Details of the Drug Pharmacogenomic Perturbation Atlas

Momelotinib Drug Info

Cyt387; 1056634-68-4; MOMELOTINIB; Cyt-387; N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide; CYT 387; CYT 11387; UNII-6O01GMS00P; N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide; 6O01GMS00P; CHEMBL1078178; AK102858; N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide; N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; CYT387 sulfate salt; N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide

Cross-matching ID

PubChem CID

25062766

ChEBI ID

CHEMBL1078178

CAS Number

CAS 1056634-68-4

TTD Drug ID

D0D5ZJ

INTEDE Drug ID

DR1880

General Information of Drug (ID: DMF98Q0)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Phenylalanine metabolism	2.28	0.00e+0	14/17 (82.35%)	MAOA;ALDH3A1;GOT2;...
Tyrosine metabolism	2.18	0.00e+0	30/36 (83.33%)	ADH1B;ADH1C;MAOA;...
Glycerolipid metabolism	1.94	1.46e-2	44/61 (72.13%)	AKR1B10;MGLL;AKR1B1;...
ABC transporters	1.92	1.10e-2	37/45 (82.22%)	ABCC3;ABCC5;ABCC1;...
One carbon pool by folate	1.91	8.76e-3	15/20 (75%)	ATIC;AMT;GART;...
Pentose and glucuronate interconversions	1.89	7.30e-3	17/34 (50%)	AKR1B10;UGT2B15;AKR1B1;...
Folate biosynthesis	1.88	6.26e-3	23/26 (88.46%)	AKR1C3;AKR1B10;AKR1B1;...
Metabolism of xenobiotics by cytochrome P450	1.85	1.10e-2	49/77 (63.64%)	AKR1C1;ADH1B;GSTM3;...
Viral protein interaction with cytokine and cytokine re...	1.81	2.11e-2	84/100 (84%)	TNFRSF10B;CCL19;CXCL13;...
N-Glycan biosynthesis	1.79	2.48e-2	38/50 (76%)	DPM3;MGAT4B;MAN1A2;...
Retinol metabolism	1.79	2.39e-2	41/68 (60.29%)	ADH1B;UGT2B15;ADH1C;...
Cysteine and methionine metabolism	1.78	2.31e-2	43/50 (86%)	TST;PHGDH;AHCYL1;...
Alanine, aspartate and glutamate metabolism	1.77	2.58e-2	27/37 (72.97%)	ASS1;CAD;CPS1;...
Lysosome	1.76	2.71e-2	115/128 (89.84%)	FUCA1;TPP1;GAA;...
Thyroid hormone synthesis	1.75	2.92e-2	66/75 (88%)	GPX2;ITPR3;GPX1;...
beta-Alanine metabolism	1.75	2.83e-2	25/30 (83.33%)	ALDH3A1;ALDH3A2;CNDP2;...
Complement and coagulation cascades	1.74	2.66e-2	76/85 (89.41%)	PLAT;CFB;FGG;...
Galactose metabolism	1.74	2.51e-2	26/31 (83.87%)	AKR1B10;PFKM;AKR1B1;...
Intestinal immune network for IgA production	1.74	2.38e-2	38/48 (79.17%)	HLA-DPA1;HLA-DPB1;HLA-DQA1;...
Drug metabolism	1.74	2.26e-2	78/151 (51.66%)	ADH1B;CES1;GSTM3;...
Axon guidance	1.74	2.16e-2	151/182 (82.97%)	NRP1;SEMA3B;PLXNB2;...
Citrate cycle (TCA cycle)	1.73	2.12e-2	30/30 (100%)	PCK2;ACO2;SDHA;...
Pentose phosphate pathway	1.72	2.10e-2	25/30 (83.33%)	PFKM;PGD;PFKL;...
Asthma	1.72	2.01e-2	25/31 (80.65%)	HLA-DPA1;HLA-DPB1;HLA-DQA1;...
Ascorbate and aldarate metabolism	1.70	2.51e-2	15/30 (50%)	UGT2B15;ALDH3A2;AKR1A1;...
Hedgehog signaling pathway	1.69	2.58e-2	43/56 (76.79%)	CCND1;SCUBE2;PRKACB;...
Fructose and mannose metabolism	1.68	2.54e-2	30/33 (90.91%)	AKR1B10;PFKM;AKR1B1;...
Collecting duct acid secretion	1.68	2.66e-2	22/27 (81.48%)	SLC12A7;ATP6V0E2;ATP6V0A1;...
Toxoplasmosis	1.65	3.78e-2	103/112 (91.96%)	LAMB3;HLA-DPA1;HLA-DPB1;...
Pyruvate metabolism	1.62	4.72e-2	41/47 (87.23%)	ADH1B;ADH1C;PCK2;...
Steroid biosynthesis	-1.69	4.54e-2	19/20 (95%)	FDFT1;DHCR7;EBP;...
DNA replication	-1.81	1.29e-2	34/36 (94.44%)	RNASEH2A;RFC4;POLA1;...
Spliceosome	-2.01	1.72e-3	101/150 (67.33%)	PQBP1;NCBP1;SMNDC1;...
Proteasome	-2.02	2.58e-3	44/46 (95.65%)	PSME2;PSMC4;PSMD6;...
Cell cycle	-2.09	0.00e+0	110/124 (88.71%)	CDC14B;E2F1;BUB1B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H

Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	6H, 24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H