Details of the Drug

General Information of Drug (ID: DMF3MV1)

Drug Name
GDC-0980/RG7422
Synonyms
Apitolisib; 1032754-93-0; GDC-0980; GDC0980; RG7422; (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one; UNII-1C854K1MIJ; GDC-0980 (RG7422); Apitolisib (GDC-0980, RG7422); 1C854K1MIJ; CHEMBL1922094; RG-7422; (2s)-1-(4-{[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)thieno[3,2-D]pyrimidin-6-Yl]methyl}piperazin-1-Yl)-2-Hydroxypropan-1-One; J-502360; C23H30N8O3S
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 498.6
Logarithm of the Partition Coefficient (xlogp) 0.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 11
Chemical Identifiers
Formula
C23H30N8O3S
IUPAC Name
(2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
Canonical SMILES
CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O
InChI
InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
InChIKey
YOVVNQKCSKSHKT-HNNXBMFYSA-N
Cross-matching ID
PubChem CID
25254071
CAS Number
1032754-93-0
UNII
1C854K1MIJ
DrugBank ID
DB12180
TTD ID
D0O6VZ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [3]
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Atos homolog protein A (ATOSA) OTWFM5G0 ATOSA_HUMAN Gene/Protein Processing [5]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Gene/Protein Processing [5]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [5]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [5]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Drug Response [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-hodgkin lymphoma
ICD Disease Classification 2B33.5
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.2135 7.8319 0.6036 34.9331
ES7 GDSC1 -3.3786 1.0557 -3.4656 81.1226
H-EMC-SS GDSC1 -3.1985 2.3506 -3.4434 76.5463
NOS-1 [Human HNSCC] GDSC1 -3.1068 0.3612 -3.1351 82.6104
EW-1 GDSC1 -3.0768 0.0403 -3.0922 83.6513
EW-13 GDSC1 -3.0609 3.7551 -3.5877 72.5058
HuO9 GDSC1 -3.0383 1.2079 -3.1222 79.4579
ES5 GDSC1 -2.96 0.2109 -2.9784 82.5712
SK-ES-1 GDSC1 -2.8522 0.8003 -2.896 80.0764
EW-7 GDSC1 -2.6469 -0.3403 -2.6497 82.954
ES4 GDSC1 -2.6287 -0.1052 -2.6341 82.0753
A-673 GDSC1 -2.3048 0.3497 -2.3148 78.6942
EW-18 GDSC1 -2.2392 0.8742 -2.2665 76.7107
ES1 GDSC1 -2.1695 0.9185 -2.1969 76.1495
HOS GDSC1 -2.0943 4.4696 -2.7212 67.0442
MHH-ES-1 GDSC1 -2.0127 0.5807 -2.0236 76.0311
EW-3 GDSC1 -1.8847 1.3265 -1.9259 73.1458
CHSA8926 GDSC1 -1.8314 4.2231 -2.3666 66.1923
EW-16 GDSC1 -1.8044 1.8223 -1.8832 71.3277
EW-22 GDSC1 -1.7399 1.1104 -1.764 72.6405
SaOS-2 GDSC1 -1.7291 3.2516 -2.0233 67.5358
G-292 clone A141B1 GDSC1 -1.5062 3.348 -1.8015 65.9814
ES8 GDSC1 -1.4016 1.9508 -1.4716 68.1173
U2OS GDSC1 -1.2728 3.646 -1.6134 63.9225
MG-63 GDSC1 -1.1687 5.1771 -1.9238 61.0149
CADO-ES1 GDSC1 -0.9643 2.2089 -1.0368 63.9705
ES6 GDSC1 -0.8137 5.7251 -1.7202 58.2575
SK-PN-DW GDSC1 -0.5506 2.4393 -0.6243 59.7457
TC-71 GDSC1 -0.3764 1.7108 -0.3898 58.4513
HuO-3N1 GDSC1 -0.3163 5.6515 -1.1565 54.9874
CAL-78 GDSC1 -0.0077 6.3007 -1.06 52.4794
CAL-72 GDSC1 0.4061 5.3606 -0.2744 49.2531
SJSA-1 GDSC1 0.5714 5.0955 -0.0058 47.6647
NY GDSC1 0.6838 9.506 -1.6945 47.9173
EW-24 GDSC1 3.211 7.0474 1.9504 22.74
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 1.1222 11.5221 -2.1994 46.0161
A4/Fukuda GDSC1 -4.7647 0.9294 -4.9158 84.5888
SU-DHL-6 GDSC1 -4.7389 -2.4633 -4.7392 96.0303
SIG-M5 GDSC1 -4.3372 0.5843 -4.4291 84.9909
RCH-ACV GDSC1 -4.2847 1.2637 -4.4465 82.7128
NK-92MI GDSC1 -4.2525 5.2191 -5.2951 73.0309
SU-DHL-16 GDSC1 -4.244 -2.1689 -4.2442 94.8336
DoHH2 GDSC1 -4.0718 -1.1384 -4.0768 90.7437
HAL-01 GDSC1 -4.0031 0.3635 -4.0624 85.1031
PL-21 GDSC1 -3.8495 2.8043 -4.2319 77.2842
MY-M12 GDSC1 -3.7452 7.1395 -5.3853 68.5916
RS4;11 GDSC1 -3.6074 4.364 -4.3431 72.9534
SU-DHL-5 GDSC1 -3.4484 -2.0881 -3.4484 93.0682
QIMR-WIL GDSC1 -3.4241 6.2734 -4.7348 68.9476
NU-DUL-1 GDSC1 -3.4178 -1.0112 -3.4197 88.7987
NALM-6 GDSC1 -3.3866 0.052 -3.4091 84.6755
P30/OHK GDSC1 -3.3847 6.861 -4.8969 67.9498
THP-1 GDSC1 -3.36 0.6697 -3.4148 82.3807
Karpas-231 GDSC1 -3.1489 0.8602 -3.2087 81.0216
GDM-1 GDSC1 -3.128 0.8802 -3.1884 80.8789
697 GDSC1 -3.102 0.199 -3.1233 83.173
SUP-B15 GDSC1 -3.0242 1.3538 -3.1216 78.9318
Ku812 GDSC1 -3.0158 -0.5744 -3.0188 85.6444
Ramos.2G6.4C10 GDSC1 -2.8981 -0.5922 -2.9002 85.1602
Reh GDSC1 -2.82 0.6498 -2.8539 80.4477
L-363 GDSC1 -2.7966 1.4245 -2.8889 77.8028
CESS GDSC1 -2.6986 1.2897 -2.7729 77.8045
Karpas-620 GDSC1 -2.5786 -0.4157 -2.5803 82.7837
MOLP-8 GDSC1 -2.5729 0.4002 -2.5894 80.0994
MHH-PREB-1 GDSC1 -2.5618 3.0936 -2.8943 72.1169
ALL-PO GDSC1 -2.5314 2.6498 -2.7761 73.1086
RPMI-8866 GDSC1 -2.4487 5.5101 -3.4227 66.7788
Karpas-45 GDSC1 -2.419 1.3864 -2.4883 76.1623
MC116 GDSC1 -2.3898 -1.0922 -2.3898 83.1071
ML-2 GDSC1 -2.3864 1.9138 -2.5095 74.4428
OCI-Ly19 GDSC1 -2.3504 4.7809 -3.0901 67.6243
LP-1 GDSC1 -2.3383 4.792 -3.0802 67.5527
KE-37 GDSC1 -2.3289 1.5748 -2.411 75.1298
HH [Human lymphoma] GDSC1 -2.3245 7.7134 -4.0748 63.3142
MOLT-16 GDSC1 -2.2391 1.3496 -2.2969 75.2998
OCI-AML-2 GDSC1 -2.2385 2.2714 -2.4 72.7013
PF-382 GDSC1 -2.2103 2.813 -2.4588 71.1659
OPM-2 GDSC1 -2.1923 -0.5808 -2.1926 80.2939
ATN-1 GDSC1 -2.1744 5.6185 -3.1599 65.4691
RPMI-8402 GDSC1 -2.1641 1.9103 -2.2731 73.2821
BV-173 GDSC1 -2.1502 1.3478 -2.2039 74.7875
CA46 GDSC1 -2.1059 4.1309 -2.6417 67.7432
RPMI-8226 GDSC1 -2.0823 4.0867 -2.6044 67.7161
SR GDSC1 -2.0762 1.2915 -2.1227 74.4961
OCI-M1 GDSC1 -1.9936 -0.0241 -1.9951 77.3614
CCRF-CEM GDSC1 -1.8952 1.9808 -1.9963 71.5103
