Details of the Drug Pharmacogenomic Perturbation Atlas

MOXONIDINE Drug Info

BDF-5895; BE-5895; Normoxin; AC1OCENE; SCHEMBL1230620; Moxonidine hydrochloride hydrate; moxonidine hydrochloride monohydrate; LY-326869; 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrate hydrochloride

Cross-matching ID

PubChem CID

4810

ChEBI ID

CHEMBL19236

CAS Number

CAS 75438-57-2

TTD Drug ID

D0E9PK

General Information of Drug (ID: DMGFB0E)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.39	0.00e+0	34/36 (94.44%)	POLE2;MCM5;RFC3;...
Mismatch repair	2.26	0.00e+0	22/23 (95.65%)	RFC3;RFC5;LIG1;...
Nucleotide excision repair	2.23	0.00e+0	40/47 (85.11%)	POLE2;RAD23B;RFC3;...
Mineral absorption	1.96	4.65e-3	48/60 (80%)	SLC26A3;HMOX1;MT2A;...
Citrate cycle (TCA cycle)	1.84	1.67e-2	30/30 (100%)	DLST;IDH2;PCK1;...
Homologous recombination	1.83	1.39e-2	35/41 (85.37%)	RAD51;SSBP1;RAD54B;...
Fanconi anemia pathway	1.79	3.06e-2	36/54 (66.67%)	USP1;RAD51;RMI1;...
Prostate cancer	1.77	3.02e-2	93/97 (95.88%)	PLAT;CCNE2;NKX3-1;...
Proximal tubule bicarbonate reclamation	1.76	2.79e-2	21/23 (91.3%)	SLC4A4;PCK1;ATP1B2;...
Spliceosome	1.72	3.63e-2	101/150 (67.33%)	PRPF4;PRPF19;HSPA2;...
Ribosome	1.65	4.90e-2	113/158 (71.52%)	MRPS16;RPS4Y1;FAU;...
Neutrophil extracellular trap formation	-1.62	4.97e-2	101/189 (53.44%)	MAPK14;C5;MAP3K7;...
PPAR signaling pathway	-1.69	4.41e-2	66/74 (89.19%)	SCD5;FADS2;ANGPTL4;...
Biosynthesis of unsaturated fatty acids	-1.70	4.32e-2	21/27 (77.78%)	HACD3;BAAT;HSD17B4;...
Viral myocarditis	-1.73	3.57e-2	53/60 (88.33%)	FYN;CASP8;RAC2;...
Cholesterol metabolism	-1.76	2.76e-2	44/50 (88%)	ANGPTL3;APOA1;SORT1;...
Cytokine-cytokine receptor interaction	-1.77	3.11e-2	246/295 (83.39%)	AMH;IL13;IFNA7;...
ECM-receptor interaction	-1.80	2.62e-2	80/88 (90.91%)	ITGA4;DMP1;GP9;...
Hematopoietic cell lineage	-1.81	2.16e-2	90/99 (90.91%)	GP9;ITGA1;IL4R;...
Malaria	-1.82	2.59e-2	44/50 (88%)	SDC1;CR1;THBS2;...
Nicotinate and nicotinamide metabolism	-1.83	2.97e-2	25/35 (71.43%)	BST1;NAMPT;NT5C;...
Phagosome	-1.87	3.24e-2	118/152 (77.63%)	TUBB1;MSR1;FCGR2A;...
Lysosome	-2.01	5.40e-3	115/128 (89.84%)	TCIRG1;GUSB;HYAL2;...
Steroid biosynthesis	-2.10	1.08e-2	19/20 (95%)	CYP51A1;SQLE;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-ES-1	CVCL_0627	Homo sapiens	1.11uM - 10uM	24H

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Brain

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	1.11uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H

MDA-MB-468	CVCL_0419	Homo sapiens	1.11uM - 10uM	24H

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
T-47D	CVCL_0553	Homo sapiens	1.11uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 2.22uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colon carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HCT 116 TP53(-/-)	CVCL_HD97	Homo sapiens	0.04uM - 10uM	24H

HCT 116	CVCL_0291	Homo sapiens	0.04uM - 10uM	24H

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

SNU-407	CVCL_5004	Homo sapiens	1.11uM - 10uM	24H

Colorectal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCT 116 (Parent)	CVCL_0291	Homo sapiens	0.04uM - 10uM	24H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 10uM	24H

HEC-1-A	CVCL_0293	Homo sapiens	1.11uM - 10uM	24H

HEC-251	CVCL_2928	Homo sapiens	1.11uM - 10uM	24H

HEC-265	CVCL_2929	Homo sapiens	1.11uM - 10uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
ASC	CVCL_U602	Homo sapiens	10uM	24H

CJM	CVCL_U797	Homo sapiens	1.11uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 2.22uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	1.11uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

NCI-H1573	CVCL_1483	Homo sapiens	1.11uM - 10uM	24H

NCI-H838	CVCL_1594	Homo sapiens	1.11uM - 10uM	24H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BEN	CVCL_1081	Homo sapiens	1.11uM - 10uM	24H

HCC95	CVCL_1276	Homo sapiens	1.11uM - 10uM	24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

NCI-H2110	CVCL_1529	Homo sapiens	1.11uM - 10uM	24H

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	1.11uM - 10uM	24H

Ovary

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OVTOKO	CVCL_3114	Homo sapiens	1.11uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 2.22uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
22Rv1	CVCL_1045	Homo sapiens	1.11uM - 10uM	24H

PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H

IGR-37	CVCL_1303	Homo sapiens	1.11uM - 10uM	24H

Mel-HO	CVCL_1402	Homo sapiens	1.11uM - 10uM	24H

SH-4	CVCL_1692	Homo sapiens	1.11uM - 10uM	24H

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	10uM	24H

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	1.11uM - 10uM	24H