658AJ192; CHEMBL254129; CHEBI:4021; 11-Deoxyjervine; ZH658AJ192; HSDB 3505; Jervine, 11-deoxo-; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- (9CI); (3beta,22S,23R)-17,23-epoxyveratraman-3-ol; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; CY8; [3H]-Cyclopamine; AC1L9DRQ; DSSTox_CID_23709; DSSTox_RID_80067; SCHEMBL29153
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 411.6
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C27H41NO2
IUPAC Name
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Canonical SMILES
C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
InChI
InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChIKey
QASFUMOKHFSJGL-LAFRSMQTSA-N
Cross-matching ID
PubChem CID
442972
ChEBI ID
CHEBI:4021
CAS Number
4449-51-8
TTD ID
D05UKJ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Smoothened homolog (SMO) TT8J1S3 SMO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [2]
Arginase-1 (ARG1) OTHZITAM ARGI1_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Drug Response [4]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Drug Response [4]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [3]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [3]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [3]
Macrophage mannose receptor 1 (MRC1) OTTVCOPT MRC1_HUMAN Gene/Protein Processing [3]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Protein Interaction/Cellular Processes [5]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Smoothened homolog (SMO) DTT SMO 4.01E-06 -0.18 -0.35
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 143 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 5.4252 8.1625 2.9523 4.2985
WIL2 NS GDSC1 2.6055 4.5882 2.285 19.6036
DoHH2 GDSC1 2.7311 4.6718 2.3876 18.2104
SU-DHL-4 GDSC1 3.1002 4.5066 2.8448 13.0018
Sc-1 GDSC1 3.1044 5.0473 2.6216 14.6162
DEL GDSC1 3.1414 6.5845 1.9373 19.4649
ALL-PO GDSC1 3.1443 7.3001 1.592 21.8004
NALM-6 GDSC1 3.168 5.623 2.4219 15.8043
SR GDSC1 3.2289 4.2368 3.0838 10.6171
P32/ISH GDSC1 3.3769 4.5407 3.1224 9.5688
Ku812 GDSC1 3.4108 5.3279 2.7983 11.8496
CTV-1 GDSC1 3.4781 4.2918 3.3308 7.5358
BL-41 GDSC1 3.5795 9.4007 0.9417 23.8444
ML-2 GDSC1 3.5908 4.7098 3.2651 7.4711
SU-DHL-6 GDSC1 3.6133 6.9707 2.1812 15.6781
GA-10 GDSC1 3.6373 5.7719 2.7962 10.8894
ARH-77 GDSC1 3.7016 4.6951 3.3807 6.0843
NB4 GDSC1 3.7147 4.3552 3.5513 4.7289
RPMI-8402 GDSC1 3.8881 6.9826 2.4144 12.851