CTB-1 GDSC1 -1.8846 8.2078 -3.8013 61.1265
OCI-AML-5 GDSC1 -1.8755 1.0643 -1.9013 73.7651
WIL2 NS GDSC1 -1.8534 1.9007 -1.943 71.4494
GA-10 GDSC1 -1.8383 2.0951 -1.9494 70.8632
MOLT-4 GDSC1 -1.8365 1.9406 -1.9295 71.2395
TUR GDSC1 -1.7883 0.7359 -1.7995 73.9139
SU-DHL-10 GDSC1 -1.7637 -0.351 -1.7638 75.6713
MOLM-13 GDSC1 -1.755 1.6472 -1.8149 71.429
SKM-1 GDSC1 -1.7091 2.6181 -1.8852 68.8001
HL-60 GDSC1 -1.6346 2.0655 -1.7299 69.5837
BC-1 GDSC1 -1.6043 0.924 -1.6176 71.9653
KMS-12-BM GDSC1 -1.5834 5.6586 -2.5317 62.6566
Farage GDSC1 -1.577 2.9426 -1.7984 67.2504
A3/Kawakami GDSC1 -1.5193 0.7123 -1.5258 71.6244
MV4-11 GDSC1 -1.4501 1.8088 -1.5094 68.7978
P32/ISH GDSC1 -1.4485 2.1699 -1.5447 68.0122
GR-ST GDSC1 -1.4071 3.7272 -1.7785 64.653
EM-2 GDSC1 -1.3583 5.0287 -2.0836 62.3115
BC-3 GDSC1 -1.2986 1.0652 -1.3101 68.9314
TK [Human B-cell lymphoma] GDSC1 -1.2536 5.9638 -2.2789 60.5578
SUP-HD1 GDSC1 -1.207 1.5202 -1.2356 67.3048
SU-DHL-4 GDSC1 -1.2063 0.9792 -1.2139 68.1553
L-1236 GDSC1 -1.2004 5.8551 -2.1835 60.3896
HT GDSC1 -1.1944 3.8417 -1.5742 63.0754
ALL-SIL GDSC1 -1.1943 3.9451 -1.5995 62.9113
Daudi GDSC1 -1.1909 7.5663 -2.8111 58.684
SU-DHL-8 GDSC1 -1.1834 5.1204 -1.9218 61.1739
H9 GDSC1 -1.1682 2.236 -1.2553 65.6817
KCL-22 GDSC1 -1.1043 2.9451 -1.2888 63.916
SK-MM-2 GDSC1 -1.03 9.0289 -3.2423 56.9047
Karpas-422 GDSC1 -1.0241 10.3344 -3.8007 56.1729
ST486 GDSC1 -1.0238 3.2547 -1.2591 62.7917
NB4 GDSC1 -0.9851 2.3012 -1.0688 64.0099
VAL GDSC1 -0.9665 7.3751 -2.4974 57.7211
HC-1 GDSC1 -0.9587 10.6951 -3.8933 55.7411
Jurkat GDSC1 -0.9525 2.2185 -1.0253 63.8499
NOMO-1 GDSC1 -0.9268 6.4832 -2.1136 58.2376
JSC-1 GDSC1 -0.91 3.2934 -1.1435 61.85
MN-60 GDSC1 -0.8544 3.835 -1.202 60.6658
DEL GDSC1 -0.8252 5.8854 -1.7884 58.1796
JJN-3 GDSC1 -0.8053 3.3429 -1.0399 60.941
LAMA-84 GDSC1 -0.7892 4.5415 -1.3175 59.3207
Hs 445 GDSC1 -0.7641 9.529 -3.1814 55.4471
Mono-Mac-6 GDSC1 -0.664 3.3344 -0.885 59.7743
RPMI-6666 GDSC1 -0.5935 7.5245 -2.1617 55.631
JURL-MK1 GDSC1 -0.5678 4.6405 -1.1047 57.6022
BALL-1 GDSC1 -0.5578 5.8766 -1.4965 56.4939
LC4-1 GDSC1 -0.5132 13.6797 -4.8141 53.1286
Loucy GDSC1 -0.4916 3.1397 -0.6621 58.4575
YT GDSC1 -0.4744 5.0229 -1.1194 56.5751
KOPN-8 GDSC1 -0.4319 5.4841 -1.2243 55.9212
KMOE-2 GDSC1 -0.3521 2.662 -0.4401 57.5302
KMS-11 GDSC1 -0.1241 7.4747 -1.6464 52.9044
DND-41 GDSC1 -0.1018 3.7386 -0.36 54.3146
EJM GDSC1 -0.0967 4.7924 -0.6365 53.7401
HEL GDSC1 -0.0895 2.8393 -0.1835 54.6489
NKM-1 GDSC1 -0.0467 8.7262 -2.0934 52.1316
Jiyoye GDSC1 0.0227 4.7278 -0.4867 52.7375
MEG-01 GDSC1 0.0375 4.4132 -0.379 52.7124
EoL-1 GDSC1 0.0556 4.0916 -0.2732 52.6498
K-562 GDSC1 0.126 5.7904 -0.7281 51.5921
SUP-T1 GDSC1 0.1454 9.6152 -2.2882 50.9559
L-428 GDSC1 0.1549 5.7905 -0.697 51.3619
AMO1 GDSC1 0.1677 3.0524 0.0612 51.7525
ROS-50 GDSC1 0.2438 13.0456 -3.7749 50.3225
P12-Ichikawa GDSC1 0.2538 4.737 -0.2376 50.6409
HDLM-2 GDSC1 0.2543 5.9669 -0.6544 50.5463
DB GDSC1 0.2654 5.4064 -0.4424 50.4898
BL-41 GDSC1 0.2953 1.8722 0.2901 50.3303
KY821 GDSC1 0.4016 4.6752 -0.0579 49.2302
KG-1 GDSC1 0.6288 6.276 -0.3706 47.502
U266B1 GDSC1 0.6442 4.611 0.2258 46.7673
Sc-1 GDSC1 0.6665 7.8641 -0.9843 47.6559
EB2 GDSC1 0.7567 6.4685 -0.3102 46.4907
L-540 GDSC1 0.7772 6.4781 -0.2923 46.3212
OCI-AML-3 GDSC1 0.9188 6.0947 0.0086 44.8625
CTV-1 GDSC1 0.9993 6.4303 -0.0381 44.3544
Raji GDSC1 1.089 9.3908 -1.2354 45.3629
SUP-M2 GDSC1 1.2543 6.8414 0.0615 42.3981
MLMA GDSC1 1.2711 7.0845 -0.0238 42.4706
BE-13 GDSC1 1.3298 6.6157 0.2346 41.4847
EHEB GDSC1 1.7822 7.3726 0.3772 38.2078
U-698-M GDSC1 1.868 8.7783 -0.178 39.2846
MOLT-13 GDSC1 1.9726 7.5498 0.491 36.7065
VL51 GDSC1 2.0525 12.819 -1.9398 41.7034
ME1 GDSC1 2.1634 9.1112 -0.045 37.3604
RC-K8 GDSC1 2.1741 7.5741 0.6827 34.8462
Karpas-299 GDSC1 2.392 9.3316 0.0705 35.8505
Granta-519 GDSC1 2.5105 14.3254 -2.2594 40.385
WSU-NHL GDSC1 2.6381 7.2754 1.2827 29.5653
SU-DHL-1 GDSC1 3.0701 7.1575 1.7618 24.6237
P31/FUJ GDSC1 3.1188 8.4931 1.1649 27.7854
SCC-3 GDSC1 3.1259 6.7161 2.0248 22.6554
DG-75 GDSC1 3.4048 9.4238 0.9714 27.4571
IM-9 GDSC1 3.4699 10.2231 0.6344 28.7407
WSU-DLCL2 GDSC1 3.9154 7.3805 2.4419 16.2085
JVM-3 GDSC1 4.2547 8.1938 2.3297 15.6899
ARH-77 GDSC1 4.3312 11.0255 0.9779 23.6863
RL GDSC1 4.6923 14.5081 -0.4659 28.4626
KM-H2 GDSC1 5.1222 12.3359 0.9608 21.028
JVM-2 GDSC1 6.677 16.2721 0.1777 20.2057
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 -2.1607 0.5246 -2.1728 77.2313
KYAE-1 GDSC1 -1.3162 4.4828 -1.8758 62.8556
ESO-26 GDSC1 -1.2644 3.953 -1.678 63.3588
OACM5.1 C GDSC1 -1.1743 4.4883 -1.7225 61.97
KYSE-220 GDSC1 -0.5734 4.5813 -1.0935 57.7002
FLO-1 GDSC1 -0.3538 8.8211 -2.4518 53.7559
SK-GT-4 GDSC1 -0.2253 5.9338 -1.1583 54.184
TE-12 GDSC1 -0.0816 11.7793 -3.5026 51.7872
HCE-4 GDSC1 1.44 11.7779 -2.0147 44.4146
KYSE-50 GDSC1 1.659 10.4134 -1.1524 42.3075
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -2.0004 6.2676 -3.1924 63.7896
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-14 GDSC1 -2.9688 4.1033 -3.576 71.4097
NB1 GDSC1 -2.4623 0.462 -2.4785 79.2933
NB69 GDSC1 -2.2839 3.4139 -2.6612 70.1043
Kelly GDSC1 -2.1348 6.7239 -3.5006 63.7602
NB(TU)1 GDSC1 -2.0227 5.0043 -2.7998 65.7716
SJNB-12 GDSC1 -1.8192 5.7567 -2.8203 63.6704
GOTO GDSC1 -1.5139 4.6002 -2.125 63.8264
CHP-134 GDSC1 -1.1564 4.6203 -1.7408 61.6727
SiMa GDSC1 -1.0859 2.901 -1.2614 63.8486
SK-N-BE(2)-M17 GDSC1 -1.0702 4.7021 -1.6707 61.0171
KP-N-YN GDSC1 -0.6681 7.091 -2.0686 56.3139
KP-N-YS GDSC1 -0.3663 3.9851 -0.7066 56.56
