Details of the Drug

General Information of Drug (ID: DMGVH6N)

• Drug Name: Axitinib
• Synonyms: AG 013736; AG013736; AG-013736; AG-13736; AG-013736, Axitinib; N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; Axitinib (VEGFR inhibitor)

Indication

Disease Entry	ICD 11	Status	REF
Renal cell carcinoma	2C90	Approved	[1]

• Therapeutic Class: Anticancer Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  L01EK01: Axitinib
  L01EK: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors
  L01E: PROTEIN KINASE INHIBITORS
  L01: ANTINEOPLASTIC AGENTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 386.5
  Logarithm of the Partition Coefficient (xlogp); 4.2
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 4
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [2]
  Clearance: The drug present in the plasma can be removed from the body at the rate of 5 mL/min/kg [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 4.3 hours [3]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.004% [3]
• Chemical Identifiers:
  Formula: C22H18N4OS
  IUPAC Name: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
  Canonical SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
  InChI: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
  InChIKey: RITAVMQDGBJQJZ-FMIVXFBMSA-N
• Cross-matching ID:
  PubChem CID: 6450551
  ChEBI ID: CHEBI:66910
  CAS Number: 319460-85-0
  UNII: C9LVQ0YUXG
  DrugBank ID: DB06626
  TTD ID: D01ZRI
  VARIDT ID: DR00035
  INTEDE ID: DR0162
  ACDINA ID: D00053

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[5]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[6]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[6]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[7]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[8]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[9]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[9]

Molecular Expression Atlas of This Drug

• The Studied Disease: Renal cell carcinoma
• ICD Disease Classification: 2C90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2
P-glycoprotein 1 (ABCB1)	DTP	P-GP	9.39E-02	1.07E-01	2.80E-01
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DTP	OATP1B1	8.15E-01	6.20E-03	5.61E-02
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME	UGT1A1	1.10E-01	-5.91E-02	-3.60E-01
Cytochrome P450 1A2 (CYP1A2)	DME	CYP1A2	7.36E-01	1.62E-02	1.08E-01
Cytochrome P450 3A5 (CYP3A5)	DME	CYP3A5	9.96E-01	-3.17E-03	-1.84E-02
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	2.40E-01	-3.31E-02	-1.97E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	1.04E-02	6.29E-02	3.54E-01

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC1; GDSC2	3.7829	7.7398	1.4844	9.9591
H-EMC-SS	GDSC1; GDSC2	-2.5571	24.3728	-12.4304	51.4431
ES8	GDSC1; GDSC2	0.1163	1.8129	0.0924	31.1721
ES5	GDSC1; GDSC2	0.4714	3.5467	0.1469	29.2143
SK-ES-1	GDSC1; GDSC2; CTRP2	1.0926	2.3672	1.0924	32.9903
ES7	GDSC1; GDSC2	1.2338	4.1668	0.7672	22.6597
EW-12	GDSC2	1.2525	3.1956	1.0967	21.5818
EW-18	GDSC1; GDSC2	1.4131	4.1016	0.9838	20.7416
MHH-ES-1	GDSC1; GDSC2; CTRP2	1.4246	3.7144	1.4001	30.8597
ES1	GDSC1; GDSC2	1.436	3.5714	1.1906	19.5327
EW-22	GDSC1; GDSC2	1.5011	3.3336	1.3316	18.5025
CADO-ES1	GDSC1; GDSC2	1.5105	3.1233	1.3956	18.1274
SK-PN-DW	GDSC1; GDSC2	1.6996	4.9237	0.9541	19.7448
G-292 clone A141B1	GDSC1; GDSC2; CTRP2	1.8082	5.1236	1.6362	28.8035
TC-71	GDSC1; GDSC2	1.8422	4.0533	1.4616	16.351
SK-N-MC	CTRP2	1.8429	4.3377	1.7881	28.1754
CAL-78	GDSC1; GDSC2; CTRP2	1.8988	4.1738	1.8617	27.7431
NOS-1 [Human HNSCC]	GDSC1; GDSC2	1.9071	11.2998	-1.8998	31.2656
HuO9	GDSC1; GDSC2	2.0291	7.208	0.2187	22.4488
TC71	CTRP2	2.2278	6.6053	1.7136	27.2019
CHSA0011	GDSC1; GDSC2	2.2387	9.7432	-0.8308	26.4551
A-673	GDSC1; GDSC2; CTRP2	2.5878	5.6674	2.368	23.7867
CAL-72	GDSC1; GDSC2	2.8871	5.3436	1.9292	9.8162
EW-7	GDSC1; GDSC2	2.9857	6.0589	1.664	11.1085
HuO-3N1	GDSC1; GDSC2	3.3625	7.9869	1.0231	13.7901
SaOS-2	GDSC1; GDSC2; CTRP2	3.7059	7.2456	3.087	17.8338
EW-13	GDSC1; GDSC2	3.7422	6.2626	2.1855	5.8516
EW-3	GDSC1; GDSC2	3.7917	7.7982	1.4623	10.0678
EW-24	GDSC1; GDSC2	3.896	6.5191	2.1729	5.5655
EW-11	GDSC1; GDSC2	4.0164	9.4833	0.7992	13.2918
U-CH2	GDSC2	4.044	9.3518	0.8855	13.1612
NY	GDSC1; GDSC2	4.0838	8.6146	1.2806	10.4033
EW-16	GDSC1; GDSC2	4.1965	7.5484	1.8857	6.5974
ES4	GDSC1; GDSC2	4.2042	6.4759	2.4057	3.5543
EW-1	GDSC1; GDSC2	4.2536	9.7193	0.8626	12.352
U2OS	GDSC1; GDSC2	4.3111	8.7598	1.3768	9.3107
ES6	GDSC1; GDSC2	4.3393	7.3567	2.0765	5.1828
CHSA0108	GDSC1; GDSC2	4.4937	8.9769	1.4014	8.7594
SJSA-1	GDSC1; GDSC2; CTRP2	4.6223	7.6887	3.8639	12.3388
MG-63	GDSC1; GDSC2; CTRP2	4.7864	9.1622	3.3439	14.0245
Hs 888.T	CTRP2	5.1768	14.9203	0.8642	22.3157
HOS	GDSC1; GDSC2; CTRP2	5.3232	9.787	3.5426	11.9842
CHSA8926	GDSC1; GDSC2	5.7127	16.3928	-1.344	19.1461
Hs 822.T	CTRP2	5.9951	12.6055	2.7227	13.9195
SW1353	CTRP2	7.5751	16.6695	1.9473	13.981