MHH-PREB-1 GDSC1 3.8913 6.2874 2.7646 10.1343
697 GDSC1 3.9001 5.3114 3.2593 6.2141
EoL-1 GDSC1 3.93 7.2388 2.3219 13.3928
MC116 GDSC1 3.9467 4.6334 3.6378 3.0557
KE-37 GDSC1 3.9789 6.7622 2.6013 11.0785
A3/Kawakami GDSC1 4.0124 4.8771 3.5718 3.3328
Daudi GDSC1 4.014 9.0254 1.499 18.8373
Karpas-422 GDSC1 4.0359 6.3313 2.8641 8.8237
Karpas-45 GDSC1 4.0399 7.9557 2.0553 14.9496
BALL-1 GDSC1 4.0541 5.7945 3.1474 6.5304
Namalwa GDSC1 4.0863 5.4067 3.3672 4.6863
VAL GDSC1 4.0944 6.6523 2.7516 9.4949
Karpas-231 GDSC1 4.1578 5.3198 3.4666 3.6689
HC-1 GDSC1 4.1616 5.7932 3.2343 5.4784
RS4;11 GDSC1 4.1641 6.9219 2.6734 9.8597
OCI-AML-2 GDSC1 4.1833 5.5867 3.3538 4.4702
NOMO-1 GDSC1 4.2049 5.8444 3.2425 5.2717
RPMI-8226 GDSC1 4.2484 8.1438 2.1313 13.6525
Karpas-299 GDSC1 4.2786 8.9595 1.7484 16.2326
MOLM-13 GDSC1 4.2904 6.9819 2.7436 8.8884
Jiyoye GDSC1 4.3128 5.8009 3.3451 4.1363
KCL-22 GDSC1 4.3194 6.7491 2.8817 7.7212
MY-M12 GDSC1 4.3557 8.2959 2.1408 13.2131
GR-ST GDSC1 4.359 7.6036 2.4879 10.623
MOLT-16 GDSC1 4.3704 5.5257 3.5194 2.6404
L-363 GDSC1 4.3853 7.6106 2.5049 10.407
K-562 GDSC1 4.4546 6.0092 3.3444 3.7378
ATN-1 GDSC1 4.4582 7.0403 2.8428 7.5847
OPM-2 GDSC1 4.5246 6.027 3.3833 3.2598
Farage GDSC1 4.5662 6.4464 3.2105 4.4499
ST486 GDSC1 4.6107 6.1795 3.3675 3.1616
LP-1 GDSC1 4.6324 6.3624 3.2951 3.6426
MV4-11 GDSC1 4.643 6.1361 3.4084 2.7864
BC-1 GDSC1 4.6735 7.4158 2.8157 7.1504
LC4-1 GDSC1 4.6856 7.2525 2.9036 6.4485
SIG-M5 GDSC1 4.6879 5.8851 3.5502 1.6972
LAMA-84 GDSC1 4.7093 9.8872 1.6246 15.5947
Ramos.2G6.4C10 GDSC1 4.7106 7.4137 2.8429 6.8379
OCI-AML-5 GDSC1 4.7701 6.1263 3.4894 1.9478
NU-DUL-1 GDSC1 4.8073 7.6182 2.8115 6.8058
HEL GDSC1 4.8087 6.2746 3.4451 2.172
Mono-Mac-6 GDSC1 4.8616 7.8153 2.7539 7.088
QIMR-WIL GDSC1 4.9637 7.4576 2.9932 5.0479
SU-DHL-1 GDSC1 4.9761 6.9415 3.2412 3.2368
Reh GDSC1 4.978 7.8747 2.8046 6.4002
SU-DHL-16 GDSC1 5.0697 6.7572 3.3777 2.1298
HT GDSC1 5.0831 8.9962 2.3368 9.5401
NK-92MI GDSC1 5.0867 9.1088 2.2848 9.903
HH [Human lymphoma] GDSC1 5.1232 7.7075 2.9777 4.7805
SCC-3 GDSC1 5.1836 7.5765 3.0754 3.9539
BE-13 GDSC1 5.2088 7.5039 3.1235 3.5671
L-540 GDSC1 5.2251 8.2467 2.7902 5.8891
U-698-M GDSC1 5.3262 10.0435 1.9994 11.2271
SUP-HD1 GDSC1 5.3344 7.5568 3.172 2.9941
CESS GDSC1 5.3418 8.328 2.8258 5.3628
SUP-B15 GDSC1 5.3699 6.9379 3.4548 1.2209
TK [Human B-cell lymphoma] GDSC1 5.3877 6.8849 3.4846 1.0445