LA-N-6 GDSC1 -0.2961 6.0077 -1.2612 54.6431
NH-12 GDSC1 -0.2447 6.7686 -1.4923 53.9286
GI-ME-N GDSC1 -0.0361 5.9592 -0.9637 52.7938
SJNB-17 GDSC1 -0.0203 7.1421 -1.402 52.3371
SJNB-7 GDSC1 0.0444 3.0567 -0.0717 53.1117
IMR-5 GDSC1 0.0658 5.2379 -0.6018 52.2108
SJNB-5 GDSC1 0.1487 3.9223 -0.1299 51.7809
SK-N-FI GDSC1 0.2092 6.2367 -0.8037 50.8772
MHH-NB-11 GDSC1 0.2815 6.7347 -0.9197 50.2991
SK-N-MC-IXC GDSC1 0.3629 2.6969 0.3129 49.5114
CHP-212 GDSC1 0.6302 5.9474 -0.2438 47.3867
SK-N-DZ GDSC1 0.6305 4.765 0.1642 46.9677
SK-N-SH GDSC1 1.0233 6.4359 -0.0149 44.142
SJNB-10 GDSC1 2.4983 4.4094 2.3072 24.0464
SJNB-13 GDSC1 2.6291 6.3641 1.6888 27.3263
SJNB-6 GDSC1 3.7784 7.2906 2.3634 17.3468
TGW GDSC1 4.545 6.9433 3.1922 8.127
SK-N-AS GDSC1 6.3016 13.3861 1.3149 15.6488
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -1.0593 2.3518 -1.1534 64.5668
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFM-19 GDSC1 -4.8431 6.6819 -6.4114 71.9628
ZR-75-30 GDSC1 -3.67 6.9386 -5.2324 68.6679
UACC-893 GDSC1 -3.4109 0.4532 -3.4537 83.2984
MRK-nu-1 GDSC1 -2.8385 -0.6567 -2.84 85.0807
HCC1187 GDSC1 -2.7605 2.2854 -2.9617 75.0833
MDA-MB-361 GDSC1 -2.7321 -0.0916 -2.7389 82.583
HCC202 GDSC1 -2.7219 7.0303 -4.244 65.5713
HCC1599 GDSC1 -2.6604 0.0941 -2.6699 81.5805
BT-474 GDSC1 -2.4651 0.366 -2.4783 79.6158
MDA-MB-453 GDSC1 -2.3751 -0.5997 -2.3755 81.8794
T-47D GDSC1 -2.3312 12.0052 -5.8752 59.7366
OCUB-M GDSC1 -2.312 -0.7986 -2.3121 81.8145
BT-483 GDSC1 -2.1453 27.7079 -13.1181 54.4952
HCC1954 GDSC1 -2.0363 1.5028 -2.0973 73.6593
Hs 578T GDSC1 -1.9994 3.1377 -2.2932 69.3011
HCC2157 GDSC1 -1.9595 3.2844 -2.2804 68.76
HCC1419 GDSC1 -1.8906 3.9118 -2.3506 67.0919
AU565 GDSC1 -1.8372 1.507 -1.8895 72.3515
DU4475 GDSC1 -1.7647 1.7726 -1.8365 71.1845
Evsa-T GDSC1 -1.5979 1.1871 -1.6214 71.3396
MDA-MB-175-VII GDSC1 -1.5529 5.1256 -2.3256 63.242
HCC1500 GDSC1 -1.473 3.5132 -1.8012 65.4577
CAL-148 GDSC1 -1.3827 1.6227 -1.4243 68.643
HCC70 GDSC1 -1.3329 2.027 -1.4069 67.4191
MDA-MB-468 GDSC1 -1.2203 2.0375 -1.2892 66.4806
MDA-MB-330 GDSC1 -1.2189 2.6972 -1.3713 65.2329
EFM-192A GDSC1 -1.1683 5.0964 -1.8978 61.1145
COLO 824 GDSC1 -1.0579 2.9106 -1.2329 63.6137
CAMA-1 GDSC1 -1.0204 2.2363 -1.099 64.4242
MDA-MB-415 GDSC1 -0.9926 4.236 -1.4547 61.1224
HCC1569 GDSC1 -0.9906 4.6994 -1.5831 60.5053
MFM-223 GDSC1 -0.8834 1.2858 -0.8935 64.4226
CAL-120 GDSC1 -0.6217 6.7732 -1.8962 56.2568
YMB-1-E GDSC1 -0.2656 6.6794 -1.4801 54.104
HDQ-P1 GDSC1 -0.1669 6.1072 -1.1587 53.6891
BT-549 GDSC1 0.0197 5.8405 -0.8608 52.4093
MDA-MB-436 GDSC1 0.1104 7.0826 -1.24 51.4759
MCF-7 GDSC1 0.2152 5.519 -0.5356 50.9063
BT-20 GDSC1 0.3323 6.6351 -0.8265 49.922
HCC38 GDSC1 0.5282 4.4836 0.1364 47.9272
HCC2218 GDSC1 0.5425 18.6997 -6.217 49.3455
HCC1428 GDSC1 0.7042 6.5724 -0.4073 46.9717
CAL-51 GDSC1 0.7156 22.8307 -8.0864 49.0349
CAL-85-1 GDSC1 1.214 11.2942 -2.0021 45.4368
HCC1806 GDSC1 1.2428 6.9644 -0.0023 42.6116
HCC1937 GDSC1 1.5053 7.7994 -0.0948 41.1573
UACC-812 GDSC1 2.1854 21.1961 -5.9557 44.7289
MDA-MB-157 GDSC1 2.4069 8.3809 0.5375 34.1469
MDA-MB-231 GDSC1 2.4871 11.1852 -0.7374 37.6233
HCC1395 GDSC1 3.0994 9.9353 0.4411 31.1714
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1 -2.0362 5.1007 -2.8442 65.6754
PFSK-1 GDSC1 -1.9324 4.4812 -2.5478 66.2395
YH-13 GDSC1 -1.6322 2.3989 -1.7699 68.7999
GI-1 GDSC1 -1.1598 2.368 -1.2621 65.3727
AM-38 GDSC1 -0.8489 3.8311 -1.195 60.6291
GaMG GDSC1 -0.6382 4.9084 -1.2621 57.8639
MOG-G-CCM GDSC1 -0.6328 4.413 -1.1105 58.3152
GB-1 GDSC1 -0.4584 4.523 -0.9513 56.8675
D-336MG GDSC1 -0.3673 3.1237 -0.5253 57.2975
DK-MG GDSC1 -0.328 6.2358 -1.3792 54.7375
YKG-1 GDSC1 -0.3063 3.1103 -0.4572 56.7141
D-542MG GDSC1 -0.2864 4.868 -0.8663 55.2497
KS-1 [Human Krukenberg tumour] GDSC1 -0.2171 3.1887 -0.3747 55.7742
D-263MG GDSC1 -0.2107 3.9737 -0.534 55.1922
CAS-1 GDSC1 -0.15 9.9794 -2.7513 52.408
U-118MG GDSC1 -0.1175 6.1694 -1.1286 53.3123
SNB-75 GDSC1 -0.0972 5.0933 -0.7315 53.6065
D-247MG GDSC1 0.0584 3.4353 -0.1223 52.8376
SW1088 GDSC1 0.1664 5.5454 -0.5977 51.3091
D-423MG GDSC1 0.3512 5.8828 -0.5194 49.7584
LN-405 GDSC1 0.5163 6.943 -0.7551 48.5572
H4 GDSC1 0.554 6.0325 -0.3574 48.0709
8-MG-BA GDSC1 0.5745 4.3727 0.2183 47.4126
Daoy GDSC1 0.5859 7.3936 -0.8682 48.1245
MOG-G-UVW GDSC1 0.6127 5.7172 -0.1775 47.4692
LN-229 GDSC1 0.7164 5.8073 -0.0991 46.5628
SW1783 GDSC1 0.8989 6.2354 -0.0674 45.1304
Hs 683 GDSC1 0.9285 5.5605 0.2194 44.4123
KINGS-1 GDSC1 0.9326 7.5712 -0.5829 45.5849
D-566MG GDSC1 0.957 5.4026 0.3067 44.0135
42-MG-BA GDSC1 0.969 6.2212 0.0127 44.4853
SF539 GDSC1 1.0192 5.7317 0.2538 43.6486
NMC-G1 GDSC1 1.0451 5.5995 0.3305 43.2831
ONS-76 GDSC1 1.0665 5.3736 0.4351 42.869
M059J GDSC1 1.095 7.2917 -0.2949 44.1268
LN-18 GDSC1 1.1424 6.9319 -0.0934 43.4624
SF126 GDSC1 1.1649 6.2623 0.2044 42.6931
D-502MG GDSC1 1.2289 6.1954 0.2988 42.0176
Becker GDSC1 1.3233 8.5546 -0.6187 43.246
SF295 GDSC1 1.403 4.9665 0.9397 38.7232
D-392MG GDSC1 1.4195 6.4295 0.4055 40.4216
Onda 11 GDSC1 1.5147 6.6189 0.4268 39.728
U-251MG GDSC1 1.6349 7.2738 0.2701 39.4272
KALS-1 GDSC1 1.6958 6.6463 0.604 37.9884
KNS-81-FD GDSC1 1.7735 9.5046 -0.6111 40.7665
LNZTA3WT4 GDSC1 1.8181 7.4154 0.3947 37.937
U-87MG ATCC GDSC1 1.9711 10.1408 -0.7211 39.9945
DBTRG-05MG GDSC1 2.1665 8.6614 0.1704 36.6945
SF268 GDSC1 2.5011 9.967 -0.1318 35.9404
SK-MG-1 GDSC1 2.5197 9.6938 0.018 35.3899
A-172 GDSC1 3.5564 13.7004 -1.0196 34.0464
Onda 10 GDSC1 3.8427 10.2806 0.9344 25.7947
