Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFLCW4)

Drug Name
AZD8931 Drug Info
Synonyms
Sapitinib; AZD8931; 848942-61-0; AZD8931 (Sapitinib); AZD-8931; Sapitinib(AZD8931); UNII-3499328002; CHEMBL2408045; 2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-n-methylacetamide; 2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide; Sapitinib [INN]; 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-((1-(n-methylcarbamoylmethyl)piperidin-4-yl)oxy)quinazoline
Cross-matching ID
PubChem CID
11488320
ChEBI ID
CHEMBL2408045
CAS Number
CAS 848942-61-0
TTD Drug ID
D0BM7M

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.23 0.00e+0 48/60 (80%) MT1F;MT1E;MT1X;...
Proximal tubule bicarbonate reclamation 2.17 0.00e+0 21/23 (91.3%) CA2;AQP1;GLUD1;...
Oxidative phosphorylation 2.12 0.00e+0 93/133 (69.92%) ATP5PD;ATP5MC2;COX7C;...
Ribosome 1.94 6.63e-3 113/158 (71.52%) MRPS2;RPS27L;MRPS15;...
Arginine and proline metabolism -1.70 1.78e-2 39/50 (78%) SRM;NOS3;MAOA;...
Rheumatoid arthritis -1.70 1.79e-2 78/93 (83.87%) ITGAL;IL23A;CCL5;...
Cocaine addiction -1.70 1.77e-2 42/49 (85.71%) MAOB;CREB3L1;TH;...
Tuberculosis -1.71 1.62e-2 159/180 (88.33%) MAPK8;CD209;RAB7A;...
NF-kappa B signaling pathway -1.71 1.67e-2 90/104 (86.54%) EDAR;LYN;BTK;...
Influenza A -1.71 1.74e-2 156/172 (90.7%) VDAC1;KPNA2;NFKBIB;...
Toxoplasmosis -1.71 1.81e-2 103/112 (91.96%) NFKBIB;CD40LG;STAT3;...
Yersinia infection -1.74 1.74e-2 120/137 (87.59%) NLRP3;MAPK14;MAP2K4;...
Progesterone-mediated oocyte maturation -1.77 1.29e-2 75/100 (75%) ANAPC5;MAPK9;BRAF;...
Inflammatory bowel disease -1.77 1.35e-2 58/65 (89.23%) IL21;STAT1;NOD2;...
Hepatitis B -1.77 1.42e-2 151/162 (93.21%) MAPK9;CDKN1A;NFATC1;...
Systemic lupus erythematosus -1.77 1.43e-2 45/135 (33.33%) HLA-DQA1;GRIN2B;HLA-DPB1;...
Alcoholism -1.79 1.15e-2 86/186 (46.24%) MAOB;CREB3L1;TH;...
TNF signaling pathway -1.80 1.14e-2 103/112 (91.96%) MAPK9;SOCS3;CREB1;...
Allograft rejection -1.81 1.13e-2 32/38 (84.21%) HLA-DRA;CD80;HLA-C;...
Natural killer cell mediated cytotoxicity -1.81 1.21e-2 99/131 (75.57%) NCR2;IFNA16;HLA-C;...
Phagosome -1.86 7.38e-3 118/152 (77.63%) CD209;RAB7A;PIKFYVE;...
Measles -1.86 7.95e-3 133/139 (95.68%) NFKBIB;CDK2;CCNE2;...
T cell receptor signaling pathway -1.87 7.54e-3 93/104 (89.42%) MAPK8;CD3E;PPP3CC;...
Toll-like receptor signaling pathway -1.90 5.87e-3 94/104 (90.38%) MAPK14;IRF7;MAP2K4;...
Complement and coagulation cascades -1.91 6.46e-3 76/85 (89.41%) SERPINA5;C2;SERPINE1;...
Chagas disease -1.93 7.18e-3 93/102 (91.18%) PLCB4;MAPK14;PPP2CB;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.93 8.08e-3 79/89 (88.76%) ALK;NFATC1;NFKBIB;...
Neutrophil extracellular trap formation -1.94 9.23e-3 101/189 (53.44%) VDAC1;HDAC2;PLCB4;...
Osteoclast differentiation -1.97 4.31e-3 117/127 (92.13%) LILRA2;MAPK8;BTK;...
Epstein-Barr virus infection -1.98 0.00e+0 189/202 (93.56%) LYN;MAPK8;BTK;...
Pertussis -1.99 0.00e+0 64/76 (84.21%) NLRP3;MAPK14;C2;...
Graft-versus-host disease -2.04 0.00e+0 32/42 (76.19%) HLA-DRA;CD80;HLA-C;...
Proteasome -2.24 0.00e+0 44/46 (95.65%) PSME4;PSMA1;PSMA3;...
Leishmaniasis -2.35 0.00e+0 67/77 (87.01%) NFKBIB;MAPK14;ELK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H