AMO1 GDSC1 5.4047 7.3784 3.2879 2.1339
RPMI-8866 GDSC1 5.4128 7.2411 3.3504 1.7484
ALL-SIL GDSC1 5.4166 8.8647 2.6225 6.6286
BV-173 GDSC1 5.4443 10.2599 1.9766 11.0576
DG-75 GDSC1 5.463 7.3639 3.3241 1.8291
EM-2 GDSC1 5.4662 10.4276 1.9109 11.4392
HAL-01 GDSC1 5.521 8.5905 2.8143 5.0479
BC-3 GDSC1 5.531 7.4311 3.3299 1.6996
KMOE-2 GDSC1 5.5447 8.2162 2.9975 3.7543
SUP-M2 GDSC1 5.5503 6.8102 3.5837 0.4644
ME1 GDSC1 5.5817 6.7115 3.6318 0.29
Raji GDSC1 5.5985 7.0978 3.495 0.7825
IM-9 GDSC1 5.6093 7.3174 3.4136 1.1547
RC-K8 GDSC1 5.6196 7.2933 3.4279 1.0729
CTB-1 GDSC1 5.6268 8.2753 3.0175 3.469
DB GDSC1 5.6402 7.4618 3.3699 1.3422
TUR GDSC1 5.6522 7.7372 3.2625 1.9158
SKM-1 GDSC1 5.6523 6.6534 3.6782 0.1496
KG-1 GDSC1 5.6691 7.8294 3.2324 2.0659
OCI-M1 GDSC1 5.686 6.7817 3.6459 0.2085
EJM GDSC1 5.7022 7.7299 3.2902 1.6926
DND-41 GDSC1 5.7168 9.6611 2.4402 7.1972
JJN-3 GDSC1 5.7176 7.3407 3.4527 0.8614
P31/FUJ GDSC1 5.7313 7.0596 3.5639 0.4194
PF-382 GDSC1 5.7427 11.7554 1.461 13.5647
SUP-T1 GDSC1 5.7595 8.2755 3.0893 2.786
WSU-DLCL2 GDSC1 5.7651 6.8092 3.6649 0.1429
KMS-12-BM GDSC1 5.8074 7.3799 3.4758 0.6887
VL51 GDSC1 5.8341 7.6302 3.3911 1.03
L-1236 GDSC1 5.8414 9.2378 2.7099 5.0933
MLMA GDSC1 5.8538 7.4536 3.4673 0.6868
HL-60 GDSC1 5.8954 7.2669 3.5525 0.3658
Granta-519 GDSC1 5.9022 8.4071 3.1071 2.4588
OCI-Ly19 GDSC1 5.9063 7.7363 3.3815 1.0053
Loucy GDSC1 5.9092 7.3344 3.5335 0.4163
A4/Fukuda GDSC1 5.9218 7.2646 3.5634 0.3223
CCRF-CEM GDSC1 5.9227 8.1417 3.2275 1.7524
JURL-MK1 GDSC1 5.9566 8.45 3.1165 2.3255
H9 GDSC1 5.9604 8.2034 3.2202 1.7445
MOLT-4 GDSC1 5.9642 7.5536 3.4751 0.5794
GDM-1 GDSC1 6.0494 8.761 3.0326 2.6791
MN-60 GDSC1 6.1262 7.934 3.3992 0.7481
L-428 GDSC1 6.1382 9.2528 2.8687 3.5279
U266B1 GDSC1 6.1603 8.0989 3.3511 0.9141
SU-DHL-8 GDSC1 6.1641 7.625 3.5264 0.3146
KY821 GDSC1 6.1647 11.5112 1.8588 10.0052
WSU-NHL GDSC1 6.1717 7.9403 3.4154 0.6557
Hs 445 GDSC1 6.1938 7.8017 3.4747 0.4454
THP-1 GDSC1 6.2062 11.5368 1.8732 9.8159
JVM-2 GDSC1 6.2201 8.6288 3.1701 1.6975
RPMI-6666 GDSC1 6.2376 7.8565 3.4718 0.4317
MOLP-8 GDSC1 6.2447 7.8178 3.4883 0.381
RL GDSC1 6.2664 12.8131 1.309 13.1129
CA46 GDSC1 6.2718 12.9054 1.2686 13.3337
MEG-01 GDSC1 6.2817 8.4028 3.2865 1.0847
YT GDSC1 6.2913 7.6167 3.5751 0.1671
SK-MM-2 GDSC1 6.3222 8.1708 3.3906 0.6452
Kasumi-1 GDSC1 6.4159 8.3164 3.3744 0.6425
OCI-AML-3 GDSC1 6.4432 7.8707 3.5422 0.1868
ROS-50 GDSC1 6.533 8.9725 3.1751 1.3487