KNS-42 GDSC1 4.118 10.1546 1.234 23.1478
T98G GDSC1 4.6912 14.346 -0.3858 28.1899
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -1.0285 1.152 -1.0375 66.1056
TGBC24TKB GDSC1 -0.548 2.381 -0.6153 59.7792
TGBC1TKB GDSC1 1.7474 5.5402 1.1059 35.6502
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 -2.4472 0.4663 -2.4632 79.194
MFE-280 GDSC1 -2.067 4.5812 -2.723 66.7119
EN GDSC1 -1.2538 3.1758 -1.4928 64.6144
RL95-2 GDSC1 -0.7117 3.9411 -1.0722 59.4396
MFE-319 GDSC1 -0.3562 2.0637 -0.3872 58.0134
MFE-296 GDSC1 -0.0659 6.3594 -1.1445 52.8773
ESS-1 GDSC1 0.5228 7.2553 -0.8765 48.5602
KLE GDSC1 1.6191 12.0795 -1.9887 43.5961
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC021 GDSC1 -1.4935 4.815 -2.1658 63.3805
KTCTL-140 GDSC1 -1.4346 2.8183 -1.6229 66.559
769-P GDSC1 -1.2273 2.8957 -1.4128 64.9306
CAL-54 GDSC1 -1.1394 3.2195 -1.3774 63.7137
KTCTL-21 GDSC1 -0.9185 4.8976 -1.5641 59.7932
KTCTL-26A GDSC1 -0.9084 4.3455 -1.3925 60.3953
HA7-RCC GDSC1 -0.8958 4.0542 -1.3015 60.6822
ACHN GDSC1 -0.814 4.7625 -1.4093 59.2451
KTCTL-13 GDSC1 -0.5935 6.9089 -1.9184 56.0025
LB2241-RCC GDSC1 -0.5302 4.0061 -0.8906 57.9197
TK-10 GDSC1 -0.5155 3.8847 -0.8446 57.9179
VMRC-RCZ GDSC1 -0.4469 6.1783 -1.4857 55.5595
KTCTL-195 GDSC1 -0.4258 5.5077 -1.2257 55.8614
LB1047-RCC GDSC1 -0.1974 5.4087 -0.9445 54.243
KTCTL-1M GDSC1 -0.1548 7.1719 -1.5562 53.1955
SN12C GDSC1 -0.0808 9.6096 -2.5161 52.1373
LB996-RCC GDSC1 -0.039 4.538 -0.498 53.3541
UO-31 GDSC1 0.0411 8.1543 -1.7571 51.7344
SW13 GDSC1 0.044 5.7917 -0.817 52.2353
786-O GDSC1 0.0892 4.1158 -0.2427 52.3182
Caki-1 GDSC1 0.3376 8.2249 -1.4799 49.9007
OS-RC-2 GDSC1 0.5265 7.8403 -1.1192 48.6256
BB65-RCC GDSC1 1.0096 7.4031 -0.4311 44.8898
SW156 GDSC1 1.2349 5.3745 0.6164 41.0944
KMRC-1 GDSC1 1.4995 6.9417 0.2743 40.2659
BFTC-909 GDSC1 2.2636 7.8105 0.6633 34.4254
KMRC-20 GDSC1 2.6677 9.4176 0.2916 33.7492
RCC10RGB GDSC1 3.4274 14.6853 -1.6229 35.943
RXF 393L GDSC1 3.4706 9.5189 0.9838 27.1085
VMRC-RCW GDSC1 4.2799 12.1967 0.3494 26.7879
A-704 GDSC1 4.6885 11.3602 1.1034 21.7473
A-498 GDSC1 5.3098 7.1378 3.6272 2.7684
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 GDSC1 -1.8875 8.1837 -3.7948 61.1607
CCK-81 GDSC1 -1.3892 3.2852 -1.6614 65.3425
LoVo GDSC1 -0.6431 5.2595 -1.3788 57.5732
SW1417 GDSC1 -0.0571 14.4604 -4.738 51.3917
RKO GDSC1 -0.0571 5.4373 -0.8022 53.142
SNU-175 GDSC1 -0.0406 8.4929 -1.9865 52.1458
COLO205 GDSC1 0.1653 6.2035 -0.8381 51.217
SNU-C1 GDSC1 0.2546 9.2301 -2.0054 50.3818
HCT 15 GDSC1 0.4125 5.4815 -0.3093 49.2076
LS513 GDSC1 0.491 5.7934 -0.3362 48.5635
RCM-1 [Human ESC] GDSC1 0.5793 8.8796 -1.5187 48.4405
SNU-407 GDSC1 0.6039 8.4177 -1.2895 48.2041
CaR-1 GDSC1 0.6047 6.8666 -0.6308 47.8607
NCI-H747 GDSC1 0.6227 11.8303 -2.8317 48.5974
HCT 116 GDSC1 0.6433 5.5346 -0.0787 47.1277
LS411N GDSC1 0.6672 5.8807 -0.1792 47.0364
COLO 320HSR GDSC1 0.7711 12.1179 -2.8228 47.9294
C2BBe1 GDSC1 0.786 8.2506 -1.0294 46.9352
SW837 GDSC1 0.8546 6.0272 -0.0339 45.4099
SNU-C2B GDSC1 0.9027 8.1 -0.8436 46.0545
HT-29 GDSC1 0.9779 10.9509 -2.0703 46.6086
GP5d GDSC1 1.1042 9.7463 -1.384 45.4278
SNU-1040 GDSC1 1.2055 7.1818 -0.1333 43.1192
LS180 GDSC1 1.3963 8.9555 -0.7285 43.0089
SNU-C5 GDSC1 1.7351 11.4132 -1.5573 42.5411
KM12 GDSC1 1.7782 7.7186 0.2184 38.7153
HT115 GDSC1 1.807 9.0596 -0.3694 40.0711
SW948 GDSC1 1.8279 8.3647 -0.0261 39.1123
HT-55 GDSC1 1.913 14.985 -3.1297 43.5891
SW1116 GDSC1 1.9538 10.1756 -0.7543 40.1478
SW626 GDSC1 2.9544 10.1232 0.2153 32.6862
CL-11 GDSC1 3.4932 11.4458 0.0478 30.991
T84 GDSC1 3.5387 10.9753 0.3219 29.7622
LS1034 GDSC1 3.5958 10.5025 0.6074 28.3308
HCC2998 GDSC1 3.8245 12.1608 -0.0194 29.9351
LS123 GDSC1 4.2972 10.8594 1.0326 23.5325
SW48 GDSC1 4.5296 14.5625 -0.6264 29.528
SW1463 GDSC1 4.8226 16.3549 -1.2826 30.5701
SW620 GDSC1 4.9518 13.3951 0.2989 24.6866
MDST8 GDSC1 5.2535 13.8091 0.3305 23.5846
CW-2 GDSC1 5.5406 13.0313 0.9364 19.838
SNU-61 GDSC1 5.7073 22.2486 -3.5146 33.1896
COLO 678 GDSC1 6.1128 14.169 0.7994 18.8606
NCI-H716 GDSC1 6.2197 18.6385 -1.3228 26.7936
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.1656 9.8284 -2.6998 52.5172
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-423 GDSC1 -2.6362 1.1479 -2.6957 77.9716
SNU-387 GDSC1 -2.621 1.0071 -2.6695 78.3524
JHH-1 GDSC1 -2.5791 7.4375 -4.2419 64.5546
Huh-7 GDSC1 -2.2397 4.0572 -2.7684 68.52
JHH-4 GDSC1 -1.7969 3.157 -2.0775 68.1317
JHH-2 GDSC1 -1.7927 2.7283 -1.9934 69.0635
Hep 3B2.1-7 GDSC1 -1.538 1.5637 -1.5818 70.0218
SNU-449 GDSC1 -1.2132 3.7657 -1.5765 63.3245
SNU-475 GDSC1 -1.0501 2.3835 -1.1475 64.4354
SNU-398 GDSC1 0.4692 5.1351 -0.1299 48.6457
HLE GDSC1 2.6529 13.2171 -1.5831 38.7198
Hep-G2/C3A GDSC1 3.5171 10.9278 0.3265 29.8328
JHH-6 GDSC1 4.1232 13.2704 -0.3189 29.8948
SK-HEP-1 GDSC1 4.6599 10.8691 1.3256 20.6343
JHH-7 GDSC1 4.9209 11.4191 1.2594 20.1042
HuH-1 GDSC1 6.3936 7.6022 3.9343 0.1573
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1048 GDSC1 -2.8692 -0.4636 -2.8723 84.5647
LCLC-97TM1 GDSC1 -2.8313 5.3125 -3.7759 68.572
NCI-H1876 GDSC1 -2.3196 1.2849 -2.3759 75.9409
NCI-H1648 GDSC1 -2.3115 0.698 -2.3329 77.6782
NCI-H69 GDSC1 -2.2858 4.3817 -2.9057 68.0888
IST-SL2 GDSC1 -1.9397 7.5526 -3.6024 62.004
HCC78 GDSC1 -1.9033 2.5922 -2.0898 70.039
NCI-H1623 GDSC1 -1.87 0.7455 -1.8831 74.5349
NCI-H2803 GDSC1 -1.8651 1.4078 -1.9112 72.799
NCI-H1793 GDSC1 -1.7037 4.3055 -2.2495 65.365
NCI-H2795 GDSC1 -1.5887 1.7362 -1.6484 70.0181
NCI-H64 GDSC1 -1.5736 0.7722 -1.5821 72.0067
