Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGVH6N)

Drug Name
Axitinib Drug Info
Synonyms
AG 013736; AG013736; AG-013736; AG-13736; AG-013736, Axitinib; N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; Axitinib (VEGFR inhibitor)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
6450551
ChEBI ID
CHEMBL66910
CAS Number
CAS 319460-85-0
TTD Drug ID
D01ZRI
VARIDT Drug ID
DR00035
INTEDE Drug ID
DR0162
ACDINA Drug ID
D00053

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 2.10 0.00e+0 86/96 (89.58%) TPM2;ACTC1;DES;...
Hypertrophic cardiomyopathy 2.03 4.64e-3 81/90 (90%) TPM2;ACTC1;DES;...
Glycine, serine and threonine metabolism 1.96 6.19e-3 31/40 (77.5%) PSAT1;CBS;PHGDH;...
p53 signaling pathway 1.91 4.64e-3 63/73 (86.3%) SERPINB5;DDB2;FAS;...
Arginine and proline metabolism 1.74 4.83e-2 39/50 (78%) MAOB;CKM;ODC1;...
DNA replication -1.59 4.22e-2 34/36 (94.44%) DNA2;LIG1;POLE3;...
NOD-like receptor signaling pathway -1.59 4.34e-2 145/181 (80.11%) AIM2;TRPV2;PLCB4;...
Mucin type O-glycan biosynthesis -1.63 3.78e-2 20/36 (55.56%) GCNT3;GALNT6;GCNT1;...
Antigen processing and presentation -1.64 3.61e-2 60/78 (76.92%) HLA-C;HSP90AA1;B2M;...
Vibrio cholerae infection -1.64 3.62e-2 44/50 (88%) TCIRG1;ATP6AP1;TJP2;...
Sphingolipid metabolism -1.65 3.42e-2 32/49 (65.31%) SPHK1;SGMS1;B4GALT6;...
Toll-like receptor signaling pathway -1.65 3.57e-2 94/104 (90.38%) IKBKE;TLR8;MAPK13;...
Inflammatory bowel disease -1.66 3.35e-2 58/65 (89.23%) IL23A;MAF;HLA-DPB1;...
NF-kappa B signaling pathway -1.68 2.77e-2 90/104 (86.54%) MAP3K7;ICAM1;CCL4;...
Ferroptosis -1.74 1.58e-2 36/41 (87.8%) ACSL4;SLC11A2;ACSL6;...
Terpenoid backbone biosynthesis -1.74 1.66e-2 18/22 (81.82%) DHDDS;PCYOX1;HMGCR;...
Metabolism of xenobiotics by cytochrome P450 -1.75 1.52e-2 49/77 (63.64%) MGST3;ADH1B;GSTP1;...
Various types of N-glycan biosynthesis -1.75 1.60e-2 26/39 (66.67%) B4GALT3;RPN2;ALG3;...
Glycosaminoglycan degradation -1.75 1.70e-2 19/19 (100%) HPSE;IDUA;IDS;...
Th17 cell differentiation -1.76 1.74e-2 95/107 (88.79%) HSP90AA1;IL6ST;CD3E;...
Fluid shear stress and atherosclerosis -1.76 1.78e-2 123/139 (88.49%) MAPK13;MAP2K7;RAC1;...
Malaria -1.78 1.60e-2 44/50 (88%) TLR2;ICAM1;SDC2;...
Legionellosis -1.79 1.56e-2 51/57 (89.47%) HSPA6;TLR4;SAR1A;...
Graft-versus-host disease -1.80 1.52e-2 32/42 (76.19%) KLRD1;HLA-DPB1;HLA-DRB1;...
Osteoclast differentiation -1.80 1.65e-2 117/127 (92.13%) TGFBR2;LILRB4;FCGR2B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.81 1.60e-2 62/70 (88.57%) TCIRG1;ATP6AP1;MAPK13;...
TNF signaling pathway -1.86 5.94e-3 103/112 (91.96%) MAPK10;PIK3R1;MAP3K8;...
Hematopoietic cell lineage -1.87 6.69e-3 90/99 (90.91%) CD4;CD3G;HLA-DPB1;...
Other glycan degradation -1.89 6.11e-3 13/18 (72.22%) MANBA;GLB1;AGA;...
Leishmaniasis -1.91 3.57e-3 67/77 (87.01%) MAPK13;TLR2;HLA-DMB;...
Lysosome -2.03 0.00e+0 115/128 (89.84%) GALC;IDUA;ATP6V0B;...
Phagosome -2.26 0.00e+0 118/152 (77.63%) FCGR2B;HLA-DPB1;TCIRG1;...
IL-17 signaling pathway -2.33 0.00e+0 84/94 (89.36%) MAPK7;IKBKE;MAPK13;...
Rheumatoid arthritis -2.38 0.00e+0 78/93 (83.87%) TLR2;HLA-DMB;ICAM1;...
Steroid biosynthesis -2.39 0.00e+0 19/20 (95%) SOAT1;LIPA;HSD17B7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 1.11uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H