PL-21 GDSC1 6.6318 8.6421 3.3404 0.6266
JVM-3 GDSC1 6.6478 8.5331 3.3859 0.4791
EB2 GDSC1 6.7908 14.713 0.7527 14.8862
NKM-1 GDSC1 6.9513 8.8504 3.3868 0.3495
KM-H2 GDSC1 7.0106 13.9766 1.2418 11.7509
HDLM-2 GDSC1 7.2304 15.9816 0.4401 15.422
P30/OHK GDSC1 7.5913 16.2114 0.5648 14.022
⏷ Show the Full List of 143 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 7.524 14.5058 1.3123 10.2809
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 5.9232 9.9062 2.4541 6.6404
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1 5.0872 7.1048 3.2328 3.0642
SJNB-7 GDSC1 5.2757 7.8976 2.9838 4.3963
SJNB-14 GDSC1 5.4707 7.6428 3.209 2.5159
TGW GDSC1 5.4758 7.1075 3.436 1.1923
SK-N-DZ GDSC1 5.5228 7.0151 3.4941 0.857
KP-N-YS GDSC1 5.5303 7.6139 3.2527 2.1522
SiMa GDSC1 5.6105 9.0592 2.6533 5.9671
IMR-5 GDSC1 5.9192 7.5686 3.4511 0.7009
NH-12 GDSC1 5.9478 8.0969 3.2575 1.5638
GOTO GDSC1 5.9702 8.0674 3.2797 1.4255
SK-N-FI GDSC1 6.0258 7.6323 3.4707 0.555
Kelly GDSC1 6.0566 7.434 3.5538 0.2892
CHP-126 GDSC1 6.1518 7.856 3.4386 0.5867
NB(TU)1 GDSC1 6.1664 7.6686 3.5119 0.352
GI-ME-N GDSC1 6.1687 11.6262 1.8073 10.3223
SK-N-BE(2)-M17 GDSC1 6.2481 7.9716 3.4343 0.5429
SJNB-17 GDSC1 6.2694 8.5726 3.2149 1.4228
NB69 GDSC1 6.2999 8.2979 3.3342 0.8717
LA-N-6 GDSC1 6.4385 8.1263 3.4517 0.3933
KP-N-YN GDSC1 6.4653 8.3022 3.3989 0.5336
MHH-NB-11 GDSC1 6.5654 8.1468 3.491 0.2512
SJNB-10 GDSC1 6.6279 8.4885 3.3942 0.4649
SJNB-6 GDSC1 6.6288 8.2247 3.4869 0.2401
SJNB-13 GDSC1 6.7553 8.481 3.4439 0.2897
SJNB-5 GDSC1 6.7964 8.3998 3.4863 0.1955
SJNB-12 GDSC1 8.0553 17.6293 0.1957 14.7824
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES6 GDSC1 4.1356 5.6414 3.2894 5.1326
NOS-1 [Human HNSCC] GDSC1 4.3824 7.1389 2.7367 8.6416
SJSA-1 GDSC1 4.5666 6.5907 3.1411 4.9754
ES8 GDSC1 4.672 6.2505 3.3733 2.9728
ES1 GDSC1 5.0178 7.2815 3.11 4.0744
ES4 GDSC1 5.1789 7.3402 3.18 3.2403
EW-13 GDSC1 5.5659 7.8767 3.1586 2.6732
SK-PN-DW GDSC1 5.6058 8.4906 2.9097 4.2232
EW-24 GDSC1 5.8065 7.4931 3.4323 0.8712
EW-1 GDSC1 6.1471 8.2613 3.2827 1.2264
EW-3 GDSC1 6.1599 8.5196 3.186 1.6853
SK-ES-1 GDSC1 6.2513 7.8025 3.4962 0.3565
EW-12 GDSC1 6.3744 8.2902 3.3675 0.6931
TC-71 GDSC1 6.4127 7.7899 3.5589 0.1651
EW-18 GDSC1 6.5137 8.7217 3.2631 0.9893
H-EMC-SS GDSC1 6.8504 9.0307 3.2845 0.6821
EW-11 GDSC1 7.0285 9.2085 3.2891 0.5723
EW-16 GDSC1 7.2497 9.0874 3.4117 0.2126
ES7 GDSC1 7.2841 9.5559 3.262 0.5282