NCI-H720 GDSC1 -1.5514 2.2233 -1.6603 68.6403
Calu-3 GDSC1 -1.337 3.769 -1.7121 64.1339
NCI-H1581 GDSC1 -1.3003 4.3831 -1.8306 62.9099
NCI-H1304 GDSC1 -1.2986 5.1628 -2.0606 61.7896
NCI-H661 GDSC1 -1.2766 2.2698 -1.3742 66.4921
Lu-135 GDSC1 -1.2258 2.2781 -1.3213 66.0726
NCI-H1341 GDSC1 -1.2114 4.7741 -1.8461 61.8009
NCI-H847 GDSC1 -1.1202 4.4538 -1.6537 61.673
DMS 114 GDSC1 -1.0841 4.1068 -1.5206 61.9287
COR-L303 GDSC1 -1.0241 2.5484 -1.1411 63.9411
NCI-H526 GDSC1 -0.993 2.7222 -1.1329 63.3995
NCI-H596 GDSC1 -0.9238 4.5974 -1.4804 60.1868
SBC-1 GDSC1 -0.9012 4.2793 -1.3666 60.4291
NCI-H2171 GDSC1 -0.8777 1.3888 -0.891 64.2522
SBC-3 GDSC1 -0.8726 2.307 -0.9503 62.9921
NCI-H2347 GDSC1 -0.8249 5.7854 -1.7532 58.2704
Ms-1 GDSC1 -0.8181 4.4317 -1.3179 59.6534
NCI-H2444 GDSC1 -0.8106 3.3015 -1.0374 61.0404
NCI-H322M GDSC1 -0.804 5.2196 -1.5408 58.6905
NCI-H1792 GDSC1 -0.6925 2.7103 -0.8095 60.7966
RERF-LC-MS GDSC1 -0.688 4.2927 -1.1375 58.8586
NCI-H524 GDSC1 -0.5996 4.8555 -1.2037 57.6359
EPLC-272H GDSC1 -0.5669 3.2499 -0.7636 59.0251
Lu-139 GDSC1 -0.5249 6.4377 -1.6656 55.8916
COR-L311 GDSC1 -0.5101 3.4228 -0.7359 58.3367
NCI-H2141 GDSC1 -0.5057 6.7767 -1.7737 55.5609
NCI-H292 GDSC1 -0.4758 5.1805 -1.1713 56.4607
NCI-H209 GDSC1 -0.454 3.1867 -0.6299 58.0616
Lu-99A GDSC1 -0.4392 8.8386 -2.5477 54.1878
NCI-H211 GDSC1 -0.4279 6.9536 -1.7594 54.9875
BEN GDSC1 -0.3779 6.3738 -1.4841 54.9917
UMC-11 GDSC1 -0.3271 2.3235 -0.3772 57.5197
LB647-SCLC GDSC1 -0.3144 3.729 -0.5892 56.3064
NCI-H1975 GDSC1 -0.3065 5.0269 -0.938 55.304
LC-2/ad GDSC1 -0.2812 3.623 -0.5294 56.0824
RERF-LC-Sq1 GDSC1 -0.2812 6.8476 -1.562 54.1283
NCI-H1666 GDSC1 -0.2304 4.8249 -0.7921 54.8281
COR-L105 GDSC1 -0.2068 6.7524 -1.4457 53.6891
NCI-H2818 GDSC1 -0.1752 6.5809 -1.3457 53.5489
SBC-5 GDSC1 -0.1727 2.639 -0.2469 55.6519
EKVX GDSC1 -0.1329 4.1076 -0.4829 54.4059
HOP-62 GDSC1 -0.1219 3.6952 -0.3721 54.5305
COLO 668 GDSC1 -0.0877 5.3415 -0.803 53.4224
NCI-H1568 GDSC1 -0.0794 3.7413 -0.3362 54.097
CAL-12T GDSC1 -0.0784 4.1674 -0.439 53.8773
NCI-H2196 GDSC1 -0.018 4.7352 -0.5333 53.0902
NCI-H2291 GDSC1 0.0071 10.6695 -2.9042 51.5355
NCI-H1688 GDSC1 0.0103 5.5592 -0.7713 52.5676
NCI-H2110 GDSC1 0.0372 2.4904 -0.0099 53.3652
NCI-H2066 GDSC1 0.0632 4.518 -0.3807 52.4427
NCI-H727 GDSC1 0.074 5.2212 -0.5874 52.1471
NCI-H1770 GDSC1 0.0889 5.1974 -0.5633 52.0275
NCI-H1869 GDSC1 0.0911 7.7791 -1.5467 51.4902
NCI-H1781 GDSC1 0.0969 5.0155 -0.4954 52.0049
NCI-H187 GDSC1 0.1541 6.0879 -0.8068 51.3204
NCI-H446 GDSC1 0.1843 2.2581 0.161 51.6717
NCI-H520 GDSC1 0.2049 5.8028 -0.6475 50.9586
NCI-H1734 GDSC1 0.2187 8.6367 -1.7811 50.6185
NCI-H1573 GDSC1 0.2337 3.3777 0.0781 50.9763
ABC-1 GDSC1 0.2815 6.6067 -0.8692 50.3035
NCI-H2135 GDSC1 0.3702 9.7897 -2.1392 49.7373
NCI-H226 GDSC1 0.3841 5.4851 -0.3412 49.4583
EMC-BAC-2 GDSC1 0.4159 5.1616 -0.1965 49.1443
NCI-H513 GDSC1 0.4662 4.4741 0.0716 48.5587
Lu-65 GDSC1 0.4957 5.9979 -0.4069 48.5596
PaCa-3 GDSC1 0.4997 5.6429 -0.2724 48.4596
NCI-H358 GDSC1 0.5075 5.1441 -0.0912 48.2864
NCI-H2869 GDSC1 0.5325 5.4097 -0.1545 48.1142
NCI-H1703 GDSC1 0.5601 12.5822 -3.2478 48.9579
Calu-6 GDSC1 0.6194 9.1702 -1.6079 48.2417
NCI-H2087 GDSC1 0.652 7.2783 -0.7509 47.6069
NCI-H835 GDSC1 0.6804 5.514 -0.0314 46.7739
DMS 273 GDSC1 0.7092 7.504 -0.7861 47.2453
NCI-H2810 GDSC1 0.7547 6.8454 -0.4641 46.6617
NCI-H2591 GDSC1 0.756 6.9174 -0.4923 46.6794
CPC-N GDSC1 0.7896 8.5824 -1.1722 47.0166
NCI-H2228 GDSC1 0.7982 6.3522 -0.2202 46.0826
HCC827 GDSC1 0.8195 5.1773 0.236 45.2518
NCI-H3255 GDSC1 0.8876 4.9695 0.379 44.417
NCI-H1993 GDSC1 0.9029 8.3305 -0.9449 46.1498
NCI-H650 GDSC1 0.9409 9.9508 -1.6409 46.5047
NCI-H1694 GDSC1 0.9617 5.2909 0.351 43.8811
NCI-H1435 GDSC1 0.9851 7.9729 -0.7032 45.3915
NCI-H2373 GDSC1 1.0127 11.9542 -2.5107 46.7119
NCI-H647 GDSC1 1.0735 5.0484 0.5549 42.4991
LK-2 GDSC1 1.1051 9.5992 -1.3152 45.3557
NCI-H2081 GDSC1 1.1289 6.022 0.2607 42.822
COR-L321 GDSC1 1.1319 6.7201 -0.0163 43.3869
PC-14 GDSC1 1.1453 4.9634 0.661 41.6322
NCI-H2731 GDSC1 1.1533 7.3476 -0.2584 43.686
NCI-H1155 GDSC1 1.1616 5.2556 0.5794 41.7536
NCI-H1944 GDSC1 1.2328 6.5219 0.1713 42.2963
COR-L23 GDSC1 1.2644 8.9105 -0.8399 43.9152
NCI-H1563 GDSC1 1.4327 9.1843 -0.7977 42.9191
NCI-H82 GDSC1 1.4406 7.363 0.0315 41.2614
NCI-H1755 GDSC1 1.4812 5.4659 0.8484 38.5264
NCI-H2029 GDSC1 1.6073 8.8242 -0.4576 41.3473
NCI-H810 GDSC1 1.6106 9.4098 -0.7265 41.8423
NCI-H2342 GDSC1 1.635 12.0022 -1.9363 43.4671
NCI-H146 GDSC1 1.6585 8.5629 -0.2863 40.6983
NCI-H290 GDSC1 1.6902 11.1484 -1.4731 42.6302
NCI-H1355 GDSC1 1.7869 9.6144 -0.6497 40.775
NCI-H1105 GDSC1 1.8073 10.9813 -1.2808 41.7987
EMC-BAC-1 GDSC1 2.0004 9.3069 -0.2963 38.8787
NCI-H3122 GDSC1 2.1504 11.694 -1.3001 40.2786
NCI-H2405 GDSC1 2.1529 11.9584 -1.4264 40.4881
LCLC-103H GDSC1 2.1786 13.8492 -2.3277 41.7253
NCI-H1836 GDSC1 2.2321 11.3149 -1.0391 39.4222
HARA [Human squamous cell lung carcinoma] GDSC1 2.2396 9.4724 -0.1433 37.2528
IST-SL1 GDSC1 2.2414 10.5093 -0.6399 38.5163
NCI-H2722 GDSC1 2.2541 10.8249 -0.7806 38.7769
NCI-H1436 GDSC1 2.3303 7.8616 0.7058 33.8917
LXF 289 GDSC1 2.3516 8.0103 0.6574 33.9712
NCI-H2009 GDSC1 2.3864 10.3145 -0.4084 37.26
Lu-134-A GDSC1 2.4779 8.9002 0.3595 34.4423
NCI-H522 GDSC1 2.5085 9.9406 -0.112 35.8459
COR-L88 GDSC1 2.5857 8.1626 0.8148 32.0825
SW1271 GDSC1 2.5953 10.586 -0.3442 36.1163
NCI-H2804 GDSC1 2.6806 11.3292 -0.6286 36.5028
NCI-H2461 GDSC1 2.7187 10.694 -0.2822 35.3796
