Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFZXI2)

Drug Name
NVP-TAE684 Drug Info
Synonyms
761439-42-3; NVP-TAE684; NVP-TAE 684; TAE684; TAE-684; 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine; TAE684 (NVP-TAE684); TAE 684; UNII-EH1713MN4K; CHEMBL509032; EH1713MN4K; 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; C30H40ClN7O3S
Cross-matching ID
PubChem CID
16038120
ChEBI ID
CHEMBL509032
CAS Number
CAS 761439-42-3
TTD Drug ID
D0R2WK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.20 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Mineral absorption 1.97 9.49e-3 48/60 (80%) TF;MT1E;MT1F;...
PPAR signaling pathway 1.90 1.58e-2 66/74 (89.19%) HMGCS1;SCD;PCK1;...
Steroid hormone biosynthesis 1.82 4.03e-2 43/61 (70.49%) AKR1C3;AKR1C2;UGT2B28;...
Tryptophan metabolism 1.80 3.42e-2 35/42 (83.33%) KYNU;ACAT2;CYP1B1;...
Metabolism of xenobiotics by cytochrome P450 1.76 4.43e-2 49/77 (63.64%) CBR3;UGT2B28;AKR1C1;...
Bile secretion 1.75 4.34e-2 68/90 (75.56%) ABCB1;UGT2B28;AQP1;...
Phenylalanine metabolism 1.74 4.15e-2 14/17 (82.35%) MAOA;PAH;AOC3;...
Fatty acid biosynthesis 1.73 3.80e-2 16/18 (88.89%) FASN;ACSL3;ACSL1;...
Terpenoid backbone biosynthesis 1.73 3.61e-2 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Pentose and glucuronate interconversions 1.73 3.45e-2 17/34 (50%) AKR1B10;UGT2B28;UGT2A3;...
Nitrogen metabolism 1.73 3.16e-2 16/17 (94.12%) CA12;GLUL;CPS1;...
Synthesis and degradation of ketone bodies 1.70 3.43e-2 9/10 (90%) HMGCS1;ACAT2;BDH1
Vitamin digestion and absorption 1.68 3.93e-2 17/24 (70.83%) SLC5A6;APOA1;APOB;...
Progesterone-mediated oocyte maturation -1.70 3.46e-2 75/100 (75%) CDC23;ADCY2;PRKACB;...
Hematopoietic cell lineage -1.74 2.54e-2 90/99 (90.91%) CD1C;FCER2;CD14;...
Ribosome biogenesis in eukaryotes -1.74 2.47e-2 52/108 (48.15%) TCOF1;EIF6;NMD3;...
Nucleotide excision repair -1.76 2.65e-2 40/47 (85.11%) RBX1;RFC1;POLD3;...
Colorectal cancer -1.82 1.06e-2 84/86 (97.67%) MSH3;MYC;BCL2;...
p53 signaling pathway -1.92 3.53e-3 63/73 (86.3%) BCL2;CCNB1;CHEK1;...
Mismatch repair -1.93 4.23e-3 22/23 (95.65%) RFC1;POLD3;MLH3;...
Homologous recombination -1.98 5.29e-3 35/41 (85.37%) RPA2;RPA1;SSBP1;...
Fanconi anemia pathway -2.06 3.53e-3 36/54 (66.67%) ERCC1;FAN1;FANCL;...
DNA replication -2.30 0.00e+0 34/36 (94.44%) RFC5;RPA2;MCM4;...
Cell cycle -2.32 0.00e+0 110/124 (88.71%) RBL1;CUL1;SMC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H