ES5 GDSC1 7.3263 10.1842 3.049 1.2112
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC1 3.5182 4.5437 3.2672 7.7995
MRK-nu-1 GDSC1 5.2229 8.0489 2.8813 5.2406
HCC2218 GDSC1 5.3053 10.4371 1.7937 12.6654
HCC1599 GDSC1 5.3332 9.2541 2.3837 8.5314
HCC2157 GDSC1 5.5238 8.0938 3.0402 3.5108
HCC1187 GDSC1 5.5352 7.4994 3.3035 1.8452
BT-474 GDSC1 5.6767 7.4186 3.4041 1.1286
DU4475 GDSC1 5.7133 6.9284 3.6043 0.3052
CAL-148 GDSC1 5.8908 7.4186 3.4955 0.5549
UACC-812 GDSC1 6.1235 7.9981 3.374 0.8501
OCUB-M GDSC1 6.1323 8.0306 3.3653 0.8784
MFM-223 GDSC1 6.1336 7.7365 3.475 0.4767
COLO 824 GDSC1 6.6379 9.4881 3.0186 1.9899
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Onda 10 GDSC1 3.0924 5.3841 2.4577 15.8923
8-MG-BA GDSC1 3.1484 4.7663 2.7891 13.1615
D-247MG GDSC1 3.7701 5.6616 2.9706 8.99
Onda 11 GDSC1 3.8737 5.3863 3.199 6.7898
D-542MG GDSC1 4.0711 5.6627 3.2271 5.843
GI-1 GDSC1 4.1799 9.0295 1.6336 17.3522
D-502MG GDSC1 4.4435 6.9884 2.8574 7.5169
SF268 GDSC1 4.5263 6.1993 3.302 3.8651
D-392MG GDSC1 4.5421 7.581 2.6388 8.8891
Becker GDSC1 4.593 6.4266 3.2382 4.169
KALS-1 GDSC1 5.1012 14.1518 -0.1899 23.9035
D-336MG GDSC1 5.3583 8.1114 2.9357 4.554
KS-1 [Human Krukenberg tumour] GDSC1 5.375 11.5225 1.314 15.4879
SNB-75 GDSC1 5.5093 8.5907 2.8072 5.122
NMC-G1 GDSC1 5.5855 6.8639 3.5779 0.4617
U-87MG ATCC GDSC1 5.7554 7.1516 3.5398 0.4864
ONS-76 GDSC1 5.7999 7.3298 3.4916 0.6325
D283 Med GDSC1 5.9664 7.4033 3.5307 0.3946
CAS-1 GDSC1 6.0272 15.7244 -0.2705 21.5978
KNS-42 GDSC1 6.0408 9.1216 2.8734 3.6615
KINGS-1 GDSC1 6.0594 8.1208 3.2989 1.2378
SF126 GDSC1 6.1388 7.5863 3.5307 0.3143
D-263MG GDSC1 6.3489 7.886 3.503 0.2992
KNS-81-FD GDSC1 6.7879 8.6396 3.4006 0.3785
AM-38 GDSC1 6.9271 8.6007 3.4639 0.2019
SF539 GDSC1 7.606 20.1545 -1.3053 21.6543
GB-1 GDSC1 7.7571 17.9217 -0.1339 16.8589
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 5.5868 7.1778 3.4587 0.9589
ETK-1 GDSC1 6.5277 8.3227 3.4154 0.4526
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 5.4817 7.4847 3.2825 2.0473
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OS-RC-2 GDSC1 2.7214 4.4875 2.4466 17.8436
RCC10RGB GDSC1 3.8957 5.0753 3.3731 5.3348
LB2241-RCC GDSC1 4.1285 5.6957 3.2567 5.4132
BB65-RCC GDSC1 4.7994 6.5377 3.3193 3.0702
LB996-RCC GDSC1 4.9589 7.3818 3.0258 4.8211
RXF 393L GDSC1 5.0571 7.8133 2.8859 5.6031
LB1047-RCC GDSC1 5.4462 8.4902 2.8151 5.205
A-498 GDSC1 5.7131 6.976 3.5872 0.3559
