Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFO7RP)

Drug Name
KW-2449 Drug Info
Synonyms Tumor antigen-specific mAb (cancer), Kyowa; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
Cross-matching ID
PubChem CID
11427553
ChEBI ID
CHEMBL91441
CAS Number
CAS 841258-76-2
TTD Drug ID
D00ABO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.41 0.00e+0 19/20 (95%) SQLE;MSMO1;DHCR7;...
Oxidative phosphorylation 2.27 0.00e+0 93/133 (69.92%) NDUFB2;COX17;COX7B;...
Diabetic cardiomyopathy 1.98 4.08e-3 162/203 (79.8%) PLN;NDUFB2;COX7B;...
PPAR signaling pathway 1.87 9.17e-3 66/74 (89.19%) FABP4;SCD;HMGCS1;...
Biosynthesis of unsaturated fatty acids 1.84 1.22e-2 21/27 (77.78%) SCD;HACD1;FADS2;...
Synthesis and degradation of ketone bodies 1.83 1.22e-2 9/10 (90%) HMGCS1;ACAT2;ACAT1;...
Terpenoid backbone biosynthesis 1.82 1.05e-2 18/22 (81.82%) HMGCS1;IDI1;GGPS1;...
Thermogenesis 1.77 1.53e-2 173/232 (74.57%) GNAS;ACSL3;NDUFB2;...
Cardiac muscle contraction 1.76 1.63e-2 64/87 (73.56%) COX7B;ATP1B3;COX7A2;...
Regulation of lipolysis in adipocytes 1.76 1.47e-2 52/55 (94.55%) FABP4;GNAS;PLIN1;...
Retrograde endocannabinoid signaling 1.76 1.45e-2 118/148 (79.73%) NDUFB2;NDUFB1;NDUFAB1;...
Butanoate metabolism 1.75 1.63e-2 23/28 (82.14%) HMGCS1;ABAT;ACAT2;...
Pyruvate metabolism 1.73 2.07e-2 41/47 (87.23%) ADH1B;ME1;ACAT2;...
Valine, leucine and isoleucine degradation 1.72 2.53e-2 42/48 (87.5%) HMGCS1;ABAT;ACAT2;...
Thyroid hormone synthesis 1.72 2.36e-2 66/75 (88%) GPX3;GNAS;GPX1;...
Leukocyte transendothelial migration 1.70 3.06e-2 90/114 (78.95%) ACTN1;CXCL12;CTNND1;...
Tight junction 1.69 3.09e-2 130/169 (76.92%) ACTN1;MYH11;AMOTL2;...
Vibrio cholerae infection 1.67 3.80e-2 44/50 (88%) GNAS;SEC61G;SLC12A2;...
DNA replication -1.95 1.79e-2 34/36 (94.44%) MCM3;LIG1;RFC3;...
Legionellosis -1.99 2.15e-2 51/57 (89.47%) BCL2L13;C3;IL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H