Details of the Drug

General Information of Drug (ID: DMEYR4K)

Drug Name
BMS-906024
Synonyms
1401066-79-2; UNII-DRL23N424R; BMS 906024; DRL23N424R; (2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; SCHEMBL12543868; DTXSID30161234; CHEBI:131164; ZINC100285156; SB16893; DB12006; KB-145938; Z-3229; BMS-906024, > Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2R,3S)-
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Lymphoma 2A80-2A86 Phase 1 [2]
T-cell acute lymphocytic leukaemia 2B33.4 Phase 1 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C26H26F6N4O3
Canonical SMILES
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
InChI
InChI=1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1
InChIKey
AYOUDDAETNMCBW-GSHUGGBRSA-N
Cross-matching ID
PubChem CID
66550890
ChEBI ID
CHEMBL131164
CAS Number
1401066-79-2
UNII
DRL23N424R
DrugBank ID
DB12006
TTD ID
D0O3CX
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References

1 ClinicalTrials.gov (NCT03691207) A Study Of AL101 In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations (ACCURACY). U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT01292655) Study to Evaluate the Safety and Tolerability of IV Doses of BMS-906024 in Subjects With Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.