Cancer Drug Sensitivity Data Curated from 218 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JK1	CTRP2	-3.2622	2.0972	-3.3673	60.8588
MEC1	CTRP2	3.6435	6.6117	3.2499	17.4005
JM1	GDSC1; GDSC2; CTRP2	2.7499	5.5897	2.5621	22.5957
EoL-1	GDSC1; GDSC2; CTRP2	-10.9186	-8.8034	-10.9186	99.2075
Kasumi-1	GDSC1; GDSC2; CTRP2	-5.503	-1.6666	-5.5077	75.4462
Ku812	GDSC1; GDSC2; CTRP2	-2.9933	-0.7741	-2.9936	60.1932
JURL-MK1	GDSC1; GDSC2; CTRP2	-2.7223	-1.1537	-2.7223	58.4041
NCO2	CTRP2	-2.4986	-1.1099	-2.4986	56.9146
LAMA-84	GDSC1; GDSC2; CTRP2	-2.4618	-1.1622	-2.4618	56.6695
MEG-01	GDSC1; GDSC2	-2.068	0.045	-2.075	52.1973
EM-2	GDSC1; GDSC2; CTRP2	-2.0167	0.6686	-2.0201	53.688
MOLM-6	CTRP2	-1.6439	0.6444	-1.6452	51.2187
ALL-SIL	GDSC1; GDSC2; CTRP2	-1.515	0.0139	-1.5151	50.362
BV-173	GDSC1; GDSC2; CTRP2	-1.3569	1.1868	-1.3608	49.3105
BE-13	GDSC1; GDSC2	-1.2714	0.8634	-1.2885	44.5582
CML-T1	GDSC1; GDSC2; CTRP2	-1.2132	1.1136	-1.2155	48.3541
KYO-1	CTRP2	-1.209	-0.4571	-1.209	48.323
KCL-22	GDSC1; GDSC2; CTRP2	-0.782	1.2198	-0.7831	45.4813
KG-1	GDSC1; GDSC2	-0.5965	2.6592	-0.7934	38.7582
MY-M12	GDSC1; GDSC2	-0.4684	3.4808	-0.8591	38.2624
ATN-1	GDSC1; GDSC2	-0.4629	0.4715	-0.463	36.6685
Peer	CTRP2	-0.441	1.0035	-0.4411	43.2068
NALM-6	GDSC1; GDSC2; CTRP2	-0.3106	1.1928	-0.3107	42.3384
K-562	GDSC1; GDSC2; CTRP2	-0.0985	3.288	-0.1547	41.0814
SUP-M2	GDSC1; GDSC2; CTRP2	-0.0513	1.6516	-0.0519	40.6124
HuT 78	CTRP2	0.0861	8.0011	-1.0808	42.0253
SUP-B15	GDSC1; GDSC2; CTRP2	0.0899	2.4731	0.0809	39.698
BL-41	GDSC1; GDSC2	0.1312	0.8262	0.1312	30.9118
NKM-1	GDSC1; GDSC2	0.2496	4.8768	-0.5545	33.3874
ALL-PO	GDSC1; GDSC2	0.3326	2.9087	0.1624	29.7936
P32/ISH	GDSC1; GDSC2	0.3846	1.2209	0.3842	28.4591
697	GDSC1; GDSC2; CTRP2	0.3906	1.4909	0.3906	37.6663
RS4;11	GDSC1; GDSC2; CTRP2	0.4014	1.4088	0.4014	37.5943
MOLT-4	GDSC1; GDSC2	0.4661	2.2198	0.4227	27.8799
CRO-AP2	GDSC1; GDSC2	0.4781	2.4025	0.4124	27.8739
MV4-11	GDSC1; GDSC2; CTRP2	0.5072	2.1779	0.5062	36.8929
MOLT-16	GDSC1; GDSC2; CTRP2	0.5133	1.4342	0.5133	36.8492
SU-DHL-16	GDSC1; GDSC2	0.6465	2.0571	0.6269	26.0157
A4/Fukuda	GDSC1; GDSC2; CTRP2	0.6577	5.1922	0.3746	36.733
NB4	GDSC1; GDSC2; CTRP2	0.667	1.6672	0.667	35.8252
MOLM-13	GDSC1; GDSC2; CTRP2	0.6791	2.6439	0.6747	35.7589
SU-DHL-5	GDSC1; GDSC2	0.6987	2.191	0.6708	25.5505
SEM	CTRP2	0.7046	1.4943	0.7046	35.5742
CCRF-CEM	GDSC1; GDSC2	0.8383	2.3753	0.7993	24.2533
KMS-26	CTRP2	0.8689	4.3043	0.7587	34.8339
KE-37	GDSC1; GDSC2; CTRP2	0.8712	2.9323	0.8637	34.4896
QIMR-WIL	GDSC1; GDSC2	0.896	2.576	0.8345	23.8063
P31/FUJ	GDSC1; GDSC2; CTRP2	0.9023	2.4392	0.9014	34.2607
P30/OHK	GDSC1; GDSC2	0.9099	1.8229	0.9074	23.3804
Kasumi-2	CTRP2	0.9147	3.247	0.898	34.2299
KMS-21-BM	CTRP2	0.974	3.2787	0.9575	33.8345
SUP-B8	GDSC1; GDSC2	0.9803	1.9583	0.9758	22.7078
BC-3	GDSC2	1.0257	3.8366	0.6587	24.9838
ST486	GDSC1; GDSC2; CTRP2	1.0319	3.6161	0.9992	33.502
NU-DUL-1	GDSC1; GDSC2; CTRP2	1.047	2.6453	1.0251	23.3776
KOPN-8	GDSC1; GDSC2	1.11	2.2324	1.0967	21.4939
OCI-Ly19	GDSC1; GDSC2; CTRP2	1.1261	2.4351	1.1258	32.7675
KY821	GDSC1; GDSC2	1.1379	4.624	0.4894	24.5284
P12-Ichikawa	GDSC1; GDSC2; CTRP2	1.1547	2.0971	1.1547	32.5756
IM-9	GDSC1; GDSC2	1.1643	1.8541	1.1636	20.9069
GDM-1	GDSC1; GDSC2; CTRP2	1.1956	3.6315	1.168	32.3953
TALL-1 [Human adult T-ALL]	GDSC2; CTRP2	1.2164	3.2947	1.205	32.2027
OCI-AML-5	GDSC1; GDSC2; CTRP2	1.2417	3.4659	1.2242	32.0543
CTB-1	GDSC1; GDSC2	1.2627	3.8941	0.8959	21.8503
MOLT-3	CTRP2	1.2665	2.9574	1.2634	31.8417
KO52	CTRP2	1.2668	3.8271	1.2288	31.9553
ML-2	GDSC1; GDSC2	1.2735	3.6554	0.9872	21.3187
JVM-3	GDSC1; GDSC2; CTRP2	1.2799	3.8492	0.93	18.1466
KMS-11	GDSC1; GDSC2; CTRP2	1.281	4.9427	1.1	32.33
HAL-01	GDSC1; GDSC2	1.2992	3.1396	1.1614	20.2907
LC4-1	GDSC1; GDSC2	1.3157	4.0576	0.8952	21.6291
DEL	GDSC1; GDSC2; CTRP2	1.3166	3.3207	1.3064	31.5313
VAL	GDSC1; GDSC2	1.3206	3.5499	1.0716	20.6662
MOLM-16	GDSC1; GDSC2; CTRP2	1.3572	3.5534	1.339	31.2876
RPMI-8866	GDSC1; GDSC2	1.3931	4.1729	0.9358	21.0849
BONNA-12	GDSC2	1.3946	4.3164	0.8828	22.1232
OPM-2	GDSC1; GDSC2; CTRP2	1.449	3.7063	1.4258	30.6926
Loucy	GDSC1; GDSC2	1.4741	3.6719	1.2	19.3183
GA-10	GDSC1; GDSC2; CTRP2	1.4846	3.268	1.4788	30.3973
RPMI-8402	GDSC1; GDSC2; CTRP2	1.5192	3.6387	1.5017	30.2059
L-540	GDSC1; GDSC2; CTRP2	1.5578	4.1783	1.5036	30.072
DoHH2	GDSC1; GDSC2; CTRP2	1.573	2.8722	1.5724	29.7909
EB1	CTRP2	1.5846	5.0188	1.4141	30.2832
BALL-1	GDSC1; GDSC2	1.6072	3.8756	1.2748	18.3496
MJ	CTRP2	1.6107	14.2883	-2.1755	38.4805
Sc-1	GDSC1	1.6267	3.0419	0.4421	2.5811
Farage	GDSC1; GDSC2	1.6305	3.219	1.5031	17.0312
SU-DHL-10	GDSC2; CTRP2	1.6698	3.709	1.6533	29.1992
Karpas-45	GDSC1; GDSC2	1.6821	4.336	1.1807	18.5574
OCI-AML-3	GDSC1; GDSC2; CTRP2	1.6867	5.5016	1.4252	29.9103
WSU-NHL	GDSC1; GDSC2	1.7202	4.0466	1.3337	17.5569
Reh	GDSC1; GDSC2; CTRP2	1.7227	3.6413	1.7104	28.8328
OCI-AML-2	GDSC1; GDSC2; CTRP2	1.7468	3.2447	1.7443	28.6394
OCI-Ly7	GDSC1; GDSC2	1.8162	3.8691	1.5024	16.2337
Daudi	GDSC1; GDSC2; CTRP2	1.831	2.9672	1.8307	28.0715
Ramos.2G6.4C10	GDSC1; GDSC2	1.8452	4.5684	1.2569	17.4819
MOTN-1	CTRP2	1.8966	4.5106	1.8259	27.8715
RCH-ACV	GDSC1; GDSC2; CTRP2	1.9791	5.1148	1.8227	27.6143
SCC-3	GDSC2	2.0268	6.6413	0.4892	21.7565
MHH-CALL-2	GDSC1; GDSC2	2.0367	4.081	1.6579	14.4716
KMS-34	CTRP2	2.087	4.6383	2.0126	26.616
AML-193	CTRP2	2.1264	6.0063	1.7789	27.2947
SKM-1	GDSC1; GDSC2; CTRP2	2.1371	5.2897	1.9601	26.6344
HPB-ALL	CTRP2	2.1899	4.9187	2.0832	26.0411
MOLT-13	GDSC1; GDSC2; CTRP2	2.2914	5.0809	2.1657	25.4308
SIG-M5	GDSC2; CTRP2	2.3352	3.615	2.3332	24.7176
KE-97	CTRP2	2.3513	5.358	2.1786	25.1949
LP-1	GDSC1; GDSC2; CTRP2	2.355	4.0733	2.3412	24.6254
KM-H2	GDSC1; GDSC2; CTRP2	2.3639	5.8403	2.0816	25.4939
KMS-20	CTRP2	2.3791	5.7401	2.1231	25.301
GR-ST	GDSC1; GDSC2	2.4043	6.6429	0.8461	17.7804
JeKo-1	GDSC1; GDSC2; CTRP2	2.4078	5.4143	2.2282	24.8433
SU-DHL-8	GDSC2; CTRP2	2.4149	5.0399	2.3056	24.5521
NOMO-1	GDSC1; GDSC2; CTRP2	2.4452	5.4616	2.2589	24.6176
SUP-T11	CTRP2	2.4486	5.3558	2.2844	24.5181
JSC-1	GDSC1; GDSC2	2.489	5.4536	1.5017	13.6967
F-36P	CTRP2	2.515	5.8163	2.2525	24.4211
BC-1	GDSC1; GDSC2	2.6008	4.5616	2.032	10.1734
M-07e	CTRP2	2.6276	6.4264	2.2046	24.2443
Mono-Mac-6	GDSC1; GDSC2	2.631	5.1809	1.7685	11.6283
TUR	GDSC1; GDSC2	2.6341	6.9768	0.8938	16.747
RPMI-6666	GDSC1; GDSC2; CTRP2	2.6348	4.9755	2.5514	22.9984
KMS-18	CTRP2	2.653	5.9755	2.3619	23.6054
KHM-1B	CTRP2	2.7284	5.1189	1.7385	7.7259
HL-60	GDSC1; GDSC2; CTRP2	2.7521	5.3704	2.6104	22.4195
Namalwa	GDSC1; GDSC2; CTRP2	2.7629	5.8268	2.5202	22.7031
SUP-HD1	GDSC1; GDSC2; CTRP2	2.7714	5.7941	2.5376	22.6152
BL-70	CTRP2	2.7722	5.7995	2.5371	22.6146
KMS-28BM	CTRP2	2.8323	6.0771	2.5299	22.4548
A3/Kawakami	GDSC1; GDSC2; CTRP2	2.8667	5.6764	2.6696	21.8513
DB	GDSC1; GDSC2; CTRP2	2.9131	6.3071	2.5519	22.1297
SET-2	CTRP2	2.9455	5.9642	2.684	21.5563
SU-DHL-6	GDSC1; GDSC2; CTRP2	2.9527	5.8241	2.7278	21.3778
ARH-77	GDSC1; GDSC2	2.9566	5.4789	1.9257	9.6169
KMOE-2	GDSC1; GDSC2	2.978	6.6907	1.343	13.0529
MOLP-8	GDSC1; GDSC2; CTRP2	2.9814	7.743	2.1222	23.4919
SUP-T1	GDSC1; GDSC2; CTRP2	2.9835	6.1347	2.6788	21.4585
NU-DHL-1	CTRP2	3.0085	5.3505	2.8917	20.6252
Ki-JK	CTRP2	3.0454	8.4718	1.8942	24.1305
PL-21	GDSC1; GDSC2	3.0502	7.3851	1.0597	14.4935
Ri-1	CTRP2	3.081	5.8292	2.8665	20.4874
HC-1	GDSC1; GDSC2	3.0951	5.907	1.8358	9.7367
L-363	GDSC1; GDSC2; CTRP2	3.1853	6.1013	2.9084	20.0171
JJN-3	GDSC1; GDSC2; CTRP2	3.2251	6.4914	2.8349	20.1646
CTV-1	GDSC1; GDSC2	3.2383	6.8066	1.5094	11.2873
RPMI-8226	GDSC1; GDSC2; CTRP2	3.2558	6.5404	2.8525	20.0088
DND-41	GDSC1; GDSC2; CTRP2	3.2772	6.6535	2.8387	19.9964
NK-92MI	GDSC2	3.2803	5.9267	1.9847	8.5854
CA46	GDSC1; GDSC2; CTRP2	3.2814	6.0132	3.0375	19.2595
KMS-12-BM	GDSC1; GDSC2; CTRP2	3.2956	5.8012	3.1073	18.9657
VL51	GDSC1; GDSC2	3.3067	5.9508	1.9948	8.153
Mono-Mac-1	CTRP2	3.3907	6.2257	3.0968	18.7133
TF-1	CTRP2	3.4044	5.9851	3.1793	18.3737
Granta-519	GDSC1; GDSC2; CTRP2	3.4066	6.4042	3.06	18.7999
Jiyoye	GDSC1; GDSC2	3.4092	6.6968	1.7067	9.6172
Hs 611.T	CTRP2	3.4106	6.3136	3.0922	18.6703
Karpas-422	GDSC1; GDSC2; CTRP2	3.4149	6.8974	2.9037	19.3532
Karpas-231	GDSC1; GDSC2	3.4312	6.0653	2.0402	7.5318
RC-K8	GDSC1; GDSC2	3.4677	6.2703	1.9673	7.8765
CESS	GDSC1; GDSC2	3.4731	6.0491	2.0821	7.1632
PF-382	GDSC1; GDSC2; CTRP2	3.4977	8.0402	2.5475	20.4591
WIL2 NS	GDSC1; GDSC2	3.5069	7.1166	1.5765	10.1346
SU-DHL-1	GDSC2; CTRP2	3.5254	6.4788	3.1655	18.0599
MHH-CALL-4	GDSC2; CTRP2	3.5328	6.6975	3.1009	18.2773
EB2	GDSC1; GDSC2	3.5473	5.8207	2.255	5.9154
L-428	GDSC1; GDSC2; CTRP2	3.5612	7.8831	2.679	19.7866
PL21	CTRP2	3.5879	6.0976	3.3488	17.2036
WSU-DLCL2	GDSC1; GDSC2; CTRP2	3.5884	6.1643	3.3305	17.2683
HH [Human lymphoma]	GDSC1; GDSC2	3.6019	6.0912	2.1631	6.3345
RL	GDSC1; GDSC2; CTRP2	3.6537	6.4326	3.3199	17.1119
MHH-CALL-3	CTRP2	3.6894	6.9549	3.1786	17.5344
U-698-M	GDSC1; GDSC2	3.7008	6.4999	2.0366	6.8527
MM1.S	GDSC1; GDSC2; CTRP2	3.7342	6.3287	3.4402	16.4307
MLMA	GDSC1; GDSC2	3.7688	6.4428	2.1164	6.2039
TK [Human B-cell lymphoma]	GDSC1; GDSC2	3.7787	6.1823	2.2523	5.362
OCI-M1	GDSC1; GDSC2; CTRP2	3.7828	7.47	3.0806	17.6435
CMK	GDSC1; CTRP2	3.8091	6.2649	3.5413	15.8371
MN-60	GDSC1; GDSC2	3.8234	7.8095	1.4811	9.8759
SR	GDSC1; GDSC2; CTRP2	3.8365	6.5377	3.4841	15.967
U266B1	GDSC1; GDSC2; CTRP2	3.8575	6.2686	3.593	15.5033
H9	GDSC1; GDSC2	3.882	10.1587	0.3584	15.9962
Jurkat	GDSC1; GDSC2; CTRP2	3.9491	7.599	3.2035	16.7148
L-1236	GDSC1; GDSC2; CTRP2	3.9603	7.2969	3.3375	16.1683
MHH-PREB-1	GDSC1; GDSC2	3.9656	8.1805	1.4061	9.9627
ROS-50	GDSC1; GDSC2	4.0109	7.1214	1.9614	6.565
YT	GDSC1; GDSC2	4.0704	5.9122	2.5848	2.7873
U-937	CTRP2	4.0858	5.7868	3.9714	13.4437
ME1	CTRP2	4.088	6.6466	3.7191	14.3593
HEL 92.1.7	CTRP2	4.1927	9.2781	2.7088	18.0059
SU-DHL-4	GDSC1; GDSC2; CTRP2	4.2719	7.546	3.5634	14.445
Hs 445	GDSC2	4.302	6.748	2.3405	3.8747
DG-75	GDSC1; GDSC2	4.37	7.276	2.1353	4.7829
HD-MY-Z	CTRP2	4.3702	7.2325	3.7966	13.2729
HEL	GDSC1; GDSC2; CTRP2	4.3825	8.5414	3.2373	15.444
ME1	GDSC1; GDSC2	4.489	8.6426	1.5602	7.8585
SK-MM-2	GDSC1; GDSC2; CTRP2	4.4988	6.3178	4.2757	11.0899
KMS-27	CTRP2	4.536	10.162	2.6245	17.4908
THP-1	GDSC1; GDSC2; CTRP2	4.5473	6.2714	4.3433	10.6974
P3HR-1	CTRP2	4.607	7.7969	3.8003	12.6312
REC-1	CTRP2	4.609	7.632	3.8753	12.3284
MOLP-2	CTRP2	4.7247	7.8904	3.8776	12.0219
OCI-Ly3	CTRP2	4.7392	7.0733	4.2497	10.5122
AMO1	GDSC1; CTRP2	4.8602	7.7975	4.0562	10.9638
Karpas-620	GDSC1; GDSC2; CTRP2	5.0274	6.8027	4.6639	8.1214
Karpas-1106P	GDSC1; GDSC2	5.0389	6.3816	2.8802	0.3462
OCI-Ly10	CTRP2	5.0781	7.8095	4.2676	9.5698
EJM	GDSC1; GDSC2; CTRP2	5.1233	7.1214	4.6267	8.0138
Toledo	CTRP2	5.2048	7.7978	4.3975	8.7338
JVM-2	GDSC1; GDSC2; CTRP2	5.2977	8.627	4.088	9.7869
Ci-1	CTRP2	5.6282	5.9665	5.6089	2.8391
HT	GDSC1; GDSC2; CTRP2	5.944	10.3077	3.8285	9.5024
EHEB	GDSC1; CTRP2	5.9474	10.6254	3.6726	10.1452
HDLM-2	GDSC1; GDSC2; CTRP2	6.744	13.9297	2.6686	12.7179
Karpas-299	GDSC1; GDSC2; CTRP2	6.8166	10.5098	4.418	5.4816
KMM-1	CTRP2	7.0773	11.8733	3.9395	7.033
MC116	GDSC1; GDSC2; CTRP2	7.3437	11.9899	4.0725	6.085
NCI-H929	GDSC1; GDSC2; CTRP2	7.4505	11.6737	4.2978	5.0275
Raji	GDSC1; GDSC2; CTRP2	7.6077	11.9303	4.2801	4.8826

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE8	CTRP2	3.1837	6.0481	2.9214	19.9753
TE15	CTRP2	3.8648	7.0824	3.3192	16.5048
TE-8	GDSC1; GDSC2	3.522	5.8458	2.2226	6.1785
EC-GI-10	GDSC1; GDSC2; CTRP2	3.5337	7.0922	2.9608	18.7982
TE-6	GDSC1; GDSC2; CTRP2	3.7237	5.795	3.5752	15.9748
KYSE-140	GDSC1; GDSC2; CTRP2	3.9251	7.474	3.2293	16.6805
TE-15	GDSC1; GDSC2	4.1683	6.4633	2.3882	3.7229
TE-11	GDSC1; GDSC2; CTRP2	4.2032	8.7815	2.9479	17.0432
T.T	GDSC1; GDSC2	4.3251	7.1191	2.1802	4.6127
KYSE-270	GDSC1; GDSC2	4.6125	6.8707	2.4727	2.4956
KYSE-510	GDSC1; GDSC2; CTRP2	4.655	7.0083	4.1879	10.9806
KYSE-410	GDSC1; GDSC2; CTRP2	4.8275	8.7909	3.5604	13.0487
KYSE-450	GDSC1; GDSC2; CTRP2	4.9322	8.1508	3.9644	11.1556
TE-14	CTRP2	5.0555	7.4254	4.4218	9.0047
TE-9	GDSC1; GDSC2; CTRP2	5.0661	9.2261	3.5794	12.4104
TE-5	GDSC1; GDSC2; CTRP2	5.146	7.6656	4.4018	8.8597
TE-4	GDSC1; GDSC2; CTRP2	5.3275	8.9226	3.9715	10.2015
KYSE-150	GDSC1; GDSC2; CTRP2	5.3985	8.9466	4.0252	9.8207
KYSE-30	CTRP2	5.5707	8.7841	4.2622	8.4583
KYSE-70	GDSC1; GDSC2; CTRP2	5.6339	9.4017	4.0125	9.3655
KYSE-520	GDSC1; GDSC2; CTRP2	5.7519	9.1671	4.233	8.197
OE21	GDSC1; GDSC2; CTRP2	6.1258	12.3634	2.9525	12.7475
COLO 680N	GDSC1; GDSC2; CTRP2	6.8459	11.2199	4.0904	6.7851
TE-10	GDSC1; GDSC2; CTRP2	7.3001	11.3529	4.3497	5.0315
OE33	GDSC1; GDSC2; CTRP2	7.7848	10.4993	5.0456	1.7999
KYSE-180	GDSC1; GDSC2; CTRP2	8.0747	12.6176	4.2563	4.3786
TE-1	GDSC1; GDSC2; CTRP2	8.1425	12.6478	4.2843	4.1913
OE19	GDSC1; GDSC2; CTRP2	8.436	17.0032	2.4074	10.9442

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	5.6676	9.5337	3.9765	9.4448
KP-4	GDSC1; GDSC2; CTRP2	3.524	7.1473	2.9299	18.942
MIA PaCa-2	GDSC1; GDSC2; CTRP2	3.7287	6.6877	3.3163	16.9053
PL4	GDSC1; GDSC2	3.8436	6.3363	2.2243	5.3785
KP-1N	GDSC1; GDSC2	4.0271	6.3874	2.3296	4.3483
HuP-T4	GDSC1; GDSC2; CTRP2	4.1298	9.973	2.3218	19.6541
HPAF-II	GDSC1; GDSC2	4.327	7.0465	2.2158	4.4044
KP-3	GDSC1; GDSC2; CTRP2	4.3334	7.4964	3.6485	13.9481
DAN-G	GDSC1; GDSC2; CTRP2	4.3984	8.2114	3.403	14.7454
Capan-1	GDSC1; GDSC2; CTRP2	4.6455	7.7419	3.864	12.2788
Panc 03.27	GDSC1; GDSC2; CTRP2	4.7276	7.5019	4.0539	11.3125
BxPC-3	GDSC1; GDSC2; CTRP2	4.7964	8.2141	3.8008	12.1511
PSN1	GDSC1; GDSC2; CTRP2	4.8124	8.1305	3.8554	11.8911
PANC-1	CTRP2	4.858	7.1284	4.3503	9.8007
SNU-410	CTRP2	5.0309	9.9449	3.1963	14.0542
Hs 766T	GDSC1; GDSC2; CTRP2	5.0943	7.2509	4.5397	8.4347
SW1990	GDSC1; GDSC2; CTRP2	5.1122	8.0775	4.1751	9.8629
SU.86.86	GDSC1; GDSC2; CTRP2	5.2085	8.4095	4.1091	9.9055
Panc 10.05	GDSC1; GDSC2	5.2264	7.7	2.4424	1.8438
Panc 08.13	GDSC1; GDSC2; CTRP2	5.292	7.7424	4.5087	8.0709
Panc 04.03	GDSC1; GDSC2; CTRP2	5.3788	8.0573	4.4409	8.1452
QGP-1	GDSC1; GDSC2; CTRP2	5.3837	11.5983	2.6993	15.2727
HuP-T3	GDSC1; GDSC2; CTRP2	5.405	7.0295	4.9533	5.9905
PaTu 8988s	CTRP2	5.5088	7.8807	4.649	6.9883
AsPC-1	GDSC1; GDSC2; CTRP2	5.8095	12.9333	2.4023	15.5432
Panc 02.03	GDSC1; GDSC2; CTRP2	5.8267	9.6408	4.0617	8.7618
Capan-2	GDSC1; GDSC2; CTRP2	5.9225	8.2586	4.8342	5.3272
KP-2	GDSC1; GDSC2; CTRP2	5.9656	8.521	4.7399	5.6374
MZ-PC-1	GDSC1; GDSC2	6.109	8.3374	2.587	0.61
PaTu 8902	GDSC1; GDSC2; CTRP2	6.2413	11.4248	3.5165	10.2269
TCC-Pan2	CTRP2	6.3765	10.0693	4.3015	6.7083
SUIT-2	GDSC1; GDSC2; CTRP2	6.6219	9.3227	4.8581	3.9764
PK-45H	CTRP2	7.0594	11.4599	4.1289	6.2869
SNU-213	CTRP2	7.6302	8.6193	5.7258	0.0872
Panc 05.04	CTRP2	7.6762	13.5645	3.5421	7.7188
PK-59	CTRP2	7.7688	12.9214	3.9151	6.1056
PaTu 8988t	GDSC1; GDSC2; CTRP2	7.8583	17.7973	1.6027	14.7257
HPAC	GDSC1; GDSC2; CTRP2	7.9483	12.6182	4.1764	4.8426
L3.3	CTRP2	7.9736	13.95	3.5609	7.2146
YAPC	GDSC1; GDSC2; CTRP2	8.1228	12.7245	4.2366	4.3956
CFPAC-1	GDSC1; GDSC2; CTRP2	8.2709	15.0908	3.2152	8.139

