Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG60XN)

• Drug Name: Phentermine Drug Info
• Synonyms: Duromine; Fastin; Fentermina; Inoamin; Ionamin; Ionamine; Linyl; Lipopill; Lonamin; Mirapront; Normephentermine; Obenix; Obermine; Omnibex; Ortetamin; Ortetamina; Ortetaminum; Phentercot; Phenterminum; Phentride; Phentrol; Wilpo; Zantryl; Ona Mast; Ortetamine [INN]; Phentermine HCl; Phentermine resin complex; AmbkkkkK744; Phentermine Resin 30; Phentrol 2; Phentrol 3; Phentrol 4; Adipex P (TN); Adipex-P; Alpha-Benzylisopropylamine; Duromine (TN); Fastin (TN); Fentermina [INN-Spanish]; Ionamin (TN); Mirapront (TN); Obenix (TN); Obephen (TN); Obermine (TN); Oby-Trim; Panbesy (TN); Phenterex (TN); Phentermine (TN); Phenterminum [INN-Latin]; Phentremene (TN); Phentrol (TN); Phentromin (TN); Pro-Fast; Redusa (TN); Sinpet (TN); Supremin (TN); Teramine (TN); Trenker (TN); Umine (TN); Weltmine (TN); Zantryl (TN); Alpha,alpha-Dimethylbenzeneethanamine; Alpha,alpha-Dimethylphenethylamine; Anoxine-AM (TN); Obestin-30 (TN); Oby-Trim (TN); Phentermine (USAN/INN); Phentermine [USAN:INN:BAN]; Phenyl-tert-butylamine; Phenyl-tertiary-butylamine; Pro-Fast SA (TN); Alpha,alpha-Dimethyl-beta-phenylethylamine; Alpha.,.alpha.-dimethyl-Benzeneethanamine; (alpha,alpha)-Dimethylphenethylamine; 1,1-Dimethyl-2-phenylethylamine; 1-(2-Methylphenyl)-2-propylamin; 1-(2-Tolyl)-2-propylamine; 2-Amino-2-methyl-1-phenylpropane; 2-Methyl-1-phenyl-2-propanamine; 2-Phenyl-tert-butylamine
• Therapeutic Class: Appetite Depressants
• Cross-matching ID:
  PubChem CID: 4771
  ChEBI ID: CHEMBL1574
  CAS Number: CAS 122-09-8
  TTD Drug ID: D0U0RZ
  VARIDT Drug ID: DR01098
  INTEDE Drug ID: DR1280
  ACDINA Drug ID: D00527

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Asthma	1.96	0.00e+0	25/31 (80.65%)	FCER1A;HLA-DQA1;RNASE3;...
Viral protein interaction with cytokine and cytokine re...	1.80	3.76e-2	84/100 (84%)	CXCL13;IL6ST;IL2RG;...
RNA degradation	1.79	3.39e-2	53/79 (67.09%)	PFKL;PFKP;BTG3;...
Carbohydrate digestion and absorption	1.77	3.39e-2	37/47 (78.72%)	SLC37A4;MGAM;AKT3;...
Inflammatory bowel disease	1.77	2.82e-2	58/65 (89.23%)	IL2RG;MAF;TGFB1;...
Glycolysis / Gluconeogenesis	1.77	2.90e-2	56/67 (83.58%)	PFKL;PFKP;PKM;...
Galactose metabolism	1.76	2.96e-2	26/31 (83.87%)	PFKL;MGAM;PFKP;...
Th17 cell differentiation	1.75	3.01e-2	95/107 (88.79%)	NFATC3;IL6ST;IL2RG;...
Osteoclast differentiation	1.73	3.61e-2	117/127 (92.13%)	AKT3;TGFB1;TGFBR2;...
Th1 and Th2 cell differentiation	1.72	3.28e-2	80/92 (86.96%)	NFATC3;IL2RG;MAF;...
Chemokine signaling pathway	1.71	3.29e-2	163/192 (84.9%)	CXCL13;PAK1;CDC42;...
Histidine metabolism	1.70	3.47e-2	16/22 (72.73%)	AOC1;ALDH3A2;ALDH7A1;...
Arginine and proline metabolism	1.69	3.87e-2	39/50 (78%)	CKB;ODC1;GATM;...
Complement and coagulation cascades	-1.79	2.55e-2	76/85 (89.41%)	C8A;C8B;MASP2;...
Metabolism of xenobiotics by cytochrome P450	-1.81	2.55e-2	49/77 (63.64%)	CYP2F1;GSTT2;UGT2B17;...
Steroid hormone biosynthesis	-1.88	1.98e-2	43/61 (70.49%)	UGT2B4;COMT;STS;...
Ovarian steroidogenesis	-2.01	4.25e-3	41/51 (80.39%)	BMP6;CGA;LDLR;...
Retinol metabolism	-2.24	0.00e+0	41/68 (60.29%)	ALDH1A2;UGT2B17;CYP2B6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