NCI-H1651 GDSC1 2.7336 9.6736 0.2295 33.6563
Lu-165 GDSC1 2.7457 9.3545 0.3958 32.989
NCI-H1915 GDSC1 2.7689 9.1747 0.5049 32.4555
EBC-1 GDSC1 2.8836 10.4721 -0.021 33.8244
IA-LM GDSC1 2.895 8.0952 1.1453 28.9636
A-427 GDSC1 2.9227 9.8669 0.3116 32.4751
NCI-H23 GDSC1 2.9498 9.9259 0.3079 32.3652
NCI-H2595 GDSC1 2.951 8.6809 0.916 29.8068
NCI-H841 GDSC1 2.9664 10.1811 0.1981 32.694
NCI-H2122 GDSC1 2.9696 8.3538 1.0919 28.8673
NCI-H441 GDSC1 3.1302 9.1332 0.863 29.2103
NCI-H2030 GDSC1 3.1466 9.3978 0.7485 29.6573
NCI-H1838 GDSC1 3.2835 11.8946 -0.3612 33.2148
SW1573 GDSC1 3.3521 13.6574 -1.1767 35.1913
COR-L95 GDSC1 3.3597 7.6309 1.8102 22.9515
DMS 53 GDSC1 3.3829 8.5087 1.4024 25.2877
HCC33 GDSC1 3.5051 10.6038 0.4767 29.2689
NCI-H2023 GDSC1 3.5376 8.9849 1.3083 25.1259
NCI-H1092 GDSC1 3.6094 11.8701 -0.0613 30.9189
NCI-H2369 GDSC1 3.8778 12.2301 -0.0081 29.6915
RERF-LC-KJ GDSC1 4.0399 14.0774 -0.7928 31.6965
SK-LU-1 GDSC1 4.0565 13.2366 -0.3585 30.2674
NCI-H460 GDSC1 4.0939 10.1499 1.2158 23.3405
LOU-NH91 GDSC1 4.141 12.5143 0.074 28.404
NCI-H1650 GDSC1 4.2516 11.8553 0.4965 26.2588
NCI-H345 GDSC1 4.311 18.5699 -2.8111 35.5148
NCI-H510A GDSC1 4.8336 12.0473 0.8769 22.4113
SHP-77 GDSC1 4.8637 10.884 1.4808 19.0371
NCI-H196 GDSC1 4.9308 13.106 0.4264 24.2016
A-549 GDSC1 5.1558 12.5197 0.8955 21.2507
HCC15 GDSC1 5.1729 11.7285 1.3017 19.0382
KNS-62 GDSC1 5.496 10.7462 2.028 13.6221
SK-MES-1 GDSC1 5.5211 7.83 3.4379 3.639
NCI-H2170 GDSC1 5.8001 16.2634 -0.4661 25.1114
HCC44 GDSC1 5.8509 14.4827 0.4527 21.2446
NCI-H838 GDSC1 5.9213 9.023 3.1327 4.9071
NCI-H1437 GDSC1 6.2963 13.2771 1.3639 15.391
NCI-H2172 GDSC1 6.4894 8.0321 3.8194 0.3916
ChaGo-K-1 GDSC1 6.6801 17.0096 -0.1801 21.6674
NCI-H1299 GDSC1 7.4619 16.4311 0.6419 16.2007
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -2.4756 3.8587 -2.9752 69.9861
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-5 GDSC1 -2.7586 -0.2048 -2.7639 83.1079
KYSE-450 GDSC1 -1.9612 0.8652 -1.9805 74.9029
TE-6 GDSC1 -1.6641 4.6443 -2.3016 64.5785
KYSE-150 GDSC1 -1.6391 5.9802 -2.7015 62.511
KYSE-270 GDSC1 -1.0049 2.1334 -1.0719 64.4534
TE-8 GDSC1 -0.9513 5.9487 -1.9469 58.8738
OE33 GDSC1 -0.6418 5.651 -1.5086 57.2246
TE-15 GDSC1 -0.5237 4.5699 -1.036 57.3328
KYSE-140 GDSC1 -0.442 3.4034 -0.6582 57.7443
TE-4 GDSC1 -0.1947 2.7103 -0.2787 55.8463
KYSE-520 GDSC1 0.1038 6.1946 -0.9007 51.6843
TE-9 GDSC1 0.1152 3.8711 -0.1542 52.1295
EC-GI-10 GDSC1 0.2081 5.0937 -0.3999 51.0189
KYSE-410 GDSC1 0.2884 3.3101 0.1493 50.3754
COLO 680N GDSC1 0.593 5.6573 -0.177 47.629
KYSE-70 GDSC1 0.6422 5.1526 0.0521 46.9978
OE21 GDSC1 0.646 4.2866 0.3198 46.6179
TE-10 GDSC1 1.0173 6.0769 0.1205 43.9338
OE19 GDSC1 1.3419 7.3403 -0.0603 42.0921
T.T GDSC1 1.5496 6.2178 0.6289 38.8509
KYSE-180 GDSC1 2.3802 9.0811 0.179 35.5587
TE-11 GDSC1 2.4696 6.0216 1.6739 28.2868
KYSE-510 GDSC1 4.6242 15.073 -0.8038 29.7829
TE-1 GDSC1 5.5719 10.6102 2.1488 12.6037
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC1 -2.4009 7.5507 -4.0941 63.7803
TOV-112D GDSC1 -1.2709 2.5405 -1.4038 65.9242
A2780 GDSC1 -1.2199 4.6255 -1.8115 62.0598
JHOS-4 GDSC1 -1.2013 3.7616 -1.5625 63.2509
OAW42 GDSC1 -1.0153 6.0207 -2.0414 59.1728
OVK18 GDSC1 -0.7303 4.4851 -1.2372 58.9608
OVCAR-4 GDSC1 -0.4311 4.8443 -1.0167 56.392
TYK-nu GDSC1 -0.2719 5.5637 -1.0781 54.7161
Kuramochi GDSC1 -0.0437 9.5894 -2.4692 51.9503
DOV13 GDSC1 -0.0416 4.852 -0.5947 53.2469
RMG-I GDSC1 -0.0263 6.8041 -1.2738 52.4668
SK-OV-3 GDSC1 0.0623 6.7079 -1.142 51.8789
OAW28 GDSC1 0.4239 6.1372 -0.5363 49.1763
OV-90 GDSC1 0.4471 5.7581 -0.3706 48.9377
OVCAR-3 GDSC1 0.5512 10.6798 -2.3653 48.8294
FU-OV-1 GDSC1 0.7064 7.2914 -0.6995 47.2
ES-2 GDSC1 0.7456 4.6433 0.3267 45.716
JHOS-2 GDSC1 0.7799 8.1237 -0.98 46.9356
EFO-21 GDSC1 0.792 9.1446 -1.4217 47.168
Caov-3 GDSC1 1.2497 8.2108 -0.5383 43.5495
OVCAR-5 GDSC1 1.3687 8.4862 -0.5419 42.8554
EFO-27 GDSC1 1.5245 6.2313 0.5969 39.1258
OVCAR-8 GDSC1 1.5742 8.2296 -0.2186 41.0289
OVISE GDSC1 1.6246 21.6098 -6.6613 46.4818
Caov-4 GDSC1 2.5751 10.8079 -0.4712 36.5564
OC 314 GDSC1 2.9129 11.8434 -0.6692 35.6216
TOV-21G GDSC1 3.2066 6.7155 2.1038 21.735
OVTOKO GDSC1 3.4851 10.2091 0.6548 28.5863
OV56 GDSC1 3.6483 9.0593 1.3709 24.3014
OVKATE GDSC1 5.5956 9.955 2.4832 10.2558
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 -1.6532 0.9421 -1.6681 72.3373
SUIT-2 GDSC1 -1.6327 2.6869 -1.8142 68.1584
MZ-PC-1 GDSC1 -1.2836 2.9078 -1.4755 65.3194
Panc 03.27 GDSC1 -0.9045 4.5715 -1.4519 60.0877
BxPC-3 GDSC1 -0.7508 3.055 -0.9268 60.8707
Capan-2 GDSC1 -0.5777 5.025 -1.2324 57.3241
HPAF-II GDSC1 -0.5395 6.0908 -1.5535 56.2199
HPAC GDSC1 -0.4114 6.0734 -1.4092 55.3899
HuP-T4 GDSC1 -0.3045 4.4711 -0.7685 55.6657
Panc 08.13 GDSC1 -0.1353 5.9234 -1.0576 53.5394
PaTu 8902 GDSC1 -0.0969 5.2788 -0.792 53.5219
Capan-1 GDSC1 0.2934 5.3427 -0.3902 50.2498
Panc 04.03 GDSC1 0.3494 5.4671 -0.3724 49.7608
HuP-T3 GDSC1 0.3957 7.4756 -1.1012 49.491
Panc 02.03 GDSC1 0.586 11.169 -2.558 48.7032
SU.86.86 GDSC1 0.6239 6.3497 -0.4045 47.5651
QGP-1 GDSC1 0.9333 7.3441 -0.4852 45.4628
MIA PaCa-2 GDSC1 1.0738 6.4933 0.0153 43.7295
CFPAC-1 GDSC1 1.1717 5.6269 0.4564 42.0224
PaTu 8988t GDSC1 1.4866 10.176 -1.2079 43.2452
PL4 GDSC1 1.5058 7.841 -0.1128 41.1953
KP-1N GDSC1 1.7904 6.6422 0.7041 37.0331
KP-3 GDSC1 2.1196 9.0917 -0.0784 37.6829
AsPC-1 GDSC1 2.1256 10.4406 -0.7169 39.2387
Hs 766T GDSC1 3.2561 11.0998 0.0084 32.1092
YAPC GDSC1 3.3262 12.8279 -0.787 34.2858
DAN-G GDSC1 3.623 11.0871 0.3406 29.3434