Cancer Drug Sensitivity Data Curated from 74 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	4.6009	6.4059	4.3573	12.1171
A-431	GDSC1; GDSC2	2.46	5.0957	1.6437	12.9605
COLO 792	GDSC1; GDSC2; CTRP2	2.5757	6.4571	2.1387	24.6372
MZ-MEL-2	GDSC1; GDSC2	3.1767	8.372	0.6749	16.285
M14	GDSC1; GDSC2	3.4424	6.2101	1.977	7.886
CP50-MEL-B	GDSC1; GDSC2	3.4992	6.6686	1.7939	8.8443
GAK	GDSC1; GDSC2	3.6036	5.6363	2.3903	4.9511
CHL-1	GDSC1; GDSC2	3.6394	6.7704	1.8546	8.1086
DJM-1	GDSC1; GDSC2	3.6545	6.2587	2.1207	6.4591
HMV-II	GDSC1; GDSC2	3.7381	7.4401	1.5986	9.3944
LOX-IMVI	GDSC1; GDSC2; CTRP2	3.7742	6.6784	3.3687	16.5779
A-388	GDSC1; GDSC2	3.8539	8.885	0.9703	12.7557
IST-MEL1	GDSC1; GDSC2	3.9839	6.6512	2.1715	5.3759
G-mel	GDSC1; GDSC2	4.0545	8.9592	1.0881	11.5789
COLO 679	GDSC1; GDSC2	4.0577	6.1678	2.4556	3.5513
CJM [Human melanoma]	CTRP2	4.1535	6.2885	3.9093	13.4619
Hs 944.T	CTRP2	4.1737	5.8626	4.0495	12.893
Hs 940.T	GDSC1; GDSC2; CTRP2	4.24	6.8638	3.8035	13.6072
WM35	GDSC1; GDSC2	4.2646	7.5004	1.9566	6.035
RPMI-7951	GDSC1; GDSC2; CTRP2	4.3263	8.2266	3.3231	15.2475
SK-MEL-5	GDSC1; GDSC2; CTRP2	4.3972	5.4384	4.3688	11.0698
SH-4	GDSC1; GDSC2	4.4598	7.0537	2.2976	3.6946
HT-144	GDSC1; GDSC2; CTRP2	4.4996	7.7086	3.7294	13.1905
Hs 895.T	CTRP2	4.5023	13.1823	1.1209	23.0211
Mel JuSo	GDSC1; GDSC2; CTRP2	4.5169	6.9463	4.0669	11.8269
451Lu	GDSC1; GDSC2	4.5726	7.7321	2.0517	4.8714
LB2518-MEL	GDSC1; GDSC2	4.6185	6.578	2.6052	1.8142
WM88	CTRP2	4.6433	6.8863	4.2246	10.871
MZ-MEL-7	GDSC1; GDSC2	4.7098	6.393	2.7308	1.123
WM115	GDSC1; GDSC2; CTRP2	4.7122	6.7518	4.3507	10.1963
LB373-MEL-D	GDSC1; GDSC2	4.7396	7.5463	2.2416	3.5245
COLO 800	GDSC1; GDSC2; CTRP2	4.8314	6.9806	4.3848	9.7371
WM266-4	CTRP2	4.8444	7.7352	4.0686	10.954
IGR-37	GDSC1; GDSC2; CTRP2	4.9872	7.9384	4.1178	10.3997
WT2-iPS	GDSC1; GDSC2; CTRP2	4.9899	7.5159	4.3146	9.6003
WM278	GDSC1; GDSC2	5.0124	7.6513	2.3508	2.5468
A-375	GDSC1; GDSC2; CTRP2	5.026	8.7505	3.771	11.7191
SK-MEL-28	GDSC1; GDSC2; CTRP2	5.0267	7.8233	4.2104	9.9275
MeWo	GDSC1; GDSC2; CTRP2	5.0293	7.2463	4.4754	8.8578
SK-MEL-31	GDSC1; GDSC2; CTRP2	5.0571	6.7596	4.7129	7.8503
VMRC-MELG	GDSC1; GDSC2	5.1212	7.0158	2.6723	0.9773
Hs 294T	CTRP2	5.1597	7.2505	4.6061	8.0026
IGR-1	GDSC1; GDSC2; CTRP2	5.1784	7.5908	4.4686	8.5097
RVH-421	GDSC1; GDSC2; CTRP2	5.2094	7.6281	4.4818	8.3797
SK-MEL-3	GDSC1; GDSC2; CTRP2	5.2171	7.4768	4.5599	8.0449
WM983B	CTRP2	5.2624	7.8897	4.4099	8.5453
UACC-62	GDSC1; GDSC2; CTRP2	5.2824	7.6914	4.5235	8.0336
UACC-257	GDSC1; GDSC2; CTRP2	5.2927	8.2568	4.2628	9.0778
COLO 783	GDSC1; GDSC2	5.3534	6.8404	2.8362	0.3181
WM1552C	GDSC1; GDSC2	5.3575	7.1382	2.7279	0.6125
CP66-MEL	GDSC1; GDSC2	5.3613	6.946	2.801	0.4015
SK-MEL-24	GDSC1; GDSC2; CTRP2	5.3698	9.2094	3.8697	10.5287
MMAc-SF	GDSC1; GDSC2	5.5028	7.5039	2.6501	0.77
HMCB	CTRP2	5.6477	13.6452	1.9085	17.7319
SK-MEL-2	GDSC1; GDSC2; CTRP2	5.7708	6.2887	5.6561	2.2509
A2058	GDSC1; GDSC2; CTRP2	5.8998	11.1912	3.3495	11.5765
Hs 688(A).T	CTRP2	5.9087	11.0467	3.4293	11.2301
Hs 934.T	CTRP2	6.0264	11.6297	3.2368	11.7887
COLO 829	GDSC1; GDSC2; CTRP2	6.1378	14.9267	1.6808	17.5584
Hs 938.T	GDSC1; GDSC2	6.1922	14.7368	-0.207	13.4738
IGR-39	CTRP2	6.4272	21.0372	-1.1354	25.2762
G-361	GDSC1; GDSC2; CTRP2	6.6898	10.5545	4.302	6.1669
IPC-298	GDSC1; GDSC2; CTRP2	6.9675	11.0054	4.2848	5.7916
K029AX	CTRP2	7.0019	12.0174	3.8135	7.6695
A101D	GDSC1; GDSC2; CTRP2	7.0762	12.5994	3.582	8.4928
WM1799	CTRP2	7.0923	11.0759	4.3394	5.3774
SK-MEL-1	GDSC1; GDSC2; CTRP2	7.2837	11.6985	4.1717	5.7728
MDA-MB-435S	CTRP2	7.36	10.6791	4.7103	3.5186
SK-MEL-30	GDSC1; GDSC2; CTRP2	7.3834	12.4567	3.874	6.8271
Hs 936.T	CTRP2	7.4282	10.5289	4.8236	2.9946
Mel Ho	GDSC1; GDSC2; CTRP2	7.649	12.3054	4.129	5.4241
WM793	GDSC1; GDSC2; CTRP2	7.8051	11.5942	4.5635	3.534
Hs 839.T	CTRP2	8.7581	31.7259	-4.6108	28.0839
EquiPSC Line K2	GDSC1; GDSC2	5.8983	15.9258	-0.9834	17.3609

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
OACP4 C	GDSC1; GDSC2	2.4268	6.6366	0.8701	17.5689
TE-12	GDSC1; GDSC2	2.8214	6.4313	1.3327	13.601
KYSE-220	GDSC1; GDSC2	2.8758	5.6853	1.7506	10.9296
OACM5.1 C	GDSC1; GDSC2	3.1173	6.5276	1.5455	11.4244
HCE-4	GDSC1; GDSC2	3.2362	7.3103	1.2558	12.8001
FLO-1	GDSC1; GDSC2	3.5526	7.5085	1.4177	10.9589
KYSE-50	GDSC1; GDSC2	3.7286	5.8538	2.3768	4.7308
ESO-26	GDSC1; GDSC2	3.9279	7.2991	1.813	7.644
ESO-51	GDSC1; GDSC2	4.5514	6.7223	2.5041	2.4236
SK-GT-4	GDSC1; GDSC2	4.8865	7.8743	2.1796	3.6201
KYAE-1	GDSC1; GDSC2	5.3608	6.8664	2.8297	0.3304

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1; GDSC2; CTRP2	3.9897	6.9277	3.5112	15.4237

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SJNB-14	GDSC1; GDSC2	-0.3995	1.7158	-0.439	36.237
CHP-134	GDSC2	-0.1844	1.5466	-0.2026	35.2761
MHH-NB-11	GDSC1; GDSC2; CTRP2	0.0902	1.7335	0.0897	39.6696
CHP-212	GDSC1; GDSC2; CTRP2	0.4183	3.1266	0.3929	37.5626
IMR-32	CTRP2	0.5594	3.2439	0.5322	36.6295
NH-12	GDSC1; GDSC2	0.6447	2.5269	0.5726	26.2926
SJNB-10	GDSC1; GDSC2	1.0049	3.2029	0.8247	23.3566
IMR-5	GDSC1; GDSC2	1.0571	2.2014	1.0438	22.0071
KP-N-YS	GDSC1; GDSC2	1.1011	2.9568	0.9873	22.085
TGW	GDSC1; GDSC2	1.1172	2.6594	1.059	21.6469
SJNB-17	GDSC1; GDSC2	1.2139	2.5824	1.1731	20.6236
CHP-126	GDSC1; GDSC2; CTRP2	1.3525	4.2852	1.2754	31.5147
NB(TU)1	GDSC1; GDSC2	1.3555	3.798	1.0294	20.7402
SJNB-6	GDSC1; GDSC2	1.3619	3.304	1.1877	19.8735
Kelly	GDSC1; GDSC2; CTRP2	1.3637	2.6614	1.3633	31.1847
KP-N-RT-BM-1	GDSC2	1.4778	6.8638	-0.1499	27.1249
SJNB-13	GDSC1; GDSC2	1.5335	3.4727	1.327	18.3849
SK-N-DZ	GDSC1; GDSC2; CTRP2	1.7113	6.0089	1.3252	30.162
SiMa	GDSC1; GDSC2; CTRP2	1.8121	6.1849	1.3864	29.631
NH-6	CTRP2	1.9991	4.901	1.881	27.3502
GOTO	GDSC1; GDSC2	2.1066	6.4863	0.6401	19.9571
SK-N-SH	GDSC1; GDSC2; CTRP2	2.3833	9.1237	0.9293	29.3034
NB1	GDSC1; CTRP2	2.6052	4.6839	2.5565	23.0767
SK-N-BE(2)	CTRP2	3.0332	7.1083	2.4167	22.2654
SJNB-12	GDSC1; GDSC2	3.0371	6.3669	1.556	11.6014
SK-N-FI	GDSC1; GDSC2; CTRP2	3.2686	7.9932	2.3262	21.925
SK-N-MC-IXC	GDSC1; GDSC2	3.285	5.8003	2.0518	7.8665
SJNB-5	GDSC1; GDSC2	3.4641	6.3019	1.9487	7.9997
NB69	GDSC1; GDSC2	3.5396	6.3062	2.0071	7.4432
KP-N-SI9s	CTRP2	3.7452	8.2906	2.699	19.2088
SK-N-BE(2)-M17	GDSC1; GDSC2	3.7773	6.9025	1.8955	7.5143
SJNB-7	GDSC1; GDSC2	3.8417	7.5292	1.6342	8.9209
GI-ME-N	GDSC1; GDSC2	4.1572	14.1262	-1.4009	23.0013
SK-N-AS	GDSC1; GDSC2; CTRP2	4.298	7.4616	3.626	14.1311
KP-N-YN	GDSC1; CTRP2	4.3565	7.9343	3.4836	14.5347
LA-N-6	GDSC1; GDSC2	4.9088	8.0468	2.1144	3.9338

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-1079	CTRP2	4.367	5.9791	4.2312	11.6481
HuCC-T1	GDSC1; GDSC2; CTRP2	4.7939	8.3253	3.7466	12.3759
SNU-1196	CTRP2	5.0027	7.6355	4.2731	9.7346
SNU-869	CTRP2	5.4473	10.2434	3.4286	12.1847
SNU-478	CTRP2	6.1884	10.2356	4.0676	8.0322
HuH-28	CTRP2	6.8262	10.5021	4.4288	5.4219
SNU-308	CTRP2	7.1751	10.074	4.876	3.1096

