Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMF3MV1)

• Drug Name: GDC-0980/RG7422 Drug Info
• Synonyms: Apitolisib; 1032754-93-0; GDC-0980; GDC0980; RG7422; (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one; UNII-1C854K1MIJ; GDC-0980 (RG7422); Apitolisib (GDC-0980, RG7422); 1C854K1MIJ; CHEMBL1922094; RG-7422; (2s)-1-(4-{[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)thieno[3,2-D]pyrimidin-6-Yl]methyl}piperazin-1-Yl)-2-Hydroxypropan-1-One; J-502360; C23H30N8O3S
• Cross-matching ID:
  PubChem CID: 25254071
  ChEBI ID: CHEMBL1922094
  CAS Number: CAS 1032754-93-0
  TTD Drug ID: D0O6VZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
ECM-receptor interaction	1.97	0.00e+0	80/88 (90.91%)	SPP1;ITGB5;THBS2;...
Antigen processing and presentation	-1.63	4.80e-2	60/78 (76.92%)	TAP1;LGMN;CALR;...
Glycine, serine and threonine metabolism	-1.64	4.92e-2	31/40 (77.5%)	CTH;BPGM;CBS;...
Glutathione metabolism	-1.73	2.39e-2	43/57 (75.44%)	RRM1;GSR;GPX2;...
Spliceosome	-1.77	1.52e-2	101/150 (67.33%)	SNRPB2;SNRNP70;SMNDC1;...
Mismatch repair	-1.78	1.46e-2	22/23 (95.65%)	POLD3;MLH1;RPA3;...
Huntington disease	-1.79	1.40e-2	233/306 (76.14%)	CLTB;TFAM;COX6A1;...
Citrate cycle (TCA cycle)	-1.82	1.06e-2	30/30 (100%)	OGDH;DLAT;ACO1;...
Fructose and mannose metabolism	-1.84	7.58e-3	30/33 (90.91%)	PFKFB4;HKDC1;KHK;...
Arginine and proline metabolism	-1.86	3.08e-3	39/50 (78%)	AOC1;LAP3;PYCR3;...
Spinocerebellar ataxia	-1.89	3.36e-3	128/143 (89.51%)	PSMA2;PSMD8;PSMA1;...
Legionellosis	-1.94	1.23e-3	51/57 (89.47%)	CD14;RAB1B;CXCL1;...
DNA replication	-1.95	1.37e-3	34/36 (94.44%)	PRIM1;RPA1;RNASEH2A;...
Parkinson disease	-1.95	1.54e-3	176/249 (70.68%)	DUSP1;COX6A1;NDUFB6;...
Folate biosynthesis	-2.01	1.76e-3	23/26 (88.46%)	AKR1C3;AKR1B1;QDPR;...
Ribosome biogenesis in eukaryotes	-2.04	2.05e-3	52/108 (48.15%)	GAR1;RIOK2;IMP3;...
Amyotrophic lateral sclerosis	-2.04	2.46e-3	267/364 (73.35%)	COX6A1;TOMM40;NDUFB6;...
Prion disease	-2.07	3.08e-3	209/273 (76.56%)	COX6A1;NDUFB6;C7;...
Protein processing in endoplasmic reticulum	-2.10	4.10e-3	127/171 (74.27%)	EDEM1;SEC24C;MAPK10;...
Steroid biosynthesis	-2.11	6.16e-3	19/20 (95%)	CYP51A1;SQLE;FDFT1;...
Proteasome	-2.70	0.00e+0	44/46 (95.65%)	PSMA3;PSMA7;PSMA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.04uM - 10uM	3H, 24H	Hide ▲
SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 24H	Show ▼

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 24H	Show ▼
Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