HA7-RCC GDSC1 6.2159 8.4679 3.2322 1.395
TK-10 GDSC1 6.6207 8.7385 3.3006 0.7693
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320HSR GDSC1 4.0973 5.8948 3.1324 6.4975
LS513 GDSC1 4.2256 6.2861 3.0391 6.7978
LS411N GDSC1 4.6461 5.9308 3.5051 2.0911
RKO GDSC1 5.0157 6.6466 3.3966 2.1039
LS1034 GDSC1 5.2325 7.3543 3.2045 2.9705
KM12 GDSC1 5.4966 16.0295 -0.8176 25.1658
LS123 GDSC1 5.8698 7.6686 3.3919 0.9927
CW-2 GDSC1 5.9582 7.9771 3.3102 1.288
MDST8 GDSC1 6.0709 7.268 3.6163 0.1505
NCI-H747 GDSC1 6.0711 8.2224 3.264 1.3932
C2BBe1 GDSC1 6.2719 8.6173 3.1984 1.4998
SNU-C1 GDSC1 6.421 8.1531 3.4355 0.4466
CL-11 GDSC1 6.6137 8.496 3.3862 0.495
NCI-H716 GDSC1 6.6822 8.5263 3.4012 0.4209
HCC2998 GDSC1 6.8885 8.6233 3.4426 0.2511
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 6.5388 8.1346 3.4856 0.2713
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1975 GDSC1 4.3711 6.2301 3.1771 5.2631
NCI-H1355 GDSC1 4.5895 8.0165 2.4593 10.0968
Ms-1 GDSC1 4.7226 6.8436 3.126 4.6719
LXF 289 GDSC1 4.8543 7.4597 2.9199 5.8677
NCI-H1770 GDSC1 4.9057 6.9488 3.1947 3.7223
NCI-H1694 GDSC1 4.9312 6.6732 3.3366 2.6681
NCI-H82 GDSC1 4.9582 7.4051 3.0144 4.9065
Calu-6 GDSC1 5.062 6.8864 3.3163 2.5485
NCI-H345 GDSC1 5.0638 5.7718 3.7708 0.1456
Lu-139 GDSC1 5.1243 7.719 2.9731 4.8114
NCI-H211 GDSC1 5.3115 8.8158 2.5777 7.2037
NCI-H1581 GDSC1 5.3129 7.1625 3.3324 2.0076
SHP-77 GDSC1 5.3701 12.1784 0.9889 17.3849
IST-SL1 GDSC1 5.4588 7.7827 3.1415 2.9668
NCI-H2171 GDSC1 5.4689 6.9609 3.4914 0.9236
NCI-H69 GDSC1 5.4789 9.3394 2.4392 7.7711
DMS 79 GDSC1 5.5126 10.9 1.7148 12.5992
COR-L88 GDSC1 5.5648 9.2877 2.5186 7.0082
IST-SL2 GDSC1 5.5657 10.1619 2.106 9.8596
NCI-H226 GDSC1 5.6554 6.908 3.5894 0.3803
NCI-H1648 GDSC1 5.6771 10.282 2.1227 9.4621
NCI-H2196 GDSC1 5.7223 7.394 3.4341 0.9406
NCI-H209 GDSC1 5.7474 7.8477 3.2635 1.7804
NCI-H526 GDSC1 5.818 7.168 3.5584 0.3884
COR-L95 GDSC1 5.8715 10.2307 2.2719 7.984
Lu-165 GDSC1 5.8977 7.3011 3.5411 0.399
NCI-H720 GDSC1 5.9178 7.0143 3.6488 0.1322
NCI-H187 GDSC1 5.9483 7.0962 3.6316 0.155
DMS 114 GDSC1 5.9628 7.8238 3.3722 0.9949
NCI-H128 GDSC1 5.9654 8.5435 3.0816 2.5151
NCI-H847 GDSC1 5.9866 7.4075 3.5369 0.3661
NCI-H1836 GDSC1 6.0803 7.9959 3.3565 0.9589
NCI-H2141 GDSC1 6.0823 7.728 3.458 0.5634
NCI-H64 GDSC1 6.1518 7.2702 3.6435 0.0921
NCI-H2081 GDSC1 6.1701 8.0304 3.3811 0.7858
COLO 668 GDSC1 6.1824 7.87 3.4455 0.5445