Cancer Drug Sensitivity Data Curated from 89 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MFM-223	GDSC1; GDSC2	0.1809	5.3252	-0.8039	34.6667
MDA-MB-468	GDSC1; GDSC2; CTRP2	1.3249	4.3587	1.2372	31.7333
DU4475	GDSC1; GDSC2; CTRP2	1.4122	3.5474	1.3958	30.9148
Evsa-T	GDSC1; GDSC2	2.1149	4.4733	1.5776	14.6169
Hs 578T	GDSC1; GDSC2; CTRP2	2.127	7.1976	1.4068	28.5586
HCC1569	GDSC1; GDSC2	2.5527	7.258	0.681	18.2018
COLO 824	GDSC1; GDSC2	2.7928	5.2852	1.8707	10.4746
OCUB-M	GDSC1; GDSC2	2.8727	4.6922	2.2339	8.0288
MDA-MB-157	GDSC1; GDSC2; CTRP2	3.0012	5.6997	2.8106	20.9334
MDA-MB-453	GDSC1; GDSC2; CTRP2	3.1431	5.0432	3.0847	19.5267
HCC2218	GDSC1; GDSC2; CTRP2	3.2003	5.7809	3.0084	19.613
MRK-nu-1	GDSC1; GDSC2	3.322	6.9148	1.5256	10.9514
HCC1599	GDSC2	3.4252	6.4114	1.8624	8.9057
CAL-148	GDSC2; CTRP2	3.4552	7.4466	2.7419	19.8444
HCC70	GDSC1; GDSC2	3.6762	6.8832	1.8272	8.1798
UACC-812	GDSC2	3.7512	6.4015	2.1236	6.4021
HCC1500	GDSC1; GDSC2; CTRP2	3.7744	7.1009	3.2155	17.1536
T-47D	GDSC1; GDSC2; CTRP2	3.8073	5.8794	3.646	15.464
CAL-51	GDSC1; GDSC2; CTRP2	3.9148	8.7743	2.66	18.909
MCF-7	GDSC1; GDSC2; CTRP2	3.9518	8.3129	2.9023	17.8742
MDA-MB-436	GDSC1; GDSC2	3.9935	6.9814	2.0173	6.2719
HCC1954	GDSC1; GDSC2	4.0299	6.763	2.1498	5.4032
HCC2157	GDSC1; GDSC2	4.1075	6.1889	2.4784	3.3231
MDA-MB-175-VII	GDSC1; GDSC2	4.1447	6.5958	2.3095	4.2242
HCC1395	GDSC1; GDSC2; CTRP2	4.1905	9.6259	2.5445	18.6492
HCC1187	GDSC1; GDSC2	4.4144	11.1486	0.2776	15.0505
BT-483	GDSC1; GDSC2	4.4434	6.9614	2.3303	3.5417
AU565	GDSC1; GDSC2	4.5087	8.7214	1.5358	7.9563
BT-20	GDSC1; GDSC2; CTRP2	4.5166	7.441	3.8626	12.6217
ZR-75-30	GDSC1; GDSC2; CTRP2	4.5328	7.0997	4.0221	11.9561
MDA-MB-231	GDSC1; GDSC2; CTRP2	4.6658	7.9796	3.7779	12.5702
BT-474	GDSC1; GDSC2; CTRP2	4.6658	7.447	4.0144	11.6302
EFM-19	GDSC1; GDSC2	4.7194	10.198	0.9675	10.6918
HCC1419	GDSC1; GDSC2; CTRP2	4.7353	8.4783	3.6175	13.0413
MDA-MB-361	GDSC1; GDSC2; CTRP2	4.7911	6.9944	4.3368	10.0332
CAL-120	GDSC1; GDSC2; CTRP2	4.8354	7.8748	3.996	11.2681
YMB-1-E	GDSC2	4.8656	8.5057	1.8758	5.5048
HCC38	GDSC1; GDSC2; CTRP2	4.9703	8.6398	3.7704	11.853
MDA-MB-415	GDSC1; GDSC2	4.9769	9.0076	1.7116	6.0258
HCC1428	GDSC1; GDSC2; CTRP2	5.0778	8.5232	3.9296	10.9479
HCC202	GDSC1; GDSC2; CTRP2	5.4142	11.3412	2.854	14.5916
SK-BR-3	CTRP2	5.5736	6.7871	5.233	4.4434
JIMT-1	GDSC1; GDSC2; CTRP2	5.7424	9.1362	4.2402	8.1867
HCC1143	GDSC1; GDSC2; CTRP2	5.7565	11.4229	3.1116	12.8378
EFM-192A	GDSC1; GDSC2; CTRP2	5.9161	10.2649	3.8263	9.5666
CAL-85-1	GDSC1; GDSC2; CTRP2	6.0543	10.3148	3.9174	8.9158
MDA-MB-330	GDSC1; GDSC2	6.3488	8.4408	2.6424	0.3761
Hs 578Bst	CTRP2	6.4317	9.8862	4.4359	6.0488
BT-549	GDSC1; GDSC2; CTRP2	6.4342	12.8719	2.9498	12.1729
HDQ-P1	GDSC1; GDSC2; CTRP2	7.2299	11.6478	4.1586	5.9057
HMC-1-8	CTRP2	7.2412	12.6051	3.7001	7.7492
UACC-893	GDSC1; GDSC2	7.8352	17.6643	-0.528	11.9282
ZR-75-1	CTRP2	7.996	9.2801	5.629	0.1356
HCC1806	GDSC1; GDSC2; CTRP2	7.9982	13.7716	2.8275	5.2474
CAMA-1	GDSC1; GDSC2; CTRP2	8.3057	15.9397	2.831	9.5561
HCC1937	GDSC1; GDSC2; CTRP2	8.5887	13.332	4.2391	3.854
BT 440	CTRP2	0.6327	3.0285	0.6176	36.1031
BT 504	CTRP2	2.1051	5.6854	1.8378	27.1587
BT 286	CTRP2	2.7651	6.9185	2.1938	23.8679
BT 145	CTRP2	2.7779	5.2101	2.6678	22.1376
BT 112	CTRP2	2.8986	6.4213	2.5014	22.3558
BT 482	CTRP2	3.0136	5.4169	2.8845	20.6342
BT164	CTRP2	3.0726	6.3529	2.712	21.069
BT 231	CTRP2	3.2749	7.6311	2.478	21.343
BT147	CTRP2	3.3383	11.3843	0.8831	26.7199
BT 139	CTRP2	3.3835	11.2268	1.0013	26.2265
BT 330	CTRP2	3.4108	7.6632	2.6095	20.4674
BT 416	CTRP2	3.4704	7.8133	2.6121	20.2912
BT 428	CTRP2	3.5931	7.7386	2.7718	19.3461
BT 271	CTRP2	3.6994	10.6966	1.5601	23.5298
BT 172	CTRP2	4.0936	8.6072	2.9163	17.4487
BT 187	CTRP2	4.3753	11.383	1.8824	20.6852
BT 340	CTRP2	4.419	10.4332	2.3824	18.7097
BT 333	CTRP2	4.5725	10.0247	2.7254	17.0078
BT 422	CTRP2	4.6506	11.0292	2.3127	18.4237
BT 131	CTRP2	4.6565	8.3345	3.6062	13.2819
BT 228	CTRP2	4.6755	11.7965	1.9607	19.6852
BT 248	CTRP2	4.7847	9.8916	2.9914	15.449
BT 245	CTRP2	4.8238	7.7939	4.0212	11.196
BT 159	CTRP2	4.845	11.124	2.4469	17.4567
BT 444	CTRP2	4.945	10.4294	2.8796	15.5254
BT 232	CTRP2	5.0222	8.7553	3.765	11.7526
BT 216	CTRP2	5.2228	9.9161	3.3874	12.8437
BT 328	CTRP2	5.4922	8.81	4.1782	8.9787
BT 359	CTRP2	5.7835	11.2948	3.1987	12.428
BT 498	CTRP2	5.8361	14.5478	1.6179	18.388
BT 320	CTRP2	5.9166	8.8742	4.5216	6.6515
BT 224	CTRP2	6.2398	12.7883	2.8339	13.0019
BT 179	CTRP2	6.4871	11.342	3.7548	8.7892

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	7.9477	11.2613	4.7994	2.5041

Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
H4	GDSC1; GDSC2	0.3505	2.5695	0.2493	29.2833
D-245MG	GDSC2	0.8524	6.0278	-0.3988	30.9228
SF539	GDSC1; GDSC2; CTRP2	1.5472	4.5342	1.4512	30.2822
PFSK-1	GDSC1	1.6075	5.3082	-0.6711	11.0101
42-MG-BA	GDSC1; GDSC2; CTRP2	1.6772	8.8884	0.2845	33.3852
MOG-G-CCM	GDSC1; GDSC2	1.6925	4.296	1.2076	18.3658
D-423MG	GDSC1; GDSC2	1.8657	4.7228	1.2124	17.6521
CAS-1	GDSC1; GDSC2	2.036	5.7212	0.934	18.584
MOG-G-UVW	GDSC1; GDSC2	2.0403	5.2079	1.1753	17.1995
D-263MG	GDSC1; GDSC2	2.2805	5.3213	1.3617	15.2491
SF126	GDSC1; GDSC2; CTRP2	2.4981	6.726	1.9688	25.4769
D283 Med	GDSC1; GDSC2; CTRP2	2.5054	7.9214	1.5459	26.9266
A-172	GDSC1; GDSC2; CTRP2	2.6858	6.2746	2.3137	23.6768
M059J	GDSC1; GDSC2	2.7323	5.1847	1.8628	10.7228
GI-1	GDSC1; GDSC2	2.8233	6.8644	1.1197	14.8441
D-392MG	GDSC1; GDSC2	2.8514	11.2273	-1.0294	25.2622
SNU-201	CTRP2	3.1486	5.5831	2.9971	19.8139
LNZTA3WT4	GDSC1; GDSC2	3.1927	8.7709	0.489	17.2424
SNU-1105	CTRP2	3.2108	5.5057	3.0807	19.3247
D-247MG	GDSC1; GDSC2	3.3125	7.3521	1.299	12.3265
KNS-60	CTRP2	3.3597	8.608	2.1636	22.2726
CCF-STTG1	CTRP2	3.4192	9.777	1.7067	23.7609
TM-31	CTRP2	3.4333	13.1489	0.1356	28.6507
D-502MG	GDSC1; GDSC2	3.4389	7.8754	1.1419	12.8899
YH-13	GDSC1; GDSC2; CTRP2	3.6442	15.1992	-0.6603	30.1359
D-566MG	GDSC1; GDSC2	3.6845	7.7412	1.4067	10.6735
SNU-738	CTRP2	3.6962	8.5465	2.5374	19.9576
D-336MG	GDSC1; GDSC2	3.7132	6.0201	2.2834	5.3302
SK-MG-1	GDSC1; GDSC2	3.8131	8.0694	1.344	10.7093
KNS-81-FD	GDSC1; GDSC2	3.9195	6.6115	2.1446	5.6809
8-MG-BA	GDSC1; GDSC2; CTRP2	3.9582	9.1748	2.5226	19.3244
Onda 10	GDSC1; GDSC2	3.9687	5.7563	2.5924	2.9375
LN-405	GDSC1; GDSC2	4.0267	6.4793	2.285	4.6116
KS-1 [Human Krukenberg tumour]	GDSC1; GDSC2	4.0497	8.0676	1.525	9.0606
SF268	GDSC1; GDSC2; CTRP2	4.0739	6.8499	3.6305	14.7334
AM-38	GDSC1; GDSC2; CTRP2	4.099	6.7571	3.6915	14.4312
SW1088	GDSC1; GDSC2; CTRP2	4.2511	8.1173	3.295	15.5528
Hs 683	GDSC1; GDSC2; CTRP2	4.2934	8.0622	3.3626	15.1765
D-542MG	GDSC1; GDSC2	4.3096	10.2849	0.6254	13.5014
SNU-489	CTRP2	4.3526	6.6132	4.0166	12.4812
GaMG	GDSC1; GDSC2; CTRP2	4.5997	8.3311	3.5511	13.6448
GB-1	GDSC1; GDSC2; CTRP2	4.6181	8.1679	3.6442	13.2257
ONS-76	GDSC1; GDSC2; CTRP2	4.6898	9.0666	3.296	14.4495
U-118MG	GDSC1; GDSC2; CTRP2	4.7516	9.5976	3.1018	15.0839
M059K	CTRP2	4.7601	13.0054	1.4431	21.3347
T98G	GDSC1; GDSC2; CTRP2	4.8905	9.6191	3.2233	14.2678
KALS-1	GDSC1; GDSC2; CTRP2	4.9046	8.7751	3.6425	12.5305
SW1783	GDSC1; GDSC2; CTRP2	5.07	8.536	3.916	11.022
YKG-1	GDSC1; GDSC2; CTRP2	5.0748	9.8383	3.2891	13.5773
SNB-75	GDSC1; GDSC2; CTRP2	5.2906	7.2126	4.755	7.075
DK-MG	GDSC1; GDSC2; CTRP2	5.3702	17.2302	-0.1199	24.801
SNU-626	CTRP2	5.4016	11.9105	2.5598	15.7829
Daoy	GDSC1; GDSC2; CTRP2	5.4023	9.7313	3.6418	11.4017
DBTRG-05MG	GDSC1; GDSC2; CTRP2	5.4914	8.2313	4.4617	7.8031
SF295	GDSC1; GDSC2; CTRP2	5.5199	11.7377	2.7496	14.7835
KG-1-C	CTRP2	5.5885	7.7012	4.811	6.1371
KINGS-1	GDSC1; GDSC2	5.6297	8.2453	2.4141	1.5502
Onda 11	GDSC1; GDSC2	5.8137	8.0438	2.5757	0.81
Becker	GDSC1; GDSC2; CTRP2	5.8326	10.2362	3.7695	9.9709
U-251MG	GDSC1; GDSC2; CTRP2	5.9901	10.5583	3.742	9.7728
NMC-G1	GDSC1; GDSC2; CTRP2	6.0088	8.2396	4.917	4.8081
KNS-42	GDSC1; GDSC2; CTRP2	6.1295	12.3524	2.961	12.7059
SNU-466	CTRP2	6.1417	9.3099	4.492	6.3395
LN-18	GDSC1; GDSC2; CTRP2	6.3239	8.8236	4.8803	4.3796
KNS-81	CTRP2	6.8874	12.4372	3.5205	9.0574
LN-229	GDSC1; GDSC2; CTRP2	7.3039	9.5474	5.1978	1.739
U-87MG ATCC	GDSC1; GDSC2; CTRP2	7.5033	11.4785	4.4258	4.4479
GMS-10	CTRP2	7.5203	16.1067	2.1841	13.2105
GOS-3	CTRP2	8.2116	19.2206	1.1636	15.6271

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TGBC24TKB	GDSC1; GDSC2	1.7242	5.2553	0.834	20.3126
ETK-1	GDSC1; GDSC2	3.2873	6.8235	1.5422	10.9503
TGBC1TKB	GDSC1; GDSC2	3.8474	5.6234	2.5742	3.2892

Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHUEM-2	CTRP2	-0.6022	2.2111	-0.6164	44.3156
AN3-CA	GDSC1; GDSC2; CTRP2	1.4417	7.5212	0.5526	33.4387
JHUEM-7	CTRP2	2.6174	6.2606	2.2432	24.1374
ESS-1	GDSC1; GDSC2; CTRP2	2.8365	5.9485	2.5692	22.3015
JHUEM-1	CTRP2	3.4079	5.646	3.2653	18.0563
MFE-296	GDSC1; GDSC2; CTRP2	3.5018	7.1161	2.9177	19.051
RL95-2	GDSC1; GDSC2; CTRP2	3.6593	8.0336	2.7192	19.3645
HEC-59	CTRP2	4.2925	11.2675	1.86	20.9676
HEC-1-A	CTRP2	4.3823	6.4158	4.117	12.0202
HEC-151	CTRP2	4.4493	6.3254	4.2195	11.4435
MFE-280	GDSC1; GDSC2	4.5303	7.9991	1.8976	5.8313
EN	GDSC1; GDSC2; CTRP2	4.5908	11.7139	1.9227	20.0234
MFE-319	GDSC1; GDSC2; CTRP2	4.9483	7.0008	4.4984	8.9798
JHUEM-3	CTRP2	6.1979	7.7769	5.3025	2.8344
EFE-184	CTRP2	6.2128	9.4346	4.4875	6.2263
HEC-50B	CTRP2	6.2799	12.3938	3.0637	12.0046
KLE	GDSC1; GDSC2; CTRP2	6.3545	10.0538	4.2919	6.7878
HEC-1-B	CTRP2	7.347	12.6097	3.7738	7.2868
HEC-6	CTRP2	7.8398	10.9012	4.8987	2.2599
HEC-265	CTRP2	7.95	9.2686	5.616	0.1636
HEC-108	CTRP2	8.3283	17.2002	2.2362	11.7312
HEC-251	CTRP2	8.7478	14.1579	3.9579	4.7094
Ishikawa (Heraklio) 02 ER-	CTRP2	7.6127	8.5141	5.7555	0.0592