Panc 10.05 GDSC1 4.1182 14.734 -1.0548 32.1794
PSN1 GDSC1 4.1321 10.8603 0.8932 24.8603
SW1990 GDSC1 4.9278 11.4628 1.243 20.1718
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 -1.1325 7.7876 -2.8373 58.2264
NCI-H2052 GDSC1 -0.1933 7.9313 -1.9076 53.1753
NCI-H28 GDSC1 1.2623 8.8894 -0.8323 43.916
IST-Mes1 GDSC1 1.7737 8.2625 -0.0333 39.437
MPP 89 GDSC1 2.3709 9.5905 -0.0739 36.3986
NCI-H2452 GDSC1 2.377 10.4241 -0.4704 37.4653
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 -1.4453 3.7171 -1.8178 64.9108
PC-3 GDSC1 -0.6736 4.5082 -1.1818 58.5205
LNCaP clone FGC GDSC1 -0.0907 3.8093 -0.364 54.1705
VCaP GDSC1 0.0949 8.4089 -1.8102 51.3742
DU145 GDSC1 1.3811 8.9868 -0.758 43.1402
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.6121 6.3655 2.6615 15.868
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM35 GDSC1 -2.7791 1.2676 -2.8554 78.227
CHL-1 GDSC1 -2.6836 3.0155 -3.0104 72.8261
CP50-MEL-B GDSC1 -2.4513 1.1107 -2.5003 77.178
COLO 800 GDSC1 -2.4056 0.4048 -2.4189 79.1463
VMRC-MELG GDSC1 -2.0597 0.8955 -2.0829 75.5023
WM115 GDSC1 -1.8517 2.0257 -1.9554 71.1223
SK-MEL-2 GDSC1 -1.7437 3.0396 -1.9968 68.0745
A-375 GDSC1 -1.5581 2.9109 -1.7723 67.1947
MZ-MEL-7 GDSC1 -1.4119 5.2795 -2.2211 62.2662
Mel Ho GDSC1 -1.3904 2.0164 -1.4664 67.8934
G-361 GDSC1 -1.3856 1.8582 -1.4462 68.184
WM793 GDSC1 -1.3387 3.5526 -1.6639 64.5209
A-431 GDSC1 -1.3364 1.5328 -1.3703 68.4296
SK-MEL-5 GDSC1 -1.2648 3.2952 -1.5285 64.478
COLO 792 GDSC1 -0.9822 2.3408 -1.0702 63.9207
IGR-1 GDSC1 -0.9047 2.3158 -0.9853 63.2712
IPC-298 GDSC1 -0.8705 3.9483 -1.2472 60.6365
Mel JuSo GDSC1 -0.8015 2.9249 -0.9593 61.4825
RVH-421 GDSC1 -0.6476 9.0247 -2.8434 55.1393
A-388 GDSC1 -0.6433 2.9658 -0.7958 60.0354
SK-MEL-28 GDSC1 -0.6311 5.13 -1.3239 57.6074
RPMI-7951 GDSC1 -0.4395 4.8443 -1.0259 56.4565
MMAc-SF GDSC1 -0.426 6.3392 -1.5227 55.3242
HT-144 GDSC1 -0.4204 4.8661 -1.0118 56.2937
SK-MEL-30 GDSC1 -0.3854 4.2802 -0.804 56.4808
SK-MEL-24 GDSC1 -0.3422 3.0552 -0.4866 57.1107
MZ-MEL-2 GDSC1 -0.3363 4.5183 -0.8167 55.8934
G-mel GDSC1 -0.3015 2.5478 -0.3729 57.0878
LOX-IMVI GDSC1 -0.2406 3.6188 -0.4844 55.7071
WM1552C GDSC1 -0.1821 5.4003 -0.9251 54.1304
IGR-37 GDSC1 -0.1757 2.5861 -0.244 55.7128
COLO 679 GDSC1 -0.1044 3.1275 -0.2428 54.6628
M14 GDSC1 -0.0611 8.7925 -2.137 52.1976
IST-MEL1 GDSC1 0.0385 5.4629 -0.7075 52.3713
COLO 783 GDSC1 0.0444 5.7769 -0.8113 52.2364
SK-MEL-3 GDSC1 0.1323 3.9417 -0.1524 51.9402
SH-4 GDSC1 0.3485 4.1422 0.0333 49.7279
Hs 938.T GDSC1 0.4225 6.9205 -0.8449 49.2598
LB2518-MEL GDSC1 0.6491 6.1853 -0.3139 47.3006
COLO 829 GDSC1 0.8104 7.1272 -0.522 46.332
CP66-MEL GDSC1 0.9283 7.1684 -0.4161 45.4096
451Lu GDSC1 0.949 6.0176 0.0705 44.5316
LB373-MEL-D GDSC1 0.9962 11.1781 -2.1593 46.5775
UACC-62 GDSC1 1.113 3.0512 1.0677 40.3504
DJM-1 GDSC1 1.113 6.1351 0.1996 43.0743
Hs 940.T GDSC1 1.3111 6.7104 0.1756 41.7555
A101D GDSC1 1.7127 11.0453 -1.4021 42.4244
HMV-II GDSC1 2.2946 8.8004 0.2297 35.8303
SK-MEL-1 GDSC1 2.6925 9.8244 0.1176 34.2389
WT2-iPS GDSC1 2.9928 9.2248 0.6906 30.6228
WM278 GDSC1 3.0865 14.1059 -1.6343 37.1834
A2058 GDSC1 3.2477 6.8496 2.0801 21.7009
GAK GDSC1 3.7138 10.9111 0.5078 28.2812
MeWo GDSC1 4.362 11.8924 0.5701 25.5271
UACC-257 GDSC1 4.8556 17.0542 -1.6051 31.3324
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.1296 8.2361 -0.6718 44.4675
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC1 -4.0542 -1.8329 -4.0547 93.3774
G-402 GDSC1 -2.4784 3.7718 -2.9568 70.1864
EW-8 GDSC1 -2.4315 -0.2184 -2.434 81.2267
Rh30 GDSC1 -2.4073 0.5123 -2.424 78.8185
G-401 GDSC1 -2.123 3.1904 -2.4382 69.8259
GCT GDSC1 -1.7349 4.7509 -2.41 64.7761
SW982 GDSC1 -1.6132 2.1557 -1.7178 69.2264
SK-LMS-1 GDSC1 -1.5808 2.1453 -1.6821 69.0232
Hs 633.T GDSC1 -1.5798 0.4718 -1.5832 72.62
Rh18 GDSC1 -0.9867 1.839 -1.0275 64.745
A-204 GDSC1 -0.8672 10.8185 -3.8552 55.3211
SK-UT-1 GDSC1 -0.6534 4.3227 -1.108 58.565
KYM-1 GDSC1 -0.6437 7.8804 -2.3591 55.7014
RD GDSC1 -0.2471 4.4003 -0.686 55.2331
SW872 GDSC1 0.1991 4.8484 -0.3315 51.1324
VA-ES-BJ GDSC1 0.9694 7.6993 -0.6002 45.3688
SW684 GDSC1 1.6799 10.905 -1.3665 42.5271
RKN GDSC1 1.9436 7.2683 0.588 36.5307
MFH-ino GDSC1 2.6648 11.7863 -0.8676 37.1619
HT-1080 GDSC1 3.5373 9.1736 1.2147 25.6336
MES-SA GDSC1 4.6023 12.8995 0.2645 26.0042
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IM95 GDSC1 -2.2785 7.4884 -3.9395 63.3987
AGS GDSC1 -2.1692 2.2498 -2.3227 72.3929
RERF-GC-1B GDSC1 -1.9812 3.7506 -2.4096 67.8849
GCIY GDSC1 -1.8873 1.5961 -1.9492 72.4563
23132/87 GDSC1 -1.7138 6.1521 -2.8421 62.6478
HSC-39 GDSC1 -1.5411 1.8206 -1.606 69.4702
Fu97 GDSC1 -1.1189 3.9671 -1.5228 62.3715
MKN1 GDSC1 -0.8392 5.4918 -1.6685 58.6427
TGBC11TKB GDSC1 -0.6415 4.2161 -1.0663 58.5877
KATO III GDSC1 -0.5138 8.4115 -2.4437 54.7514
SNU-1 GDSC1 -0.3107 6.8975 -1.6129 54.2919
MKN7 GDSC1 0.0316 6.7823 -1.2038 52.0761
ECC10 GDSC1 0.093 6.2649 -0.9387 51.7508
HGC-27 GDSC1 0.258 5.7372 -0.5668 50.5317
Hs 746.T GDSC1 0.3563 9.1939 -1.8857 49.8022
OCUM-1 GDSC1 0.9659 7.8972 -0.6899 45.4968
SCH GDSC1 1.7012 17.5174 -4.5696 45.3424
NUGC-3 GDSC1 1.8854 8.0209 0.1891 38.1822
NUGC-4 GDSC1 3.0711 6.5664 2.0409 22.8154
MKN45 GDSC1 4.3761 11.7469 0.6545 25.0899
RF-48 GDSC1 4.5727 12.8979 0.2411 26.2033
NCI-N87 GDSC1 4.5792 15.8756 -1.2419 31.2047
MKN28 GDSC1 5.2359 11.9134 1.2583 19.0772
SNU-5 GDSC1 5.7171 7.8017 3.5611 2.4523
SNU-16 GDSC1 5.7981 7.508 3.7262 1.3598
SNG-M GDSC1 -0.6313 2.9952 -0.7878 59.8924
