Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFEGB0)

Drug Name
Segesterone acetate; ethinyl estradiol Drug Info
Cross-matching ID
TTD Drug ID
D06LDT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Citrate cycle (TCA cycle) -1.71 4.54e-2 30/30 (100%) FH;DLST;PDHB;...
Malaria -1.72 4.00e-2 44/50 (88%) ITGAL;TGFB1;THBS1;...
Cytokine-cytokine receptor interaction -1.72 4.22e-2 246/295 (83.39%) CX3CL1;CCL20;CCL1;...
Primary immunodeficiency -1.73 4.33e-2 33/38 (86.84%) PTPRC;LCK;BTK;...
Glycerolipid metabolism -1.73 4.52e-2 44/61 (72.13%) MBOAT2;DGKA;DGKI;...
Phagosome -1.73 4.74e-2 118/152 (77.63%) ATP6V1D;OLR1;SFTPA2;...
Lysosome -1.77 3.68e-2 115/128 (89.84%) GGA3;ATP6V0A1;AP1S2;...
Insulin signaling pathway -1.78 3.68e-2 121/137 (88.32%) PYGM;PPP1CB;ACACB;...
Ascorbate and aldarate metabolism -1.79 3.99e-2 15/30 (50%) UGT2B17;GUSB;UGT2B4;...
Rheumatoid arthritis -1.79 4.35e-2 78/93 (83.87%) ATP6V1D;CXCL6;TCIRG1;...
Other glycan degradation -1.80 4.66e-2 13/18 (72.22%) FUCA1;HEXB;MAN2B1;...
Toll-like receptor signaling pathway -1.82 4.22e-2 94/104 (90.38%) PIK3CB;MAP2K3;IKBKG;...
Valine, leucine and isoleucine degradation -1.83 4.60e-2 42/48 (87.5%) ACAD8;HMGCL;DLD;...
Viral protein interaction with cytokine and cytokine re... -1.87 3.68e-2 84/100 (84%) CX3CL1;CCL20;CCL1;...
Glyoxylate and dicarboxylate metabolism -1.90 4.09e-2 23/30 (76.67%) MDH1;DLD;CAT;...
Fatty acid biosynthesis -1.93 3.19e-2 16/18 (88.89%) HSD17B8;ACSL5;FASN;...
Peroxisome -1.95 3.07e-2 72/82 (87.8%) ECH1;PEX2;PECR;...
Pentose phosphate pathway -1.98 2.86e-2 25/30 (83.33%) PFKP;PFKL;PFKM;...
Pentose and glucuronate interconversions -2.07 1.23e-2 17/34 (50%) AKR1B10;AKR1B1;UGT2B17;...
Neutrophil extracellular trap formation -2.08 2.45e-2 101/189 (53.44%) SIGLEC9;CTSG;PIK3CA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H