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-704	GDSC1; GDSC2	3.0534	6.6881	1.4101	12.4256
KTCTL-13	GDSC1; GDSC2	3.2979	7.0537	1.4359	11.5558
SW13	GDSC1; GDSC2	3.5058	6.1622	2.052	7.2596
NCC010	GDSC1; GDSC2	3.5712	7.0904	1.6412	9.5738
TUHR14TKB	CTRP2	3.5809	9.7881	1.8641	22.7661
RXF 393L	GDSC1; GDSC2	3.7129	6.8739	1.8603	7.8873
KTCTL-195	GDSC1; GDSC2	3.772	7.1799	1.754	8.3787
LB996-RCC	GDSC2	3.8224	7.6757	1.5467	9.8211
SN12C	GDSC1; GDSC2	3.9744	6.8512	2.0671	6.0189
786-O	GDSC1; GDSC2; CTRP2	4.1339	7.2296	3.5483	14.8792
KTCTL-140	GDSC1; GDSC2	4.1657	10.8544	0.2337	15.8941
TUHR4TKB	CTRP2	4.2793	8.4741	3.1641	15.9968
BFTC-909	GDSC1; GDSC2; CTRP2	4.3383	7.8372	3.5074	14.4886
LB2241-RCC	GDSC1; GDSC2	4.3822	7.9355	1.8278	6.537
KMRC-2	CTRP2	4.4373	8.0669	3.5072	14.2323
KTCTL-21	GDSC1; GDSC2	4.4765	8.2657	1.7335	6.8856
UO-31	GDSC1; GDSC2; CTRP2	4.5689	7.3764	3.9444	12.1614
BB65-RCC	GDSC1; GDSC2	4.58	9.9863	0.9712	10.985
HA7-RCC	GDSC1; GDSC2	4.6362	8.4531	1.7517	6.4547
SW156	GDSC1; GDSC2	4.8708	8.5861	1.8415	5.4988
TK-10	GDSC1; GDSC2	4.9492	7.0649	2.5695	1.5796
KTCTL-26A	GDSC1; GDSC2	4.9668	11.508	0.5056	12.5971
CAL-54	GDSC1; GDSC2; CTRP2	5.1207	9.184	3.6512	11.9908
KMRC-20	GDSC1; GDSC2; CTRP2	5.1848	8.815	3.8906	10.859
NCC021	GDSC1; GDSC2	5.2262	10.0169	1.3972	7.2932
KTCTL-1M	GDSC1; GDSC2	5.2951	9.6619	1.6065	6.0296
LB1047-RCC	GDSC1; GDSC2	5.3143	12.5736	0.2329	13.2075
KMRC-3	CTRP2	5.9425	9.653	4.1545	8.1414
769-P	GDSC1; GDSC2	6.0144	13.3123	0.353	11.2022
RCC10RGB	GDSC1; GDSC2; CTRP2	6.3046	9.8508	4.3534	6.6203
ACHN	GDSC1; GDSC2; CTRP2	6.3098	11.7725	3.3984	10.5847
TUHR10TKB	CTRP2	6.5329	8.4278	5.2312	5.5455
KMRC-1	GDSC1; GDSC2; CTRP2	6.586	12.6914	3.1608	11.0467
A-498	GDSC1; GDSC2; CTRP2	6.8263	10.7829	4.291	5.9894
VMRC-RCZ	GDSC1; GDSC2; CTRP2	6.9586	13.0091	3.2915	9.8662
Caki-2	CTRP2	7.0437	13.7851	2.972	10.999
Caki-1	GDSC1; GDSC2; CTRP2	7.4962	13.8815	3.2601	9.1144
VMRC-RCW	GDSC1; GDSC2; CTRP2	7.5021	12.5996	3.8878	6.5951
OS-RC-2	GDSC1; GDSC2; CTRP2	7.8954	14.2441	3.3659	8.0919
SNU-1272	CTRP2	7.9624	13.8454	3.6034	7.0636

Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H716	GDSC1; GDSC2; CTRP2	-2.0897	1.4768	-2.1111	54.1068
SNU-175	GDSC2	1.2051	3.31	1.015	22.2409
SW948	GDSC1; GDSC2; CTRP2	1.5063	2.9374	1.5051	30.2375
NCI-H508	GDSC1; GDSC2; CTRP2	1.9925	6.2388	1.5679	28.4421
SW48	GDSC1; GDSC2; CTRP2	2.0487	5.1651	1.8885	27.1644
GP2d	CTRP2	2.1078	4.8834	2.0005	26.5897
COLO205	GDSC1; GDSC2; CTRP2	2.2496	4.0873	2.2319	25.3409
CL-11	GDSC1; GDSC2; CTRP2	2.5437	5.8256	2.2815	24.2294
CaR-1	GDSC1; GDSC2	2.8218	5.5158	1.7847	10.8971
KM12	GDSC1; GDSC2; CTRP2	2.934	6.6182	2.4776	22.3361
SNU-407	GDSC1; GDSC2; CTRP2	3.5099	5.9031	3.3157	17.5607
GP5d	GDSC1; GDSC2	3.5146	8.2989	0.9921	13.5413
SW1463	GDSC1; GDSC2	3.8414	6.9592	1.9159	7.2353
SNU-81	GDSC1; GDSC2	3.8441	6.5952	2.0975	6.1384
SW620	GDSC1; GDSC2; CTRP2	3.9473	6.371	3.6589	14.9945
LoVo	GDSC1; GDSC2; CTRP2	4.0859	8.2694	3.0589	16.9112
LS513	GDSC1; GDSC2; CTRP2	4.124	7.8098	3.2977	15.8777
COLO 320HSR	GDSC1; GDSC2	4.1669	8.4796	1.409	9.4603
SW1116	GDSC1; GDSC2	4.1997	6.4026	2.4373	3.3829
RKO	GDSC1; GDSC2; CTRP2	4.3471	6.5618	4.0289	12.4508
LS123	GDSC1; GDSC2; CTRP2	4.3971	6.6759	4.0418	12.2589
SNU-61	GDSC1; GDSC2; CTRP2	4.4188	6.8643	3.9944	12.3774
T84	GDSC1; GDSC2; CTRP2	4.4512	6.5538	4.1441	11.7186
SW837	GDSC1; GDSC2	4.6007	6.9016	2.4521	2.6214
SNU-C1	GDSC1; GDSC2; CTRP2	4.7121	6.7661	4.345	10.218
SNU-C5	GDSC1; GDSC2; CTRP2	4.7533	7.8857	3.9086	11.8254
DiFi	GDSC1; GDSC2	4.8942	11.4016	0.5057	12.7586
SK-CO-1	GDSC1; GDSC2; CTRP2	4.9421	9.7064	3.2296	14.1228
HT115	GDSC1; GDSC2; CTRP2	4.9898	9.697	3.2788	13.813
SW626	GDSC1; GDSC2	5.0158	7.5785	2.3844	2.3757
SNU-C2B	GDSC1; GDSC2	5.3166	8.4956	2.1475	3.1463
SNU-C4	CTRP2	5.3247	6.1325	5.2333	5.1181
NCI-H747	GDSC1; GDSC2; CTRP2	5.3306	8.5699	4.1467	9.4697
SNU-283	GDSC2	5.3813	7.0922	2.755	0.5362
SW1417	GDSC1; GDSC2; CTRP2	5.4372	8.3687	4.3442	8.4115
DLD-1	CTRP2	5.4795	9.2109	3.9688	9.8773
LS1034	GDSC1; GDSC2; CTRP2	5.5547	8.0273	4.6201	7.0041
COLO201	CTRP2	5.7497	9.2041	4.2127	8.2865
HCT 8	CTRP2	5.8503	7.0219	5.3857	3.1674
HCC-56	CTRP2	5.9141	6.4504	5.7247	1.6182
RCM-1 [Human ESC]	GDSC1; GDSC2; CTRP2	5.9887	6.9478	5.5455	2.207
SNU-503	CTRP2	6.0461	9.6278	4.2542	7.5205
HCC2998	GDSC1; GDSC2	6.1589	7.8431	2.7812	0.1812
SNU-1033	CTRP2	6.231	10.7571	3.8417	8.8964
COLO 678	GDSC1; GDSC2; CTRP2	6.2673	10.5089	3.9951	8.1885
HCT 15	GDSC1; GDSC2; CTRP2	6.5426	12.4158	3.2638	10.7074
CCK-81	GDSC1; GDSC2; CTRP2	6.6121	10.4216	4.309	6.268
HT-55	GDSC1; GDSC2; CTRP2	6.8492	12.0176	3.6991	8.391
C2BBe1	GDSC1; GDSC2; CTRP2	6.854	14.3647	2.5382	13.0259
OUMS-23	CTRP2	7.0491	9.6257	5.0058	2.7643
LS411N	GDSC1; GDSC2; CTRP2	7.2929	8.9378	5.458	0.862
LS180	GDSC1; GDSC2; CTRP2	7.6207	11.4988	4.4923	4.0339
CW-2	GDSC1; GDSC2; CTRP2	7.7446	11.2927	4.6654	3.2197
SNU-C2A	CTRP2	7.7624	15.3522	2.733	10.7521
MDST8	GDSC1; GDSC2; CTRP2	7.7964	10.3529	5.1155	1.5531
HT-29	GDSC1; GDSC2; CTRP2	7.9399	9.4307	5.5537	0.2685
HCT 116	GDSC1; GDSC2; CTRP2	7.967	9.1539	5.6623	0.101

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1; GDSC2	3.4028	7.6044	1.2477	12.3732

Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-886	CTRP2	0.8289	5.27	0.5438	35.6243
Li-7	CTRP2	2.0377	10.1085	0.1498	32.5871
SNU-878	CTRP2	2.5081	5.5894	2.2991	24.2788
JHH-7	GDSC1; GDSC2	2.7632	5.805	1.5887	12.2629
Huh-7	GDSC1; GDSC2	2.9059	7.584	0.835	16.2152
HuH-6	CTRP2	3.0544	7.1671	2.4181	22.1985
JHH-5	CTRP2	3.1071	6.0358	2.8411	20.4979
Hep 3B2.1-7	GDSC1; GDSC2; CTRP2	3.286	9.47	1.7101	24.1119
Hep-G2/C3A	GDSC1; GDSC2	3.9784	6.0404	2.4632	3.6671
HLE	GDSC1; GDSC2	3.9791	9.6165	0.7041	13.9076
HuH-1	GDSC1; GDSC2; CTRP2	4.016	12.4058	1.0476	24.4411
JHH-4	GDSC1; GDSC2; CTRP2	4.2244	7.5671	3.505	14.8004
SNU-182	CTRP2	4.3614	7.6133	3.628	13.9539
JHH-2	GDSC1; GDSC2; CTRP2	4.4555	6.3769	4.2094	11.4624
SNU-398	GDSC1; GDSC2; CTRP2	4.533	10.4627	2.4767	18.0726
SK-HEP-1	GDSC1; GDSC2; CTRP2	4.5651	7.1595	4.0314	11.8323
SNU-761	CTRP2	4.6016	8.4152	3.5143	13.7875
PLC/PRF/5	CTRP2	4.6218	7.9447	3.7491	12.7969
SNU-475	CTRP2	4.666	7.3358	4.0625	11.4404
SNU-387	GDSC1; GDSC2; CTRP2	4.6851	7.4656	4.0262	11.5327
JHH-1	GDSC1; GDSC2; CTRP2	5.3555	9.262	3.8307	10.722
SNU-449	GDSC1; GDSC2; CTRP2	5.4016	10.6865	3.168	13.3505
HLF	CTRP2	5.425	9.4047	3.8237	10.5988
JHH-6	GDSC1; GDSC2; CTRP2	6.0581	6.7649	5.6955	1.4402
SNU-423	GDSC1; GDSC2; CTRP2	6.1375	11.7438	3.2719	11.4298
Hep-G2	CTRP2	6.8289	12.3331	3.5275	9.1279