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1 -2.1742 2.1495 -2.314 72.6871
IHH-4 GDSC1 -1.7722 4.0949 -2.2682 66.1145
HTC-C3 GDSC1 -1.5467 4.471 -2.124 64.2184
K5 GDSC1 -1.3231 3.5879 -1.6548 64.3563
B-CPAP GDSC1 -0.975 4.4194 -1.4857 60.7589
8505C GDSC1 -0.9649 2.7959 -1.1141 63.0499
BHT-101 GDSC1 -0.2994 3.6373 -0.5523 56.2399
TT2609-C02 GDSC1 -0.2582 4.1087 -0.6199 55.5253
CAL-62 GDSC1 -0.2385 5.7218 -1.097 54.3863
ASH-3 GDSC1 0.8438 4.8466 0.3709 44.7955
8305C GDSC1 0.9501 9.339 -1.3507 46.2321
CGTH-W-1 GDSC1 2.6145 8.8911 0.4949 33.2513
ML-1 [Human leukemia] GDSC1 3.1739 11.7795 -0.402 33.7855
TT GDSC1 5.2133 8.18 3.0757 7.0075
FTC-133 GDSC1 5.32 10.448 2.0456 14.0344
WRO GDSC1 6.5975 16.8501 -0.1618 21.8072
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-15 GDSC1 -1.6804 0.8644 -1.6933 72.7358
SCC-9 GDSC1 -1.6802 2.131 -1.7859 69.7426
DOK GDSC1 -1.3083 2.7418 -1.4744 65.8152
NCI-H3118 GDSC1 -1.292 3.8367 -1.6793 63.7282
JHU-011 GDSC1 -0.916 3.2096 -1.1336 62.0208
PCI-04B GDSC1 -0.7795 3.2893 -1.0012 60.8013
PCI-15A GDSC1 -0.7022 3.1866 -0.898 60.2834
CAL-33 GDSC1 -0.6625 4.4603 -1.1562 58.4887
BHY GDSC1 -0.6308 2.5852 -0.7269 60.3696
SCC-25 GDSC1 -0.4584 4.1271 -0.8431 57.2151
BB30-HNC GDSC1 -0.4473 3.1629 -0.6184 58.0215
BICR 31 GDSC1 -0.0372 6.6585 -1.2286 52.5835
PCI-06A GDSC1 0.0431 5.3586 -0.6669 52.3644
OSC-20 GDSC1 0.1375 5.0188 -0.4524 51.6515
PE/CA-PJ15 GDSC1 0.2388 3.876 -0.0207 50.8686
SCC-4 GDSC1 0.4738 4.8584 -0.0355 48.5525
Ca9-22 GDSC1 0.7653 3.4947 0.631 44.8913
LB771-HNC GDSC1 1.1263 4.3645 0.8227 41.2463
SAT [Human HNSCC] GDSC1 1.18 11.8842 -2.3156 45.8373
HO-1-N-1 GDSC1 1.4878 5.3183 0.9092 38.244
BICR 10 GDSC1 1.5967 6.9526 0.3703 39.3711
Detroit 562 GDSC1 1.8777 6.8844 0.6899 36.5486
OSC-19 GDSC1 2.0259 6.3892 1.0564 34.1261
KOSC-2 GDSC1 2.2336 7.0351 0.987 33.2243
HSC-3 GDSC1 2.4665 6.773 1.3407 30.1824
CAL-27 GDSC1 2.5689 9.2641 0.272 34.2999
JHU-022 GDSC1 2.5823 9.1471 0.3411 33.9873
HO-1-u-1 GDSC1 3.9596 6.9673 2.6864 14.2098
PCI-30 GDSC1 4.8893 8.3948 2.7369 10.498
BICR 78 GDSC1 5.1609 10.8226 1.7415 16.4811
SKN-3 GDSC1 6.1535 11.1394 2.2921 10.0932
HSC-4 GDSC1 6.2602 7.6543 3.8674 0.3652
BICR 22 GDSC1 6.3992 7.8344 3.8557 0.3326
HSC-2 GDSC1 6.4988 7.5947 3.9731 0.0788
FaDu GDSC1 6.5696 7.9985 3.861 0.2525
KON GDSC1 6.621 8.221 3.8018 0.3793
PCI-38 GDSC1 6.9684 8.5403 3.8172 0.2186
SAS GDSC1 6.9791 8.9385 3.6814 0.5523
BB49-HNC GDSC1 7.0937 9.075 3.6763 0.5095
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 -1.7127 1.9909 -1.8042 70.2968
CAL-29 GDSC1 -0.9832 3.563 -1.2795 62.0127
UM-UC-3 GDSC1 -0.7441 2.2952 -0.8133 61.8054
639V GDSC1 -0.0758 5.0653 -0.6993 53.4441
5637 GDSC1 0.0291 3.1555 -0.1038 53.2424
SW780 GDSC1 0.2843 7.3549 -1.1679 50.2597
SW1710 GDSC1 0.3041 4.8597 -0.2206 50.1659
HT-1197 GDSC1 0.541 11.7548 -2.8763 48.9788
BFTC-905 GDSC1 0.6135 4.4249 0.2463 47.018
T24 GDSC1 1.1662 6.5022 0.1092 42.894
RT-4 GDSC1 1.3273 8.2939 -0.497 43.0207
HT-1376 GDSC1 1.6075 7.4649 0.1579 39.9084
TCCSUP GDSC1 1.8163 11.1282 -1.3428 41.8539
J82 GDSC1 2.379 8.9013 0.2636 35.2814
647V GDSC1 3.2396 10.1617 0.4574 30.484
KU-19-19 GDSC1 3.6787 9.8278 1.0162 26.0605
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KGN GDSC1 -3.9669 1.7981 -4.1808 80.3863
ME-180 GDSC1 -3.3702 3.0225 -3.7569 75.3141
Ca Ski GDSC1 -2.8864 1.7772 -3.024 77.0774
UWB1.289 GDSC1 -2.2069 3.6725 -2.637 69.1682
NEC8 GDSC1 -2.1542 3.882 -2.6305 68.475
TC-YIK GDSC1 -1.787 2.6993 -1.9823 69.0957
BPH-1 GDSC1 -1.7452 0.87 -1.7596 73.2527
OMC-1 [Human cervical carcinoma] GDSC1 -1.4252 4.166 -1.9082 64.0135
PA-1 GDSC1 -1.3989 0.9637 -1.4094 70.052
SW954 GDSC1 -1.1197 2.4726 -1.2329 64.8595
C-33 A GDSC1 -1.0664 2.0421 -1.1278 65.1503
HEY GDSC1 -1.0413 3.859 -1.4115 61.9951
OVMIU GDSC1 -1.0337 7.3869 -2.5734 58.0548
NT2-D1 GDSC1 -0.8977 0.8259 -0.8997 64.9785
NCC-IT GDSC1 -0.6722 3.1328 -0.8558 60.0901
PEO1 GDSC1 -0.5024 4.6034 -1.0225 57.1393
DSH1 GDSC1 -0.3052 2.1624 -0.3411 57.3856
SW962 GDSC1 -0.2848 5.6165 -1.1103 54.7805
SKN GDSC1 -0.2782 4.3664 -0.7105 55.5196
HT-3 GDSC1 -0.2671 7.5578 -1.8308 53.7423
PWR-1E GDSC1 -0.0086 4.9733 -0.5968 52.9203
OVCA433 GDSC1 0.4149 6.6436 -0.7421 49.2933
OVCA420 GDSC1 0.4352 5.5428 -0.3064 49.0144
C-4-I GDSC1 0.5775 7.4002 -0.8796 48.1868
SiHa GDSC1 0.6656 12.1886 -2.9589 48.4374
ACC-OV7 GDSC1 1.0757 6.1476 0.1551 43.4382
SiSo GDSC1 1.2054 6.9138 -0.0199 42.8964
CAL-39 GDSC1 1.3588 4.6767 0.9847 38.8616
JHOS-3 GDSC1 1.3726 9.4078 -0.9608 43.4904
HEC-1 GDSC1 1.6699 8.5605 -0.2739 40.6067
LB831-BLC GDSC1 1.9967 8.5069 0.0756 37.8958
JEG-3 GDSC1 2.2011 11.4784 -1.1476 39.7728
OV17R GDSC1 2.2601 12.1 -1.3954 39.9753
JAR GDSC1 2.4532 8.6803 0.4405 34.2722
HeLa GDSC1 3.0453 9.2416 0.7312 30.2002
DoTc2 4510 GDSC1 4.4957 8.9937 2.1292 16.2064
MS751 GDSC1 5.0895 9.6363 2.2742 13.2032
SKG-IIIa GDSC1 6.5664 14.9041 0.7645 17.8091
SW756 GDSC1 7.3952 19.3512 -0.811 22.2612
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of Roche.
2 Clinical pipeline report, company report or official report of Genentech (2011).
3 GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther. 2011 Dec;10(12):2426-36.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109).
5 Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res. 2012 Dec 15;18(24):6771-83. doi: 10.1158/1078-0432.CCR-12-2347. Epub 2012 Nov 7.
6 Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells. Mol Cancer Ther. 2012 Jul;11(7):1510-7. doi: 10.1158/1535-7163.MCT-11-0907. Epub 2012 Apr 24.