NCI-H2227 GDSC1 6.1988 8.0317 3.3924 0.7216
NCI-H510A GDSC1 6.2054 7.8647 3.4565 0.4956
NCI-H1304 GDSC1 6.2156 7.4573 3.6027 0.1387
NCI-H1666 GDSC1 6.2516 8.3869 3.2796 1.1417
LC-2/ad GDSC1 6.2649 8.1418 3.3783 0.7279
NCI-H1155 GDSC1 6.2892 7.7052 3.5441 0.2277
NCI-H1838 GDSC1 6.2913 7.9389 3.4628 0.4313
SBC-1 GDSC1 6.306 8.0598 3.4248 0.5401
NCI-H1092 GDSC1 6.3596 7.9676 3.4783 0.3568
NCI-H524 GDSC1 6.4157 8.3256 3.3709 0.6544
NCI-H1436 GDSC1 6.4635 8.0091 3.5019 0.2611
NCI-H748 GDSC1 6.4796 8.4049 3.3671 0.6281
CPC-N GDSC1 6.5071 21.1115 -2.5668 27.8397
NCI-H2135 GDSC1 6.5139 8.0516 3.5053 0.2377
NCI-H1963 GDSC1 6.5734 8.9223 3.2119 1.1517
NCI-H322M GDSC1 6.5776 9.9422 2.8026 3.2423
NCI-H1869 GDSC1 6.65 8.2669 3.4799 0.2477
LB647-SCLC GDSC1 6.7595 19.4893 -1.5826 24.4796
HOP-62 GDSC1 6.7753 8.6155 3.4044 0.374
Lu-65 GDSC1 6.8034 8.8732 3.3233 0.5857
NCI-H1876 GDSC1 6.8186 8.6375 3.4126 0.338
NCI-H23 GDSC1 6.9801 8.7448 3.4335 0.2427
NCI-H1650 GDSC1 6.9913 8.591 3.4894 0.1483
HCC33 GDSC1 7.0016 14.6477 0.9216 13.5118
EKVX GDSC1 7.0492 10.5183 2.7951 2.6537
Lu-134-A GDSC1 7.3726 9.6805 3.251 0.5187
NCI-H446 GDSC1 8.9131 20.5114 -0.6086 16.4492
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 5.3294 13.2379 0.4368 20.3912
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-9 GDSC1 4.5204 6.2749 3.2616 4.1871
TE-6 GDSC1 6.2282 7.9734 3.4258 0.583
TE-1 GDSC1 6.3274 14.5354 0.5232 17.1975
TE-10 GDSC1 6.4201 8.094 3.4562 0.3893
EC-GI-10 GDSC1 6.6054 8.3972 3.4182 0.4092
TE-5 GDSC1 6.6455 8.1434 3.5205 0.1741
TE-15 GDSC1 6.6531 8.8711 3.2645 0.8793
TE-8 GDSC1 7.2872 9.4088 3.3148 0.3945
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 GDSC1 4.4758 6.8446 2.9521 6.6878
ES-2 GDSC1 4.538 6.703 3.0664 5.6259
Kuramochi GDSC1 7.2565 9.2467 3.3598 0.3066
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 5.1868 7.7518 2.9967 4.5006
PSN1 GDSC1 6.8287 8.3502 3.5142 0.1444
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 4.2956 6.2559 3.1079 6.0342
MSTO-211H GDSC1 5.4301 8.6477 2.7323 5.8217
IST-Mes1 GDSC1 5.4385 14.0541 0.1157 21.5759
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 6.2411 9.6924 2.7332 4.196
VCaP GDSC1 6.2562 8.0041 3.4256 0.5667
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.0435 7.9118 3.3731 0.9198
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-388 GDSC1 4.1306 5.941 3.1361 6.3542
LB2518-MEL GDSC1 4.1393 5.1577 3.5327 3.2106