Cancer Drug Sensitivity Data Curated from 222 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H1703	GDSC1; GDSC2; CTRP2	-4.9904	19.1706	-11.0378	57.6685
SBC-3	GDSC1; GDSC2	0.5455	2.4839	0.4727	27.2564
A-427	GDSC1; GDSC2	0.6324	4.3546	0.0518	28.9288
LB647-SCLC	GDSC1; GDSC2	0.6387	2.7824	0.5214	26.5767
IST-SL1	GDSC1; GDSC2	0.6428	2.1772	0.6133	26.1
NCI-H1581	GDSC1; GDSC2; CTRP2	0.7441	4.3316	0.6217	35.6983
LK-2	GDSC1; GDSC2	0.8097	3.4132	0.5547	25.6245
NCI-H2227	GDSC1; GDSC2	0.8942	1.8855	0.8901	23.5399
NCI-H2171	GDSC2	0.9327	2.4387	0.8919	24.1838
NCI-H446	GDSC1; GDSC2; CTRP2	0.9402	3.2061	0.9257	34.0526
NCI-H847	GDSC1; GDSC2	0.955	2.2194	0.9365	23.0214
NCI-H524	GDSC1; GDSC2	1.0058	2.4837	0.9642	22.6433
NCI-H1048	GDSC1; GDSC2	1.0227	2.6381	0.9609	22.5806
NCI-H1963	GDSC1; GDSC2	1.0734	2.5609	1.0262	22.0164
NCI-H1876	GDSC1; GDSC2	1.0896	2.5891	1.0396	21.8738
NCI-H510A	GDSC1; GDSC2; CTRP2	1.1172	4.7437	0.9583	33.3432
UMC-11	GDSC1; GDSC2	1.1901	3.1977	1.0281	21.4721
Lu-135	GDSC1; GDSC2	1.1949	3.1819	1.0374	21.4021
LC-2/ad	GDSC1; GDSC2	1.4045	4.2099	0.9341	21.0468
NCI-H720	GDSC1; GDSC2	1.4642	4.1609	1.0165	20.3511
NCI-H209	GDSC1; GDSC2	1.4864	5.041	0.683	22.0702
SBC-1	GDSC1; GDSC2	1.5348	3.4239	1.3428	18.2949
NCI-H82	GDSC1; GDSC2	1.5761	4.1691	1.1331	19.2517
NCI-H2795	GDSC1; GDSC2	1.617	5.7057	0.5232	22.4089
NCI-H1436	GDSC1; GDSC2	1.689	3.7097	1.4207	17.2131
NCI-H211	GDSC1; GDSC2; CTRP2	1.7154	5.1599	1.5288	29.4692
NCI-H2081	GDSC1; GDSC2; CTRP2	1.8168	4.6671	1.7207	28.4887
NCI-H1341	GDSC1; GDSC2; CTRP2	1.8446	5.1096	1.6782	28.5425
NCI-H2731	GDSC1; GDSC2	1.9055	5.2496	1.0206	18.5814
NCI-H187	GDSC1	1.9437	3.7048	0.3296	2.6905
VMRC-LCD	GDSC1; GDSC2; CTRP2	1.9762	4.5399	1.9069	27.3363
HARA [Human squamous cell lung carcinoma]	GDSC1; GDSC2; CTRP2	2.0129	4.1548	1.9822	26.9613
COR-L311	GDSC2	2.1744	6.4707	0.7124	19.9768
NCI-H748	GDSC2	2.1843	6.7661	0.5794	20.6802
NCI-H1105	GDSC1; GDSC2; CTRP2	2.2615	5.425	2.0671	25.8677
NCI-H1770	GDSC1; GDSC2	2.291	4.9851	1.5283	14.2421
HCC15	GDSC1; GDSC2; CTRP2	2.3674	5.1049	2.2435	24.919
Ms-1	GDSC1; GDSC2	2.4154	4.5188	1.8657	11.8219
HCC95	CTRP2	2.4363	6.125	2.0845	25.2584
HCC44	GDSC1; GDSC2; CTRP2	2.4551	5.0265	2.3509	24.2667
NCI-H810	GDSC1; GDSC2; CTRP2	2.4683	5.8078	2.2037	24.7389
NCI-H1155	GDSC1; GDSC2; CTRP2	2.4936	6.1749	2.1329	24.9102
NCI-H1385	CTRP2	2.561	4.2895	2.5425	23.2688
COR-L279	GDSC1; GDSC2	2.5697	4.816	1.8826	11.1642
NCI-H1694	GDSC1; GDSC2; CTRP2	2.5818	6.1733	2.2296	24.2953
EMC-BAC-2	GDSC1; GDSC2	2.6087	6.3043	1.2014	15.0593
COR-L321	GDSC1; GDSC2	2.6188	4.8591	1.9102	10.8282
DV-90	CTRP2	2.6387	6.8843	2.0686	24.6961
NCI-H841	GDSC1; GDSC2; CTRP2	2.6608	7.8513	1.7386	25.7975
DMS 273	GDSC1; GDSC2; CTRP2	2.7498	6.7258	2.2422	23.7394
NCI-H1184	CTRP2	2.7905	6.2138	2.4457	22.8842
CPC-N	GDSC1; GDSC2	2.8345	6.0321	1.5419	12.3145
NCI-H2286	CTRP2	2.8551	5.5049	2.6949	21.7987
NCI-H69	GDSC1; GDSC2; CTRP2	2.8998	7.0012	2.3108	23.0446
Lu-139	GDSC1; GDSC2	2.956	4.7484	2.2847	7.4477
LXF 289	GDSC1; GDSC2; CTRP2	3.0122	6.1878	2.6951	21.3127
ABC-1	GDSC1; GDSC2	3.1272	9.8847	-0.1231	20.5242
HCC33	GDSC2	3.163	5.8806	1.9079	9.4216
COR-L51	CTRP2	3.1887	5.34	3.0881	19.369
NCI-H250	GDSC2	3.2272	9.1301	0.3385	18.491
COR-L32	GDSC2	3.3111	6.4876	1.7301	10.0952
NCI-H146	GDSC1; GDSC2	3.332	5.792	2.0953	7.4684
Lu-134-A	GDSC1; GDSC2	3.3776	6.3704	1.8439	8.8731
DMS 53	GDSC1; GDSC2; CTRP2	3.3827	6.1406	3.1128	18.6793
NCI-H889	CTRP2	3.4358	6.1296	3.1739	18.2974
NCI-H2009	GDSC1; GDSC2; CTRP2	3.4449	6.6578	3.0191	18.8376
NCI-H290	GDSC1; GDSC2	3.4755	7.5416	1.3386	11.6367
NCI-H1688	GDSC1; GDSC2	3.4958	6.37	1.9402	7.966
NCI-H2106	CTRP2	3.4976	6.8365	3.0145	18.7009
NCI-H2141	GDSC1; GDSC2; CTRP2	3.5443	6.8334	3.066	18.3738
NCI-H23	GDSC1; GDSC2; CTRP2	3.5476	7.2394	2.9204	18.9107
NCI-H64	GDSC1; GDSC2	3.5641	7.0726	1.6444	9.5738
NCI-H835	GDSC1; GDSC2	3.5893	7.4711	1.4658	10.5748
NCI-H1304	GDSC1	3.5947	4.8951	0.5861	0.0917
DMS 454	CTRP2	3.6375	6.6585	3.2276	17.501
LC-1F	CTRP2	3.6444	9.4433	2.085	21.7925
NCI-H2373	GDSC1; GDSC2	3.6487	12.5341	-1.0148	22.887
COR-L23	GDSC1; GDSC2	3.6597	6.425	2.0421	6.9224
NCI-H520	GDSC1; GDSC2; CTRP2	3.6744	8.1382	2.6907	19.4319
NCI-H2196	GDSC2; CTRP2	3.6881	7.4045	3.0061	18.1909
Lu-99A	GDSC1; GDSC2	3.7468	6.0732	2.2823	5.2568
PC-14	GDSC1; GDSC2; CTRP2	3.7527	7.1041	3.1911	17.3072
NCI-H2591	GDSC1; GDSC2	3.7611	6.2353	2.2131	5.6396
NCI-H2135	GDSC1; GDSC2	3.7629	6.2601	2.2022	5.701
NCI-H1755	GDSC1; GDSC2; CTRP2	3.7634	6.633	3.3727	16.594
NCI-H596	GDSC1; GDSC2	3.7755	7.168	1.7626	8.3179
NCI-H1781	GDSC1; GDSC2	3.7957	6.3087	2.2026	5.6207
NCI-H2810	GDSC1; GDSC2	3.7971	9.5172	0.6108	14.8896
Lu-99	CTRP2	3.7992	6.6264	3.4138	16.337
NCI-H1092	GDSC1; GDSC2; CTRP2	3.7993	6.6014	3.4223	16.3051
NCI-H1975	GDSC1; GDSC2	3.8011	7.6527	1.5418	9.5727
NCI-H2347	GDSC1; GDSC2	3.8048	6.2198	2.253	5.2963
NCI-H2110	GDSC1; GDSC2; CTRP2	3.8093	7.7619	2.9894	17.9202
NCI-H2461	GDSC1; GDSC2	3.8574	8.3605	1.2338	11.2388
NCI-H2803	GDSC1; GDSC2	3.8722	7.984	1.4321	10.042
COLO 668	GDSC1; GDSC2; CTRP2	3.8902	6.6259	3.5124	15.7047
COR-L303	GDSC2	3.8991	6.7378	2.0679	6.4072
NCI-H2722	GDSC1; GDSC2	3.9036	7.3641	1.7627	8.0024
RERF-LC-KJ	GDSC1; GDSC2	3.9207	6.9922	1.9587	6.7899
NCI-H2804	GDSC1; GDSC2	3.969	7.5321	1.7287	8.048
LCLC-97TM1	GDSC1; GDSC2; CTRP2	3.9952	8.4913	2.8681	17.893
NCI-H1993	GDSC1; GDSC2	4.0113	6.9196	2.0602	5.9763
NCI-H2066	GDSC1; GDSC2	4.0216	7.4161	1.8246	7.3536
NCI-H1437	GDSC1; GDSC2	4.0414	7.5209	1.7877	7.5273
LC-1/sq	GDSC1; GDSC2	4.0416	10.5396	0.2939	15.9078
EBC-1	GDSC1; GDSC2; CTRP2	4.0504	6.7715	3.634	14.7871
NCI-H2085	GDSC1; GDSC2; CTRP2	4.0575	9.2662	2.58	18.8487
NCI-H1563	GDSC1; GDSC2; CTRP2	4.0612	6.317	3.7999	14.1378
Lu-165	GDSC1; GDSC2	4.1225	7.8992	1.6613	8.0865
Calu-3	GDSC1; GDSC2; CTRP2	4.1798	7.2808	3.5763	14.6448
HCC1588	CTRP2	4.1962	8.3321	3.1437	16.2914
RERF-LC-MS	GDSC1; GDSC2; CTRP2	4.2036	7.2721	3.6048	14.4697
NCI-H1836	GDSC1; GDSC2	4.2143	7.0294	2.1488	5.0173
SW1573	GDSC1; GDSC2	4.2327	8.5384	1.4283	9.1941
COR-L95	GDSC1; GDSC2; CTRP2	4.2641	6.5797	3.9329	13.0503
EMC-BAC-1	GDSC1; GDSC2	4.3098	10.2089	0.663	13.2995
SBC-5	GDSC1; GDSC2; CTRP2	4.3125	7.9074	3.4502	14.7817
HOP-92	GDSC1; GDSC2; CTRP2	4.3176	7.6184	3.5803	14.2571
DMS 79	GDSC1; GDSC2; CTRP2	4.3441	7.8142	3.5233	14.4108
Lu-65	GDSC1; GDSC2; CTRP2	4.3583	6.8644	3.9297	12.794
CAL-12T	GDSC1; GDSC2; CTRP2	4.3788	8.0132	3.4715	14.5248
EPLC-272H	GDSC1; GDSC2; CTRP2	4.382	7.3749	3.7502	13.4213
NCI-H3255	GDSC1; GDSC2	4.3863	6.2693	2.6124	2.1062
NCI-H2172	GDSC1; GDSC2; CTRP2	4.3882	7.5718	3.6734	13.7046
NCI-H2228	GDSC1; GDSC2; CTRP2	4.4287	8.7652	3.1806	15.5535
LK2	CTRP2	4.4292	7.4029	3.7878	13.1477
NCI-H661	GDSC1; GDSC2; CTRP2	4.4307	8.5379	3.2873	15.1235
RERF-LC-A1	CTRP2	4.4444	7.7996	3.6328	13.7165
IST-SL2	GDSC1; GDSC2	4.4688	10.0996	0.8349	11.9893
NCI-H3122	GDSC1; GDSC2	4.4874	8.2066	1.7694	6.6558
NCI-H1373	CTRP2	4.5017	6.396	4.2532	11.1649
HCC2279	CTRP2	4.5077	6.478	4.2317	11.2275
HCC1195	CTRP2	4.5177	7.3128	3.9179	12.402
NCI-H2595	GDSC1; GDSC2	4.5184	9.1602	1.3298	9.1133
COR-L88	GDSC1; GDSC2; CTRP2	4.5194	7.4249	3.8723	12.576
NCI-H1650	GDSC1; GDSC2; CTRP2	4.5209	7.2935	3.9294	12.3486
NCI-H513	GDSC1; GDSC2	4.5215	6.7899	2.4563	2.7225
NCI-H2029	GDSC1; GDSC2; CTRP2	4.5287	10.1563	2.6203	17.525
NCI-H838	GDSC1; GDSC2; CTRP2	4.5408	7.6277	3.807	12.7766
SW1271	GDSC1; GDSC2; CTRP2	4.561	6.6134	4.241	11.0395
PaCa-3	GDSC1; GDSC2	4.596	6.9095	2.4458	2.6619
NCI-H1944	GDSC1; GDSC2; CTRP2	4.6355	9.7055	2.9389	16.0117
SHP-77	GDSC1; GDSC2; CTRP2	4.6403	7.7791	3.8421	12.3793
NCI-H345	GDSC1; GDSC2	4.682	5.7011	2.9882	0.2332
HCC1438	CTRP2	4.6831	7.3025	4.0945	11.2694
NCI-H522	GDSC2; CTRP2	4.6877	8.8222	3.4095	13.9969
HCC366	GDSC1; GDSC2; CTRP2	4.7118	8.5107	3.5792	13.2536
NCI-H1648	GDSC1; GDSC2	4.7132	8.4922	1.784	6.1192
NCI-H1355	GDSC1; GDSC2; CTRP2	4.7599	8.0317	3.8486	12.0498
NCI-H647	GDSC1; GDSC2; CTRP2	4.7881	8.427	3.6935	12.6048
RERF-LC-Sq1	GDSC1; GDSC2	4.7946	11.3442	0.4621	13.2085
NCI-H1339	CTRP2	4.8347	8.748	3.5877	12.9206
ChaGo-K-1	GDSC1; GDSC2; CTRP2	4.8359	8.0555	3.9135	11.5985
NCI-H322M	GDSC1; GDSC2	4.8444	8.3529	1.9337	5.0338
NCI-H226	GDSC1; GDSC2; CTRP2	4.8852	8.2961	3.8502	11.7332
NCI-H2087	GDSC1; GDSC2; CTRP2	4.8968	7.4754	4.2385	10.1417
NCI-H1792	GDSC1; GDSC2; CTRP2	4.9144	8.642	3.7153	12.2108
NCI-H1568	GDSC1; GDSC2; CTRP2	4.9645	11.0201	2.6078	16.5577
LOU-NH91	GDSC1; GDSC2; CTRP2	5.0106	8.18	4.0276	10.7085
DMS 114	GDSC1; GDSC2; CTRP2	5.024	10.4129	2.9607	15.0213
COR-L105	GDSC1; GDSC2; CTRP2	5.0411	11.1225	2.6274	16.308
SK-MES-1	GDSC1; GDSC2; CTRP2	5.0433	7.7432	4.264	9.6701
NCI-H2122	GDSC1; GDSC2; CTRP2	5.0768	9.5754	3.4194	13.041
IA-LM	GDSC1; GDSC2; CTRP2	5.0842	7.7861	4.2846	9.4861
NCI-H2405	GDSC1; GDSC2; CTRP2	5.0856	9.5346	3.4475	12.906
NCI-H1573	GDSC1; GDSC2; CTRP2	5.087	7.7645	4.2974	9.427
HCC4006	CTRP2	5.0925	9.0412	3.6939	11.8803
NCI-H1693	GDSC1; GDSC2; CTRP2	5.099	8.5532	3.9356	10.8737
NCI-H358	GDSC1; GDSC2; CTRP2	5.1216	10.13	3.1895	13.8773
NCI-H1793	GDSC1; GDSC2	5.1447	6.9595	2.7052	0.8355
NCI-H2869	GDSC1; GDSC2	5.1593	11.1926	0.7926	10.6849
NCI-H1915	GDSC1; GDSC2; CTRP2	5.2127	8.2949	4.1682	9.6529
NCI-H740	GDSC2	5.2171	8.2609	2.1957	3.1502
NCI-H1666	GDSC1; GDSC2; CTRP2	5.232	9.7401	3.4824	12.4336
SK-LU-1	GDSC1; GDSC2; CTRP2	5.3499	9.5522	3.6827	11.3472
KNS-62	GDSC1; GDSC2; CTRP2	5.362	7.6936	4.5996	7.5324
NCI-H2818	GDSC1; GDSC2	5.3908	23.3606	-5.0298	29.7884
HCC2108	CTRP2	5.4374	10.1703	3.456	12.0932
Calu-1	CTRP2	5.4513	8.09	4.4933	7.7629
NCI-H2369	GDSC1; GDSC2	5.4568	12.3806	0.4246	11.9582
NCI-H2170	GDSC1; GDSC2; CTRP2	5.4616	10.0298	3.5474	11.6643
A-549	GDSC1; GDSC2; CTRP2	5.4713	9.3768	3.8794	10.2669
HCC1833	CTRP2	5.4814	10.868	3.1488	13.2585
LUDLU-1	CTRP2	5.5231	9.0665	4.0796	9.3216
NCI-H1623	GDSC1; GDSC2; CTRP2	5.7087	9.7329	3.9134	9.6231
LC-1/sq-SF	CTRP2	5.7166	6.9498	5.2961	3.841
NCI-H526	GDSC1; GDSC2; CTRP2	5.7667	11.2721	3.1957	12.4744
NCI-H1651	GDSC1; GDSC2; CTRP2	5.7789	8.5911	4.5436	6.8402
HOP-62	GDSC1; GDSC2; CTRP2	5.7839	9.6984	3.996	9.1234
RERF-LC-Ad2	CTRP2	5.802	10.5181	3.6025	10.7271
NCI-H322	CTRP2	5.8123	9.7482	3.9957	9.067
T3M-10	CTRP2	5.871	7.9941	4.9215	5.0654
NCI-H1734	GDSC1; GDSC2; CTRP2	5.8852	9.8547	4.005	8.8814
NCI-H1869	GDSC1; GDSC2; CTRP2	5.9678	10.877	3.564	10.5563
NCI-H460	GDSC1; GDSC2; CTRP2	5.9962	15.4295	1.3116	19.1233
NCI-H727	GDSC1; GDSC2; CTRP2	5.9973	9.7153	4.1696	7.9702
NCI-H2342	GDSC1; GDSC2; CTRP2	6.1651	11.4652	3.4339	10.7116
HCC827	GDSC1; GDSC2; CTRP2	6.222	11.9239	3.2513	11.3527
NCI-H2444	GDSC1; GDSC2; CTRP2	6.2328	9.405	4.5184	6.0595
HCC78	GDSC1; GDSC2; CTRP2	6.2517	12.4661	3.0046	12.2962
HCC2935	CTRP2	6.3088	9.2112	4.6756	5.2631
EKVX	GDSC1; GDSC2; CTRP2	6.5985	9.7657	4.6229	4.9866
NCI-H1395	CTRP2	6.7741	10.0738	4.6007	4.7963
NCI-H1299	GDSC1; GDSC2; CTRP2	6.7951	12.1469	3.594	8.914
NCI-H292	GDSC1; GDSC2; CTRP2	6.9677	15.7164	1.9547	15.0085
NCI-H650	GDSC1; GDSC2; CTRP2	7.0135	14.4955	2.5968	12.5185
NCI-H2126	CTRP2	7.0385	11.792	3.9511	7.0472
BEN	GDSC1; GDSC2; CTRP2	7.1633	8.2488	5.6769	0.3252
Calu-6	GDSC1; GDSC2; CTRP2	7.184	12.3383	3.7893	7.4771
NCI-H1435	GDSC1; GDSC2; CTRP2	7.2058	10.887	4.5093	4.5247
COLO 699	CTRP2	7.2765	15.4495	2.325	13.0986
RERF-LC-Ad1	CTRP2	7.3318	8.2493	5.7455	0.1247
HCC1171	CTRP2	7.4324	11.7201	4.2633	5.1904
MOR/CPR	CTRP2	7.4835	9.9921	5.1017	1.8984
NCI-H196	GDSC1; GDSC2; CTRP2	7.5359	12.084	4.159	5.4616
NCI-H441	GDSC1; GDSC2; CTRP2	7.5484	9.9129	5.1731	1.5835
NCI-H2030	GDSC1; GDSC2; CTRP2	7.6368	10.9171	4.7725	2.9416
LCLC-103H	GDSC1; GDSC2; CTRP2	7.9642	9.1794	5.6525	0.1128
NCI-H1838	GDSC1; GDSC2; CTRP2	8.3503	14.0035	3.7833	5.8458
NCI-H2023	GDSC1; GDSC2; CTRP2	8.3782	13.9774	3.8132	5.6958
NCI-H2291	GDSC1; GDSC2; CTRP2	8.4394	10.2833	5.4388	0.3133
Hs 888.Lu	CTRP2	4.9055	11.5067	2.3144	17.8276

