Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEYR4K)

• Drug Name: BMS-906024 Drug Info
• Synonyms: 1401066-79-2; UNII-DRL23N424R; BMS 906024; DRL23N424R; (2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; SCHEMBL12543868; DTXSID30161234; CHEBI:131164; ZINC100285156; SB16893; DB12006; KB-145938; Z-3229; BMS-906024, > Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2R,3S)-
• Cross-matching ID:
  PubChem CID: 66550890
  ChEBI ID: CHEMBL131164
  CAS Number: CAS 1401066-79-2
  TTD Drug ID: D0O3CX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Biosynthesis of unsaturated fatty acids	2.01	1.90e-2	21/27 (77.78%)	FADS2;ELOVL6;FADS1;...
Pathogenic Escherichia coli infection	1.91	2.37e-2	152/197 (77.16%)	TUBB2A;CXCL8;CYCS;...
Proximal tubule bicarbonate reclamation	-1.94	2.09e-2	21/23 (91.3%)	ATP1A1;MDH1;ATP1B3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.5uM	6H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.5uM	6H	Hide ▲

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.5uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.5uM	6H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.5uM	6H	Show ▼