COLO 829 GDSC1 4.2977 8.6493 1.9185 14.997
DJM-1 GDSC1 4.3201 8.5307 1.9955 14.3772
LOX-IMVI GDSC1 4.6495 8.2598 2.3842 10.4695
HT-144 GDSC1 4.6777 6.7568 3.1373 4.7041
MZ-MEL-7 GDSC1 4.7344 7.6461 2.7469 7.4965
SH-4 GDSC1 4.9366 6.6658 3.343 2.6129
SK-MEL-2 GDSC1 5.0518 10.0739 1.7888 13.4402
MZ-MEL-2 GDSC1 5.1871 7.1612 3.2647 2.6555
SK-MEL-1 GDSC1 5.203 6.944 3.3684 1.9621
LB373-MEL-D GDSC1 5.4192 8.3318 2.8715 4.8702
A101D GDSC1 5.4351 6.7955 3.541 0.7271
IST-MEL1 GDSC1 5.4918 7.7018 3.1947 2.5701
CP66-MEL GDSC1 5.5191 6.8584 3.5528 0.6056
GAK GDSC1 5.8905 7.3443 3.5227 0.4618
MMAc-SF GDSC1 6.0201 7.3161 3.5816 0.2362
UACC-257 GDSC1 6.2911 7.6842 3.5521 0.2107
COLO 800 GDSC1 6.3351 7.9459 3.4768 0.3714
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.2434 5.4742 3.4546 3.4964
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC1 5.2916 6.9064 3.4298 1.4619
SK-UT-1 GDSC1 5.296 6.9382 3.4187 1.519
SW684 GDSC1 5.8568 7.064 3.6099 0.2301
VA-ES-BJ GDSC1 5.8575 7.5721 3.4238 0.863
SW872 GDSC1 6.2091 7.8486 3.4637 0.4709
EW-8 GDSC1 6.407 7.8973 3.5202 0.2404
SK-LMS-1 GDSC1 6.6495 8.4826 3.4045 0.4267
MFH-ino GDSC1 6.6844 8.3943 3.4483 0.3042
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GCIY GDSC1 4.7499 7.0608 3.0405 5.2405
SNU-1 GDSC1 5.1491 7.601 3.0432 4.2553
SNU-16 GDSC1 5.186 7.4423 3.138 3.5139
HSC-39 GDSC1 5.5591 7.286 3.4029 1.2663
SCH GDSC1 5.8175 7.0048 3.6162 0.2298
ECC12 GDSC1 5.8682 7.2185 3.5595 0.3589
RF-48 GDSC1 5.8976 7.9972 3.2742 1.5361
SNU-5 GDSC1 5.8984 7.0015 3.6463 0.1414
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 6.2432 7.693 3.5317 0.2708
K5 GDSC1 6.8418 8.3054 3.5336 0.1161
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 4.1521 6.0631 3.0923 6.6255
LB771-HNC GDSC1 5.2741 8.2344 2.827 5.5092
SCC-15 GDSC1 6.9703 15.9317 0.2911 16.7324
BB49-HNC GDSC1 6.977 8.6847 3.4529 0.2086
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1 4.5304 6.4853 3.1668 4.8797
NCC-IT GDSC1 4.6192 6.7373 3.1067 5.0922
JAR GDSC1 4.6447 6.1433 3.4062 2.7985
NT2-D1 GDSC1 4.7354 7.4187 2.8579 6.6549
SW962 GDSC1 5.9258 8.2295 3.1929 1.9365
SW954 GDSC1 6.3062 8.1499 3.3919 0.651
LB831-BLC GDSC1 6.6907 8.8829 3.2754 0.8132
KGN GDSC1 6.8222 9.0441 3.2685 0.7527
DSH1 GDSC1 6.9229 8.6577 3.4431 0.2405
OMC-1 [Human cervical carcinoma] GDSC1 7.0139 8.7478 3.4444 0.2141
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

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