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1; GDSC2	3.4558	6.3642	1.9109	8.2518

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
H-STS	CTRP2	2.9999	7.9494	2.0602	23.6634
SYO-1	CTRP2	3.2406	9.252	1.7605	24.0591
P-STS	CTRP2	5.3895	10.6201	3.1903	13.2857

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	6.6211	9.9884	4.53	11.3036

Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Aska-SS	CTRP2	7.6914	9.1676	5.5504	0.3699
Yamato-SS	CTRP2	8.4269	21.7385	0.0836	18.5916
A-204	GDSC1; GDSC2; CTRP2	-3.2357	4.7022	-3.7508	59.1197
G-402	GDSC1; GDSC2; CTRP2	-2.3873	6.6282	-3.3232	54.4563
STS-0421	GDSC1; GDSC2	1.0995	4.6579	0.4353	24.9712
EW-8	GDSC1; GDSC2	1.4855	2.935	1.4086	18.175
G-401	GDSC1; GDSC2; CTRP2	1.6721	4.5315	1.5847	29.4224
Rh41	GDSC1; GDSC2; CTRP2	2.0246	4.6151	1.9492	27.0349
TTC-709	CTRP2	2.0246	7.1098	1.3264	29.148
Rh18	GDSC1; CTRP2	3.3312	5.8634	3.1308	18.7719
MES-SA	GDSC1; GDSC2; CTRP2	3.3596	7.1881	2.7384	20.1294
SW684	GDSC1; GDSC2	3.8101	5.9612	2.3837	4.5013
Hs 633.T	GDSC1; GDSC2	3.9975	6.5839	2.2139	5.0948
TE 441.T	GDSC2; CTRP2	4.0166	7.6235	3.2641	16.2967
GCT	GDSC1; GDSC2; CTRP2	4.0325	6.0651	3.843	14.067
SW872	GDSC1; GDSC2	4.1316	6.2251	2.4769	3.2857
VA-ES-BJ	GDSC1; GDSC2	4.3334	8.5984	1.4717	8.7121
KYM-1	GDSC1; GDSC2; CTRP2	4.4289	7.8442	3.5974	13.8966
HT-1080	GDSC1; GDSC2; CTRP2	4.4703	6.7646	4.0874	11.8784
SK-UT-1	GDSC1; GDSC2; CTRP2	4.5879	9.009	3.2239	14.987
Hs 729.T	CTRP2	4.6272	9.6538	2.9556	15.9651
TE 617.T	CTRP2	4.692	8.3762	3.6222	13.1293
MFH-ino	GDSC1; GDSC2	4.9883	7.5709	2.3728	2.4699
RKN	GDSC1; GDSC2; CTRP2	5.1886	9.3348	3.641	11.8783
Rh30	GDSC1; GDSC2	5.4157	14.1106	-0.4426	16.1291
SK-LMS-1	GDSC1; GDSC2; CTRP2	5.5609	9.7779	3.7608	10.5679
RD	GDSC1; GDSC2; CTRP2	5.7916	10.1727	3.766	10.0683
BT-12	CTRP2	7.3076	13.8726	3.1267	9.9455
Tm87-16	CTRP2	7.4472	17.4331	1.4727	15.8662
BT-16	CTRP2	7.6949	9.1364	5.5637	0.3396
SW982	GDSC1; GDSC2; CTRP2	7.9166	9.0822	5.669	0.1021

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A2780	GDSC1; GDSC2; CTRP2	1.0826	4.6877	0.9304	33.5512
COV434	CTRP2	2.4101	7.8665	1.4655	27.4876
Caov-3	GDSC2; CTRP2	2.6463	4.9747	2.5638	22.9185
JHOS-4	GDSC1; GDSC2	3.1206	7.1334	1.2459	13.1971
TOV-112D	GDSC1; GDSC2; CTRP2	3.6243	8.3714	2.5391	20.1448
OVK18	GDSC1; GDSC2; CTRP2	3.6789	10.1881	1.7774	22.8182
DOV13	GDSC1; GDSC2; CTRP2	4.0032	6.965	2.0322	5.1776
ES-2	GDSC1; GDSC2	4.2118	7.7132	1.8165	6.971
OVCAR-3	GDSC1; GDSC2	4.2899	8.0554	1.7053	7.45
OV-90	GDSC1; GDSC2; CTRP2	4.3206	6.903	3.8747	13.1093
OAW42	GDSC1; GDSC2; CTRP2	4.3971	8.3268	3.3496	14.9608
OVISE	GDSC1; GDSC2; CTRP2	4.5151	6.9306	2.3884	2.6035
JHOM-1	CTRP2	4.5807	7.4623	3.9199	12.2263
MCAS	CTRP2	4.5931	7.705	3.8269	12.5614
OVCAR-8	GDSC1; GDSC2; CTRP2	4.6717	7.3409	4.0663	11.4104
IGROV-1	GDSC1; GDSC2; CTRP2	4.7386	10.3628	2.7194	16.6384
TYK-nu	GDSC1; GDSC2; CTRP2	4.7484	7.6576	4.0063	11.4478
COV362	CTRP2	4.9161	18.4634	-1.1287	28.2917
OVCAR-5	GDSC1; GDSC2; CTRP2	5.0035	9.0771	3.5923	12.5023
OVKATE	GDSC1; GDSC2	5.0132	8.7074	1.8742	5.0641
ONCO-DG-1	CTRP2	5.0483	8.8517	3.7436	11.7789
Caov-4	GDSC1; GDSC2	5.3528	12.9675	0.0689	13.9183
SNU-119	CTRP2	5.369	9.7166	3.619	11.5686
JHOS-2	GDSC1; GDSC2; CTRP2	5.3718	9.8424	3.5594	11.8085
OVCAR-4	GDSC1; GDSC2; CTRP2	5.3743	11.3774	2.8008	14.8899
OV7	CTRP2	5.4295	13.3007	1.8919	18.2535
SNU-8	CTRP2	5.4746	9.5918	3.776	10.6891
EFO-21	GDSC1; GDSC2; CTRP2	5.5443	7.7314	4.7548	6.4699
FU-OV-1	GDSC1; GDSC2; CTRP2	5.6297	9.1998	4.1091	8.9708
HEY A8	CTRP2	5.7102	10.1617	3.701	10.505
EFO-27	GDSC1; GDSC2; CTRP2	5.8335	8.7825	4.4959	6.9277
COV644	CTRP2	5.8939	8.0616	4.9078	5.0759
TOV-21G	GDSC1; GDSC2; CTRP2	6.0167	10.464	3.8115	9.4311
SNU-840	CTRP2	6.0265	8.7249	4.6892	5.7307
OC 314	GDSC1; GDSC2; CTRP2	6.3374	10.689	3.9616	8.1997
RMG-I	GDSC1; GDSC2; CTRP2	6.6888	11.0325	4.0649	7.1517
OAW28	GDSC1; GDSC2; CTRP2	6.762	10.8894	4.1908	6.508
OV56	GDSC1; GDSC2; CTRP2	7.2039	13.4359	3.2649	9.564
OVSAHO	CTRP2	7.5214	13.894	3.2721	9.0272
Kuramochi	GDSC1; GDSC2; CTRP2	7.575	10.8954	4.7447	3.1192
OVTOKO	GDSC1; GDSC2; CTRP2	7.7276	11.5214	4.5492	3.6814
SK-OV-3	GDSC1; GDSC2; CTRP2	7.8866	11.2568	4.7662	2.6878
JHOC-5	CTRP2	8.6602	13.3896	4.2548	3.7209

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MSTO-211H	GDSC1; GDSC2; CTRP2	2.8031	4.8683	2.7451	21.7903
MPP 89	GDSC1; GDSC2; CTRP2	3.6527	7.119	3.0784	18.0162
NCI-H28	GDSC1; GDSC2; CTRP2	4.1869	7.515	3.4876	14.9693
NCI-H2452	GDSC1; GDSC2; CTRP2	4.193	7.3417	3.5654	14.6509
IST-Mes1	GDSC1; GDSC2; CTRP2	4.333	9.5115	2.7379	17.5418
ACC-MESO-1	CTRP2	5.1655	8.16	4.1876	9.6845
JL-1	CTRP2	5.3644	7.7016	4.5981	7.5329
NCI-H2052	GDSC1; GDSC2; CTRP2	6.6015	11.7672	3.633	9.0896

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
PC-3	GDSC1; GDSC2	4.0109	7.1379	1.9532	6.6136
LNCaP clone FGC	GDSC1; GDSC2; CTRP2	4.2074	9.2962	2.7149	17.9451
VCaP	GDSC1; GDSC2; CTRP2	4.6347	9.0272	3.2609	14.7241
NCI-H660	GDSC2	4.7417	6.1354	2.8493	0.645
22Rv1	GDSC1; GDSC2	4.7612	10.713	0.7464	11.7944
PaCa-3	CTRP2	5.5744	7.0331	5.1191	4.903
DU145	GDSC1; GDSC2; CTRP2	5.6523	9.7309	3.865	9.9422

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-15	CTRP2	4.7561	7.5496	4.0621	11.2061
A-253	GDSC1; GDSC2; CTRP2	5.1847	8.8563	3.8705	10.9424

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1; GDSC2	-0.8008	3.6696	-1.2769	41.4674

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HSC-39	GDSC1; GDSC2	-2.4612	-0.8582	-2.4617	56.0158
SNU-16	GDSC1; GDSC2; CTRP2	-1.1836	2.5703	-1.2326	48.1994
NCC-StC-K140	CTRP2	1.1924	10.9909	-1.1046	38.0515
HGC-27	GDSC1; GDSC2; CTRP2	1.5457	4.769	1.415	30.4084
SNU-620	CTRP2	1.6109	2.7526	1.6107	29.5375
ECC10	GDSC1; GDSC2; CTRP2	1.7111	3.9585	1.682	28.9665
KATO III	GDSC1; GDSC2; CTRP2	1.9044	9.5553	0.2481	32.7479
SK-GT-2	GDSC1; GDSC2	2.0116	5.572	0.9793	18.4181
GSS	CTRP2	2.4509	5.2541	2.3068	24.4326
MKN1	GDSC1; GDSC2	3.2693	5.788	2.0448	7.9543
TGBC11TKB	GDSC1; GDSC2	3.3686	7.2637	1.3897	11.6309
SNU-1	GDSC1; GDSC2; CTRP2	3.4885	6.2773	3.1882	18.0866
SCH	GDSC1; GDSC2	3.6414	5.9591	2.2592	5.6523
RF-48	GDSC1; GDSC2	3.678	6.1531	2.191	5.9748
Fu97	GDSC1; GDSC2; CTRP2	3.7506	10.6578	1.6286	23.1576
TMK-1	GDSC1; GDSC2	3.9888	7.1798	1.9166	6.8825
GCIY	GDSC1; GDSC2	4.2596	7.2766	2.0609	5.4358
ECC12	GDSC2; CTRP2	4.3347	7.5111	3.6436	13.9639
23132/87	GDSC1; GDSC2; CTRP2	4.3844	6.5211	4.0834	12.1391
LMSU	CTRP2	4.5218	17.7363	-1.1144	29.1214
HuG1-N	CTRP2	4.5454	7.8786	3.7012	13.1833
IM95	GDSC1; GDSC2; CTRP2	4.648	7.3517	4.037	11.588
OCUM-1	GDSC1; GDSC2; CTRP2	4.7928	10.3256	2.7884	16.2394
SNU-216	CTRP2	4.863	6.2974	4.6781	8.5302
SNU-601	CTRP2	5.0822	7.1774	4.56	8.3851
RERF-GC-1B	GDSC1; GDSC2	5.3957	18.4473	-2.5897	23.9846
MKN7	GDSC1; GDSC2; CTRP2	5.5106	8.7796	4.21	8.8062
MKN28	GDSC1; GDSC2	5.6315	13.4725	0.0186	13.567
KE-39	CTRP2	5.8621	10.3189	3.7533	9.9789
SNU-719	CTRP2	5.9142	10.5728	3.6708	10.2188
SH-10-TC	CTRP2	5.9338	9.0087	4.4691	6.838
SNU-5	GDSC1; GDSC2; CTRP2	6.0102	9.9547	4.0607	8.4015
Hs 746.T	GDSC1; GDSC2; CTRP2	6.0289	10.9265	3.5904	10.3273
MKN74	CTRP2	6.1125	9.3938	4.4261	6.6717
GSU	CTRP2	6.224	8.4358	4.9949	4.0768
NUGC-4	GDSC1; GDSC2; CTRP2	7.1702	12.1515	3.8707	7.1675
SNU-668	CTRP2	7.1895	11.112	4.3897	5.0296
MKN45	GDSC1; GDSC2; CTRP2	7.2725	12.0154	4.0102	6.4434
NCI-N87	GDSC1; GDSC2; CTRP2	7.9204	10.6714	5.0439	1.6824
AGS	GDSC1; GDSC2; CTRP2	8.0763	13.8895	3.6586	6.6895
NUGC-3	GDSC1; GDSC2; CTRP2	8.7628	15.8225	3.1928	7.5568
SNG-M	GDSC1; GDSC2; CTRP2	4.8496	8.0377	3.9353	11.477
SNU-1077	CTRP2	5.171	9.7987	3.3975	12.9178
SNU-685	CTRP2	5.9244	9.9759	3.9777	8.9176

Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW579	CTRP2	-2.2225	4.4674	-2.601	54.2735
CGTH-W-1	GDSC1; GDSC2; CTRP2	-2.0023	1.7601	-2.0332	53.5179
K5	GDSC1; GDSC2	3.1206	4.9481	2.3355	6.6192
KMH-2	GDSC1; GDSC2	3.425	7.2322	1.452	11.1035
HTC-C3	GDSC1; GDSC2	3.551	6.0319	2.1528	6.5281
FTC-238	CTRP2	3.5748	8.7425	2.327	21.0785
IHH-4	GDSC1; GDSC2	3.6763	7.1708	1.6843	9.0401
TT2609-C02	GDSC1; GDSC2; CTRP2	3.9363	7.433	3.2577	16.5409
ML-1 [Human leukemia]	GDSC1; GDSC2; CTRP2	3.9378	8.5139	2.7995	18.3097
8305C	GDSC1; GDSC2; CTRP2	4.1303	6.6651	3.7582	14.091
B-CPAP	GDSC1; GDSC2; CTRP2	4.1858	6.6744	3.8148	13.719
8505C	GDSC1; GDSC2; CTRP2	4.4502	8.3073	3.4119	14.5779
CAL-62	GDSC1; GDSC2; CTRP2	4.6041	6.9316	4.1652	11.2079
ASH-3	GDSC1; GDSC2	4.6412	7.2865	2.3014	3.3629
TT	GDSC1; GDSC2; CTRP2	4.8887	8.6303	3.696	12.351
FTC-133	GDSC1; GDSC2; CTRP2	5.4516	9.6267	3.738	10.8964
BHT-101	GDSC1; GDSC2; CTRP2	7.2527	9.981	4.9688	2.652
WRO	GDSC1; GDSC2	7.5526	18.7432	-1.2122	15.0918

Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
PCI-06A	GDSC1; GDSC2	0.949	4.42	0.3672	25.966
HO-1-N-1	GDSC1; GDSC2	1.3289	2.53	1.3011	19.4447
BB30-HNC	GDSC1; GDSC2	1.9575	4.5678	1.374	16.3824
DOK	GDSC1; GDSC2	2.2738	5.9036	1.0795	16.9046
PCI-38	GDSC1	2.3807	5.2221	-0.1015	4.7652
BB49-HNC	GDSC1	2.4336	4.9052	0.0731	3.4636
CAL-27	GDSC1; GDSC2; CTRP2	2.5671	7.8438	1.6417	26.4129
JHU-011	GDSC1; GDSC2	2.742	7.4434	0.7599	17.1506
OSC-20	GDSC1; GDSC2	2.8005	6.8742	1.0945	15.0621
BICR 18	CTRP2	3.0544	10.2889	1.1071	26.7895
PCI-15A	GDSC1; GDSC2	3.2883	7.6411	1.1343	13.3607
YD-8	CTRP2	3.3319	5.7809	3.1517	18.6954
PCI-04B	GDSC1; GDSC2	3.6122	8.1045	1.1681	12.2631
NCI-H3118	GDSC1; GDSC2	3.7934	8.6921	1.0189	12.6384
Ca9-22	GDSC1; GDSC2	3.8363	6.6177	2.0806	6.258
KON	GDSC1; GDSC2	3.877	11.1491	-0.1392	18.4723
PE/CA-PJ34 (clone C12)	CTRP2	3.9929	6.4223	3.692	14.7378
KOSC-2	GDSC1; GDSC2	4.0821	10.9566	0.1181	16.6859
BICR 78	GDSC1; GDSC2	4.0868	9.0634	1.0611	11.6522
HSC-2	GDSC1; GDSC2; CTRP2	4.1237	7.4013	3.4682	15.2159
SCC-15	GDSC1; GDSC2	4.1261	8.5014	1.368	9.7955
OSC-19	GDSC1; GDSC2	4.1386	6.5049	2.3488	4.0082
SCC-25	GDSC1; GDSC2; CTRP2	4.1414	7.1492	3.5881	14.7056
BICR 10	GDSC1; GDSC2	4.2091	8.8131	1.276	10.1291
UPCI-SCC-090	GDSC1; GDSC2	4.4452	8.3992	1.6476	7.4485
PE/CA-PJ49	CTRP2	4.4616	6.857	4.0429	12.0727
HO-1-u-1	GDSC1; GDSC2	4.5379	8.2554	1.7802	6.4898
SAS	GDSC1; GDSC2	4.5951	9.2349	1.3475	8.8448
SKN-3	GDSC1; GDSC2	4.6653	7.3354	2.2935	3.366
LB771-HNC	GDSC1; GDSC2	4.6872	13.4027	-0.6308	18.6221
PE/CA-PJ15	GDSC1; GDSC2; CTRP2	4.7335	7.0196	4.266	10.464
PCI-30	GDSC1; GDSC2	4.7409	9.7825	1.1842	9.448
Detroit 562	GDSC1; GDSC2; CTRP2	4.8436	10.0403	2.9748	15.3783
SAT [Human HNSCC]	GDSC1; GDSC2	4.9239	15.1307	-1.3064	20.7715
BHY	GDSC1; GDSC2; CTRP2	4.9363	7.8425	4.1116	10.5506
JHU-029	GDSC1; GDSC2	4.9561	13.3772	-0.4173	17.0533
YD-10B	CTRP2	4.9764	8.8318	3.6844	12.1896
JHU-022	GDSC1; GDSC2	5.0038	12.4326	0.0809	14.6329
SCC-4	GDSC1; GDSC2; CTRP2	5.164	9.7714	3.4044	12.9052
FaDu	GDSC1; GDSC2; CTRP2	5.4089	9.6917	3.6674	11.2815
CAL-33	GDSC1; GDSC2; CTRP2	5.5253	9.7891	3.7236	10.7982
BICR 16	CTRP2	5.5936	9.7896	3.784	10.4025
SCC-9	GDSC1; GDSC2; CTRP2	5.6855	10.1293	3.6957	10.5779
SNU-1076	CTRP2	5.6948	9.4473	4.0434	9.1087
BICR 6	CTRP2	5.712	10.4557	3.5559	11.1036
BICR 56	CTRP2	5.7462	11.7388	2.945	13.5325
HSC-4	GDSC1; GDSC2; CTRP2	5.8745	10.4567	3.6951	10.1967
SNU-1214	CTRP2	6.6636	9.9975	4.5572	5.1528
PE/CA-PJ41 (clone D2)	CTRP2	6.9226	12.6934	3.4204	9.4053
SNU-46	CTRP2	7.0254	11.0174	4.3204	5.5562
BICR 22	GDSC1; GDSC2; CTRP2	7.2234	14.8024	2.605	12.1256
SNU-899	CTRP2	7.4739	10.4299	4.8974	2.6604
HSC-3	GDSC1; GDSC2; CTRP2	7.9943	12.4401	4.2887	4.3532
SNU-1066	CTRP2	8.2294	9.5091	5.6339	0.0901
SNU-1041	CTRP2	8.4887	12.26	4.6596	2.4661
BICR 31	GDSC2; CTRP2	9.9819	23.1378	0.5149	15.0019

Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JMSU-1	CTRP2	0.0898	3.1738	0.05	39.7893
UM-UC-1	CTRP2	0.2313	5.5474	-0.1711	39.7676
RT-112	GDSC1; GDSC2; CTRP2	1.4338	5.8601	1.0619	31.9357
5637	GDSC1; GDSC2; CTRP2	1.9448	3.7055	1.9353	27.3437
U-BLC1	CTRP2	2.4884	8.7656	1.1888	28.1656
RT-4	GDSC1; GDSC2; CTRP2	3.2675	10.2865	1.3222	25.4942
SW780	GDSC1; GDSC2	3.7439	7.739	1.4544	10.2367
CAL-29	GDSC1; GDSC2	3.8209	7.5277	1.619	9.0635
647V	GDSC1; GDSC2; CTRP2	3.9426	8.6925	2.7248	18.5863
253J	CTRP2	4.1395	6.5703	3.8014	13.9024
VM-CUB-1	CTRP2	4.3817	7.687	3.6172	13.9424
TCCSUP	GDSC1; GDSC2; CTRP2	4.3861	8.4412	3.2866	15.239
BFTC-905	GDSC1; GDSC2; CTRP2	4.6259	6.9464	4.1823	11.0819
UM-UC-3	GDSC1; GDSC2; CTRP2	4.6265	7.2485	4.0586	11.5608
639V	GDSC1; GDSC2; CTRP2	4.844	8.1928	3.8579	11.8029
J82	GDSC1; GDSC2; CTRP2	4.8446	9.7354	3.1236	14.7778
SW1710	GDSC1; GDSC2; CTRP2	4.8886	8.6447	3.6891	12.3793
KMBC-2	CTRP2	4.8993	9.7564	3.165	14.4831
253J-BV	CTRP2	4.9543	8.8436	3.6576	12.351
HT-1197	GDSC1; CTRP2	5.1347	7.4912	4.4713	8.6068
BC-3C	CTRP2	5.151	8.9233	3.8063	11.2838
T24	GDSC1; GDSC2; CTRP2	5.4318	11.7197	2.6813	15.2407
HT-1376	GDSC1; GDSC2; CTRP2	5.8067	9.6779	4.0259	8.952
SCaBER	CTRP2	6.422	16.8351	0.9604	19.4475
KU-19-19	GDSC1; GDSC2; CTRP2	7.1047	12.0105	3.8922	7.1827

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NEC8	GDSC1; GDSC2	-0.1264	3.0966	-0.3822	34.5704
NT2-D1	GDSC1; GDSC2	0.4499	2.5827	0.3541	28.2956
TC-YIK	GDSC1; GDSC2	1.05	2.7371	0.9742	22.3864
PWR-1E	GDSC1; GDSC2	1.4455	5.5496	0.4191	23.6299
MS751	GDSC1; GDSC2	1.9004	5.0559	1.1022	18.1408
SW954	GDSC1; GDSC2	1.9473	4.3499	1.4548	15.9666
CAL-39	GDSC1; GDSC2	2.6889	5.5158	1.6612	12.0728
C-33 A	GDSC1; GDSC2	2.7412	5.5107	1.7125	11.5934
DSH1	GDSC1; GDSC2	2.9355	5.0103	2.1374	8.4031
HeLa	GDSC1; GDSC2; CTRP2	3.3428	8.2389	2.3025	21.8054
Ca Ski	GDSC1; GDSC2	3.3609	7.5658	1.2324	12.5812
SW756	GDSC1; GDSC2	3.4006	48.8577	-19.3804	43.734
BPH-1	GDSC1; GDSC2	3.4446	7.6516	1.2584	12.194
OV17R	GDSC1; GDSC2	3.5096	8.3332	0.9709	13.6758
NCC-IT	GDSC2	3.5256	7.7581	1.2712	12.3056
JEG-3	GDSC1; GDSC2	3.5695	8.7235	0.8246	14.3346
JAR	GDSC1; GDSC2	3.5868	6.415	1.9902	7.4231
PA-1	GDSC1; GDSC2	3.637	7.3237	1.5772	9.7841
HEC-1	GDSC1; GDSC2	3.6821	7.1488	1.6997	8.9325
UWB1.289	GDSC1; GDSC2	3.6996	6.1168	2.2254	5.7141
LB831-BLC	GDSC1; GDSC2	3.7187	6.1485	2.2241	5.675
SKN	GDSC1; GDSC2	3.7225	18.6734	-4.0226	31.3881
SKG-IIIa	GDSC1; GDSC2	3.8488	5.8847	2.4487	4.0277
HT-3	GDSC1; GDSC2	3.9639	6.5224	2.22	5.1322
SiHa	GDSC1; GDSC2	3.9804	7.1448	1.9276	6.8364
ME-180	GDSC1; GDSC2	4.2441	8.8862	1.266	10.1039
KGN	GDSC1; GDSC2	4.2642	7.0647	2.1656	4.818
SiSo	GDSC1; GDSC2	4.3231	8.8203	1.3559	9.4038
DoTc2 4510	GDSC1; GDSC2	4.3425	6.9045	2.293	3.9349
ACC-OV7	GDSC1; GDSC2	4.5225	9.6035	1.1168	10.3067
HEY	GDSC1; GDSC2	4.5327	29.7867	-8.9155	36.6918
OVCA420	GDSC1; GDSC2	4.662	7.0131	2.4373	2.6062
SW962	GDSC1; GDSC2	4.7036	8.1086	1.9588	5.1508
OVMIU	GDSC1; GDSC2	5.0056	7.9043	2.2351	3.1447
OMC-1 [Human cervical carcinoma]	GDSC1; GDSC2	5.2602	7.734	2.4451	1.794
C-4-I	GDSC1; GDSC2	5.2623	17.0512	-2.0003	22.4401
OVCA433	GDSC1; GDSC2	5.2921	11.6975	0.6406	11.202
PEO1	GDSC1; GDSC2	5.4437	12.6938	0.2647	12.7771
JHOS-3	GDSC1; GDSC2	6.2521	8.0022	2.7598	0.1925

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Axitinib (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Axitinib and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[10]
Ivosidenib	DM8S6T7	Moderate	Increased metabolism of Axitinib caused by Ivosidenib mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[11]
Arn-509	DMT81LZ	Major	Increased metabolism of Axitinib caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[11]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Axitinib and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[12]
Pexidartinib	DMS2J0Z	Major	Increased metabolism of Axitinib caused by Pexidartinib mediated induction of CYP450 enzyme.	Bone/articular cartilage neoplasm [2F7B]	[11]
Tucatinib	DMBESUA	Major	Decreased metabolism of Axitinib caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[10]
Osilodrostat	DMIJC9X	Moderate	Decreased metabolism of Axitinib caused by Osilodrostat mediated inhibition of CYP450 enzyme.	Cushing syndrome [5A70]	[13]
Lumacaftor	DMCLWDJ	Major	Increased metabolism of Axitinib caused by Lumacaftor mediated induction of CYP450 enzyme.	Cystic fibrosis [CA25]	[11]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Axitinib caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[13]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Axitinib caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[13]
SODIUM CITRATE	DMHPD2Y	Minor	Decreased absorption of Axitinib due to altered gastric pH caused by SODIUM CITRATE.	Discovery agent [N.A.]	[14]
Eslicarbazepine	DMZREFQ	Moderate	Increased metabolism of Axitinib caused by Eslicarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[11]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Axitinib and Cannabidiol.	Epileptic encephalopathy [8A62]	[13]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Axitinib caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[11]
Boceprevir	DMBSHMF	Major	Decreased metabolism of Axitinib caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[10]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Axitinib and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[15]
Cobicistat	DM6L4H2	Major	Decreased metabolism of Axitinib caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[10]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Axitinib and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[16]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Axitinib and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[17]
Levamlodipine	DM92S6N	Moderate	Decreased metabolism of Axitinib caused by Levamlodipine mediated inhibition of CYP450 enzyme.	Hypertension [BA00-BA04]	[13]
Lesinurad	DMUR64T	Moderate	Increased metabolism of Axitinib caused by Lesinurad mediated induction of CYP450 enzyme.	Inborn purine/pyrimidine/nucleotide metabolism error [5C55]	[11]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Axitinib caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[13]
Suvorexant	DM0E6S3	Moderate	Decreased metabolism of Axitinib caused by Suvorexant mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[13]
Crizotinib	DM4F29C	Moderate	Decreased metabolism of Axitinib caused by Crizotinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
Ceritinib	DMB920Z	Major	Decreased metabolism of Axitinib caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[10]
Selpercatinib	DMZR15V	Moderate	Decreased metabolism of Axitinib caused by Selpercatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[13]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Axitinib and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[18]
Idelalisib	DM602WT	Major	Decreased metabolism of Axitinib caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[10]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Axitinib caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[13]
Vemurafenib	DM62UG5	Moderate	Increased metabolism of Axitinib caused by Vemurafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[11]
Dabrafenib	DMX6OE3	Major	Increased metabolism of Axitinib caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[11]
Fedratinib	DM4ZBK6	Moderate	Decreased metabolism of Axitinib caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[13]
Netupitant	DMEKAYI	Moderate	Decreased metabolism of Axitinib caused by Netupitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[13]
Entrectinib	DMMPTLH	Moderate	Decreased metabolism of Axitinib caused by Entrectinib mediated inhibition of CYP450 enzyme.	Non-small cell lung cancer [2C25]	[13]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Axitinib caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[13]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Axitinib caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[19]
Lefamulin	DME6G97	Moderate	Decreased metabolism of Axitinib caused by Lefamulin mediated inhibition of CYP450 enzyme.	Pneumonia [CA40]	[20]
Enzalutamide	DMGL19D	Major	Increased metabolism of Axitinib caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[11]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Axitinib caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[13]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Axitinib caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[13]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Axitinib caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
LEE011	DMMX75K	Moderate	Decreased metabolism of Axitinib caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Axitinib caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[21]
Brilinta	DMBR01X	Moderate	Decreased metabolism of Axitinib caused by Brilinta mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[13]
Elagolix	DMB2C0E	Moderate	Increased metabolism of Axitinib caused by Elagolix mediated induction of CYP450 enzyme.	Uterine fibroid [2E86]	[11]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Carmellose sodium	E00625	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Axitinib 1 mg tablet	1 mg	Oral Tablet	Oral
Axitinib 5 mg tablet	5 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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• [2] BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
• [3] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [4] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [5] Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55.
• [6] Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25.
• [7] Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. Arch Toxicol. 2022 Jul;96(7):1975-1987. doi: 10.1007/s00204-022-03291-5. Epub 2022 Apr 18.
• [8] Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
• [9] MEK inhibition abrogates sunitinib resistance in a renal cell carcinoma patient-derived xenograft model. Br J Cancer. 2016 Oct 11;115(8):920-928. doi: 10.1038/bjc.2016.263. Epub 2016 Aug 25.
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• [11] Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
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• [13] Cerner Multum, Inc. "UK Summary of Product Characteristics.".
• [14] Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
• [15] Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
• [16] Canadian Pharmacists Association.
• [17] Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
• [18] Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
• [19] Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
• [20] Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
• [21] Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.